KR20100120293A - 양이온성 ｓｉＲＮＡ, 합성 및 ＲＮＡ 간섭을 위한 용도 - Google Patents
양이온성 ｓｉＲＮＡ, 합성 및 ＲＮＡ 간섭을 위한 용도 Download PDFInfo
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- KR20100120293A KR20100120293A KR1020107019289A KR20107019289A KR20100120293A KR 20100120293 A KR20100120293 A KR 20100120293A KR 1020107019289 A KR1020107019289 A KR 1020107019289A KR 20107019289 A KR20107019289 A KR 20107019289A KR 20100120293 A KR20100120293 A KR 20100120293A
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- cationic
- sirna
- formula
- grafted
- lower alkylene
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- Engineering & Computer Science (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| FR0800492A FR2926818B1 (fr) | 2008-01-30 | 2008-01-30 | siRNA CATIONIQUES, SYNTHESE ET UTILISATION POUR L'ARN INTERFERENCE |
| FR08/00492 | 2008-01-30 |
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| KR20100120293A true KR20100120293A (ko) | 2010-11-15 |
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| NZ (1) | NZ587117A (enExample) |
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| AU2006325054B2 (en) * | 2005-12-15 | 2013-05-02 | Centre National De La Recherche Scientifique (Cnrs) | Cationic oligonucleotides, automated methods for preparing same and their uses |
| WO2015015498A1 (en) * | 2013-07-31 | 2015-02-05 | Qbi Enterprises Ltd. | Methods of use of sphingolipid polyalkylamine oligonucleotide compounds |
| AU2016226418B2 (en) | 2015-03-02 | 2022-05-26 | Synthetic Genomics, Inc. | Regulatory elements from labyrinthulomycetes microorganisms |
| US10633454B2 (en) | 2016-11-01 | 2020-04-28 | Conagen Inc. | Expression of modified glycoproteins and glycopeptides |
| EP3535385A4 (en) * | 2016-11-01 | 2020-06-17 | Conagen Inc. | EXPRESSION OF MODIFIED GLYCOPROTEINS AND GLYCOPEPTIDES |
| CN106498072B (zh) * | 2016-11-24 | 2019-09-10 | 青岛千卓分子生物科技有限公司 | 一种液态产品中外源dna内标物的保护方法及其应用 |
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| US6071890A (en) | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
| EP1013770A1 (en) | 1998-12-23 | 2000-06-28 | Université Louis Pasteur de Strasbourg | Non-viral transfection vector |
| DE10207177A1 (de) | 2002-02-19 | 2003-09-04 | Novosom Ag | Fakultativ kationische Lipide |
| US20040019008A1 (en) | 2002-05-28 | 2004-01-29 | Lewis David L. | Compositions and processes using siRNA, amphipathic compounds and polycations |
| JP2004137143A (ja) | 2002-08-21 | 2004-05-13 | Fuji Photo Film Co Ltd | 有機変性層状珪酸塩及びその組成物 |
| EP1585756B1 (en) * | 2002-11-26 | 2010-04-21 | University of Massachusetts | Delivery of sirnas |
| EP1638919B1 (en) * | 2003-06-18 | 2012-09-26 | Biolab Ltd. | Sphingolipids polyalkylamines conjugates |
| WO2005060697A2 (en) * | 2003-12-19 | 2005-07-07 | Chiron Corporation | Cell transfecting formulations of small interfering rna, related compositions and methods of making and use |
| US20060073505A1 (en) * | 2004-09-21 | 2006-04-06 | Isis Pharmaceuticals, Inc. | Oligomeric compounds effecting drosha-mediated cleavage |
| JP2008519053A (ja) * | 2004-11-04 | 2008-06-05 | アンディーノ，ラウル | 小さい干渉ＲＮＡ（ｓｉＲＮＡ）のポリアミン共役体の合成及びそれによって形成された共役体 |
| CA2587962A1 (en) * | 2004-11-17 | 2006-06-08 | University Of Maryland, Baltimore | Highly branched hk peptides as effective carriers of sirna |
| AU2006325054B2 (en) | 2005-12-15 | 2013-05-02 | Centre National De La Recherche Scientifique (Cnrs) | Cationic oligonucleotides, automated methods for preparing same and their uses |
| EP1844772A1 (en) | 2006-04-06 | 2007-10-17 | Polyplus-Transfection SA | Compositions for transfection of oligonucleotides active for gene silencing and their biological and therapeutical applications |
| EP2992875A1 (en) * | 2006-04-20 | 2016-03-09 | Silence Therapeutics GmbH | Lipoplex formulations for specific delivery to vascular endothelium |
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2009
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- 2009-01-30 CA CA2713075A patent/CA2713075A1/fr not_active Abandoned
- 2009-01-30 AU AU2009208646A patent/AU2009208646A1/en not_active Abandoned
- 2009-01-30 WO PCT/IB2009/050379 patent/WO2009095887A1/fr not_active Ceased
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- 2009-01-30 JP JP2010544836A patent/JP2011511776A/ja active Pending
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- 2009-01-30 US US12/735,595 patent/US10927371B2/en active Active
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- 2009-01-30 BR BRPI0907494A patent/BRPI0907494A2/pt not_active IP Right Cessation
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2009208646A1 (en) | 2009-08-06 |
| JP2011511776A (ja) | 2011-04-14 |
| US10927371B2 (en) | 2021-02-23 |
| CA2713075A1 (fr) | 2009-08-06 |
| EP2250267B1 (fr) | 2016-09-14 |
| CN101960009A (zh) | 2011-01-26 |
| EP2250267A1 (fr) | 2010-11-17 |
| FR2926818B1 (fr) | 2012-04-06 |
| WO2009095887A1 (fr) | 2009-08-06 |
| IL207290A0 (en) | 2010-12-30 |
| FR2926818A1 (fr) | 2009-07-31 |
| NZ587117A (en) | 2012-09-28 |
| BRPI0907494A2 (pt) | 2019-09-24 |
| RU2010136047A (ru) | 2012-03-10 |
| US20110118331A1 (en) | 2011-05-19 |
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