DOP2010000364A - Vacuna de vesicula de membrana externa nativa multivalente del miningococo metodo para su fabricacion y uso - Google Patents
Vacuna de vesicula de membrana externa nativa multivalente del miningococo metodo para su fabricacion y usoInfo
- Publication number
- DOP2010000364A DOP2010000364A DO2010000364A DO2010000364A DOP2010000364A DO P2010000364 A DOP2010000364 A DO P2010000364A DO 2010000364 A DO2010000364 A DO 2010000364A DO 2010000364 A DO2010000364 A DO 2010000364A DO P2010000364 A DOP2010000364 A DO P2010000364A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- multivally
- miningococo
- manufacture
- membrane vesicle
- external membrane
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5746208P | 2008-05-30 | 2008-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2010000364A true DOP2010000364A (es) | 2011-07-15 |
Family
ID=41444870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2010000364A DOP2010000364A (es) | 2008-05-30 | 2010-11-26 | Vacuna de vesicula de membrana externa nativa multivalente del miningococo metodo para su fabricacion y uso |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9387239B2 (enExample) |
| EP (1) | EP2296699A4 (enExample) |
| JP (2) | JP5723768B2 (enExample) |
| KR (1) | KR20110053314A (enExample) |
| CN (1) | CN102105166A (enExample) |
| AU (1) | AU2009262893B2 (enExample) |
| BR (1) | BRPI0913268A2 (enExample) |
| CA (1) | CA2726465A1 (enExample) |
| CO (1) | CO6341569A2 (enExample) |
| CR (1) | CR11812A (enExample) |
| DO (1) | DOP2010000364A (enExample) |
| EC (1) | ECSP10010723A (enExample) |
| IL (1) | IL209660A0 (enExample) |
| MX (1) | MX2010012999A (enExample) |
| NZ (1) | NZ589812A (enExample) |
| RU (1) | RU2477145C2 (enExample) |
| UA (1) | UA99659C2 (enExample) |
| WO (1) | WO2009158142A1 (enExample) |
| ZA (1) | ZA201008548B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU783894B2 (en) | 1999-05-19 | 2005-12-22 | Novartis Vaccines And Diagnostics S.R.L. | Combination neisserial compositions |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| EP2544714A1 (en) * | 2010-03-10 | 2013-01-16 | GlaxoSmithKline Biologicals S.A. | Vaccine composition |
| RU2580620C2 (ru) | 2010-08-23 | 2016-04-10 | ВАЙЕТ ЭлЭлСи | СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086 |
| GB201015132D0 (en) * | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
| BR112013005626B1 (pt) | 2010-09-10 | 2022-07-26 | Glaxosmithkline Biologicals Sa | Meningococo, processo para a preparação de uma cepa meningocócica, vesículas de membrana externa, composição farmacêutica imunogênica, e, uso de uma composição |
| WO2012032489A1 (en) | 2010-09-10 | 2012-03-15 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| MX2014002375A (es) * | 2011-08-31 | 2014-09-15 | Children S Hospital & Res Ct Oakland | Secuencias diseñadas para facilitar la expresion de antigenos en neisseria y metodos de uso. |
| MX2014008988A (es) * | 2012-02-02 | 2014-08-27 | Novartis Ag | Promotores para aumento de expresion de proteinas en meningococo. |
| ES2750366T3 (es) | 2012-03-08 | 2020-03-25 | Glaxosmithkline Biologicals Sa | Ensayo de potencia in vitro para vacunas meningocócicas basadas en proteína |
| CA2865745C (en) | 2012-03-09 | 2018-01-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| KR101452830B1 (ko) * | 2012-04-06 | 2014-10-21 | 아이진 주식회사 | 두 가지 항암물질을 동시에 제공하는 대장균 균주 |
| RU2662970C2 (ru) | 2012-09-18 | 2018-07-31 | Новартис Аг | Везикулы наружной мембраны |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| AU2016221318B2 (en) | 2015-02-19 | 2020-06-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US11292808B2 (en) * | 2016-01-28 | 2022-04-05 | Intravacc B.V. | Modified hexa-acylated neisserial LPS |
| EP3263695A1 (en) * | 2016-06-29 | 2018-01-03 | GlaxoSmithKline Biologicals SA | Immunogenic compositions |
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| HUE052751T2 (hu) * | 2016-11-25 | 2021-05-28 | Glaxosmithkline Biologicals Sa | Natív OMV-antigén konjugátumok és alkalmazásuk |
| US10183070B2 (en) | 2017-01-31 | 2019-01-22 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN107151270B (zh) * | 2017-03-22 | 2018-07-31 | 武汉博沃生物科技有限公司 | 重组ΔfHbp-NadA融合蛋白载体及其制备方法和应用 |
| US12502427B2 (en) | 2019-03-21 | 2025-12-23 | Lonza Sales Ag | Extracellular vesicles for vaccine delivery |
| EP4034157A1 (en) | 2019-09-27 | 2022-08-03 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN113151354B (zh) * | 2021-03-22 | 2022-03-08 | 中国农业科学院兰州兽医研究所 | 一种用于条件性敲除目的基因的载体及条件性敲除目的基因的方法 |
| IT202400003229A1 (it) | 2024-02-15 | 2025-08-15 | Cioccio Vito Di | Procedimento per la purificazione di omv da batteri gram-negativi, e relativi usi |
| CN119020251A (zh) * | 2024-08-26 | 2024-11-26 | 南昌大学 | 一株脂多糖修饰b群脑膜炎球菌与其外膜囊泡制备及应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4601903A (en) * | 1985-05-01 | 1986-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease |
| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| EP0449958B9 (en) | 1988-12-19 | 2003-05-28 | American Cyanamid Company | Meningococcal class 1 outer-membrane protein vaccine |
| US7118757B1 (en) * | 1988-12-19 | 2006-10-10 | Wyeth Holdings Corporation | Meningococcal class 1 outer-membrane protein vaccine |
| DE4023721A1 (de) | 1990-07-26 | 1992-01-30 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von vakzinen und ihre verwendung |
| US5552146A (en) | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
| NL9201716A (nl) * | 1992-10-02 | 1994-05-02 | Nederlanden Staat | Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. |
| US7112332B1 (en) * | 1992-10-08 | 2006-09-26 | The United States Of America As Represented By The Secretary Of The Army | Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides |
| DE69423383T2 (de) * | 1993-05-13 | 2000-08-24 | American Cyanamid Co., Wayne | Herstellung und Verwendungen von LOS-verminderten Aussenmembran-Proteinen von Gram-negativen Kokken |
| US5961970A (en) * | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| EP0854729B2 (en) * | 1995-09-18 | 2008-10-22 | United States Army Medical Research Materiel Command (USAMRMC) | Improved methods for the production of non-covalently complexed and multivalent proteosome sub-unit vaccines |
| US6558677B2 (en) * | 1996-10-15 | 2003-05-06 | Wendell D. Zollinger | Vaccine against gram negative bacteria |
| GB9726398D0 (en) | 1997-12-12 | 1998-02-11 | Isis Innovation | Polypeptide and coding sequences |
| GB9808866D0 (en) | 1998-04-24 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
| GB9823978D0 (en) * | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| US20030215469A1 (en) * | 1998-11-02 | 2003-11-20 | Microbiological Research Authority | Multicomponent meningococcal vaccine |
| CA2371928C (en) | 1999-02-22 | 2013-08-13 | Microbiological Research Authority | Neisserial vaccine compositions and methods |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| CA2871789C (en) * | 2000-01-17 | 2017-04-04 | Novartis Vaccines And Diagnostics S.R.L. | Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins |
| NO20002828D0 (no) * | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| DK1296715T4 (en) * | 2000-06-29 | 2016-03-07 | Smithkline Beecham Biolog | Multivalent vaccine composition. |
| GB0103170D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| GB0024200D0 (en) * | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
| GB0103169D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| JP2004527524A (ja) * | 2001-04-05 | 2004-09-09 | カイロン コーポレイション | 非経口初回抗原刺激後の粘膜追加免疫 |
| GB0130123D0 (en) * | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| EP1374892A1 (en) * | 2002-06-28 | 2004-01-02 | Braun, Jan Matthias, Dr. | Medicament for the treatment of diseases due to infection by Neisseria Meningitidis |
| CA2493124C (en) | 2002-08-02 | 2014-04-29 | Glaxosmithkline Biologicals S.A. | Vaccine |
| CU23377A1 (es) | 2003-11-04 | 2009-05-28 | Ct De Ingenieria Genetica Y Biotecnologia | Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes |
| JP5173194B2 (ja) * | 2003-12-23 | 2013-03-27 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
| CN1997392B (zh) * | 2004-05-11 | 2011-06-01 | 荷兰健康、福利与体育部部长代表的荷兰国 | 作为佐剂的脑膜炎奈瑟氏菌lgtB LOS |
| US7537766B2 (en) * | 2004-08-30 | 2009-05-26 | Wyeth | Neisseria meningitidis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof |
| GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| LT2682126T (lt) * | 2005-01-27 | 2017-02-27 | Children`s Hospital & Research Center at Oakland | Gna1870 pagrindu gaminamos pūslelių pavidalo vakcinos, skirtos plataus spektro apsaugai nuo neisseria meningitidis sukeltų ligų |
| DE602007003596D1 (de) * | 2006-06-12 | 2010-01-14 | Glaxosmithkline Biolog Sa | Impfstoff |
-
2009
- 2009-06-01 RU RU2010153658/15A patent/RU2477145C2/ru not_active IP Right Cessation
- 2009-06-01 CN CN200980125861XA patent/CN102105166A/zh active Pending
- 2009-06-01 EP EP09770677.4A patent/EP2296699A4/en not_active Withdrawn
- 2009-06-01 MX MX2010012999A patent/MX2010012999A/es unknown
- 2009-06-01 KR KR1020107029750A patent/KR20110053314A/ko not_active Ceased
- 2009-06-01 WO PCT/US2009/045818 patent/WO2009158142A1/en not_active Ceased
- 2009-06-01 US US12/995,268 patent/US9387239B2/en not_active Expired - Fee Related
- 2009-06-01 UA UAA201015812A patent/UA99659C2/uk unknown
- 2009-06-01 BR BRPI0913268A patent/BRPI0913268A2/pt not_active IP Right Cessation
- 2009-06-01 JP JP2011511892A patent/JP5723768B2/ja not_active Expired - Fee Related
- 2009-06-01 AU AU2009262893A patent/AU2009262893B2/en not_active Ceased
- 2009-06-01 NZ NZ589812A patent/NZ589812A/xx not_active IP Right Cessation
- 2009-06-01 CA CA2726465A patent/CA2726465A1/en not_active Abandoned
-
2010
- 2010-11-25 CR CR11812A patent/CR11812A/es unknown
- 2010-11-26 DO DO2010000364A patent/DOP2010000364A/es unknown
- 2010-11-29 ZA ZA2010/08548A patent/ZA201008548B/en unknown
- 2010-11-30 IL IL209660A patent/IL209660A0/en unknown
- 2010-12-27 EC EC2010010723A patent/ECSP10010723A/es unknown
- 2010-12-29 CO CO10164103A patent/CO6341569A2/es not_active Application Discontinuation
-
2014
- 2014-12-11 JP JP2014250805A patent/JP2015061870A/ja not_active Withdrawn
-
2016
- 2016-07-12 US US15/208,067 patent/US20170100471A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2726465A1 (en) | 2009-12-30 |
| NZ589812A (en) | 2012-08-31 |
| CR11812A (es) | 2011-07-06 |
| CN102105166A (zh) | 2011-06-22 |
| UA99659C2 (uk) | 2012-09-10 |
| RU2010153658A (ru) | 2012-08-10 |
| JP2015061870A (ja) | 2015-04-02 |
| JP5723768B2 (ja) | 2015-05-27 |
| IL209660A0 (en) | 2011-02-28 |
| CO6341569A2 (es) | 2011-11-21 |
| AU2009262893A9 (en) | 2015-05-21 |
| AU2009262893A1 (en) | 2009-12-30 |
| ZA201008548B (en) | 2012-06-27 |
| US9387239B2 (en) | 2016-07-12 |
| EP2296699A1 (en) | 2011-03-23 |
| US20110182942A1 (en) | 2011-07-28 |
| WO2009158142A1 (en) | 2009-12-30 |
| KR20110053314A (ko) | 2011-05-20 |
| AU2009262893B2 (en) | 2015-05-21 |
| MX2010012999A (es) | 2012-03-07 |
| ECSP10010723A (es) | 2011-05-31 |
| RU2477145C2 (ru) | 2013-03-10 |
| JP2011521976A (ja) | 2011-07-28 |
| US20170100471A1 (en) | 2017-04-13 |
| BRPI0913268A2 (pt) | 2016-03-15 |
| EP2296699A4 (en) | 2013-11-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0913268A2 (pt) | vacina de vesícula de membrana externa nativa multivalente meningocócica, métodos de fabricação e uso da mesma | |
| IL248607A (en) | Methods and compositions for immunization against virus | |
| SMT201600254B (it) | Procedimento per la preparazione di idromagnesite | |
| PL2437051T3 (pl) | System pseudo dwuenergetyczny i metoda identyfikacji materiałów z wykorzystaniem podpróbkowania | |
| BR112012010396A2 (pt) | seringa de ar, água e vácuo e método de uso | |
| EP2689828A4 (en) | WAVY CERAMIC DISCONNECTED MEMBRANE STRUCTURE | |
| FI20130087L (fi) | Patjan rakenne, patjajärjestelmä ja patjan käyttötapa | |
| DK2643029T3 (da) | Præparat og/eller formulering af proteiner, som er tværbundet med polysaccharider | |
| DK2897625T3 (da) | Amnionmembran og anvendelse deraf til sårheling og tissue engineering-konstrukter | |
| UY33094A (es) | Procedimiento para la preparacion de dronedarona | |
| BR112013023414A2 (pt) | membrana e dispositivo | |
| BRPI0924225A2 (pt) | linhagens de células que expressam nav e métodos de uso | |
| EP3459563C0 (en) | IMPROVEMENTS IN THE PREPARATION OF ANTIGENS FOR THE INFLUENZA VIRUS VACCINE | |
| BRPI1008887A2 (pt) | peptídeos de foxm1 e vacinas contendo os mesmo | |
| BR112013014751A2 (pt) | sistema de manta para esterilização e métodos de uso | |
| IT1395561B1 (it) | Apparato di collaudo e relativo procedimento | |
| BR112012022720A2 (pt) | geometria de suporte e membrana de filtração | |
| DK2627656T3 (da) | Fremgangsmåde til fremstilling af dihydropteridinon og intermediater deraf | |
| DK2588620T3 (da) | Fremgangsmåde til fremstilling af butanol eller acetone | |
| BR112013002017A2 (pt) | aparelho e método de separação de membrana | |
| PT2408913T (pt) | Péptidos neil3 e vacinas que incluem os mesmos | |
| IL232461A0 (en) | Melk epitope peptides and vaccines containing the same | |
| BRPI0918221A2 (pt) | vacinas inicial, composta por vesícula de membrana externa, e reforço, composta por proteína. | |
| CL2014002658A1 (es) | Composición inmunogénica que comprende proteínas de la membrana exterior de histophilus somni; usos y sus métodos de preparación. | |
| HRP20180617T1 (hr) | Protutijela anti-p-selektin i postupci njihove uporabe i identifikacije |