NZ595433A - 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2 - Google Patents
4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2Info
- Publication number
- NZ595433A NZ595433A NZ595433A NZ59543310A NZ595433A NZ 595433 A NZ595433 A NZ 595433A NZ 595433 A NZ595433 A NZ 595433A NZ 59543310 A NZ59543310 A NZ 59543310A NZ 595433 A NZ595433 A NZ 595433A
- Authority
- NZ
- New Zealand
- Prior art keywords
- methyl
- ylcarbamoyl
- azetidin
- benzamide
- trifluoromethyl
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- 208000011580 syndromic disease Diseases 0.000 abstract 3
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000002975 chemoattractant Substances 0.000 abstract 1
- 102000003675 cytokine receptors Human genes 0.000 abstract 1
- 108010057085 cytokine receptors Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- DPCUJUSPJRBELZ-UHFFFAOYSA-N n-[2-[[1-[4-(1,3-benzodioxol-5-ylcarbamoylamino)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=CC(C(=O)NCC(=O)NC2CN(C2)C2CCC(CC2)NC(=O)NC=2C=C3OCOC3=CC=2)=C1 DPCUJUSPJRBELZ-UHFFFAOYSA-N 0.000 abstract 1
- OEKTZWKCHPJLMT-UHFFFAOYSA-N n-[2-[[1-[4-(2,5-dimethylpyrrol-1-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Chemical compound CC1=CC=C(C)N1C1CCC(N2CC(C2)NC(=O)CNC(=O)C=2C=C(C=CC=2)C(F)(F)F)CC1 OEKTZWKCHPJLMT-UHFFFAOYSA-N 0.000 abstract 1
- OEDILMILNVRNIQ-UHFFFAOYSA-N n-[2-[[1-[4-(4-iodopyrazol-1-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=CC(C(=O)NCC(=O)NC2CN(C2)C2CCC(CC2)N2N=CC(I)=C2)=C1 OEDILMILNVRNIQ-UHFFFAOYSA-N 0.000 abstract 1
- YHKVPWCTDDFFFY-UHFFFAOYSA-N n-[2-[[1-[4-(4-methylpyridin-2-yl)oxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Chemical compound CC1=CC=NC(OC2CCC(CC2)N2CC(C2)NC(=O)CNC(=O)C=2C=C(C=CC=2)C(F)(F)F)=C1 YHKVPWCTDDFFFY-UHFFFAOYSA-N 0.000 abstract 1
- KSIDEJORWQRBEU-UHFFFAOYSA-N n-[2-[[1-[4-(5-methylpyridin-2-yl)oxycyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide Chemical compound N1=CC(C)=CC=C1OC1CCC(N2CC(C2)NC(=O)CNC(=O)C=2C=C(C=CC=2)C(F)(F)F)CC1 KSIDEJORWQRBEU-UHFFFAOYSA-N 0.000 abstract 1
- NAWWABAQSDGYPX-UHFFFAOYSA-N n-[2-oxo-2-[[1-(4-pyrimidin-4-yloxycyclohexyl)azetidin-3-yl]amino]ethyl]-3-(trifluoromethyl)benzamide Chemical compound FC(F)(F)C1=CC=CC(C(=O)NCC(=O)NC2CN(C2)C2CCC(CC2)OC=2N=CN=CC=2)=C1 NAWWABAQSDGYPX-UHFFFAOYSA-N 0.000 abstract 1
- JCCGSOVTBIJRGP-UHFFFAOYSA-N n-piperidin-1-ylprop-2-enamide Chemical class C=CC(=O)NN1CCCCC1 JCCGSOVTBIJRGP-UHFFFAOYSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17022509P | 2009-04-17 | 2009-04-17 | |
| PCT/US2010/031255 WO2010121036A1 (en) | 2009-04-17 | 2010-04-15 | 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ595433A true NZ595433A (en) | 2013-12-20 |
Family
ID=42169493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ595433A NZ595433A (en) | 2009-04-17 | 2010-04-15 | 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8324186B2 (enExample) |
| EP (1) | EP2419418B1 (enExample) |
| JP (1) | JP5685581B2 (enExample) |
| KR (1) | KR20120006051A (enExample) |
| CN (1) | CN102459226B (enExample) |
| AR (1) | AR076329A1 (enExample) |
| AU (1) | AU2010236336B2 (enExample) |
| BR (1) | BRPI1016205A2 (enExample) |
| CA (1) | CA2758929A1 (enExample) |
| ES (1) | ES2541607T3 (enExample) |
| MX (1) | MX2011010963A (enExample) |
| NZ (1) | NZ595433A (enExample) |
| TW (1) | TW201102379A (enExample) |
| WO (1) | WO2010121036A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2376475B1 (en) | 2008-12-10 | 2015-09-02 | Janssen Pharmaceutica NV | 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2 |
| EP2419417B1 (en) * | 2009-04-16 | 2015-03-25 | Janssen Pharmaceutica NV | 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2 |
| WO2010121036A1 (en) | 2009-04-17 | 2010-10-21 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2 |
| NZ595432A (en) * | 2009-04-17 | 2013-12-20 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 |
| TW201211027A (en) * | 2010-06-09 | 2012-03-16 | Janssen Pharmaceutica Nv | Cyclohexyl-azetidinyl antagonists of CCR2 |
| KR101743280B1 (ko) | 2010-06-17 | 2017-06-02 | 얀센 파마슈티카 엔.브이. | Ccr2의 사이클로헥실-아제티디닐 길항제 |
| US20140329809A1 (en) | 2011-10-28 | 2014-11-06 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| WO2015056782A1 (ja) * | 2013-10-17 | 2015-04-23 | 塩野義製薬株式会社 | 新規アルキレン誘導体 |
| US20230174633A1 (en) * | 2020-03-30 | 2023-06-08 | Memorial Sloan Kettering Cancer Center | Methods and compositions for modulating lipid storage in adipose tissue |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998057641A1 (en) | 1997-06-18 | 1998-12-23 | Merck & Co., Inc. | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS |
| US6037354A (en) | 1997-06-18 | 2000-03-14 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| EP1201239A4 (en) | 1999-08-04 | 2004-12-08 | Teijin Ltd | CCR3 CYCLIC AMINE ANTAGONISTS |
| US6245799B1 (en) | 1999-11-08 | 2001-06-12 | American Home Products Corp | [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders |
| AU1446601A (en) | 1999-11-08 | 2001-06-06 | American Home Products Corporation | ((indol-3-yl)-cycloalkyl)-3-substituted azetidines for the treatment of central nervous system disorders |
| AR035773A1 (es) | 2000-12-20 | 2004-07-14 | Bristol Myers Squibb Pharma Co | Compuestos diamino ciclico, composicion farmaceutica y su uso en la fabricacion de un medicamento util para modular la actividad de una quimioquina |
| UA87449C2 (ru) * | 2002-11-27 | 2009-07-27 | Инсайт Корпорейшн | Производные 3-аминопиролидина как модуляторы рецепторов хемокина |
| ATE555087T1 (de) | 2002-11-27 | 2012-05-15 | Incyte Corp | 3-aminopyrrolidinderivate als modulatoren von chemokinrezeptoren |
| GB0417801D0 (en) * | 2004-08-10 | 2004-09-15 | Novartis Ag | Organic compounds |
| JP2008514700A (ja) | 2004-09-28 | 2008-05-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 置換されたジピペリジンｃｃｒ２アンタゴニスト |
| UY29219A1 (es) * | 2004-11-22 | 2006-04-28 | Incyte Corp | Sales de la n-(2- (((3r)-1-(trans-4-hidroxi-4-(6-metoxipiridin-3-il)-cilohexil) pirrolidin-3-il)amino)-2-oxoetil)-3- (trifluorometil) benzamida |
| GB0513747D0 (en) | 2005-07-06 | 2005-08-10 | Merck Sharp & Dohme | Therapeutic compounds |
| WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| US20070197590A1 (en) | 2006-01-31 | 2007-08-23 | Demong Duane E | Substituted dipiperidine ccr2 antagonists |
| CA2708364A1 (en) * | 2007-12-11 | 2009-06-18 | Efrat Ben-Zeev | Carboxamide compounds and their use as chemokine receptor agonists |
| EP2376475B1 (en) * | 2008-12-10 | 2015-09-02 | Janssen Pharmaceutica NV | 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2 |
| EP2419417B1 (en) | 2009-04-16 | 2015-03-25 | Janssen Pharmaceutica NV | 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2 |
| WO2010121036A1 (en) | 2009-04-17 | 2010-10-21 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2 |
| NZ595432A (en) | 2009-04-17 | 2013-12-20 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 |
-
2010
- 2010-04-15 WO PCT/US2010/031255 patent/WO2010121036A1/en not_active Ceased
- 2010-04-15 ES ES10714151.7T patent/ES2541607T3/es active Active
- 2010-04-15 AU AU2010236336A patent/AU2010236336B2/en not_active Ceased
- 2010-04-15 US US12/760,855 patent/US8324186B2/en not_active Expired - Fee Related
- 2010-04-15 EP EP10714151.7A patent/EP2419418B1/en active Active
- 2010-04-15 KR KR1020117026820A patent/KR20120006051A/ko not_active Withdrawn
- 2010-04-15 JP JP2012506227A patent/JP5685581B2/ja not_active Expired - Fee Related
- 2010-04-15 CA CA2758929A patent/CA2758929A1/en not_active Abandoned
- 2010-04-15 BR BRPI1016205A patent/BRPI1016205A2/pt not_active Application Discontinuation
- 2010-04-15 NZ NZ595433A patent/NZ595433A/en not_active IP Right Cessation
- 2010-04-15 MX MX2011010963A patent/MX2011010963A/es active IP Right Grant
- 2010-04-15 CN CN201080027621.9A patent/CN102459226B/zh not_active Expired - Fee Related
- 2010-04-16 TW TW099111900A patent/TW201102379A/zh unknown
- 2010-04-19 AR ARP100101288A patent/AR076329A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102459226A (zh) | 2012-05-16 |
| EP2419418A1 (en) | 2012-02-22 |
| WO2010121036A1 (en) | 2010-10-21 |
| CN102459226B (zh) | 2014-09-17 |
| JP5685581B2 (ja) | 2015-03-18 |
| KR20120006051A (ko) | 2012-01-17 |
| CA2758929A1 (en) | 2010-10-21 |
| AR076329A1 (es) | 2011-06-01 |
| BRPI1016205A2 (pt) | 2016-04-19 |
| TW201102379A (en) | 2011-01-16 |
| MX2011010963A (es) | 2011-11-02 |
| AU2010236336B2 (en) | 2015-01-15 |
| JP2012524110A (ja) | 2012-10-11 |
| EP2419418B1 (en) | 2015-04-15 |
| US20100267668A1 (en) | 2010-10-21 |
| AU2010236336A1 (en) | 2011-11-03 |
| US8324186B2 (en) | 2012-12-04 |
| ES2541607T3 (es) | 2015-07-22 |
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