OA11351A - Use of antifungal agents for the topical treatmentof fungus-induced mucositis. - Google Patents
Use of antifungal agents for the topical treatmentof fungus-induced mucositis. Download PDFInfo
- Publication number
- OA11351A OA11351A OA1200000119A OA1200000119A OA11351A OA 11351 A OA11351 A OA 11351A OA 1200000119 A OA1200000119 A OA 1200000119A OA 1200000119 A OA1200000119 A OA 1200000119A OA 11351 A OA11351 A OA 11351A
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- OA
- OAPI
- Prior art keywords
- formulation
- mammal
- fungus
- induced
- antifungal
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Applications Claiming Priority (5)
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| US6270997P | 1997-10-22 | 1997-10-22 | |
| US6341497P | 1997-10-28 | 1997-10-28 | |
| US6341897P | 1997-10-28 | 1997-10-28 | |
| US8327298P | 1998-04-28 | 1998-04-28 | |
| US8639798P | 1998-05-22 | 1998-05-22 |
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| OA11351A true OA11351A (en) | 2003-12-18 |
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| OA1200000119A OA11351A (en) | 1997-10-22 | 2000-04-20 | Use of antifungal agents for the topical treatmentof fungus-induced mucositis. |
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| US (9) | US20010006944A1 (sk) |
| EP (2) | EP1857113A3 (sk) |
| JP (3) | JP2001520188A (sk) |
| KR (4) | KR100883149B1 (sk) |
| CN (1) | CN1143679C (sk) |
| AP (1) | AP2000001805A0 (sk) |
| AT (1) | ATE371457T1 (sk) |
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| BG (1) | BG104371A (sk) |
| BR (1) | BR9814615A (sk) |
| CA (1) | CA2308201C (sk) |
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| HK (1) | HK1029935A1 (sk) |
| HU (1) | HUP0004170A3 (sk) |
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| PT (1) | PT1024814E (sk) |
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| US6844004B2 (en) | 1997-08-15 | 2005-01-18 | Board Of Regents, The University Of Texas System | Topical formulations of natamycin/pimaricin |
| US6045815A (en) * | 1997-08-15 | 2000-04-04 | Board Of Regents, The University Of Texas System | Parenteral pimaricin as treatment of systemic infections |
| PT1024814E (pt) * | 1997-10-22 | 2007-11-29 | Mayo Foundation | Utilização de agentes antifúngicos para o tratamento tópico de mucosite induzida por fungo |
| GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| WO2001001955A1 (en) * | 1999-07-02 | 2001-01-11 | Janssen Pharmaceutica N.V. | Nasal formulation of an antifungal |
| US6576224B1 (en) | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US20020061281A1 (en) * | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| SE521431C2 (sv) * | 1999-12-02 | 2003-11-04 | Sca Hygiene Prod Ab | Användning av en pH-buffrande substans för att förhindra hudinfektioner orsakade av Candida Albicans |
| US6930125B2 (en) * | 2000-01-14 | 2005-08-16 | John F. Hunt | Airway alkalinization as a therapy for airway diseases |
| WO2001060395A2 (en) * | 2000-02-18 | 2001-08-23 | Eli Lilly And Company | Methods of treatment for non-invasive fungus-induced mucositis with cyclohexapeptide antifungal agents |
| US7048953B2 (en) * | 2000-04-03 | 2006-05-23 | Inhalation, Inc. | Methods and apparatus to prevent, treat and cure infections of the human respiratory system by pathogens causing severe acute respiratory syndrome (SARS) |
| US7150888B1 (en) | 2000-04-03 | 2006-12-19 | Inhalation, Inc. | Methods and apparatus to prevent colds, influenzaes, tuberculosis and opportunistic infections of the human respiratory system |
| US8404217B2 (en) * | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US6767537B2 (en) | 2000-05-26 | 2004-07-27 | Phil Arnold Nicolay | Composition and method for the treatment of sinusitis |
| WO2002007682A1 (en) * | 2000-07-26 | 2002-01-31 | Vyden John K | Methods for treating atopic disorders |
| WO2002022118A1 (de) * | 2000-09-14 | 2002-03-21 | Waldemar Gottardi | Fungizides mittel enthaltend n-chlortaurin sowie dessen verwendung |
| WO2002041837A2 (en) * | 2000-11-22 | 2002-05-30 | Rxkinetix, Inc. | Treatment of mucositis |
| CA2432319A1 (en) | 2000-12-21 | 2002-07-18 | Nektar Therapeutics | Pulmonary delivery of polyene antifungal agents |
| US7770577B2 (en) * | 2001-05-15 | 2010-08-10 | Gregory E Conner | Methods and devices for treating lung dysfunction |
| JPWO2002098463A1 (ja) * | 2001-06-05 | 2004-09-16 | 財団法人新産業創造研究機構 | 抗真菌組成物 |
| US7244703B2 (en) * | 2001-06-22 | 2007-07-17 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for peptide treatment |
| AUPS017702A0 (en) * | 2002-01-25 | 2002-02-14 | Atopic Pty Ltd | Methods and compositions for the treatment of asthma and related disorders |
| US20040019316A1 (en) * | 2002-03-13 | 2004-01-29 | Morris John K. | Nasal airway delivery, decongestion system (NADDS) |
| AU2003259028A1 (en) * | 2002-06-10 | 2003-12-22 | Combinatorx, Incorporated | Combinations for the treatment of rheumatoid arthritis |
| NZ537186A (en) * | 2002-06-20 | 2006-10-27 | Novartis Consumer Health S | Nasal compositions comprising a mucopolysaccharide and propylene glycol |
| US20050032896A1 (en) * | 2002-06-21 | 2005-02-10 | Liisa Neumann | Use of synthetic retinoic acid in form of 13-cis vitamin A for treatment of autism |
| WO2004004700A1 (en) * | 2002-07-02 | 2004-01-15 | Novartis Ag | Methods for the treatment of sinusitis |
| US20040029893A1 (en) * | 2002-07-23 | 2004-02-12 | Lane Edward M. | Method of treatment of non-invasive mucositis |
| PT1539157E (pt) | 2002-09-18 | 2013-10-04 | Univ Pennsylvania | Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal |
| US7879351B2 (en) * | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
| SI2363114T1 (sl) * | 2002-10-29 | 2015-07-31 | Insmed Incorporated | Zadržano sproščanje antiinfektivov |
| US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
| WO2005000195A2 (en) * | 2002-11-13 | 2005-01-06 | Rosenberg Yvonne J | A pretreatment or post exposure treatment for exposure to a toxic substance by pulmonary delivery (inhaler) of a bioscavenger |
| US6890323B1 (en) * | 2002-12-03 | 2005-05-10 | University Of Florida | Small volume effusion trap |
| AU2003302274A1 (en) * | 2002-12-31 | 2004-07-29 | Novartis Ag | Aerosolizable pharmaceutical formulation for fungal infection therapy |
| WO2004082525A2 (en) * | 2003-03-14 | 2004-09-30 | Sinexus, Inc. | Sinus delivery of sustained release therapeutics |
| US7811606B2 (en) * | 2003-04-16 | 2010-10-12 | Dey, L.P. | Nasal pharmaceutical formulations and methods of using the same |
| US9808471B2 (en) | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
| US8912174B2 (en) | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
| US20050043251A1 (en) * | 2003-08-20 | 2005-02-24 | Fairfield Clinical Trials, Llc | Method of treatment of otitis externa |
| US20070078116A1 (en) * | 2003-08-20 | 2007-04-05 | Fairfield Clinical Trials, Llc | Method of treatment of otitis externa |
| US20050159369A1 (en) * | 2003-08-20 | 2005-07-21 | Qtm Llc | Method of treatment of otitis externa |
| US8192733B2 (en) | 2003-08-29 | 2012-06-05 | Cobb & Associates | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
| US7731976B2 (en) * | 2003-08-29 | 2010-06-08 | Cobb And Company, Llp | Treatment of irritable bowel syndrome using probiotic composition |
| US20060177424A1 (en) * | 2003-08-29 | 2006-08-10 | Cobb Mark L | Treatment of disease states and adverse physiological conditions utilizing anti-fungal compositions |
| US7759105B2 (en) * | 2003-08-29 | 2010-07-20 | Cobb & Company, Llp | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
| US7749509B2 (en) * | 2003-08-29 | 2010-07-06 | Cobb And Company, Llp | Treatment of autism using probiotic composition |
| AU2004270266B2 (en) * | 2003-09-09 | 2011-02-10 | 3M Innovative Properties Company | Concentrated antimicrobial compositions and methods |
| EP1662873B1 (en) * | 2003-09-09 | 2016-01-13 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| US9072728B2 (en) * | 2003-09-18 | 2015-07-07 | Children's Medical Center Corporation | Treatment of severe distal colitis |
| KR100978717B1 (ko) * | 2003-12-08 | 2010-08-30 | 씨펙스 파마슈티칼스, 인코포레이티드 | 인슐린 치료를 위한 약제 조성물 및 방법 |
| US20070190124A1 (en) * | 2004-06-07 | 2007-08-16 | Jie Zhang | Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs |
| US20070196325A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Compositions and methods for dermally treating infections |
| US20070189978A1 (en) * | 2004-06-07 | 2007-08-16 | Jie Zhang | Compositions and methods for dermally treating musculoskeletal pain |
| US20070196452A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Flux-enabling compositions and methods for dermal delivery of drugs |
| US8741332B2 (en) * | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for dermally treating neuropathic pain |
| US20070196457A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more volatile solvent-containing compositions and methods for dermal delivery of drugs |
| US20070196293A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Compositions and methods for treating photo damaged skin |
| US8907153B2 (en) | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
| US20070196453A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more non-volatile solvent-containing compositions and methods for dermal delivery of drugs |
| US20080019927A1 (en) * | 2004-06-07 | 2008-01-24 | Jie Zhang | Compositions and methods for dermally treating neuropathy with minoxidil |
| US8741333B2 (en) * | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
| US20060009424A1 (en) * | 2004-07-06 | 2006-01-12 | Anatoly Kogan | Nasaleaze |
| UA89793C2 (uk) * | 2004-08-13 | 2010-03-10 | Шерінг-Плау Лтд. | Фармацевтична композиція, яка містить антибіотик, триазол і кортикостероїд |
| US20060051384A1 (en) * | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Antiseptic compositions and methods of use |
| US8198326B2 (en) * | 2004-09-07 | 2012-06-12 | 3M Innovative Properties Company | Phenolic antiseptic compositions and methods of use |
| US9028852B2 (en) * | 2004-09-07 | 2015-05-12 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
| US8109981B2 (en) | 2005-01-25 | 2012-02-07 | Valam Corporation | Optical therapies and devices |
| KR100675379B1 (ko) * | 2005-01-25 | 2007-01-29 | 삼성전자주식회사 | 프린팅 시스템 및 프린팅 방법 |
| EP1848431B1 (en) | 2005-02-09 | 2016-02-03 | Santen Pharmaceutical Co., Ltd. | Liquid formulations for treatment of diseases or conditions |
| EP3025704B1 (en) * | 2005-03-10 | 2019-01-16 | 3M Innovative Properties Company | Methods of reducing microbial contamination |
| WO2006099325A2 (en) * | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of treating ear infections |
| US20060204558A1 (en) * | 2005-03-10 | 2006-09-14 | Kantner Steven S | Antimicrobial pet wipes and methods |
| US20060229364A1 (en) * | 2005-03-10 | 2006-10-12 | 3M Innovative Properties Company | Antiviral compositions and methods of use |
| WO2006099358A2 (en) * | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Antimicrobial compositions comprising esters of hydroxycarboxylic acids |
| CN101189016B (zh) | 2005-04-04 | 2013-03-27 | 因特尔赛克特耳鼻喉公司 | 治疗鼻窦病症的装置 |
| WO2006119292A2 (en) * | 2005-04-29 | 2006-11-09 | Henkin, Robert | Methods for detection of biological substances |
| US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
| WO2007038466A2 (en) * | 2005-09-27 | 2007-04-05 | Cobb & Company | Treatment of bipolar disorder utilizing anti-fungal compositions |
| ITRM20050561A1 (it) * | 2005-11-10 | 2007-05-11 | D M G Italia S R L | Soluzione otologica e metodo per la sua preparazione. |
| PT1965787E (pt) * | 2005-11-30 | 2013-07-05 | Endo Pharmaceuticals Inc | Tratamento de xerostomia com um antioxidante que contém enxofre |
| PL1962805T3 (pl) | 2005-12-08 | 2017-01-31 | Insmed Incorporated | Kompozycje środków przeciwzapalnych oparte na lipidach do leczenia infekcji płucnych |
| WO2007070661A2 (en) * | 2005-12-13 | 2007-06-21 | Naryx Pharma, Inc. | Methods of measuring symptoms of chronic rhinosinusitis |
| WO2007092620A2 (en) | 2006-02-09 | 2007-08-16 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
| US20070219600A1 (en) * | 2006-03-17 | 2007-09-20 | Michael Gertner | Devices and methods for targeted nasal phototherapy |
| ES2563288T3 (es) | 2006-03-23 | 2016-03-14 | Santen Pharmaceutical Co., Ltd | Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular |
| US20100190735A1 (en) * | 2006-03-28 | 2010-07-29 | Myrex Pharmaceuticals Inc. | Mouthwash and Method of Using Same for the Treatment of Mucositis or Stomatitis |
| ES2668554T3 (es) * | 2006-04-06 | 2018-05-18 | Insmed Incorporated | Métodos para la encapsulación liposomal inducida por coacervación y sus formulaciones |
| US20070280972A1 (en) * | 2006-04-25 | 2007-12-06 | Zars, Inc. | Adhesive solid gel-forming formulations for dermal drug delivery |
| US20070286812A1 (en) * | 2006-06-09 | 2007-12-13 | Toutounghi Camille | Nasal formulation |
| US20070286813A1 (en) * | 2006-06-09 | 2007-12-13 | Toutounghi Camille | Nasal formulation |
| US8535707B2 (en) | 2006-07-10 | 2013-09-17 | Intersect Ent, Inc. | Devices and methods for delivering active agents to the osteomeatal complex |
| WO2008008494A2 (en) * | 2006-07-13 | 2008-01-17 | Accentia Biopharmaceuticals, Inc. | Methods and compositions for treating mucosal inflammation |
| US20080075793A1 (en) * | 2006-09-21 | 2008-03-27 | Dunshee Wayne K | Antiviral compositions and methods of use |
| US20080107723A1 (en) * | 2006-09-28 | 2008-05-08 | Perkins Walter R | Methods of Treating Pulmonary Distress |
| EP2079306A4 (en) * | 2006-10-03 | 2009-12-30 | Accentia Biopharmaceuticals In | NON-MOLECULE-BREAKING AMPHOTERICIN B FORMULATIONS AND METHOD FOR TREATING NON-INVASIVE PULSE-INDUCED MUCOSITIS |
| BRPI0716325A2 (pt) | 2006-10-27 | 2014-03-04 | 3M Innovative Properties Co | Composição antimicrobianas |
| US20110146671A1 (en) * | 2006-12-01 | 2011-06-23 | James Zhou Liu | Pharmaceutical compositions and methods of delivering the same |
| WO2008095136A2 (en) | 2007-01-31 | 2008-08-07 | Henkin Robert I | Methods for detection of biological substances |
| ES2492943T3 (es) * | 2007-04-30 | 2014-09-10 | Glaxosmithkline Llc | Procedimientos de administración de anticuerpos anti-IL5 |
| WO2008137717A1 (en) | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
| US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| US9114081B2 (en) * | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
| DK2231065T3 (da) | 2007-12-18 | 2021-02-01 | Intersect Ent Inc | Selvekspanderende anordninger |
| CN101214221A (zh) * | 2007-12-27 | 2008-07-09 | 黄明 | 治疗鼻炎鼻窦炎药物制剂 |
| US9314524B2 (en) * | 2007-12-31 | 2016-04-19 | Calla Therapeutics Llc | Topical formulations of Flucytosine |
| AU2009228163B2 (en) | 2008-03-28 | 2012-08-30 | Glaxosmithkline Llc | Methods of treatment |
| WO2009146104A1 (en) * | 2008-04-02 | 2009-12-03 | Accentia Biopharmaceuticals, Inc. | Formulations, devices and methods for treating and preventing mucositis |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| RU2499592C2 (ru) | 2008-04-21 | 2013-11-27 | Отономи, Инк. | Фармацевтическая композиция для лечения ушных заболеваний |
| RU2469726C2 (ru) | 2008-05-14 | 2012-12-20 | Отономи, Инк. | Композиции с контролируемым высвобождением на основе кортикостероидов для лечения ушных болезней |
| KR101367479B1 (ko) * | 2008-07-21 | 2014-03-14 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 귀 질병 치료를 위한 제어 방출형 항미생물성 조성물 및 방법 |
| US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
| US8580801B2 (en) * | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
| AU2009276505B2 (en) | 2008-08-01 | 2015-04-23 | Intersect Ent, Inc. | Methods and devices for crimping self-expanding devices |
| EP2429624B1 (en) | 2009-05-15 | 2014-04-02 | Intersect ENT, Inc. | A combination of an expandable device and a delivery device. |
| WO2011100170A1 (en) * | 2010-02-10 | 2011-08-18 | Albert Cha | Nasal irrigation systems |
| US20120003300A1 (en) * | 2010-06-30 | 2012-01-05 | Pangaea Laboratories Ltd | Composition Comprising Vascular Endothelial Growth Factor (VEGF) for the Treatment of Hair Loss |
| US9669044B2 (en) | 2010-12-14 | 2017-06-06 | Utah State University | Aminoglycoside and azole compositions and methods |
| CN110075310A (zh) * | 2011-12-20 | 2019-08-02 | 维奥姆治疗有限公司 | 用于治疗真菌感染的局部油组合物 |
| CN108743537B (zh) | 2012-05-21 | 2021-06-11 | 英斯麦德公司 | 治疗肺部感染的系统 |
| RU2018135921A (ru) | 2012-11-29 | 2019-02-05 | Инсмед Инкорпорейтед | Стабилизированные составы ванкомицина |
| EP3636227A1 (en) | 2013-03-14 | 2020-04-15 | Intersect ENT, Inc. | Systems and devices for treating a sinus condition |
| EP2996471A4 (en) * | 2013-05-17 | 2016-12-28 | Univ Utah State | AMINOGLYCOSIDE AND AZOL COMPOSITIONS AND METHODS |
| CN104208701A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 含有抗真菌药物的复方吸入制剂 |
| FR3009622B1 (fr) * | 2013-08-09 | 2015-08-07 | Novacyt | Procede et dispositif de lavage d'un dispositif de pipetage-distribution |
| CA2921816A1 (en) | 2013-08-27 | 2015-03-05 | Otonomy, Inc. | Treatment of pediatric otic disorders |
| US10598672B2 (en) | 2014-02-18 | 2020-03-24 | Cyrano Therapeutics, Inc. | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell |
| ES2755941T3 (es) | 2014-05-15 | 2020-04-24 | Insmed Inc | Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas |
| LT3221308T (lt) * | 2014-11-21 | 2018-12-27 | F2G Limited | Priešgrybeliniai agentai |
| US20180071281A1 (en) * | 2016-08-19 | 2018-03-15 | Gerbe Labs Inc. | Treating chronic rhinosinusitis |
| EP3512513A4 (en) | 2016-09-16 | 2020-04-15 | Otonomy, Inc. | GEL FORMULA FOR THE EAR FOR TREATING OTITIS EXTERNA |
| CA3064859A1 (en) | 2017-06-06 | 2018-12-13 | Glaxosmithkline Llc | Biopharmaceutical compositions and methods for pediatric patients |
| JP2021517558A (ja) * | 2018-03-19 | 2021-07-26 | シェオ ファーマスーティカルズ | 特発性肺線維症を治療するための方法および組成物 |
| WO2019191627A1 (en) | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| CN111249219B (zh) * | 2018-11-30 | 2023-08-11 | 中南大学湘雅三医院 | 治疗耳道真菌的滴耳液及其制备方法 |
| CA3130138A1 (en) * | 2019-02-27 | 2020-09-03 | Oticara, Inc. | Method for treating nasal, sinonasal, and nasopharyngeal tissue infection and/or inflammation |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| DE2350315C2 (de) * | 1973-10-06 | 1984-01-12 | Johnson & Johnson GmbH, 4000 Düsseldorf | Pharmazeutische und kosmetische Präparate zur äußerlichen Anwendung |
| US4209447A (en) | 1975-01-27 | 1980-06-24 | Janssen Pharmaceutica N.V. | Imidazole derivatives and intermediates in their preparation |
| US3991750A (en) | 1975-04-28 | 1976-11-16 | Syntex Corporation | Dromostanolone propionate implant pellet useful for producing weight gains in animals and suppressing estrus in female animals |
| US4402957A (en) | 1979-04-04 | 1983-09-06 | Janssen Pharmaceutica N.V. | Heterocyclic derivatives of [4-(piperazin-1-ylphenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| US4334538A (en) | 1979-12-12 | 1982-06-15 | Juhn Steven K | Aspirator for collecting liquid samples |
| US4432991A (en) | 1981-07-13 | 1984-02-21 | American Cyanamid Company | Therapeutically active 3-amino-1-phenyl(and substituted phenyl)-2-pyrazolines |
| US4883785A (en) | 1984-07-27 | 1989-11-28 | Chow Wing Sun | Complex of anti-fungal agent and cyclodextrin and method |
| US4916134A (en) | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
| US5487739A (en) | 1987-11-17 | 1996-01-30 | Brown University Research Foundation | Implantable therapy systems and methods |
| US5075309A (en) | 1989-06-09 | 1991-12-24 | Janssen Pharmaceutica N.V. | Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones |
| US5080899A (en) | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
| US5310545A (en) * | 1991-04-11 | 1994-05-10 | Drore Eisen | Method of treatment using mouthwashes containing steroids and antifungal agents and compositions of matter |
| US5248504A (en) | 1992-03-02 | 1993-09-28 | Friedman William H | Method of treatment for nasal and sinus dysfunction |
| ATE210969T1 (de) | 1992-09-10 | 2002-01-15 | Childrens Medical Center | Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika |
| CA2106034A1 (en) | 1992-09-24 | 1994-03-25 | Ralph J. Russo | 21-norrapamycin |
| US5654293A (en) | 1993-01-21 | 1997-08-05 | Janssen Pharmaceutica N.V. | Topical oil-in-water emulsion compositions containing ketoconazole and an acetonide glucocorticosteroid |
| RU2128053C1 (ru) | 1993-03-19 | 1999-03-27 | Налепо Лидия Филимоновна | Средство для лечения бронхиальной астмы (варианты) |
| PH31594A (en) | 1993-09-30 | 1998-11-03 | Janssen Pharmaceutica Nv | Oral formulations on an antifungal. |
| US5582167A (en) | 1994-03-02 | 1996-12-10 | Thomas Jefferson University | Methods and apparatus for reducing tracheal infection using subglottic irrigation, drainage and servoregulation of endotracheal tube cuff pressure |
| US5952314A (en) * | 1994-04-01 | 1999-09-14 | Demichele; Stephen Joseph | Nutritional product for a person having ulcerative colitis |
| CA2194049A1 (en) * | 1994-06-28 | 1996-01-11 | Georgi Stankov | Novel clinical uses of polyene macrolides |
| US5599795A (en) * | 1994-08-19 | 1997-02-04 | Mccann; Michael | Method for treatment of idiopathic inflammatory bowel disease (IIBD) |
| US5658881A (en) | 1994-10-14 | 1997-08-19 | Twk, Inc. | Method for topical inhibition of the metabolic activity of cytochrome P450 |
| US5679648A (en) * | 1994-11-30 | 1997-10-21 | The University Hospital | Methods for the treatment and prevention of fungal infections by administration of 3'-deoxypurine nucleosides |
| US5614206A (en) | 1995-03-07 | 1997-03-25 | Wright Medical Technology, Inc. | Controlled dissolution pellet containing calcium sulfate |
| JP3434396B2 (ja) * | 1995-06-30 | 2003-08-04 | 株式会社日立ユニシアオートモティブ | 鼻腔用投薬器 |
| GB9514878D0 (en) | 1995-07-20 | 1995-09-20 | Danbiosyst Uk | Vitamin E as a solubilizer for drugs contained in lipid vehicles |
| DE19541815B4 (de) * | 1995-11-09 | 2008-04-10 | Bannert, Christian, Dr. | Verwendung einer Lösung von Polyethylenglykol in Wasser als wässrige Spüllösung zur Prävention oder Behandlung von zähem Schleim, der in Verbindung mit Strahlen- oder/und Chemotherapie-induzierten Erkrankungen der Schleimhäute auftritt |
| US5756127A (en) | 1996-10-29 | 1998-05-26 | Wright Medical Technology, Inc. | Implantable bioresorbable string of calcium sulfate beads |
| RU2139707C1 (ru) | 1996-12-24 | 1999-10-20 | ОАО Нижегородский химико-фармацевтический завод | Суппозитории, обладающие противогрибковым действием (варианты) |
| PT1024814E (pt) * | 1997-10-22 | 2007-11-29 | Mayo Foundation | Utilização de agentes antifúngicos para o tratamento tópico de mucosite induzida por fungo |
| US5897872A (en) | 1997-11-12 | 1999-04-27 | Picciano; Dante J. | Iodine-containing nasal moisturizing saline solution |
| CA2318264A1 (en) | 1998-01-30 | 1999-08-05 | Wilk Patent Development Corporation | Transmyocardial coronary artery bypass and revascularization |
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1998
- 1998-10-22 PT PT98955065T patent/PT1024814E/pt unknown
- 1998-10-22 AU AU11959/99A patent/AU1195999A/en not_active Abandoned
- 1998-10-22 US US09/177,164 patent/US20010006944A1/en not_active Abandoned
- 1998-10-22 US US09/177,273 patent/US6291500B2/en not_active Expired - Fee Related
- 1998-10-22 EP EP07016335A patent/EP1857113A3/en not_active Withdrawn
- 1998-10-22 KR KR1020057022219A patent/KR100883149B1/ko not_active IP Right Cessation
- 1998-10-22 US US09/177,659 patent/US20020052390A1/en not_active Abandoned
- 1998-10-22 TR TR2000/01117T patent/TR200001117T2/xx unknown
- 1998-10-22 EA EA200000439A patent/EA200000439A1/ru unknown
- 1998-10-22 AT AT98955065T patent/ATE371457T1/de not_active IP Right Cessation
- 1998-10-22 DK DK98955065T patent/DK1024814T3/da active
- 1998-10-22 BR BR9814615-7A patent/BR9814615A/pt not_active Application Discontinuation
- 1998-10-22 CA CA2308201A patent/CA2308201C/en not_active Expired - Fee Related
- 1998-10-22 EP EP98955065A patent/EP1024814B1/en not_active Expired - Lifetime
- 1998-10-22 KR KR1020007004368A patent/KR20010031363A/ko active Search and Examination
- 1998-10-22 EE EEP200000253A patent/EE200000253A/xx unknown
- 1998-10-22 DE DE69838338T patent/DE69838338T2/de not_active Expired - Lifetime
- 1998-10-22 SK SK573-2000A patent/SK5732000A3/sk unknown
- 1998-10-22 KR KR1020077012909A patent/KR20070069220A/ko not_active Application Discontinuation
- 1998-10-22 US US09/176,990 patent/US6207703B1/en not_active Expired - Lifetime
- 1998-10-22 ID IDW20000973A patent/ID26104A/id unknown
- 1998-10-22 IL IL13577498A patent/IL135774A0/xx active IP Right Grant
- 1998-10-22 HU HU0004170A patent/HUP0004170A3/hu unknown
- 1998-10-22 CN CNB988123959A patent/CN1143679C/zh not_active Expired - Fee Related
- 1998-10-22 JP JP2000516659A patent/JP2001520188A/ja not_active Withdrawn
- 1998-10-22 PL PL98340606A patent/PL340606A1/xx unknown
- 1998-10-22 ES ES98955065T patent/ES2292210T3/es not_active Expired - Lifetime
- 1998-10-22 WO PCT/US1998/022403 patent/WO1999020261A2/en active IP Right Grant
- 1998-10-22 AP APAP/P/2000/001805A patent/AP2000001805A0/en unknown
- 1998-10-22 KR KR1020067009173A patent/KR20060066753A/ko not_active Application Discontinuation
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2000
- 2000-02-08 US US09/500,115 patent/US20030091510A1/en not_active Abandoned
- 2000-04-19 IS IS5463A patent/IS5463A/is unknown
- 2000-04-19 IL IL135774A patent/IL135774A/en not_active IP Right Cessation
- 2000-04-19 NO NO20002069A patent/NO325714B1/no not_active IP Right Cessation
- 2000-04-20 OA OA1200000119A patent/OA11351A/en unknown
- 2000-04-24 BG BG104371A patent/BG104371A/xx unknown
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2001
- 2001-02-06 HK HK01100853A patent/HK1029935A1/xx not_active IP Right Cessation
- 2001-05-25 US US09/865,785 patent/US6555566B2/en not_active Expired - Lifetime
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2002
- 2002-11-13 US US10/293,924 patent/US20030153516A1/en not_active Abandoned
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2004
- 2004-10-08 US US10/962,196 patent/US20050124561A1/en not_active Abandoned
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2005
- 2005-12-27 JP JP2005375253A patent/JP2006096770A/ja not_active Withdrawn
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2006
- 2006-07-26 JP JP2006202740A patent/JP2007008951A/ja active Pending
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2009
- 2009-05-13 US US12/465,394 patent/US20090253645A1/en not_active Abandoned
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