NZ702242A - Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent - Google Patents

Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent

Info

Publication number
NZ702242A
NZ702242A NZ702242A NZ70224213A NZ702242A NZ 702242 A NZ702242 A NZ 702242A NZ 702242 A NZ702242 A NZ 702242A NZ 70224213 A NZ70224213 A NZ 70224213A NZ 702242 A NZ702242 A NZ 702242A
Authority
NZ
New Zealand
Prior art keywords
agent
prophylactic
neuropathic pain
therapeutic treatment
peripheral neuropathic
Prior art date
Application number
NZ702242A
Other languages
English (en)
Inventor
Atsufumi Kawabata
Hideaki Suzuki
Original Assignee
Asahi Kasei Pharma Corp
Univ Kinki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Pharma Corp, Univ Kinki filed Critical Asahi Kasei Pharma Corp
Publication of NZ702242A publication Critical patent/NZ702242A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/366Thrombomodulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/7455Thrombomodulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NZ702242A 2012-05-31 2013-05-17 Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent NZ702242A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012125316 2012-05-31
PCT/JP2013/063743 WO2013179910A1 (ja) 2012-05-31 2013-05-17 抗癌剤に起因する末梢性神経障害性疼痛の予防及び/又は治療剤

Publications (1)

Publication Number Publication Date
NZ702242A true NZ702242A (en) 2016-03-31

Family

ID=49673113

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ702242A NZ702242A (en) 2012-05-31 2013-05-17 Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent

Country Status (20)

Country Link
US (1) US10709767B2 (https=)
EP (1) EP2857037B1 (https=)
JP (3) JP6124417B2 (https=)
KR (1) KR101672114B1 (https=)
CN (1) CN104394885B (https=)
AU (1) AU2013268725B2 (https=)
BR (1) BR112014028852A2 (https=)
CA (1) CA2875069C (https=)
DK (1) DK2857037T3 (https=)
ES (1) ES2743767T3 (https=)
HU (1) HUE045997T2 (https=)
IL (1) IL235984B (https=)
IN (1) IN2014DN10075A (https=)
MX (1) MX364934B (https=)
NZ (1) NZ702242A (https=)
PL (1) PL2857037T3 (https=)
PT (1) PT2857037T (https=)
RU (1) RU2595857C2 (https=)
WO (1) WO2013179910A1 (https=)
ZA (1) ZA201408769B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2857037T3 (pl) 2012-05-31 2019-12-31 Kinki University Środek do leczenia profilaktycznego i/lub terapeutycznego obwodowego bólu neuropatycznego wywoływanego przez środek przeciwnowotworowy
JP6325036B2 (ja) * 2016-08-19 2018-05-16 株式会社明治 抗がん剤に起因する末梢神経障害を改善するための組成物
RU2770307C2 (ru) * 2017-03-31 2022-04-15 Торэй Индастриз, Инк. Терапевтическое или профилактическое средство против периферических невропатий
US11628147B2 (en) 2017-12-19 2023-04-18 Synergia Life Sciences Pvt. Ltd. Vitamin K2 compositions for the treatment of drug induced neuropathy
WO2020067389A1 (ja) * 2018-09-28 2020-04-02 旭化成ファーマ株式会社 抗悪性腫瘍剤による末梢神経障害の症状軽減及び/又は発症抑制のための医薬
RU2707954C1 (ru) * 2019-01-24 2019-12-02 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ лечения онкологической боли
CN116897010A (zh) * 2021-02-26 2023-10-17 韦博辛斯动力公司 用于预测化疗引起的神经病变的生物标志物

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816494A1 (en) 1987-01-08 1998-01-07 Asahi Kasei Kogyo Kabushiki Kaisha DNA coding for a peptide promoting the activation of protein C by thrombin, and process for producing the same
JP2738428B2 (ja) 1987-01-08 1998-04-08 旭化成工業株式会社 トロンビンによるプロテインcの活性化を促進する作用を有するペプチド
DE3876124T2 (de) 1987-04-01 1993-05-06 Mitsubishi Gas Chemical Co Immunoassay fuer thrombomodulin.
DK299087D0 (da) 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
JPS6445398A (en) 1987-08-13 1989-02-17 Kowa Co Antithrombin-binding substance monoclonal antibody, hybridoma producing said antibody and method for purifying and measuring thrombin-binding substance utilizing said monoclonal antibody
JPH0720997B2 (ja) 1988-08-29 1995-03-08 興和株式会社 新規なトロンビン結合性物質及びその製法
JPH02255699A (ja) 1989-03-28 1990-10-16 Asahi Chem Ind Co Ltd 新規血液抗凝固物質及びその製法
JP3189052B2 (ja) 1990-06-27 2001-07-16 持田製薬株式会社 抗血液凝固活性を有するポリペプチド
JPH05213998A (ja) 1990-08-03 1993-08-24 Asahi Chem Ind Co Ltd 新規なポリペプチド及びこれを有効成分とする 医薬組成物
US5571786A (en) 1990-08-16 1996-11-05 Immuno Aktiengesellschaft Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation
JPH05310787A (ja) 1992-05-01 1993-11-22 Asahi Chem Ind Co Ltd 新規なポリペプチド
JPH06205692A (ja) 1993-01-08 1994-07-26 Asahi Chem Ind Co Ltd 新規な抗ヒトトロンボモジュリンモノクロ−ナル抗体およびその抗体を用いたヒトトロンボモジュリンの高感度測定方法
EP0685994B1 (en) 1993-02-25 2007-03-21 Abbott Laboratories Multipurpose reagent system for rapid lysis of whole blood samples
JP3007785B2 (ja) 1993-03-16 2000-02-07 旭化成工業株式会社 トロンボモジュリン組成物およびその変性防止方法
US5916874A (en) 1994-04-20 1999-06-29 Asahi Kasei Kogyo Kabushiki Kaisha Method for treating liver injury
DE69534016T2 (de) 1994-04-20 2006-03-23 Asahi Kasei Pharma Corp. Verwendung von thrombomodulin gegen lebererkrankungen
JPH083065A (ja) 1994-04-20 1996-01-09 Asahi Chem Ind Co Ltd 肝臓障害に対する治療剤
JP2824392B2 (ja) 1994-05-31 1998-11-11 旭化成工業株式会社 トロンビンによるプロテインcの活性化を促進する作用を有するペプチドを含有する培養上澄液
US5827832A (en) 1995-03-06 1998-10-27 Interneuron Pharmaceuticals, Inc. Method of protecting brain tissue from cerebral infarction subsequent to ischemia
ES2244968T3 (es) 1995-03-06 2005-12-16 Interneuron Pharmaceuticals Incorporated Reduccion del volumen de infarto usando citocolina.
US5872108A (en) 1995-03-06 1999-02-16 Interneuron Pharmaceuticals, Inc. Reduction of infarct volume using citicoline
JP3789147B2 (ja) 1995-04-11 2006-06-21 旭化成ファーマ株式会社 脊髄損傷後の神経障害に対する治療剤
JPH08301783A (ja) 1995-05-11 1996-11-19 Mochida Pharmaceut Co Ltd 吸収性骨疾患予防・治療剤
EP0743066A3 (en) 1995-05-16 1998-09-30 Mitsui Pharmaceuticals, Inc. Wound-healing agent
JP3931353B2 (ja) 1995-06-30 2007-06-13 持田製薬株式会社 創傷治癒剤
JP3745805B2 (ja) 1995-10-24 2006-02-15 日本ケミカルリサーチ株式会社 トロンボモジュリンの精製方法
JPH101439A (ja) 1996-06-11 1998-01-06 Mochida Pharmaceut Co Ltd 神経変性疾患治療剤
JP4157644B2 (ja) 1998-03-30 2008-10-01 旭化成ファーマ株式会社 高純度可溶性トロンボモジュリンの製造方法
AU2001245319A1 (en) * 2000-03-28 2001-10-08 Eli Lilly And Company Methods of treating diseases with activated protein c
US20020111296A1 (en) 2000-08-31 2002-08-15 Festoff Barry W. Thrombomodulin analogs for use in recovery of spinal cord injury
EP1475098B1 (en) * 2002-01-18 2015-08-05 Asahi Kasei Pharma Corporation High-concentration preparation of soluble thrombomodulin
PL1664041T3 (pl) * 2003-09-22 2008-12-31 Euro Celtique Sa Przydatne do leczenia bólu związki fenylowo-karboksyamidowe
EP1848994A2 (en) * 2005-02-16 2007-10-31 Wyeth Methods and systems for diagnosis, prognosis and selection of treatment of leukemia
US9394267B2 (en) 2007-07-13 2016-07-19 The Cleveland Clinic Foundation Heterocyclic modulators of cannabinoid receptors
US8440832B2 (en) 2007-07-13 2013-05-14 Board Of Regents, The University Of Texas System Heterocyclic modulators of cannabinoid receptors
ES2665042T3 (es) 2008-02-18 2018-04-24 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos que se unen a ligandos del receptor sigma para el tratamiento del dolor neuropático que se desarrolla como consecuencia de la quimioterapia
EP2320936A1 (en) * 2008-07-16 2011-05-18 PAION Deutschland GmbH Prevention and treatment of radiation injury
TWI438009B (zh) * 2010-02-19 2014-05-21 Teikoku Pharma Usa Inc 紫杉烷前-乳劑調配物及其製造與使用之方法
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および/または治療剤
US20110287110A1 (en) * 2010-04-23 2011-11-24 Mark Wesley Dewhirst Combination cancer treatment
JP5924611B2 (ja) 2010-06-16 2016-05-25 国立大学法人高知大学 造血細胞移植に伴う生着症候群の予防及び/又は治療のための医薬
JP2013533286A (ja) * 2010-07-30 2013-08-22 セントルイス ユニバーシティ 疼痛を治療する方法
PL2857037T3 (pl) 2012-05-31 2019-12-31 Kinki University Środek do leczenia profilaktycznego i/lub terapeutycznego obwodowego bólu neuropatycznego wywoływanego przez środek przeciwnowotworowy

Also Published As

Publication number Publication date
EP2857037B1 (en) 2019-06-26
ES2743767T3 (es) 2020-02-20
KR20150004855A (ko) 2015-01-13
RU2014148171A (ru) 2016-07-20
RU2595857C2 (ru) 2016-08-27
PT2857037T (pt) 2019-07-19
AU2013268725A1 (en) 2014-12-18
HUE045997T2 (hu) 2020-01-28
IN2014DN10075A (https=) 2015-08-21
IL235984A0 (en) 2015-01-29
US10709767B2 (en) 2020-07-14
IL235984B (en) 2019-09-26
MX364934B (es) 2019-03-28
BR112014028852A2 (pt) 2018-04-24
JP6124417B2 (ja) 2017-05-10
JPWO2013179910A1 (ja) 2016-01-18
CA2875069C (en) 2018-01-02
CA2875069A1 (en) 2013-12-05
JP2017141268A (ja) 2017-08-17
JP2018095652A (ja) 2018-06-21
JP6279788B2 (ja) 2018-02-14
HK1203846A1 (en) 2015-11-06
US20150148296A1 (en) 2015-05-28
ZA201408769B (en) 2015-12-23
CN104394885A (zh) 2015-03-04
KR101672114B1 (ko) 2016-11-02
WO2013179910A1 (ja) 2013-12-05
EP2857037A1 (en) 2015-04-08
DK2857037T3 (da) 2019-07-22
CN104394885B (zh) 2017-06-30
JP6427284B2 (ja) 2018-11-21
EP2857037A4 (en) 2016-04-06
AU2013268725B2 (en) 2017-02-16
MX2014014505A (es) 2015-06-02
PL2857037T3 (pl) 2019-12-31

Similar Documents

Publication Publication Date Title
PH12014501997A1 (en) Esketamine for the treatment of treatment-refractory or treatment-resistant depression
MX373851B (es) Métodos de administración de tratamiento con pirfenidona.
NZ749217A (en) Androgen receptor modulator and uses thereof
NZ702242A (en) Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent
IN2014DN09434A (https=)
IL239488A0 (en) A gpc3-targeted medicinal agent for the treatment of patients for whom treatment with a gpc3-targeted medicinal agent is beneficial
PH12015500274B1 (en) Alkylpyrimidine derivatives for the treatment of viral infections and further diseases
MY181828A (en) Bicyclically substituted uracils and the use therapy
MY176489A (en) Novel tricyclic compounds as anticancer agents
NZ727304A (en) Compositions and methods of use of phorbol esters for the treatment of stroke
TN2012000610A1 (en) Heterocyclic compounds, their preparation and their therapeutic application
MX364220B (es) Metodos de tratamientos de fibrosis.
NZ701553A (en) Medicine comprising combination of general anesthetic drug and hydrogen
MX2013002261A (es) N-fenetiltriazolonacetamidas sustituidas y su uso.
NZ707773A (en) Methods of treating liver diseases
MX2015008454A (es) Uso de pregn-4-en-20-in-3-ona para el tratamiento de trastornos depresivos.
MX365192B (es) Derivados de bendamustina y compuestos relacionados, y uso medico de los mismos para la terapia de cancer.
PH12015501210A1 (en) Use of pidotimod to treat psoriasis
WO2014177510A3 (en) Polymer conjugates of indolocarbazole compounds in the treatment of pruritus
AU2014269144A8 (en) Bioactive compounds
PH12015501211A1 (en) Use of pidotimod to treat atopic dermatitis
WO2012158776A3 (en) Combination therapy for treatment of cancer
GB2519004A (en) Quinone compounds and their uses for the treatment of cancer
MD4291B1 (ro) Preparat medicamentos pentru tratamentul otitelor
IN2014DN10683A (https=)

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 MAY 2018 BY CPA GLOBAL

Effective date: 20170331

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 MAY 2019 BY CPA GLOBAL

Effective date: 20180412

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 MAY 2020 BY CPA GLOBAL

Effective date: 20190404

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 MAY 2021 BY CPA GLOBAL

Effective date: 20200403

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 MAY 2022 BY CPA GLOBAL

Effective date: 20210422

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 MAY 2023 BY CPA GLOBAL

Effective date: 20220415

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 MAY 2024 BY CPA GLOBAL

Effective date: 20230331

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 MAY 2025 BY DENNEMEYER + CO.

Effective date: 20240506

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 MAY 2026 BY DENNEMEYER AND CO. SARL

Effective date: 20250505