CN102105166A - 脑膜炎球菌多价原始外膜囊泡疫苗、其制备方法和应用 - Google Patents

脑膜炎球菌多价原始外膜囊泡疫苗、其制备方法和应用 Download PDF

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CN102105166A
CN102105166A CN200980125861XA CN200980125861A CN102105166A CN 102105166 A CN102105166 A CN 102105166A CN 200980125861X A CN200980125861X A CN 200980125861XA CN 200980125861 A CN200980125861 A CN 200980125861A CN 102105166 A CN102105166 A CN 102105166A
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strain
gene
vaccine
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W·D·佐林格
M·多内茨
D·施米尔
B·约宁
R·马奎斯
E·E·莫兰
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200980125861XA 2008-05-30 2009-06-01 脑膜炎球菌多价原始外膜囊泡疫苗、其制备方法和应用 Pending CN102105166A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5746208P 2008-05-30 2008-05-30
US61/057,462 2008-05-30
PCT/US2009/045818 WO2009158142A1 (en) 2008-05-30 2009-06-01 Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof

Publications (1)

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CN102105166A true CN102105166A (zh) 2011-06-22

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CN200980125861XA Pending CN102105166A (zh) 2008-05-30 2009-06-01 脑膜炎球菌多价原始外膜囊泡疫苗、其制备方法和应用

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US (2) US9387239B2 (enExample)
EP (1) EP2296699A4 (enExample)
JP (2) JP5723768B2 (enExample)
KR (1) KR20110053314A (enExample)
CN (1) CN102105166A (enExample)
AU (1) AU2009262893B2 (enExample)
BR (1) BRPI0913268A2 (enExample)
CA (1) CA2726465A1 (enExample)
CO (1) CO6341569A2 (enExample)
CR (1) CR11812A (enExample)
DO (1) DOP2010000364A (enExample)
EC (1) ECSP10010723A (enExample)
IL (1) IL209660A0 (enExample)
MX (1) MX2010012999A (enExample)
NZ (1) NZ589812A (enExample)
RU (1) RU2477145C2 (enExample)
UA (1) UA99659C2 (enExample)
WO (1) WO2009158142A1 (enExample)
ZA (1) ZA201008548B (enExample)

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CN107961370A (zh) * 2017-03-22 2018-04-27 武汉博沃生物科技有限公司 多价肺炎球菌缀合疫苗及其制备方法
CN110248681A (zh) * 2016-11-25 2019-09-17 葛兰素史密丝克莱恩生物有限公司 nOMV-抗原缀合物及其用途
CN113151354A (zh) * 2021-03-22 2021-07-23 中国农业科学院兰州兽医研究所 一种用于条件性敲除目的基因的载体及条件性敲除目的基因的方法
CN119020251A (zh) * 2024-08-26 2024-11-26 南昌大学 一株脂多糖修饰b群脑膜炎球菌与其外膜囊泡制备及应用

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GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
JP2013521326A (ja) * 2010-03-10 2013-06-10 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物
PT3246044T (pt) 2010-08-23 2021-02-15 Wyeth Llc Formulações estáveis de antigénios de rlp2086 de neisseria meningitidis
AU2011300418B2 (en) * 2010-09-10 2016-05-12 Glaxosmithkline Biologicals Sa Meningococcus overexpressing NadA and/or NHBA and outer membrane vesicles derived therefrom
GB201015132D0 (en) * 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
AU2011300409B2 (en) 2010-09-10 2015-03-26 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
JP2014529407A (ja) 2011-08-31 2014-11-13 チルドレンズホスピタル アンド リサーチ センター オークランド ナイセリアにおいて抗原の発現を促進するための操作された配列および使用方法
MX2014008988A (es) * 2012-02-02 2014-08-27 Novartis Ag Promotores para aumento de expresion de proteinas en meningococo.
US10598666B2 (en) 2012-03-08 2020-03-24 Glaxosmithkline Biologicals Sa In vitro potency assay for protein-based meningococcal vaccines
US8986710B2 (en) 2012-03-09 2015-03-24 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
KR101452830B1 (ko) * 2012-04-06 2014-10-21 아이진 주식회사 두 가지 항암물질을 동시에 제공하는 대장균 균주
RU2662970C2 (ru) 2012-09-18 2018-07-31 Новартис Аг Везикулы наружной мембраны
WO2014136064A2 (en) 2013-03-08 2014-09-12 Pfizer Inc. Immunogenic fusion polypeptides
MX369534B (es) 2013-09-08 2019-11-11 Pfizer Composiciones de neisseria meningitidis y sus metodos.
RU2723045C2 (ru) 2015-02-19 2020-06-08 Пфайзер Инк. Композиции neisseria meningitidis и способы их получения
JP7008901B2 (ja) * 2016-01-28 2022-01-25 イントラヴァック ビー．ブイ． 改変されたヘキサアシル化ナイセリアｌｐｓ
EP3263695A1 (en) * 2016-06-29 2018-01-03 GlaxoSmithKline Biologicals SA Immunogenic compositions
SG10202111092UA (en) 2017-01-31 2021-11-29 Pfizer Neisseria meningitidis compositions and methods thereof
CA3155669A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110248681A (zh) * 2016-11-25 2019-09-17 葛兰素史密丝克莱恩生物有限公司 nOMV-抗原缀合物及其用途
CN107961370A (zh) * 2017-03-22 2018-04-27 武汉博沃生物科技有限公司 多价肺炎球菌缀合疫苗及其制备方法
CN107961370B (zh) * 2017-03-22 2020-08-11 武汉博沃生物科技有限公司 多价肺炎球菌缀合疫苗及其制备方法
CN113151354A (zh) * 2021-03-22 2021-07-23 中国农业科学院兰州兽医研究所 一种用于条件性敲除目的基因的载体及条件性敲除目的基因的方法
CN113151354B (zh) * 2021-03-22 2022-03-08 中国农业科学院兰州兽医研究所 一种用于条件性敲除目的基因的载体及条件性敲除目的基因的方法
CN119020251A (zh) * 2024-08-26 2024-11-26 南昌大学 一株脂多糖修饰b群脑膜炎球菌与其外膜囊泡制备及应用

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RU2010153658A (ru) 2012-08-10
KR20110053314A (ko) 2011-05-20
IL209660A0 (en) 2011-02-28
AU2009262893A1 (en) 2009-12-30
CA2726465A1 (en) 2009-12-30
ZA201008548B (en) 2012-06-27
EP2296699A1 (en) 2011-03-23
MX2010012999A (es) 2012-03-07
JP2011521976A (ja) 2011-07-28
DOP2010000364A (es) 2011-07-15
NZ589812A (en) 2012-08-31
JP5723768B2 (ja) 2015-05-27
JP2015061870A (ja) 2015-04-02
AU2009262893A9 (en) 2015-05-21
WO2009158142A1 (en) 2009-12-30
AU2009262893B2 (en) 2015-05-21
UA99659C2 (uk) 2012-09-10
CR11812A (es) 2011-07-06
RU2477145C2 (ru) 2013-03-10
US20170100471A1 (en) 2017-04-13
ECSP10010723A (es) 2011-05-31
BRPI0913268A2 (pt) 2016-03-15
EP2296699A4 (en) 2013-11-13
CO6341569A2 (es) 2011-11-21
US9387239B2 (en) 2016-07-12
US20110182942A1 (en) 2011-07-28

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