NZ587117A - Cationic siRNAs, synthesis and use for RNA interference - Google Patents
Cationic siRNAs, synthesis and use for RNA interferenceInfo
- Publication number
- NZ587117A NZ587117A NZ587117A NZ58711709A NZ587117A NZ 587117 A NZ587117 A NZ 587117A NZ 587117 A NZ587117 A NZ 587117A NZ 58711709 A NZ58711709 A NZ 58711709A NZ 587117 A NZ587117 A NZ 587117A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cationic
- sirna
- synthesis
- strand
- grafted
- Prior art date
Links
- 125000002091 cationic group Chemical group 0.000 title abstract 5
- 108020004459 Small interfering RNA Proteins 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 title 1
- 230000009368 gene silencing by RNA Effects 0.000 title 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 2
- 238000010168 coupling process Methods 0.000 abstract 2
- 238000005859 coupling reaction Methods 0.000 abstract 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 1
- 108091027075 5S-rRNA precursor Proteins 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 108091028664 Ribonucleotide Proteins 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 238000007385 chemical modification Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 239000002336 ribonucleotide Substances 0.000 abstract 1
- 125000002652 ribonucleotide group Chemical group 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800492A FR2926818B1 (fr) | 2008-01-30 | 2008-01-30 | siRNA CATIONIQUES, SYNTHESE ET UTILISATION POUR L'ARN INTERFERENCE |
| PCT/IB2009/050379 WO2009095887A1 (fr) | 2008-01-30 | 2009-01-30 | siRNA CATIONIQUES, SYNTHÈSE ET UTILISATION POUR L'ARN INTERFÉRENCE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ587117A true NZ587117A (en) | 2012-09-28 |
Family
ID=39683957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ587117A NZ587117A (en) | 2008-01-30 | 2009-01-30 | Cationic siRNAs, synthesis and use for RNA interference |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10927371B2 (enExample) |
| EP (1) | EP2250267B1 (enExample) |
| JP (1) | JP2011511776A (enExample) |
| KR (1) | KR20100120293A (enExample) |
| CN (1) | CN101960009A (enExample) |
| AU (1) | AU2009208646A1 (enExample) |
| BR (1) | BRPI0907494A2 (enExample) |
| CA (1) | CA2713075A1 (enExample) |
| FR (1) | FR2926818B1 (enExample) |
| IL (1) | IL207290A0 (enExample) |
| NZ (1) | NZ587117A (enExample) |
| RU (1) | RU2010136047A (enExample) |
| WO (1) | WO2009095887A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006325054B2 (en) * | 2005-12-15 | 2013-05-02 | Centre National De La Recherche Scientifique (Cnrs) | Cationic oligonucleotides, automated methods for preparing same and their uses |
| WO2015015498A1 (en) * | 2013-07-31 | 2015-02-05 | Qbi Enterprises Ltd. | Methods of use of sphingolipid polyalkylamine oligonucleotide compounds |
| AU2016226418B2 (en) | 2015-03-02 | 2022-05-26 | Synthetic Genomics, Inc. | Regulatory elements from labyrinthulomycetes microorganisms |
| US10633454B2 (en) | 2016-11-01 | 2020-04-28 | Conagen Inc. | Expression of modified glycoproteins and glycopeptides |
| EP3535385A4 (en) * | 2016-11-01 | 2020-06-17 | Conagen Inc. | EXPRESSION OF MODIFIED GLYCOPROTEINS AND GLYCOPEPTIDES |
| CN106498072B (zh) * | 2016-11-24 | 2019-09-10 | 青岛千卓分子生物科技有限公司 | 一种液态产品中外源dna内标物的保护方法及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071890A (en) | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
| EP1013770A1 (en) | 1998-12-23 | 2000-06-28 | Université Louis Pasteur de Strasbourg | Non-viral transfection vector |
| DE10207177A1 (de) | 2002-02-19 | 2003-09-04 | Novosom Ag | Fakultativ kationische Lipide |
| US20040019008A1 (en) | 2002-05-28 | 2004-01-29 | Lewis David L. | Compositions and processes using siRNA, amphipathic compounds and polycations |
| JP2004137143A (ja) | 2002-08-21 | 2004-05-13 | Fuji Photo Film Co Ltd | 有機変性層状珪酸塩及びその組成物 |
| EP1585756B1 (en) * | 2002-11-26 | 2010-04-21 | University of Massachusetts | Delivery of sirnas |
| EP1638919B1 (en) * | 2003-06-18 | 2012-09-26 | Biolab Ltd. | Sphingolipids polyalkylamines conjugates |
| WO2005060697A2 (en) * | 2003-12-19 | 2005-07-07 | Chiron Corporation | Cell transfecting formulations of small interfering rna, related compositions and methods of making and use |
| US20060073505A1 (en) * | 2004-09-21 | 2006-04-06 | Isis Pharmaceuticals, Inc. | Oligomeric compounds effecting drosha-mediated cleavage |
| JP2008519053A (ja) * | 2004-11-04 | 2008-06-05 | アンディーノ，ラウル | 小さい干渉ＲＮＡ（ｓｉＲＮＡ）のポリアミン共役体の合成及びそれによって形成された共役体 |
| CA2587962A1 (en) * | 2004-11-17 | 2006-06-08 | University Of Maryland, Baltimore | Highly branched hk peptides as effective carriers of sirna |
| AU2006325054B2 (en) | 2005-12-15 | 2013-05-02 | Centre National De La Recherche Scientifique (Cnrs) | Cationic oligonucleotides, automated methods for preparing same and their uses |
| EP1844772A1 (en) | 2006-04-06 | 2007-10-17 | Polyplus-Transfection SA | Compositions for transfection of oligonucleotides active for gene silencing and their biological and therapeutical applications |
| EP2992875A1 (en) * | 2006-04-20 | 2016-03-09 | Silence Therapeutics GmbH | Lipoplex formulations for specific delivery to vascular endothelium |
-
2008
- 2008-01-30 FR FR0800492A patent/FR2926818B1/fr active Active
-
2009
- 2009-01-30 NZ NZ587117A patent/NZ587117A/xx not_active IP Right Cessation
- 2009-01-30 RU RU2010136047/10A patent/RU2010136047A/ru not_active Application Discontinuation
- 2009-01-30 CA CA2713075A patent/CA2713075A1/fr not_active Abandoned
- 2009-01-30 AU AU2009208646A patent/AU2009208646A1/en not_active Abandoned
- 2009-01-30 WO PCT/IB2009/050379 patent/WO2009095887A1/fr not_active Ceased
- 2009-01-30 EP EP09707000.7A patent/EP2250267B1/fr active Active
- 2009-01-30 JP JP2010544836A patent/JP2011511776A/ja active Pending
- 2009-01-30 KR KR1020107019289A patent/KR20100120293A/ko not_active Withdrawn
- 2009-01-30 US US12/735,595 patent/US10927371B2/en active Active
- 2009-01-30 CN CN200980107841XA patent/CN101960009A/zh active Pending
- 2009-01-30 BR BRPI0907494A patent/BRPI0907494A2/pt not_active IP Right Cessation
-
2010
- 2010-07-29 IL IL207290A patent/IL207290A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009208646A1 (en) | 2009-08-06 |
| JP2011511776A (ja) | 2011-04-14 |
| US10927371B2 (en) | 2021-02-23 |
| CA2713075A1 (fr) | 2009-08-06 |
| EP2250267B1 (fr) | 2016-09-14 |
| CN101960009A (zh) | 2011-01-26 |
| EP2250267A1 (fr) | 2010-11-17 |
| FR2926818B1 (fr) | 2012-04-06 |
| KR20100120293A (ko) | 2010-11-15 |
| WO2009095887A1 (fr) | 2009-08-06 |
| IL207290A0 (en) | 2010-12-30 |
| FR2926818A1 (fr) | 2009-07-31 |
| BRPI0907494A2 (pt) | 2019-09-24 |
| RU2010136047A (ru) | 2012-03-10 |
| US20110118331A1 (en) | 2011-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ASS | Change of ownership |
Owner name: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (, FR Free format text: OLD OWNER(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Owner name: UNIVERSITE DE STRASBOURG, FR Free format text: OLD OWNER(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
|
| PSEA | Patent sealed | ||
| LAPS | Patent lapsed |