NZ562796A - Method of determining whether a compound is a neurotrypsin inhibitor using agrin - Google Patents
Method of determining whether a compound is a neurotrypsin inhibitor using agrinInfo
- Publication number
- NZ562796A NZ562796A NZ562796A NZ56279606A NZ562796A NZ 562796 A NZ562796 A NZ 562796A NZ 562796 A NZ562796 A NZ 562796A NZ 56279606 A NZ56279606 A NZ 56279606A NZ 562796 A NZ562796 A NZ 562796A
- Authority
- NZ
- New Zealand
- Prior art keywords
- neurotrypsin
- agrin
- fragment
- cleavage
- protein
- Prior art date
Links
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid group Chemical class S(N)(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/64—X and Y being nitrogen atoms, e.g. N-sulfonylguanidine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/976—Trypsin; Chymotrypsin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05102481 | 2005-03-30 | ||
| PCT/EP2006/061152 WO2006103261A2 (en) | 2005-03-30 | 2006-03-29 | Inhibitors of neurotrypsin and determination thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ562796A true NZ562796A (en) | 2010-02-26 |
Family
ID=34939082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ562796A NZ562796A (en) | 2005-03-30 | 2006-03-29 | Method of determining whether a compound is a neurotrypsin inhibitor using agrin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7897364B2 (https=) |
| EP (1) | EP1868989A2 (https=) |
| JP (1) | JP4920675B2 (https=) |
| KR (1) | KR20070116932A (https=) |
| CN (1) | CN101193858B (https=) |
| AU (1) | AU2006228150B2 (https=) |
| BR (1) | BRPI0609654A2 (https=) |
| CA (1) | CA2600791A1 (https=) |
| IL (1) | IL186120A (https=) |
| MX (1) | MX2007011961A (https=) |
| NO (1) | NO20075461L (https=) |
| NZ (1) | NZ562796A (https=) |
| RU (1) | RU2424228C2 (https=) |
| WO (1) | WO2006103261A2 (https=) |
| ZA (1) | ZA200707359B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008074813A2 (en) * | 2006-12-21 | 2008-06-26 | Neurotune Ag | Optiogenin for the treatment of neural diseases |
| PL1990420T3 (pl) * | 2007-05-10 | 2011-01-31 | Neurotune Ag | Sposób wykrywania aktywności neurotrypsyny in vivo, zastosowanie tego sposobu i zastosowanie C-końcowego fragmentu agryny 22 kDa jako biomarkera w diagnozowaniu i monitorowaniu zaburzeń związanych z neurotrypsyną |
| EP2295068A1 (en) * | 2009-09-04 | 2011-03-16 | Neurotune AG | Modified agrin-fragment capable of restoring muscle strength for use as a medicament |
| EP2635559A2 (en) | 2010-11-01 | 2013-09-11 | Neurotune AG | Neurotrypsin inhibitors |
| WO2012059443A2 (en) | 2010-11-01 | 2012-05-10 | Neurotune Ag | Novel neurotrypsin inhibitors |
| EP2631657A1 (en) * | 2012-02-25 | 2013-08-28 | Neurotune AG | Immunoassay for the detection of the 22kDa C-terminal fragment (CAF) of agrin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH692507A5 (de) * | 1997-04-26 | 2002-07-15 | Peter Prof Dr Sonderegger | Neurotrypsin als aktive Verbindung in einem Medikament. |
| DE19919634C2 (de) * | 1999-04-30 | 2001-06-07 | Aventis Pharma Gmbh | Test zur Bestimmung der Integrität komplexer Phospholipid/Lipid-Strukturen mit Hilfe synthetischer fluoreszenz-markierter Acylglyceride und dessen Anwendung zur Bestimmung der Aktivität von Lipasen |
| DE10247478A1 (de) * | 2002-10-11 | 2004-06-24 | Bioagency Ag | Verfahren zur Bestimmung der enzymatischen Aktivität von Proteinen |
-
2006
- 2006-03-29 WO PCT/EP2006/061152 patent/WO2006103261A2/en not_active Ceased
- 2006-03-29 RU RU2007139754/04A patent/RU2424228C2/ru not_active IP Right Cessation
- 2006-03-29 AU AU2006228150A patent/AU2006228150B2/en not_active Ceased
- 2006-03-29 JP JP2008503516A patent/JP4920675B2/ja not_active Expired - Fee Related
- 2006-03-29 KR KR1020077024937A patent/KR20070116932A/ko not_active Withdrawn
- 2006-03-29 US US11/887,136 patent/US7897364B2/en not_active Expired - Fee Related
- 2006-03-29 CA CA002600791A patent/CA2600791A1/en not_active Abandoned
- 2006-03-29 CN CN2006800101171A patent/CN101193858B/zh not_active Expired - Fee Related
- 2006-03-29 MX MX2007011961A patent/MX2007011961A/es not_active Application Discontinuation
- 2006-03-29 NZ NZ562796A patent/NZ562796A/en not_active IP Right Cessation
- 2006-03-29 BR BRPI0609654-9A patent/BRPI0609654A2/pt not_active IP Right Cessation
- 2006-03-29 EP EP06725408A patent/EP1868989A2/en not_active Withdrawn
-
2007
- 2007-08-29 ZA ZA200707359A patent/ZA200707359B/xx unknown
- 2007-09-20 IL IL186120A patent/IL186120A/en not_active IP Right Cessation
- 2007-10-29 NO NO20075461A patent/NO20075461L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4920675B2 (ja) | 2012-04-18 |
| EP1868989A2 (en) | 2007-12-26 |
| KR20070116932A (ko) | 2007-12-11 |
| WO2006103261A9 (en) | 2010-05-27 |
| CN101193858A (zh) | 2008-06-04 |
| CA2600791A1 (en) | 2006-10-05 |
| JP2008538178A (ja) | 2008-10-16 |
| RU2424228C2 (ru) | 2011-07-20 |
| WO2006103261A3 (en) | 2007-02-22 |
| IL186120A (en) | 2012-08-30 |
| AU2006228150A1 (en) | 2006-10-05 |
| RU2007139754A (ru) | 2009-05-10 |
| WO2006103261A2 (en) | 2006-10-05 |
| AU2006228150B2 (en) | 2011-09-29 |
| US7897364B2 (en) | 2011-03-01 |
| US20090170950A1 (en) | 2009-07-02 |
| ZA200707359B (en) | 2009-08-26 |
| IL186120A0 (en) | 2008-01-20 |
| NO20075461L (no) | 2007-11-20 |
| BRPI0609654A2 (pt) | 2010-04-20 |
| MX2007011961A (es) | 2008-03-14 |
| CN101193858B (zh) | 2012-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| LAPS | Patent lapsed |