NZ598208A - Inhibitors of flaviviridae viruses - Google Patents
Inhibitors of flaviviridae virusesInfo
- Publication number
- NZ598208A NZ598208A NZ598208A NZ59820810A NZ598208A NZ 598208 A NZ598208 A NZ 598208A NZ 598208 A NZ598208 A NZ 598208A NZ 59820810 A NZ59820810 A NZ 59820810A NZ 598208 A NZ598208 A NZ 598208A
- Authority
- NZ
- New Zealand
- Prior art keywords
- inhibitors
- trans
- dimethyl
- viral infection
- flaviviridae viruses
- Prior art date
Links
- 241000710781 Flaviviridae Species 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- JEKIGZSNURWNOL-GNAWZBFMSA-N CC(C#CC1=CC(=C(S1)C(=O)O)N(C(=O)[C@@H]1CC[C@H](CC1)C)[C@@H]1CC[C@H](CC1)OP(=O)(C(C)C)C)(C)C Chemical compound CC(C#CC1=CC(=C(S1)C(=O)O)N(C(=O)[C@@H]1CC[C@H](CC1)C)[C@@H]1CC[C@H](CC1)OP(=O)(C(C)C)C)(C)C JEKIGZSNURWNOL-GNAWZBFMSA-N 0.000 abstract 1
- 241000711549 Hepacivirus C Species 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/67—Phosphorus compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65681—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a (thio)phosphinic acid or ester thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24087409P | 2009-09-09 | 2009-09-09 | |
| PCT/US2010/047983 WO2011031669A1 (en) | 2009-09-09 | 2010-09-07 | Inhibitors of flaviviridae viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ598208A true NZ598208A (en) | 2014-02-28 |
Family
ID=43028061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ598208A NZ598208A (en) | 2009-09-09 | 2010-09-07 | Inhibitors of flaviviridae viruses |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8501714B2 (OSRAM) |
| EP (1) | EP2507249B1 (OSRAM) |
| JP (1) | JP5774008B2 (OSRAM) |
| KR (1) | KR20120081123A (OSRAM) |
| CN (1) | CN102498118A (OSRAM) |
| AU (1) | AU2010292411B2 (OSRAM) |
| BR (1) | BR112012005438A2 (OSRAM) |
| CA (1) | CA2771124C (OSRAM) |
| ES (1) | ES2559437T3 (OSRAM) |
| IN (1) | IN2012DN01855A (OSRAM) |
| MX (1) | MX2012002925A (OSRAM) |
| NZ (1) | NZ598208A (OSRAM) |
| PT (1) | PT2507249E (OSRAM) |
| WO (1) | WO2011031669A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101330547A (zh) * | 2007-06-20 | 2008-12-24 | 朗迅科技公司 | 在VoIP网络中分布的用于提供服务的媒体资源 |
| WO2011011303A1 (en) * | 2009-07-21 | 2011-01-27 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| NZ598208A (en) * | 2009-09-09 | 2014-02-28 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
| EP2523950B1 (en) * | 2010-01-15 | 2017-03-15 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| CN102712632A (zh) * | 2010-01-15 | 2012-10-03 | 吉里德科学公司 | 黄病毒科病毒的抑制剂 |
| JP2013531011A (ja) * | 2010-06-28 | 2013-08-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス感染の処置または予防のための化合物および方法 |
| EA201300160A1 (ru) | 2010-07-22 | 2013-06-28 | Новартис Аг | 2,3,5-тризамещенные тиофены и их применение |
| US20130203706A1 (en) * | 2011-06-28 | 2013-08-08 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
| ES2561888T3 (es) * | 2011-07-13 | 2016-03-01 | Gilead Sciences, Inc. | Derivados de ácido tiofeno-2-carboxílico útiles como inhibidores de virus Flaviviridae |
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
| US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| IL296496B2 (en) | 2014-12-26 | 2024-10-01 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| CN120887906A (zh) | 2016-05-10 | 2025-11-04 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| WO2018237026A1 (en) | 2017-06-20 | 2018-12-27 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| WO2019113462A1 (en) | 2017-12-07 | 2019-06-13 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861421A (en) | 1995-12-21 | 1999-01-19 | Smithkline Beecham Corporation | 4,4-(disubstituted) cyclohexan-1-one monomers and related compounds |
| US20050119332A1 (en) | 1998-03-12 | 2005-06-02 | Lone Jeppesen | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) |
| US20020002199A1 (en) | 1998-03-12 | 2002-01-03 | Lone Jeppesen | Modulators of protein tyrosine phosphatases (ptpases) |
| CA2450007C (en) | 2001-06-11 | 2012-04-17 | Shire Biochem Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| JP2005500287A (ja) | 2001-06-11 | 2005-01-06 | シャイアー バイオケム インコーポレイテッド | Ｆｌａｖｉｖｉｒｕｓ感染の処置または予防のための化合物および方法 |
| DE60332482D1 (de) | 2002-12-10 | 2010-06-17 | Virochem Pharma Inc | Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen |
| EP1569929B9 (en) * | 2002-12-10 | 2011-09-14 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| DE10359791A1 (de) | 2003-12-19 | 2005-07-21 | Bayer Healthcare Ag | Substituierte Thiophene |
| AR047894A1 (es) | 2004-02-25 | 2006-03-01 | Wyeth Corp | Derivados de tiofeno como inhibidores de la proteina tirosina fosfatasa 1b (ptpasa 1b); metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades mediadas por ptpasa 1b |
| BRPI0508230A (pt) | 2004-03-30 | 2007-07-17 | Chiron Corp | derivados de tiofeno substituìdo como agentes anti-cáncer |
| DE102004061746A1 (de) | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
| DE102005028077A1 (de) | 2004-12-22 | 2006-07-13 | Aicuris Gmbh & Co. Kg | Alkinyl-substituierte Thiophene |
| CN102718744A (zh) | 2005-05-13 | 2012-10-10 | Viro化学制药公司 | 治疗或预防黄病毒感染的组合物和方法 |
| CA2636879A1 (en) | 2006-02-15 | 2007-08-23 | Sanofi-Aventis | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
| ES2423219T3 (es) | 2006-11-15 | 2013-09-18 | Vertex Pharmaceuticals (Canada) Incorporated | Análogos de tiofeno para el tratamiento o prevención de infecciones por flavivirus |
| WO2008059042A1 (en) | 2006-11-17 | 2008-05-22 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti viral agents |
| PE20120207A1 (es) | 2008-12-03 | 2012-03-31 | Presidio Pharmaceuticals Inc | Derivados de naftaleno, como inhibidores de hcv ns5a |
| WO2011011303A1 (en) | 2009-07-21 | 2011-01-27 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| NZ598208A (en) * | 2009-09-09 | 2014-02-28 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
| AU2010326225A1 (en) | 2009-11-25 | 2012-06-07 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
| CN102712632A (zh) | 2010-01-15 | 2012-10-03 | 吉里德科学公司 | 黄病毒科病毒的抑制剂 |
| EP2523950B1 (en) | 2010-01-15 | 2017-03-15 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| EP2585447A2 (en) | 2010-06-28 | 2013-05-01 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
| ES2561888T3 (es) | 2011-07-13 | 2016-03-01 | Gilead Sciences, Inc. | Derivados de ácido tiofeno-2-carboxílico útiles como inhibidores de virus Flaviviridae |
-
2010
- 2010-09-07 NZ NZ598208A patent/NZ598208A/en not_active IP Right Cessation
- 2010-09-07 EP EP10763902.3A patent/EP2507249B1/en active Active
- 2010-09-07 JP JP2012528855A patent/JP5774008B2/ja not_active Expired - Fee Related
- 2010-09-07 MX MX2012002925A patent/MX2012002925A/es active IP Right Grant
- 2010-09-07 CN CN2010800404113A patent/CN102498118A/zh active Pending
- 2010-09-07 AU AU2010292411A patent/AU2010292411B2/en not_active Ceased
- 2010-09-07 US US13/392,467 patent/US8501714B2/en active Active
- 2010-09-07 ES ES10763902.3T patent/ES2559437T3/es active Active
- 2010-09-07 IN IN1855DEN2012 patent/IN2012DN01855A/en unknown
- 2010-09-07 PT PT107639023T patent/PT2507249E/pt unknown
- 2010-09-07 WO PCT/US2010/047983 patent/WO2011031669A1/en not_active Ceased
- 2010-09-07 BR BR112012005438A patent/BR112012005438A2/pt not_active IP Right Cessation
- 2010-09-07 KR KR1020127008996A patent/KR20120081123A/ko not_active Withdrawn
- 2010-09-07 CA CA2771124A patent/CA2771124C/en not_active Expired - Fee Related
-
2013
- 2013-06-26 US US13/927,355 patent/US8765722B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1170740A1 (zh) | 2013-03-08 |
| US20120156166A1 (en) | 2012-06-21 |
| JP5774008B2 (ja) | 2015-09-02 |
| KR20120081123A (ko) | 2012-07-18 |
| AU2010292411B2 (en) | 2015-04-09 |
| IN2012DN01855A (OSRAM) | 2015-08-21 |
| US8765722B2 (en) | 2014-07-01 |
| CA2771124C (en) | 2019-01-15 |
| PT2507249E (pt) | 2016-02-15 |
| AU2010292411A1 (en) | 2012-03-15 |
| US8501714B2 (en) | 2013-08-06 |
| CA2771124A1 (en) | 2011-03-17 |
| BR112012005438A2 (pt) | 2018-03-20 |
| EP2507249B1 (en) | 2015-11-11 |
| MX2012002925A (es) | 2012-08-03 |
| WO2011031669A1 (en) | 2011-03-17 |
| US20130302280A1 (en) | 2013-11-14 |
| EP2507249A1 (en) | 2012-10-10 |
| CN102498118A (zh) | 2012-06-13 |
| ES2559437T3 (es) | 2016-02-12 |
| JP2013504576A (ja) | 2013-02-07 |
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