CN102459226B - Ccr2的4-氮杂环丁烷基-1-杂原子连接的-环己烷拮抗剂 - Google Patents

Ccr2的4-氮杂环丁烷基-1-杂原子连接的-环己烷拮抗剂 Download PDF

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CN102459226B
CN102459226B CN201080027621.9A CN201080027621A CN102459226B CN 102459226 B CN102459226 B CN 102459226B CN 201080027621 A CN201080027621 A CN 201080027621A CN 102459226 B CN102459226 B CN 102459226B
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base
compound
alkyl
disease
methyl
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CN102459226A (zh
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张旭庆
H·R·赫夫奈格尔
随治华
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Janssen Pharmaceutica NV
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CN201080027621.9A 2009-04-17 2010-04-15 Ccr2的4-氮杂环丁烷基-1-杂原子连接的-环己烷拮抗剂 Expired - Fee Related CN102459226B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17022509P 2009-04-17 2009-04-17
US61/170225 2009-04-17
US61/170,225 2009-04-17
PCT/US2010/031255 WO2010121036A1 (en) 2009-04-17 2010-04-15 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2

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CN102459226A CN102459226A (zh) 2012-05-16
CN102459226B true CN102459226B (zh) 2014-09-17

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US (1) US8324186B2 (enExample)
EP (1) EP2419418B1 (enExample)
JP (1) JP5685581B2 (enExample)
KR (1) KR20120006051A (enExample)
CN (1) CN102459226B (enExample)
AR (1) AR076329A1 (enExample)
AU (1) AU2010236336B2 (enExample)
BR (1) BRPI1016205A2 (enExample)
CA (1) CA2758929A1 (enExample)
ES (1) ES2541607T3 (enExample)
MX (1) MX2011010963A (enExample)
NZ (1) NZ595433A (enExample)
TW (1) TW201102379A (enExample)
WO (1) WO2010121036A1 (enExample)

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* Cited by examiner, † Cited by third party
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EP2376475B1 (en) 2008-12-10 2015-09-02 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
EP2419417B1 (en) * 2009-04-16 2015-03-25 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2
WO2010121036A1 (en) 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
NZ595432A (en) * 2009-04-17 2013-12-20 Janssen Pharmaceutica Nv 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
KR101743280B1 (ko) 2010-06-17 2017-06-02 얀센 파마슈티카 엔.브이. Ccr2의 사이클로헥실-아제티디닐 길항제
US20140329809A1 (en) 2011-10-28 2014-11-06 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
WO2015056782A1 (ja) * 2013-10-17 2015-04-23 塩野義製薬株式会社 新規アルキレン誘導体
US20230174633A1 (en) * 2020-03-30 2023-06-08 Memorial Sloan Kettering Cancer Center Methods and compositions for modulating lipid storage in adipose tissue

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EP2376475B1 (en) * 2008-12-10 2015-09-02 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
EP2419417B1 (en) 2009-04-16 2015-03-25 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2
WO2010121036A1 (en) 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
NZ595432A (en) 2009-04-17 2013-12-20 Janssen Pharmaceutica Nv 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2

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US20030004151A1 (en) * 2000-12-20 2003-01-02 Robert Cherney Cyclic derivatives as modulators of chemokine receptor activity
CN1741994A (zh) * 2002-11-27 2006-03-01 因塞特公司 作为趋化因子受体调节剂的3－氨基吡咯烷衍生物
US20060252751A1 (en) * 2002-11-27 2006-11-09 Chu-Biao Xue 3-Aminopyrrolidine derivaties as modulators of chemokine receptors
TW200633703A (en) * 2004-11-22 2006-10-01 Incyte Corp Salts of n-[2-({3R)-1-[trans-4-hydroxy-4-(6-methoxypyridin-3-yl)-cyclohexyl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide

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CN102459226A (zh) 2012-05-16
EP2419418A1 (en) 2012-02-22
WO2010121036A1 (en) 2010-10-21
JP5685581B2 (ja) 2015-03-18
KR20120006051A (ko) 2012-01-17
CA2758929A1 (en) 2010-10-21
AR076329A1 (es) 2011-06-01
NZ595433A (en) 2013-12-20
BRPI1016205A2 (pt) 2016-04-19
TW201102379A (en) 2011-01-16
MX2011010963A (es) 2011-11-02
AU2010236336B2 (en) 2015-01-15
JP2012524110A (ja) 2012-10-11
EP2419418B1 (en) 2015-04-15
US20100267668A1 (en) 2010-10-21
AU2010236336A1 (en) 2011-11-03
US8324186B2 (en) 2012-12-04
ES2541607T3 (es) 2015-07-22

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