NZ629730A - Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage - Google Patents
Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhageInfo
- Publication number
- NZ629730A NZ629730A NZ629730A NZ62973014A NZ629730A NZ 629730 A NZ629730 A NZ 629730A NZ 629730 A NZ629730 A NZ 629730A NZ 62973014 A NZ62973014 A NZ 62973014A NZ 629730 A NZ629730 A NZ 629730A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compositions
- aneurysmal subarachnoid
- treat complications
- subarachnoid hemorrhage
- kda
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 title abstract 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 abstract 1
- 206010047163 Vasospasm Diseases 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
- 229960000715 nimodipine Drugs 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/793,767 US10092524B2 (en) | 2008-06-11 | 2013-03-11 | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
| PCT/US2014/023748 WO2014164904A1 (en) | 2013-03-11 | 2014-03-11 | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ629730A true NZ629730A (en) | 2017-03-31 |
Family
ID=49157870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ629730A NZ629730A (en) | 2013-03-11 | 2014-03-11 | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10092524B2 (enExample) |
| EP (1) | EP2968166A4 (enExample) |
| JP (1) | JP2016512527A (enExample) |
| KR (1) | KR101902319B1 (enExample) |
| CN (1) | CN105324108A (enExample) |
| AU (1) | AU2014248877A1 (enExample) |
| BR (1) | BR112015022218A2 (enExample) |
| CA (1) | CA2905327A1 (enExample) |
| GB (1) | GB2528801A (enExample) |
| HK (1) | HK1216002A1 (enExample) |
| NZ (1) | NZ629730A (enExample) |
| RU (1) | RU2015143206A (enExample) |
| SG (1) | SG11201507398XA (enExample) |
| WO (1) | WO2014164904A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10092524B2 (en) | 2008-06-11 | 2018-10-09 | Edge Therapeutics, Inc. | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
| SG10201602665UA (en) | 2011-04-05 | 2016-05-30 | Edge Therapeutics | Intraventricular Drug Delivery System For Improving Outcome After A Brain Injury Affecting Cerebral Blood Flow |
| CA2986692A1 (en) * | 2015-05-29 | 2016-12-08 | Edge Therapeutics, Inc. | Compositions and methods for reducing visual loss |
| WO2017176914A1 (en) * | 2016-04-07 | 2017-10-12 | Edge Therapeutics, Inc. | Formulations of site-specific, microparticulate compositions and their use to improve outcome after aneurysmal subarachnoid hemorrhage |
| CN108403629B (zh) * | 2018-04-26 | 2019-11-05 | 徐州医科大学 | 一种尼莫地平口服长效悬浮液及其制备方法 |
| WO2020227558A2 (en) * | 2019-05-07 | 2020-11-12 | Yale University | Maximizing distribution and minimizing washout of injectates in bone and method for enhanced aspirate extraction |
| WO2020235947A1 (ko) * | 2019-05-22 | 2020-11-26 | 경북대학교 산학협력단 | Cacb1 유래 펩타이드, Cacb1 유래 펩타이드의 변이체 및 이의 용도 |
| WO2021168351A1 (en) * | 2020-02-20 | 2021-08-26 | Postsurgical Therapeutics, Inc. | Brain drug delivery system and method |
| WO2021262725A1 (en) * | 2020-06-22 | 2021-12-30 | Curelator, Inc. | Systems and methods for segmentation of a user population based on time-based variations in biomarker levels |
| US11452690B1 (en) | 2021-01-27 | 2022-09-27 | ECI Pharmaceuticals, LLC | Oral liquid compositions comprising amlodipine besylate and methods of using the same |
| JP2024508888A (ja) * | 2021-03-03 | 2024-02-28 | クランメド リミテッド | 一時的塞栓剤としてのアルギネートベースの粒子 |
| WO2025151741A1 (en) * | 2024-01-10 | 2025-07-17 | Brown David Donaldson | Methods of treating migraine headache or tension headache with hyaluronic acid |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
| US4937270A (en) | 1987-09-18 | 1990-06-26 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
| US5527893A (en) | 1987-09-18 | 1996-06-18 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| ATE133087T1 (de) | 1989-05-04 | 1996-02-15 | Southern Res Inst | Einkapselungsverfahren |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
| US5399665A (en) | 1992-11-05 | 1995-03-21 | Massachusetts Institute Of Technology | Biodegradable polymers for cell transplantation |
| EP0740791A4 (en) | 1994-01-05 | 2000-04-05 | Arqule Inc | SYSTEMATIC MODULAR PRODUCTION OF AMINIMID AND OXAZOLONE-BASED MOLECULES WITH SELECTED PROPERTIES |
| US5712171A (en) | 1995-01-20 | 1998-01-27 | Arqule, Inc. | Method of generating a plurality of chemical compounds in a spatially arranged array |
| US5968542A (en) | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
| US5747058A (en) | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| AT404429B (de) | 1995-06-09 | 1998-11-25 | Immuno Ag | Anti-plasma-antikörper-präparation |
| JP2909418B2 (ja) | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
| EP0932399B1 (en) | 1996-03-12 | 2006-01-04 | PG-TXL Company, L.P. | Water soluble paclitaxel prodrugs |
| WO1998027963A2 (en) | 1996-12-20 | 1998-07-02 | Alza Corporation | Gel composition and methods |
| US6123956A (en) * | 1997-07-10 | 2000-09-26 | Keith Baker | Methods for universally distributing therapeutic agents to the brain |
| WO1999018949A1 (en) | 1997-10-15 | 1999-04-22 | Thomas Jefferson University | Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal |
| JP2000070366A (ja) | 1998-09-02 | 2000-03-07 | Arute:Kk | 容器兼用注射器及び容器兼用注射器への凍結乾燥製剤の封入方法 |
| US20050214227A1 (en) * | 1999-03-08 | 2005-09-29 | Powderject Research Limited | Microparticle formulations for sustained-release of bioactive compounds |
| US7651703B2 (en) | 1999-10-15 | 2010-01-26 | Genentech, Inc. | Injection vehicle for polymer-based formulations |
| US6284283B1 (en) | 1999-10-21 | 2001-09-04 | Alkermes Controlled Therapeutics, Inc. | Method of producing sub-micron particles of biologically active agents and uses thereof |
| CA2396016A1 (en) | 1999-12-29 | 2001-07-05 | Andy Bernhardt | System for reconstituting pastes and methods of using same |
| EP1250166B1 (en) | 2000-01-25 | 2010-03-17 | Edwards Lifesciences Corporation | Delivery systems for treatment of restenosis and anastomotic intimal hyperplasia |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| JP2002003406A (ja) | 2000-06-21 | 2002-01-09 | Sankyo Co Ltd | 脳血管攣縮予防製剤 |
| US20030032676A1 (en) | 2001-08-09 | 2003-02-13 | Kimelberg Harold K. | Drugs for treatment of cerebral injury and methods of use thereof |
| AU2002335658A1 (en) | 2001-08-31 | 2003-03-18 | Neuron Therapeutics, Inc. | Treatment of neurologic hemorrhage |
| US20040235801A1 (en) | 2001-10-25 | 2004-11-25 | Jean-Pierre Julien | Therapy for stroke |
| EP1459727B1 (en) | 2001-11-22 | 2010-06-09 | Japan Science and Technology Agency | Nonhuman model animal unresponsive to immunopotentiating synthetic compound |
| JP2005524657A (ja) | 2002-02-27 | 2005-08-18 | ファーメイン， エルティーディー． | 治療剤及び他の物質を送達するための組成物、及び、前記組成物を作製し使用する方法 |
| TW200307011A (en) | 2002-04-18 | 2003-12-01 | Chugai Pharmaceutical Co Ltd | Hyaluronic acid modifier |
| CN1665925A (zh) | 2002-04-30 | 2005-09-07 | 马克西根控股公司 | 凝血因子Ⅶ或Ⅶa多肽变体 |
| CN1671400A (zh) | 2002-07-03 | 2005-09-21 | 派瑞克科学公司 | 透明质酸组合物以及使用方法 |
| DK1553927T3 (da) | 2002-09-11 | 2011-01-31 | Elan Pharma Int Ltd | Gel-stabiliserede, nanopartikulære aktivstof-sammensætninger |
| JP4092994B2 (ja) | 2002-09-13 | 2008-05-28 | ニプロ株式会社 | プレフィルドシリンジキット |
| WO2004047768A2 (en) | 2002-11-26 | 2004-06-10 | Seacoast Neuroscience, Inc. | Buoyant polymer particles delivering therapeutic agents |
| JP2007515392A (ja) | 2003-04-10 | 2007-06-14 | ピーアール ファーマシューティカルズ，インコーポレイテッド | エマルジョンベースの微粒子の製造のための方法 |
| US20070207211A1 (en) | 2003-04-10 | 2007-09-06 | Pr Pharmaceuticals, Inc. | Emulsion-based microparticles and methods for the production thereof |
| CA2533592C (en) | 2003-07-23 | 2015-11-10 | Pr Pharmaceuticals, Inc. | Controlled release compositions |
| US9149440B2 (en) * | 2003-09-02 | 2015-10-06 | University Of South Florida | Nanoparticles for drug-delivery |
| WO2005042048A2 (en) | 2003-10-22 | 2005-05-12 | Encelle, Inc. | Bioactive hydrogel compositions for regenerating connective tissue |
| WO2006002365A2 (en) | 2004-06-24 | 2006-01-05 | Angiotech International Ag | Microparticles with high loadings of a bioactive agent |
| US20060205733A1 (en) | 2004-08-26 | 2006-09-14 | Encysive Pharmaceuticals | Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof |
| US8034762B2 (en) | 2004-09-02 | 2011-10-11 | Cognosci, Inc. | Treatment of subarachnoid hemorrhage with Apo E analogs |
| WO2006084005A2 (en) | 2005-02-02 | 2006-08-10 | University Of Vermont And State Agricultural College | Emergence of a r-type ca2+channel(cav2.3) contributes to cerebral artery constriction following subarachnoid hemorrhage |
| EP2500031A3 (en) | 2005-02-24 | 2012-12-26 | Joslin Diabetes Center, Inc. | Compositions and Methods for Treating Vascular Permeability |
| US20060217340A1 (en) | 2005-03-23 | 2006-09-28 | University Of Vermont And State Agricultural College | Methods and products for treating hypertension by modulation of TRPC3 channel activity |
| EP1893230A2 (en) | 2005-04-26 | 2008-03-05 | Maxygen Holdings Ltd. | Use of modified factor vii for treating bleeding |
| JP2009501188A (ja) | 2005-07-15 | 2009-01-15 | ノボ ノルディスク ヘルス ケア アーゲー | 抗血小板療法で治療される患者における脳内出血（ＩＣＨ）後の出血増大及び／又は浮腫形成を予防又は軽減するための第ＶＩＩａ因子又は第ＶＩＩａ因子等価物の使用 |
| GB0515492D0 (en) | 2005-07-28 | 2005-08-31 | Reckitt Benckiser Healthcare | Improvements in or relating to compositions,articles and methods |
| WO2007047406A2 (en) | 2005-10-14 | 2007-04-26 | Transform Pharmaceuticals, Inc. | Liquid pharmaceutical compositions of nimodipine |
| JP2009516751A (ja) | 2005-11-21 | 2009-04-23 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティー・オブ・アラバマ・フォー・アンド・オン・ビハーフ・オブ・ザ・ユニバーシティー・オブ・アラバマ | 神経保護のための小分子化合物を使用する方法 |
| EP2108041A1 (en) | 2007-01-18 | 2009-10-14 | Reckitt Benckiser N.V. | Dosage element and a method of manufacturing a dosage element |
| WO2008134541A2 (en) | 2007-04-25 | 2008-11-06 | Musculoskeletal Transplant Foundation | Reinforced biological mesh for surgical reinforcement |
| US9005183B2 (en) | 2007-05-16 | 2015-04-14 | Health Knight, Llc | System and method for treating erectile dysfunction |
| KR101554250B1 (ko) | 2007-06-11 | 2015-09-18 | 알. 로치 맥도날드 | 뇌혈관 연축의 예방을 위한 약물 전달 시스템 |
| US10092524B2 (en) | 2008-06-11 | 2018-10-09 | Edge Therapeutics, Inc. | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
| US20120164226A1 (en) | 2007-06-11 | 2012-06-28 | Leuthner Brian A | Compositions and Methods for Improving Prognosis of a Human with Subarachnoid Hemorrhage |
| JP5502751B2 (ja) | 2007-12-20 | 2014-05-28 | エボニック コーポレイション | 低残留溶媒濃度を有する微粒子を調製するためのプロセス |
| US20100008968A1 (en) | 2008-06-26 | 2010-01-14 | Lampe John W | Method for treating cardiovascular diseases using rho kinase inhibitor compounds |
| CN102131496B (zh) | 2008-08-22 | 2013-10-23 | 雷克特本克斯尔保健(英国)有限公司 | 组合物的改进或与组合物有关的改进 |
| EP2331082B1 (en) | 2008-09-11 | 2021-01-06 | Evonik Corporation | Solvent extraction microencapsulation with tunable extraction rates |
| EP2334288B1 (en) | 2008-09-18 | 2021-05-19 | Evonik Corporation | Microencapsulation process with solvent and salt |
| US20100216948A1 (en) | 2009-01-23 | 2010-08-26 | Tipton Arthur J | Polymer mixtures comprising polymers having different non-repeating units and methods for making and using same |
| US20130059008A1 (en) | 2009-01-23 | 2013-03-07 | Jeffrey L. Atkinson | Drying methods for tuning microparticle properties |
| WO2010085609A2 (en) | 2009-01-23 | 2010-07-29 | Surmodics Pharmaceuticals, Inc. | Controlled release systems from polymer blends |
| US20100291027A1 (en) | 2009-05-14 | 2010-11-18 | Jason Campbell | Hyaluronic acid (ha) injection vehicle |
| US20110033463A1 (en) | 2009-08-06 | 2011-02-10 | Medtronic, Inc. | Apheresis, administration of agent, or combination thereof |
| WO2011087689A2 (en) | 2009-12-22 | 2011-07-21 | Surmodics Pharmaceuticals,Inc. | Emulsion-based process for preparing microparticles and workhead assembly for use with same |
| GB2490084A (en) | 2010-02-22 | 2012-10-17 | Edge Therapeutics Inc | Methods and compositions to treat hemorrhagic conditions of the brain |
| US9504643B2 (en) | 2010-03-29 | 2016-11-29 | Evonik Corporation | Compositions and methods for improved retention of a pharmaceutical composition at a local administration site |
| SG10201602665UA (en) | 2011-04-05 | 2016-05-30 | Edge Therapeutics | Intraventricular Drug Delivery System For Improving Outcome After A Brain Injury Affecting Cerebral Blood Flow |
| US9399019B2 (en) * | 2012-05-09 | 2016-07-26 | Evonik Corporation | Polymorph compositions, methods of making, and uses thereof |
-
2013
- 2013-03-11 US US13/793,767 patent/US10092524B2/en not_active Expired - Fee Related
-
2014
- 2014-03-11 JP JP2016501330A patent/JP2016512527A/ja active Pending
- 2014-03-11 EP EP14780318.3A patent/EP2968166A4/en not_active Withdrawn
- 2014-03-11 CA CA2905327A patent/CA2905327A1/en not_active Abandoned
- 2014-03-11 GB GB1516997.2A patent/GB2528801A/en not_active Withdrawn
- 2014-03-11 CN CN201480026815.5A patent/CN105324108A/zh active Pending
- 2014-03-11 KR KR1020157028454A patent/KR101902319B1/ko not_active Expired - Fee Related
- 2014-03-11 BR BR112015022218A patent/BR112015022218A2/pt not_active IP Right Cessation
- 2014-03-11 SG SG11201507398XA patent/SG11201507398XA/en unknown
- 2014-03-11 WO PCT/US2014/023748 patent/WO2014164904A1/en not_active Ceased
- 2014-03-11 RU RU2015143206A patent/RU2015143206A/ru not_active Application Discontinuation
- 2014-03-11 NZ NZ629730A patent/NZ629730A/en not_active IP Right Cessation
- 2014-03-11 HK HK16103935.4A patent/HK1216002A1/zh unknown
- 2014-03-11 AU AU2014248877A patent/AU2014248877A1/en not_active Abandoned
-
2016
- 2016-05-16 US US15/156,152 patent/US20160324796A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR101902319B1 (ko) | 2018-09-28 |
| JP2016512527A (ja) | 2016-04-28 |
| RU2015143206A (ru) | 2017-04-18 |
| US20160324796A1 (en) | 2016-11-10 |
| GB201516997D0 (en) | 2015-11-11 |
| AU2014248877A1 (en) | 2015-10-01 |
| BR112015022218A2 (pt) | 2017-07-18 |
| EP2968166A1 (en) | 2016-01-20 |
| SG11201507398XA (en) | 2015-10-29 |
| EP2968166A4 (en) | 2016-10-05 |
| US20130243864A1 (en) | 2013-09-19 |
| KR20150136084A (ko) | 2015-12-04 |
| GB2528801A (en) | 2016-02-03 |
| AU2014248877A8 (en) | 2015-10-29 |
| HK1216002A1 (zh) | 2016-10-07 |
| CN105324108A (zh) | 2016-02-10 |
| US10092524B2 (en) | 2018-10-09 |
| WO2014164904A1 (en) | 2014-10-09 |
| CA2905327A1 (en) | 2014-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ629730A (en) | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage | |
| EP4509520A3 (en) | Silk protein fragment compositions and articles manufactured therefrom | |
| IN2015DN04178A (enExample) | ||
| TW201612225A (en) | Additive for LDS plastics | |
| MX2015000921A (es) | Polimeros de organopolisiloxano. | |
| HK1214618A1 (zh) | 含有透明質酸的穩定化組合物 | |
| MX340992B (es) | Copolimeros de bloque para micelas estables. | |
| PH12013501571A1 (en) | Extensional viscosity to promote safe swallowing of food boluses | |
| PH12016500393A1 (en) | Furanoic polymer preforms, containers and processing | |
| BR112014015909A2 (pt) | composição | |
| EP4541955A3 (en) | Polymer composition comprising basic additive, process and articles comprising said polymer composition | |
| CY1125511T1 (el) | Συνθεση που περιλαμβανει χιτοζανη και ενα μυκητοκτονο | |
| MX376192B (es) | Articulo moldeado por inyeccion. | |
| MX344487B (es) | Polimeros de propileno-alfa-olefina, composiciones de adhesivos de fusion por calor que incluyen polimeros de propileno-alfa-olefina y articulos que los incluyen. | |
| MX344635B (es) | Composiciones y usos de materiales antimicrobianos con propiedades compatibles con el tejido. | |
| MX2018012682A (es) | Conjugados de acido hialuronico y usos de los mismos. | |
| MX373828B (es) | Composiciones poliméricas curables con humedad que tienen polímeros halogenados y mercáptidos de metal. | |
| EA201890698A1 (ru) | Химически инертный термоплавкий клей с улучшителем времени схватывания | |
| MX2018006194A (es) | Peptidos con propiedades antiangiogenicas, antilinfangiogenicas y antiedemicas y formulaciones de nanoparticulas. | |
| IN2014DE03288A (enExample) | ||
| BR112015020895A2 (pt) | composto de siloxano substancialmente linear, terminado em amina e produtos époxi feitos com o mesmo | |
| EP2998338A4 (en) | Highly functional polyamide polymer, spinning dope composition containing same, and molded product thereof | |
| MX2016010231A (es) | Conjugados del factor viii. | |
| MX2016010229A (es) | Conjugados del factor vii. | |
| MX2016011440A (es) | Promocion de la adhesion a sustratos dificiles para adhesivos de fusion en caliente. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 MAR 2019 BY CPA GLOBAL Effective date: 20180201 |
|
| LAPS | Patent lapsed |