JP6505222B2 - ヒストンリジン脱メチル化触媒活性を調節するための新規ピリドピリミジノン化合物 - Google Patents

ヒストンリジン脱メチル化触媒活性を調節するための新規ピリドピリミジノン化合物 Download PDF

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JP6505222B2
JP6505222B2 JP2017523293A JP2017523293A JP6505222B2 JP 6505222 B2 JP6505222 B2 JP 6505222B2 JP 2017523293 A JP2017523293 A JP 2017523293A JP 2017523293 A JP2017523293 A JP 2017523293A JP 6505222 B2 JP6505222 B2 JP 6505222B2
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methyl
pyrimidin
pyrido
amino
chloro
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JP2017533215A5 (enExample
JP2017533215A (ja
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キム，ミョンソプ
パク，テスン
ユン，テヨン
ヤン，スンミン
キム，ヘスン
キム，ジュンギュ
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ドン−ア エスティ カンパニー リミテッド
ドン−ア エスティ カンパニー リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
JP2017523293A 2014-10-29 2015-10-27 ヒストンリジン脱メチル化触媒活性を調節するための新規ピリドピリミジノン化合物 Expired - Fee Related JP6505222B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462069915P 2014-10-29 2014-10-29
US62/069,915 2014-10-29
PCT/KR2015/011386 WO2016068580A2 (en) 2014-10-29 2015-10-27 Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms)

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JP2017533215A JP2017533215A (ja) 2017-11-09
JP2017533215A5 JP2017533215A5 (enExample) 2018-11-01
JP6505222B2 true JP6505222B2 (ja) 2019-04-24

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JP2017523293A Expired - Fee Related JP6505222B2 (ja) 2014-10-29 2015-10-27 ヒストンリジン脱メチル化触媒活性を調節するための新規ピリドピリミジノン化合物

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US (1) US9834550B2 (enExample)
EP (1) EP3212647B1 (enExample)
JP (1) JP6505222B2 (enExample)
KR (1) KR101978899B1 (enExample)
CN (1) CN107001358A (enExample)
AU (1) AU2015340215B2 (enExample)
BR (1) BR112017008312A2 (enExample)
CA (1) CA2962917C (enExample)
MX (1) MX2017005346A (enExample)
NZ (1) NZ730475A (enExample)
RU (1) RU2684396C2 (enExample)
SG (1) SG11201702075QA (enExample)
WO (1) WO2016068580A2 (enExample)

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* Cited by examiner, † Cited by third party
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JP6853819B2 (ja) * 2015-10-08 2021-03-31 スーチョウ ユンシュアン イーヤオ カジ ヨウシェン ゴンス Ｗｎｔシグナル伝達経路阻害剤およびその治療用途
US10221191B2 (en) 2015-12-22 2019-03-05 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
SG11201911929XA (en) 2017-06-21 2020-01-30 SHY Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
WO2020011086A1 (zh) * 2018-07-13 2020-01-16 四川科伦博泰生物医药股份有限公司 苯并二氮杂环类化合物、其制备方法及用途
WO2020132071A1 (en) 2018-12-19 2020-06-25 Shy Therapeutics. Llc Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and f1brotic disease
EP4098650B1 (en) 2020-01-31 2025-12-10 Kumiai Chemical Industry Co., Ltd. 3-alkoxy benzoic acid amide derivative, and pest control agent
EP4126847A1 (en) 2020-03-30 2023-02-08 ENYO Pharma Quinazolinone derivatives and uses thereof for treating a cancer
WO2021198191A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer
JP7768592B2 (ja) * 2021-03-31 2025-11-12 デューク ストリート バイオ リミテッド 医薬化合物
GB202114315D0 (en) * 2021-10-06 2021-11-17 Duke Street Bio Ltd Pharmaceutical compound

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GB9909135D0 (en) * 1999-04-22 1999-06-16 Univ Wales Medicine Cystic fibrosis medicaments
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FR2846657B1 (fr) 2002-11-05 2004-12-24 Servier Lab Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2005032481A2 (en) * 2003-09-30 2005-04-14 Scios Inc. Quinazoline derivatives as medicaments
NZ546477A (en) 2006-04-07 2009-04-30 Auckland Uniservices Ltd 4-Alkylamino-2-(heterocyclic)quinazolines and their use in cancer therapy
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AU2015340215B2 (en) 2018-11-15
SG11201702075QA (en) 2017-04-27
CA2962917C (en) 2019-04-30
KR20170072943A (ko) 2017-06-27
RU2684396C2 (ru) 2019-04-09
CN107001358A (zh) 2017-08-01
US20160122343A1 (en) 2016-05-05
WO2016068580A3 (en) 2016-08-18
EP3212647A4 (en) 2018-04-18
EP3212647A2 (en) 2017-09-06
AU2015340215A1 (en) 2017-04-13
US9834550B2 (en) 2017-12-05
NZ730475A (en) 2018-09-28
RU2017113007A3 (enExample) 2018-11-29
MX2017005346A (es) 2017-08-02
RU2017113007A (ru) 2018-11-29
KR101978899B1 (ko) 2019-05-15
CA2962917A1 (en) 2016-05-06
JP2017533215A (ja) 2017-11-09
WO2016068580A2 (en) 2016-05-06
EP3212647B1 (en) 2019-04-03
BR112017008312A2 (pt) 2017-12-19

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