NZ730475A - Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms) - Google Patents
Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms)Info
- Publication number
- NZ730475A NZ730475A NZ730475A NZ73047515A NZ730475A NZ 730475 A NZ730475 A NZ 730475A NZ 730475 A NZ730475 A NZ 730475A NZ 73047515 A NZ73047515 A NZ 73047515A NZ 730475 A NZ730475 A NZ 730475A
- Authority
- NZ
- New Zealand
- Prior art keywords
- modulating
- kdms
- catalytic activity
- histone lysine
- compounds
- Prior art date
Links
- 102000008157 Histone Demethylases Human genes 0.000 title abstract 2
- 108010074870 Histone Demethylases Proteins 0.000 title abstract 2
- IAAQUOVTPAMQCR-UHFFFAOYSA-N 1h-pyrido[3,2-d]pyrimidin-2-one Chemical class C1=CC=C2NC(=O)N=CC2=N1 IAAQUOVTPAMQCR-UHFFFAOYSA-N 0.000 title 1
- 230000003197 catalytic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000008482 dysregulation Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462069915P | 2014-10-29 | 2014-10-29 | |
| PCT/KR2015/011386 WO2016068580A2 (en) | 2014-10-29 | 2015-10-27 | Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ730475A true NZ730475A (en) | 2018-09-28 |
Family
ID=55851908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ730475A NZ730475A (en) | 2014-10-29 | 2015-10-27 | Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms) |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9834550B2 (enExample) |
| EP (1) | EP3212647B1 (enExample) |
| JP (1) | JP6505222B2 (enExample) |
| KR (1) | KR101978899B1 (enExample) |
| CN (1) | CN107001358A (enExample) |
| AU (1) | AU2015340215B2 (enExample) |
| BR (1) | BR112017008312A2 (enExample) |
| CA (1) | CA2962917C (enExample) |
| MX (1) | MX2017005346A (enExample) |
| NZ (1) | NZ730475A (enExample) |
| RU (1) | RU2684396C2 (enExample) |
| SG (1) | SG11201702075QA (enExample) |
| WO (1) | WO2016068580A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3359154B1 (en) * | 2015-10-08 | 2021-05-26 | Suzhou Yunxuan Yiyao Keji Youxian Gongsi | Wnt signaling pathway inhibitors and therapeutic applications thereof |
| CA3008171A1 (en) | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| WO2018237084A1 (en) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | COMPOUNDS INTERACTING WITH RAS SUPERFAMIL FOR USE IN THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES AND FIBROTIC DISEASES |
| WO2020011086A1 (zh) * | 2018-07-13 | 2020-01-16 | 四川科伦博泰生物医药股份有限公司 | 苯并二氮杂环类化合物、其制备方法及用途 |
| JP7407461B2 (ja) | 2018-12-19 | 2024-01-04 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物 |
| US20230110603A1 (en) | 2020-01-31 | 2023-04-13 | Kumiai Chemical Industry Co., Ltd. | 3-alkoxybenzamide derivative, and pest control agent |
| WO2021198191A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| EP4126847A1 (en) | 2020-03-30 | 2023-02-08 | ENYO Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| IL305956A (en) * | 2021-03-31 | 2023-11-01 | Duke Street Bio Ltd | Pharmaceutical material |
| GB202114315D0 (en) * | 2021-10-06 | 2021-11-17 | Duke Street Bio Ltd | Pharmaceutical compound |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5939421A (en) * | 1997-07-01 | 1999-08-17 | Signal Pharmaceuticals, Inc. | Quinazoline analogs and related compounds and methods for treating inflammatory conditions |
| GB9909135D0 (en) | 1999-04-22 | 1999-06-16 | Univ Wales Medicine | Cystic fibrosis medicaments |
| AU2002347653A1 (en) * | 2001-11-26 | 2003-06-10 | Dsm Ip Assets B.V. | Process for recovering caprolactam |
| FR2846657B1 (fr) | 2002-11-05 | 2004-12-24 | Servier Lab | Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2005032481A2 (en) * | 2003-09-30 | 2005-04-14 | Scios Inc. | Quinazoline derivatives as medicaments |
| NZ546477A (en) * | 2006-04-07 | 2009-04-30 | Auckland Uniservices Ltd | 4-Alkylamino-2-(heterocyclic)quinazolines and their use in cancer therapy |
| WO2013012915A1 (en) * | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| JP6535430B2 (ja) * | 2012-09-28 | 2019-06-26 | イグニタ、インク． | 非定型プロテインキナーゼｃのアザキナゾリン阻害薬 |
| RS55764B1 (sr) | 2012-10-02 | 2017-07-31 | Gilead Sciences | Inhibitori histonskih demetilaza |
| WO2014055634A1 (en) | 2012-10-02 | 2014-04-10 | Yale University | Identification of small molecule inhibitors of jumonji at-rich interactive domain 1a (jarid1a) and 1b (jarid1b) histone demethylase |
| WO2014087165A1 (en) * | 2012-12-06 | 2014-06-12 | University Of Bath | Tankyrase inhibitors |
| JP6514117B2 (ja) | 2013-02-27 | 2019-05-15 | エピセラピューティクス アーペーエス | ヒストン脱メチル化酵素の阻害剤 |
| JP6320506B2 (ja) | 2013-03-12 | 2018-05-09 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
| CN105980386B (zh) | 2013-03-13 | 2021-08-13 | 基因泰克公司 | 吡唑并化合物及其用途 |
| HUE034906T2 (hu) | 2013-03-15 | 2018-03-28 | Quanticel Pharmaceuticals Inc | Hiszton-demetiláz inhibitorok |
| WO2015035062A1 (en) | 2013-09-05 | 2015-03-12 | Genentech, Inc. | Antiproliferative compounds |
| CN103694255A (zh) * | 2014-01-09 | 2014-04-02 | 华中师范大学 | 吡啶并噁嗪酮和吡啶并嘧啶酮类化合物及其制备方法与应用 |
| TWI675836B (zh) * | 2014-03-25 | 2019-11-01 | 美商伊格尼塔公司 | 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑 |
-
2015
- 2015-10-27 WO PCT/KR2015/011386 patent/WO2016068580A2/en not_active Ceased
- 2015-10-27 BR BR112017008312A patent/BR112017008312A2/pt not_active Application Discontinuation
- 2015-10-27 SG SG11201702075QA patent/SG11201702075QA/en unknown
- 2015-10-27 KR KR1020177014472A patent/KR101978899B1/ko active Active
- 2015-10-27 EP EP15853996.5A patent/EP3212647B1/en not_active Not-in-force
- 2015-10-27 MX MX2017005346A patent/MX2017005346A/es unknown
- 2015-10-27 NZ NZ730475A patent/NZ730475A/en unknown
- 2015-10-27 AU AU2015340215A patent/AU2015340215B2/en active Active
- 2015-10-27 JP JP2017523293A patent/JP6505222B2/ja not_active Expired - Fee Related
- 2015-10-27 RU RU2017113007A patent/RU2684396C2/ru active
- 2015-10-27 US US14/923,525 patent/US9834550B2/en active Active
- 2015-10-27 CA CA2962917A patent/CA2962917C/en active Active
- 2015-10-27 CN CN201580061545.6A patent/CN107001358A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3212647A4 (en) | 2018-04-18 |
| CN107001358A (zh) | 2017-08-01 |
| AU2015340215A1 (en) | 2017-04-13 |
| JP6505222B2 (ja) | 2019-04-24 |
| US20160122343A1 (en) | 2016-05-05 |
| RU2684396C2 (ru) | 2019-04-09 |
| RU2017113007A3 (enExample) | 2018-11-29 |
| BR112017008312A2 (pt) | 2017-12-19 |
| EP3212647A2 (en) | 2017-09-06 |
| US9834550B2 (en) | 2017-12-05 |
| JP2017533215A (ja) | 2017-11-09 |
| WO2016068580A2 (en) | 2016-05-06 |
| KR20170072943A (ko) | 2017-06-27 |
| RU2017113007A (ru) | 2018-11-29 |
| KR101978899B1 (ko) | 2019-05-15 |
| AU2015340215B2 (en) | 2018-11-15 |
| CA2962917A1 (en) | 2016-05-06 |
| EP3212647B1 (en) | 2019-04-03 |
| CA2962917C (en) | 2019-04-30 |
| WO2016068580A3 (en) | 2016-08-18 |
| SG11201702075QA (en) | 2017-04-27 |
| MX2017005346A (es) | 2017-08-02 |
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|---|---|---|---|
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