NZ589812A - Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof - Google Patents

Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof

Info

Publication number
NZ589812A
NZ589812A NZ589812A NZ58981209A NZ589812A NZ 589812 A NZ589812 A NZ 589812A NZ 589812 A NZ589812 A NZ 589812A NZ 58981209 A NZ58981209 A NZ 58981209A NZ 589812 A NZ589812 A NZ 589812A
Authority
NZ
New Zealand
Prior art keywords
gene
outer membrane
inactivation
pora
genetically modified
Prior art date
Application number
NZ589812A
Other languages
English (en)
Inventor
Wendell David Zollinger
Mikhail Donets
Deborah Schmiel
Boris Ionin
Ryan Marques
Elizabeth Ellen Moran
Original Assignee
U S A As Represented By The Secretary Of The Army On Behalf Of Walter Reed Army Inst Of Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by U S A As Represented By The Secretary Of The Army On Behalf Of Walter Reed Army Inst Of Res filed Critical U S A As Represented By The Secretary Of The Army On Behalf Of Walter Reed Army Inst Of Res
Publication of NZ589812A publication Critical patent/NZ589812A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NZ589812A 2008-05-30 2009-06-01 Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof NZ589812A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5746208P 2008-05-30 2008-05-30
PCT/US2009/045818 WO2009158142A1 (en) 2008-05-30 2009-06-01 Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof

Publications (1)

Publication Number Publication Date
NZ589812A true NZ589812A (en) 2012-08-31

Family

ID=41444870

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ589812A NZ589812A (en) 2008-05-30 2009-06-01 Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof

Country Status (19)

Country Link
US (2) US9387239B2 (enExample)
EP (1) EP2296699A4 (enExample)
JP (2) JP5723768B2 (enExample)
KR (1) KR20110053314A (enExample)
CN (1) CN102105166A (enExample)
AU (1) AU2009262893B2 (enExample)
BR (1) BRPI0913268A2 (enExample)
CA (1) CA2726465A1 (enExample)
CO (1) CO6341569A2 (enExample)
CR (1) CR11812A (enExample)
DO (1) DOP2010000364A (enExample)
EC (1) ECSP10010723A (enExample)
IL (1) IL209660A0 (enExample)
MX (1) MX2010012999A (enExample)
NZ (1) NZ589812A (enExample)
RU (1) RU2477145C2 (enExample)
UA (1) UA99659C2 (enExample)
WO (1) WO2009158142A1 (enExample)
ZA (1) ZA201008548B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1860191A3 (en) 1999-05-19 2008-02-13 Novartis Vaccines and Diagnostics S.r.l. Combination neisserial compositions
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
JP2013521326A (ja) * 2010-03-10 2013-06-10 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物
PT3246044T (pt) 2010-08-23 2021-02-15 Wyeth Llc Formulações estáveis de antigénios de rlp2086 de neisseria meningitidis
AU2011300418B2 (en) * 2010-09-10 2016-05-12 Glaxosmithkline Biologicals Sa Meningococcus overexpressing NadA and/or NHBA and outer membrane vesicles derived therefrom
GB201015132D0 (en) * 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
AU2011300409B2 (en) 2010-09-10 2015-03-26 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
JP2014529407A (ja) 2011-08-31 2014-11-13 チルドレンズホスピタル アンド リサーチ センター オークランド ナイセリアにおいて抗原の発現を促進するための操作された配列および使用方法
MX2014008988A (es) * 2012-02-02 2014-08-27 Novartis Ag Promotores para aumento de expresion de proteinas en meningococo.
US10598666B2 (en) 2012-03-08 2020-03-24 Glaxosmithkline Biologicals Sa In vitro potency assay for protein-based meningococcal vaccines
US8986710B2 (en) 2012-03-09 2015-03-24 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
KR101452830B1 (ko) * 2012-04-06 2014-10-21 아이진 주식회사 두 가지 항암물질을 동시에 제공하는 대장균 균주
RU2662970C2 (ru) 2012-09-18 2018-07-31 Новартис Аг Везикулы наружной мембраны
WO2014136064A2 (en) 2013-03-08 2014-09-12 Pfizer Inc. Immunogenic fusion polypeptides
MX369534B (es) 2013-09-08 2019-11-11 Pfizer Composiciones de neisseria meningitidis y sus metodos.
RU2723045C2 (ru) 2015-02-19 2020-06-08 Пфайзер Инк. Композиции neisseria meningitidis и способы их получения
JP7008901B2 (ja) * 2016-01-28 2022-01-25 イントラヴァック ビー．ブイ． 改変されたヘキサアシル化ナイセリアｌｐｓ
EP3263695A1 (en) * 2016-06-29 2018-01-03 GlaxoSmithKline Biologicals SA Immunogenic compositions
MX2019006105A (es) * 2016-11-25 2019-08-21 Glaxosmithkline Biologicals Sa Conjugados de vmen-antigeno y uso de los mismos.
SG10202111092UA (en) 2017-01-31 2021-11-29 Pfizer Neisseria meningitidis compositions and methods thereof
CN107961370B (zh) * 2017-03-22 2020-08-11 武汉博沃生物科技有限公司 多价肺炎球菌缀合疫苗及其制备方法
CA3155669A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN113151354B (zh) * 2021-03-22 2022-03-08 中国农业科学院兰州兽医研究所 一种用于条件性敲除目的基因的载体及条件性敲除目的基因的方法
CN119020251A (zh) * 2024-08-26 2024-11-26 南昌大学 一株脂多糖修饰b群脑膜炎球菌与其外膜囊泡制备及应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4601903A (en) * 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
US4727136A (en) * 1985-10-01 1988-02-23 Canadian Patents And Development Ltd. Modified meningococcal group B polysaccharide for conjugate vaccine
US7118757B1 (en) * 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
WO1990006696A2 (en) 1988-12-19 1990-06-28 Praxis Biologics, Inc. Meningococcal class 1 outer-membrane protein vaccine
DE4023721A1 (de) 1990-07-26 1992-01-30 Boehringer Mannheim Gmbh Verfahren zur herstellung von vakzinen und ihre verwendung
US5552146A (en) 1991-08-15 1996-09-03 Board Of Regents, The University Of Texas System Methods and compositions relating to useful antigens of Moraxella catarrhalis
NL9201716A (nl) * 1992-10-02 1994-05-02 Nederlanden Staat Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat.
US7112332B1 (en) * 1992-10-08 2006-09-26 The United States Of America As Represented By The Secretary Of The Army Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides
ES2145072T3 (es) * 1993-05-13 2000-07-01 American Cyanamid Co Preparacion y usos de proteinas de membranas externas carentes de los de cocos gramnegativos.
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
DK0854729T3 (da) * 1995-09-18 2004-07-12 Id Biomedical Corp Quebec Forbedrede fremgangsmåder til fremstillingen af ikke-kovalent kompleksdannede og multivalente proteosom-subunit-vacciner
US6558677B2 (en) * 1996-10-15 2003-05-06 Wendell D. Zollinger Vaccine against gram negative bacteria
GB9726398D0 (en) 1997-12-12 1998-02-11 Isis Innovation Polypeptide and coding sequences
GB9808866D0 (en) 1998-04-24 1998-06-24 Smithkline Beecham Biolog Novel compounds
US20030215469A1 (en) * 1998-11-02 2003-11-20 Microbiological Research Authority Multicomponent meningococcal vaccine
GB9823978D0 (en) 1998-11-02 1998-12-30 Microbiological Res Authority Multicomponent meningococcal vaccine
DK1154791T3 (da) 1999-02-22 2008-06-16 Health Prot Agency Neisseria-vaccinesammensætninger og fremgangsmåder
GB9918319D0 (en) * 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
EP2275129A3 (en) * 2000-01-17 2013-11-06 Novartis Vaccines and Diagnostics S.r.l. Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins
NO20002828D0 (no) * 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
CZ20024224A3 (cs) * 2000-06-29 2003-05-14 Glaxosmithkline Biologicals S. A. Farmaceutický prostředek
GB0103170D0 (en) * 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
GB0024200D0 (en) * 2000-10-03 2000-11-15 Smithkline Beecham Sa Component vaccine
GB0103169D0 (en) * 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
US20030072764A1 (en) * 2001-04-05 2003-04-17 O'hagan Derek Mucosal boosting following parenteral priming
GB0130123D0 (en) * 2001-12-17 2002-02-06 Microbiological Res Agency Outer membrane vesicle vaccine and its preparation
EP1374892A1 (en) * 2002-06-28 2004-01-02 Braun, Jan Matthias, Dr. Medicament for the treatment of diseases due to infection by Neisseria Meningitidis
DK2255826T3 (en) * 2002-08-02 2016-06-20 Glaxosmithkline Biologicals Sa Neisserial vaccine compositions comprising a combination of antigens.
CU23377A1 (es) * 2003-11-04 2009-05-28 Ct De Ingenieria Genetica Y Biotecnologia Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes
US7628995B2 (en) * 2003-12-23 2009-12-08 Glaxosmithkline Biologicals S.A. Outer membrane vesicles and uses thereof
CN1997392B (zh) * 2004-05-11 2011-06-01 荷兰健康、福利与体育部部长代表的荷兰国 作为佐剂的脑膜炎奈瑟氏菌lgtB LOS
US7537766B2 (en) * 2004-08-30 2009-05-26 Wyeth Neisseria meningitidis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof
GB0419627D0 (en) * 2004-09-03 2004-10-06 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
DK2682126T3 (en) * 2005-01-27 2017-02-27 Children's Hospital & Res Center At Oakland GNA1870-based vesicle vaccines for broad-spectrum protection against diseases caused by Neisseria meningitidis
US20090246224A1 (en) 2006-06-12 2009-10-01 Nathalie Devos Vaccine

Also Published As

Publication number Publication date
RU2010153658A (ru) 2012-08-10
KR20110053314A (ko) 2011-05-20
IL209660A0 (en) 2011-02-28
AU2009262893A1 (en) 2009-12-30
CA2726465A1 (en) 2009-12-30
ZA201008548B (en) 2012-06-27
EP2296699A1 (en) 2011-03-23
MX2010012999A (es) 2012-03-07
JP2011521976A (ja) 2011-07-28
DOP2010000364A (es) 2011-07-15
JP5723768B2 (ja) 2015-05-27
JP2015061870A (ja) 2015-04-02
AU2009262893A9 (en) 2015-05-21
WO2009158142A1 (en) 2009-12-30
AU2009262893B2 (en) 2015-05-21
UA99659C2 (uk) 2012-09-10
CR11812A (es) 2011-07-06
RU2477145C2 (ru) 2013-03-10
US20170100471A1 (en) 2017-04-13
ECSP10010723A (es) 2011-05-31
BRPI0913268A2 (pt) 2016-03-15
EP2296699A4 (en) 2013-11-13
CN102105166A (zh) 2011-06-22
CO6341569A2 (es) 2011-11-21
US9387239B2 (en) 2016-07-12
US20110182942A1 (en) 2011-07-28

Similar Documents

Publication Publication Date Title
NZ589812A (en) Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof
AU2018266705B2 (en) Alphavirus neoantigen vectors
Chroboczek et al. Virus-like particles as vaccine.
JP2011521976A5 (enExample)
WO2010019262A3 (en) Polyvalent vaccine
US20180133321A1 (en) Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules
MA35110B1 (fr) Protéines de fusion et polyvaccins comprenant la protéine e et la piline a d'haemophilus influenzae
WO2009082664A8 (en) Genetically modified attenuated vesicular stomatitis virus, compositions and methods of use thereof
TW200806316A (en) Yeast-based vaccine for inducing an immune response
MX2023006203A (es) Vacunas novedosas contra el virus de zika.
MX2013014109A (es) Proteina de fusion que comprende el mutante crm197 no toxico de toxina de difteria.
MX2010007461A (es) Nuevas vacunas contra multiples subtipos del virus del dengue.
WO2009082593A3 (en) Dendritic cell vaccine compositions and uses of same
Sarkar et al. A systematic and reverse vaccinology approach to design novel subunit vaccines against Dengue virus type-1 (DENV-1) and human Papillomavirus-16 (HPV-16)
WO2010132112A3 (en) Immunogenic compositions against tuberculosis
PH12013501116A1 (en) Raccoon poxvirus expressing rabies glycoproteins
BR112014019166A2 (pt) promotores para expressão aumentada de proteína em meningococos
Stuart et al. Cassette-based presentation of SIV epitopes with recombinant gas vesicles from halophilic archaea
WO2012138754A3 (en) Mycobacterial vaccine vectors and methods of using the same
WO2010040847A3 (en) Recombinant protein bodies as immunogen-specific adjuvants
MX2010005699A (es) Genes que codifican para la proteina l1 mayor de la capside del virus del papiloma humano y uso de los mismos.
MX2023002786A (es) Vesículas de membrana exterior.
WO2006073625A3 (en) Inhibition of li expression in mammalian cells
IN2014DN10123A (enExample)
WO2012003320A3 (en) Flavivirus host-range mutations and uses thereof

Legal Events

Date Code Title Description
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 01 JUN 2016 BY CPA GLOBAL

Effective date: 20130531

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 JUN 2017 BY CPA GLOBAL

Effective date: 20160415

LAPS Patent lapsed