KR20120006051A - Ｃｃｒ2의 4-아제티디닐-1-헤테로원자 연결된 사이클로헥산 길항제 - Google Patents

Ｃｃｒ2의 4-아제티디닐-1-헤테로원자 연결된 사이클로헥산 길항제 Download PDF

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Publication number
KR20120006051A
KR20120006051A KR1020117026820A KR20117026820A KR20120006051A KR 20120006051 A KR20120006051 A KR 20120006051A KR 1020117026820 A KR1020117026820 A KR 1020117026820A KR 20117026820 A KR20117026820 A KR 20117026820A KR 20120006051 A KR20120006051 A KR 20120006051A
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alkyl
compound
prepared
optionally substituted
methyl
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Korean (ko)
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쑤큉 장
헤더 래이 후프나젤
지후아 수이
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얀센 파마슈티카 엔.브이.
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings

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  • Obesity (AREA)
  • Endocrinology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
KR1020117026820A 2009-04-17 2010-04-15 Ｃｃｒ2의 4-아제티디닐-1-헤테로원자 연결된 사이클로헥산 길항제 Withdrawn KR20120006051A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17022509P 2009-04-17 2009-04-17
US61/170,225 2009-04-17

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KR20120006051A true KR20120006051A (ko) 2012-01-17

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KR1020117026820A Withdrawn KR20120006051A (ko) 2009-04-17 2010-04-15 Ｃｃｒ2의 4-아제티디닐-1-헤테로원자 연결된 사이클로헥산 길항제

Country Status (14)

Country Link
US (1) US8324186B2 (enExample)
EP (1) EP2419418B1 (enExample)
JP (1) JP5685581B2 (enExample)
KR (1) KR20120006051A (enExample)
CN (1) CN102459226B (enExample)
AR (1) AR076329A1 (enExample)
AU (1) AU2010236336B2 (enExample)
BR (1) BRPI1016205A2 (enExample)
CA (1) CA2758929A1 (enExample)
ES (1) ES2541607T3 (enExample)
MX (1) MX2011010963A (enExample)
NZ (1) NZ595433A (enExample)
TW (1) TW201102379A (enExample)
WO (1) WO2010121036A1 (enExample)

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EP2376475B1 (en) 2008-12-10 2015-09-02 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
EP2419417B1 (en) * 2009-04-16 2015-03-25 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2
WO2010121036A1 (en) 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
NZ595432A (en) * 2009-04-17 2013-12-20 Janssen Pharmaceutica Nv 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
KR101743280B1 (ko) 2010-06-17 2017-06-02 얀센 파마슈티카 엔.브이. Ccr2의 사이클로헥실-아제티디닐 길항제
US20140329809A1 (en) 2011-10-28 2014-11-06 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
WO2015056782A1 (ja) * 2013-10-17 2015-04-23 塩野義製薬株式会社 新規アルキレン誘導体
US20230174633A1 (en) * 2020-03-30 2023-06-08 Memorial Sloan Kettering Cancer Center Methods and compositions for modulating lipid storage in adipose tissue

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UA87449C2 (ru) * 2002-11-27 2009-07-27 Инсайт Корпорейшн Производные 3-аминопиролидина как модуляторы рецепторов хемокина
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UY29219A1 (es) * 2004-11-22 2006-04-28 Incyte Corp Sales de la n-(2- (((3r)-1-(trans-4-hidroxi-4-(6-metoxipiridin-3-il)-cilohexil) pirrolidin-3-il)amino)-2-oxoetil)-3- (trifluorometil) benzamida
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EP2419417B1 (en) 2009-04-16 2015-03-25 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2
WO2010121036A1 (en) 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
NZ595432A (en) 2009-04-17 2013-12-20 Janssen Pharmaceutica Nv 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2

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Publication number Publication date
CN102459226A (zh) 2012-05-16
EP2419418A1 (en) 2012-02-22
WO2010121036A1 (en) 2010-10-21
CN102459226B (zh) 2014-09-17
JP5685581B2 (ja) 2015-03-18
CA2758929A1 (en) 2010-10-21
AR076329A1 (es) 2011-06-01
NZ595433A (en) 2013-12-20
BRPI1016205A2 (pt) 2016-04-19
TW201102379A (en) 2011-01-16
MX2011010963A (es) 2011-11-02
AU2010236336B2 (en) 2015-01-15
JP2012524110A (ja) 2012-10-11
EP2419418B1 (en) 2015-04-15
US20100267668A1 (en) 2010-10-21
AU2010236336A1 (en) 2011-11-03
US8324186B2 (en) 2012-12-04
ES2541607T3 (es) 2015-07-22

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