JP2011511776A - RNA干渉のためのカチオン性siRNA、合成及び使用 - Google Patents

RNA干渉のためのカチオン性siRNA、合成及び使用 Download PDF

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JP2011511776A
JP2011511776A JP2010544836A JP2010544836A JP2011511776A JP 2011511776 A JP2011511776 A JP 2011511776A JP 2010544836 A JP2010544836 A JP 2010544836A JP 2010544836 A JP2010544836 A JP 2010544836A JP 2011511776 A JP2011511776 A JP 2011511776A
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cationic
sirna
formula
sirna according
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JP2011511776A5 (enExample
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ジャン−ポール ベア
光治 小寺
ナデージュ プフェンダー
ジャン−セルジュ レミー
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サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/32Special delivery means, e.g. tissue-specific

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JP2010544836A 2008-01-30 2009-01-30 RNA干渉のためのカチオン性siRNA、合成及び使用 Pending JP2011511776A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0800492A FR2926818B1 (fr) 2008-01-30 2008-01-30 siRNA CATIONIQUES, SYNTHESE ET UTILISATION POUR L'ARN INTERFERENCE
PCT/IB2009/050379 WO2009095887A1 (fr) 2008-01-30 2009-01-30 siRNA CATIONIQUES, SYNTHÈSE ET UTILISATION POUR L'ARN INTERFÉRENCE

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JP2011511776A true JP2011511776A (ja) 2011-04-14
JP2011511776A5 JP2011511776A5 (enExample) 2011-12-15

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JP2010544836A Pending JP2011511776A (ja) 2008-01-30 2009-01-30 RNA干渉のためのカチオン性siRNA、合成及び使用

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US (1) US10927371B2 (enExample)
EP (1) EP2250267B1 (enExample)
JP (1) JP2011511776A (enExample)
KR (1) KR20100120293A (enExample)
CN (1) CN101960009A (enExample)
AU (1) AU2009208646A1 (enExample)
BR (1) BRPI0907494A2 (enExample)
CA (1) CA2713075A1 (enExample)
FR (1) FR2926818B1 (enExample)
IL (1) IL207290A0 (enExample)
NZ (1) NZ587117A (enExample)
RU (1) RU2010136047A (enExample)
WO (1) WO2009095887A1 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
AU2006325054B2 (en) * 2005-12-15 2013-05-02 Centre National De La Recherche Scientifique (Cnrs) Cationic oligonucleotides, automated methods for preparing same and their uses
WO2015015498A1 (en) * 2013-07-31 2015-02-05 Qbi Enterprises Ltd. Methods of use of sphingolipid polyalkylamine oligonucleotide compounds
AU2016226418B2 (en) 2015-03-02 2022-05-26 Synthetic Genomics, Inc. Regulatory elements from labyrinthulomycetes microorganisms
US10633454B2 (en) 2016-11-01 2020-04-28 Conagen Inc. Expression of modified glycoproteins and glycopeptides
EP3535385A4 (en) * 2016-11-01 2020-06-17 Conagen Inc. EXPRESSION OF MODIFIED GLYCOPROTEINS AND GLYCOPEPTIDES
CN106498072B (zh) * 2016-11-24 2019-09-10 青岛千卓分子生物科技有限公司 一种液态产品中外源dna内标物的保护方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006052854A2 (en) * 2004-11-04 2006-05-18 Raul Andino Syntheses of polyamine conjugates of small interfering rnas (si-rnas) and conjugates formed thereby
WO2007069092A2 (en) * 2005-12-15 2007-06-21 Centre National De La Recherche Scientifique (Cnrs) Cationic oligonucleotides, automated methods for preparing same and their uses

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US6071890A (en) 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
EP1013770A1 (en) 1998-12-23 2000-06-28 Université Louis Pasteur de Strasbourg Non-viral transfection vector
DE10207177A1 (de) 2002-02-19 2003-09-04 Novosom Ag Fakultativ kationische Lipide
US20040019008A1 (en) 2002-05-28 2004-01-29 Lewis David L. Compositions and processes using siRNA, amphipathic compounds and polycations
JP2004137143A (ja) 2002-08-21 2004-05-13 Fuji Photo Film Co Ltd 有機変性層状珪酸塩及びその組成物
EP1585756B1 (en) * 2002-11-26 2010-04-21 University of Massachusetts Delivery of sirnas
EP1638919B1 (en) * 2003-06-18 2012-09-26 Biolab Ltd. Sphingolipids polyalkylamines conjugates
WO2005060697A2 (en) * 2003-12-19 2005-07-07 Chiron Corporation Cell transfecting formulations of small interfering rna, related compositions and methods of making and use
US20060073505A1 (en) * 2004-09-21 2006-04-06 Isis Pharmaceuticals, Inc. Oligomeric compounds effecting drosha-mediated cleavage
CA2587962A1 (en) * 2004-11-17 2006-06-08 University Of Maryland, Baltimore Highly branched hk peptides as effective carriers of sirna
EP1844772A1 (en) 2006-04-06 2007-10-17 Polyplus-Transfection SA Compositions for transfection of oligonucleotides active for gene silencing and their biological and therapeutical applications
EP2992875A1 (en) * 2006-04-20 2016-03-09 Silence Therapeutics GmbH Lipoplex formulations for specific delivery to vascular endothelium

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006052854A2 (en) * 2004-11-04 2006-05-18 Raul Andino Syntheses of polyamine conjugates of small interfering rnas (si-rnas) and conjugates formed thereby
WO2007069092A2 (en) * 2005-12-15 2007-06-21 Centre National De La Recherche Scientifique (Cnrs) Cationic oligonucleotides, automated methods for preparing same and their uses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6013030804; Bioconjugate Chemistry Vol.18, No.5, 2007, pp.1450-1459 *
JPN6013030806; FEBS Letters Vol.558, No.1-3, 2004, pp.63-68 *

Also Published As

Publication number Publication date
AU2009208646A1 (en) 2009-08-06
US10927371B2 (en) 2021-02-23
CA2713075A1 (fr) 2009-08-06
EP2250267B1 (fr) 2016-09-14
CN101960009A (zh) 2011-01-26
EP2250267A1 (fr) 2010-11-17
FR2926818B1 (fr) 2012-04-06
KR20100120293A (ko) 2010-11-15
WO2009095887A1 (fr) 2009-08-06
IL207290A0 (en) 2010-12-30
FR2926818A1 (fr) 2009-07-31
NZ587117A (en) 2012-09-28
BRPI0907494A2 (pt) 2019-09-24
RU2010136047A (ru) 2012-03-10
US20110118331A1 (en) 2011-05-19

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