RU2015143206A - Композиции и их применение для лечения осложнений аневризматического субарахноидального кровоизлияния - Google Patents
Композиции и их применение для лечения осложнений аневризматического субарахноидального кровоизлияния Download PDFInfo
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- RU2015143206A RU2015143206A RU2015143206A RU2015143206A RU2015143206A RU 2015143206 A RU2015143206 A RU 2015143206A RU 2015143206 A RU2015143206 A RU 2015143206A RU 2015143206 A RU2015143206 A RU 2015143206A RU 2015143206 A RU2015143206 A RU 2015143206A
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- Prior art keywords
- therapeutic agent
- application
- pharmaceutically acceptable
- delayed
- acceptable carrier
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- 239000000203 mixture Substances 0.000 title claims 16
- 208000032843 Hemorrhage Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 claims 45
- 238000000034 method Methods 0.000 claims 44
- 229940124597 therapeutic agent Drugs 0.000 claims 44
- 239000003937 drug carrier Substances 0.000 claims 24
- 230000003111 delayed effect Effects 0.000 claims 22
- 210000001627 cerebral artery Anatomy 0.000 claims 17
- 239000002245 particle Substances 0.000 claims 14
- 230000001225 therapeutic effect Effects 0.000 claims 14
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims 13
- 239000012530 fluid Substances 0.000 claims 12
- 206010008118 cerebral infarction Diseases 0.000 claims 10
- 239000011859 microparticle Substances 0.000 claims 10
- 239000002105 nanoparticle Substances 0.000 claims 10
- 238000002347 injection Methods 0.000 claims 9
- 239000007924 injection Substances 0.000 claims 9
- 201000006474 Brain Ischemia Diseases 0.000 claims 8
- 108090000312 Calcium Channels Proteins 0.000 claims 8
- 102000003922 Calcium Channels Human genes 0.000 claims 8
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 8
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 229940125400 channel inhibitor Drugs 0.000 claims 7
- 239000011159 matrix material Substances 0.000 claims 6
- 231100000682 maximum tolerated dose Toxicity 0.000 claims 6
- 208000024891 symptom Diseases 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 5
- 238000013268 sustained release Methods 0.000 claims 5
- 239000012730 sustained-release form Substances 0.000 claims 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 4
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 claims 4
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 4
- 229940125968 Voltage-Gated Calcium Channel inhibitor Drugs 0.000 claims 4
- 229920002988 biodegradable polymer Polymers 0.000 claims 4
- 239000004621 biodegradable polymer Substances 0.000 claims 4
- 239000000480 calcium channel blocker Substances 0.000 claims 4
- 230000002490 cerebral effect Effects 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 229920002674 hyaluronan Polymers 0.000 claims 4
- 229960003160 hyaluronic acid Drugs 0.000 claims 4
- 238000007913 intrathecal administration Methods 0.000 claims 4
- 238000007914 intraventricular administration Methods 0.000 claims 4
- 229960000715 nimodipine Drugs 0.000 claims 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 4
- 210000002330 subarachnoid space Anatomy 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 3
- 210000001367 artery Anatomy 0.000 claims 3
- 210000004556 brain Anatomy 0.000 claims 3
- HMJIYCCIJYRONP-UHFFFAOYSA-N (+-)-Isradipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC2=NON=C12 HMJIYCCIJYRONP-UHFFFAOYSA-N 0.000 claims 2
- PVHUJELLJLJGLN-INIZCTEOSA-N (S)-nitrendipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC([N+]([O-])=O)=C1 PVHUJELLJLJGLN-INIZCTEOSA-N 0.000 claims 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 claims 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 2
- NSVFSAJIGAJDMR-UHFFFAOYSA-N 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate Chemical compound CC=1NC(C)=C(C(=O)OCCN(CC=2C=CC=CC=2)C=2C=CC=CC=2)C(C=2C=C(C=CC=2)[N+]([O-])=O)C=1P1(=O)OCC(C)(C)CO1 NSVFSAJIGAJDMR-UHFFFAOYSA-N 0.000 claims 2
- XTFPDGZNWTZCMF-DHZHZOJOSA-N 3-o-methyl 5-o-[(e)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC\C=C\C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 XTFPDGZNWTZCMF-DHZHZOJOSA-N 0.000 claims 2
- RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 claims 2
- NCUCGYYHUFIYNU-UHFFFAOYSA-N Aranidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)=O)C1C1=CC=CC=C1[N+]([O-])=O NCUCGYYHUFIYNU-UHFFFAOYSA-N 0.000 claims 2
- ZKFQEACEUNWPMT-UHFFFAOYSA-N Azelnidipine Chemical compound CC(C)OC(=O)C1=C(C)NC(N)=C(C(=O)OC2CN(C2)C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZKFQEACEUNWPMT-UHFFFAOYSA-N 0.000 claims 2
- KJEBULYHNRNJTE-DHZHZOJOSA-N Cinalong Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC\C=C\C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 KJEBULYHNRNJTE-DHZHZOJOSA-N 0.000 claims 2
- 206010010071 Coma Diseases 0.000 claims 2
- WTOVRSWDBLIFHU-UHFFFAOYSA-N Lemildipine Chemical compound COC(=O)C1=C(C)NC(COC(N)=O)=C(C(=O)OC(C)C)C1C1=CC=CC(Cl)=C1Cl WTOVRSWDBLIFHU-UHFFFAOYSA-N 0.000 claims 2
- ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 claims 2
- FAIIFDPAEUKBEP-UHFFFAOYSA-N Nilvadipine Chemical compound COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC([N+]([O-])=O)=C1 FAIIFDPAEUKBEP-UHFFFAOYSA-N 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 206010047163 Vasospasm Diseases 0.000 claims 2
- 229960000528 amlodipine Drugs 0.000 claims 2
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 2
- 210000002551 anterior cerebral artery Anatomy 0.000 claims 2
- 229950007556 aranidipine Drugs 0.000 claims 2
- 229950004646 azelnidipine Drugs 0.000 claims 2
- -1 bamidipine Chemical compound 0.000 claims 2
- 229960004916 benidipine Drugs 0.000 claims 2
- QZVNQOLPLYWLHQ-ZEQKJWHPSA-N benidipine Chemical compound C1([C@H]2C(=C(C)NC(C)=C2C(=O)OC)C(=O)O[C@H]2CN(CC=3C=CC=CC=3)CCC2)=CC=CC([N+]([O-])=O)=C1 QZVNQOLPLYWLHQ-ZEQKJWHPSA-N 0.000 claims 2
- 230000002051 biphasic effect Effects 0.000 claims 2
- 230000006931 brain damage Effects 0.000 claims 2
- 231100000874 brain damage Toxicity 0.000 claims 2
- 208000029028 brain injury Diseases 0.000 claims 2
- 210000001715 carotid artery Anatomy 0.000 claims 2
- 210000004004 carotid artery internal Anatomy 0.000 claims 2
- 208000026106 cerebrovascular disease Diseases 0.000 claims 2
- 229960003020 cilnidipine Drugs 0.000 claims 2
- 230000001054 cortical effect Effects 0.000 claims 2
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims 2
- 239000006185 dispersion Substances 0.000 claims 2
- 238000009826 distribution Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229950003102 efonidipine Drugs 0.000 claims 2
- 239000002308 endothelin receptor antagonist Substances 0.000 claims 2
- 229960003580 felodipine Drugs 0.000 claims 2
- 210000004055 fourth ventricle Anatomy 0.000 claims 2
- 238000007917 intracranial administration Methods 0.000 claims 2
- 208000028867 ischemia Diseases 0.000 claims 2
- 229960004427 isradipine Drugs 0.000 claims 2
- 229960004340 lacidipine Drugs 0.000 claims 2
- GKQPCPXONLDCMU-CCEZHUSRSA-N lacidipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1C1=CC=CC=C1\C=C\C(=O)OC(C)(C)C GKQPCPXONLDCMU-CCEZHUSRSA-N 0.000 claims 2
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 2
- 210000003140 lateral ventricle Anatomy 0.000 claims 2
- 229950001530 lemildipine Drugs 0.000 claims 2
- 229960004294 lercanidipine Drugs 0.000 claims 2
- ZDXUKAKRHYTAKV-UHFFFAOYSA-N lercanidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-UHFFFAOYSA-N 0.000 claims 2
- 229960003963 manidipine Drugs 0.000 claims 2
- ANEBWFXPVPTEET-UHFFFAOYSA-N manidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ANEBWFXPVPTEET-UHFFFAOYSA-N 0.000 claims 2
- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 claims 2
- 210000003657 middle cerebral artery Anatomy 0.000 claims 2
- 229960001783 nicardipine Drugs 0.000 claims 2
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims 2
- 229960001597 nifedipine Drugs 0.000 claims 2
- 229960005366 nilvadipine Drugs 0.000 claims 2
- 229960000227 nisoldipine Drugs 0.000 claims 2
- 229960005425 nitrendipine Drugs 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229950004891 pranidipine Drugs 0.000 claims 2
- 238000001179 sorption measurement Methods 0.000 claims 2
- 210000000278 spinal cord Anatomy 0.000 claims 2
- 230000001839 systemic circulation Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 210000000211 third ventricle Anatomy 0.000 claims 2
- 230000001052 transient effect Effects 0.000 claims 2
- 238000009827 uniform distribution Methods 0.000 claims 2
- 210000002385 vertebral artery Anatomy 0.000 claims 2
- 108091006146 Channels Proteins 0.000 claims 1
- 102100032950 GPI mannosyltransferase 1 Human genes 0.000 claims 1
- 101000730688 Homo sapiens GPI mannosyltransferase 1 Proteins 0.000 claims 1
- 210000004289 cerebral ventricle Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940076372 protein antagonist Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/793,767 | 2013-03-11 | ||
| US13/793,767 US10092524B2 (en) | 2008-06-11 | 2013-03-11 | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
| PCT/US2014/023748 WO2014164904A1 (en) | 2013-03-11 | 2014-03-11 | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015143206A true RU2015143206A (ru) | 2017-04-18 |
Family
ID=49157870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015143206A RU2015143206A (ru) | 2013-03-11 | 2014-03-11 | Композиции и их применение для лечения осложнений аневризматического субарахноидального кровоизлияния |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10092524B2 (enExample) |
| EP (1) | EP2968166A4 (enExample) |
| JP (1) | JP2016512527A (enExample) |
| KR (1) | KR101902319B1 (enExample) |
| CN (1) | CN105324108A (enExample) |
| AU (1) | AU2014248877A1 (enExample) |
| BR (1) | BR112015022218A2 (enExample) |
| CA (1) | CA2905327A1 (enExample) |
| GB (1) | GB2528801A (enExample) |
| HK (1) | HK1216002A1 (enExample) |
| NZ (1) | NZ629730A (enExample) |
| RU (1) | RU2015143206A (enExample) |
| SG (1) | SG11201507398XA (enExample) |
| WO (1) | WO2014164904A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10092524B2 (en) | 2008-06-11 | 2018-10-09 | Edge Therapeutics, Inc. | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
| SG10201602665UA (en) | 2011-04-05 | 2016-05-30 | Edge Therapeutics | Intraventricular Drug Delivery System For Improving Outcome After A Brain Injury Affecting Cerebral Blood Flow |
| CA2986692A1 (en) * | 2015-05-29 | 2016-12-08 | Edge Therapeutics, Inc. | Compositions and methods for reducing visual loss |
| WO2017176914A1 (en) * | 2016-04-07 | 2017-10-12 | Edge Therapeutics, Inc. | Formulations of site-specific, microparticulate compositions and their use to improve outcome after aneurysmal subarachnoid hemorrhage |
| CN108403629B (zh) * | 2018-04-26 | 2019-11-05 | 徐州医科大学 | 一种尼莫地平口服长效悬浮液及其制备方法 |
| WO2020227558A2 (en) * | 2019-05-07 | 2020-11-12 | Yale University | Maximizing distribution and minimizing washout of injectates in bone and method for enhanced aspirate extraction |
| WO2020235947A1 (ko) * | 2019-05-22 | 2020-11-26 | 경북대학교 산학협력단 | Cacb1 유래 펩타이드, Cacb1 유래 펩타이드의 변이체 및 이의 용도 |
| WO2021168351A1 (en) * | 2020-02-20 | 2021-08-26 | Postsurgical Therapeutics, Inc. | Brain drug delivery system and method |
| WO2021262725A1 (en) * | 2020-06-22 | 2021-12-30 | Curelator, Inc. | Systems and methods for segmentation of a user population based on time-based variations in biomarker levels |
| US11452690B1 (en) | 2021-01-27 | 2022-09-27 | ECI Pharmaceuticals, LLC | Oral liquid compositions comprising amlodipine besylate and methods of using the same |
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| NZ629730A (en) | 2017-03-31 |
| KR101902319B1 (ko) | 2018-09-28 |
| JP2016512527A (ja) | 2016-04-28 |
| US20160324796A1 (en) | 2016-11-10 |
| GB201516997D0 (en) | 2015-11-11 |
| AU2014248877A1 (en) | 2015-10-01 |
| BR112015022218A2 (pt) | 2017-07-18 |
| EP2968166A1 (en) | 2016-01-20 |
| SG11201507398XA (en) | 2015-10-29 |
| EP2968166A4 (en) | 2016-10-05 |
| US20130243864A1 (en) | 2013-09-19 |
| KR20150136084A (ko) | 2015-12-04 |
| GB2528801A (en) | 2016-02-03 |
| AU2014248877A8 (en) | 2015-10-29 |
| HK1216002A1 (zh) | 2016-10-07 |
| CN105324108A (zh) | 2016-02-10 |
| US10092524B2 (en) | 2018-10-09 |
| WO2014164904A1 (en) | 2014-10-09 |
| CA2905327A1 (en) | 2014-10-09 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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