NZ544684A - Methods and compositions for treating amyloid-related diseases - Google Patents
Methods and compositions for treating amyloid-related diseasesInfo
- Publication number
- NZ544684A NZ544684A NZ544684A NZ54468404A NZ544684A NZ 544684 A NZ544684 A NZ 544684A NZ 544684 A NZ544684 A NZ 544684A NZ 54468404 A NZ54468404 A NZ 54468404A NZ 544684 A NZ544684 A NZ 544684A
- Authority
- NZ
- New Zealand
- Prior art keywords
- amyloid
- substituted
- compound
- disease
- hydrogen
- Prior art date
Links
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61P27/02—Ophthalmic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
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- C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
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- C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
- C07C309/15—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton the nitrogen atom of at least one of the amino groups being part of any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/69—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a carbon skeleton substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/32—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/02—Thiosulfates
-
- C—CHEMISTRY; METALLURGY
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- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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EP1644325A2 (en) * | 2003-06-23 | 2006-04-12 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
AU2005310979A1 (en) * | 2004-11-16 | 2006-06-08 | Bellus Health (International) Limited | Compounds for the treatment of CNS and amyloid associated diseases |
WO2006085149A2 (en) | 2004-12-22 | 2006-08-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
JP2009510050A (ja) * | 2005-09-30 | 2009-03-12 | ベルス ヘルス (インターナショナル) リミティッド | カルボキシアルキルスルホン酸を含む薬学的組成物および方法 |
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JP5650642B2 (ja) | 2008-08-01 | 2015-01-07 | バイオキシネス ファーマシューティカルズ, インコーポレイテッド | メチオニンアナログおよびそれらを使用する方法 |
CN102170882B (zh) * | 2008-08-29 | 2014-04-02 | 特温蒂斯公司 | 治疗淀粉状蛋白疾病的组合物和其制药用途 |
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WO2011044221A2 (en) | 2009-10-06 | 2011-04-14 | Massachusetts Institute Of Technology | Method and apparatus for determining radiation |
KR101173677B1 (ko) | 2009-12-11 | 2012-08-13 | 한국과학기술연구원 | Epps를 유효성분으로 함유하는 베타아밀로이드 집적 관련 질환의 예방 또는 치료용 약학적 조성물 |
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JP6928385B2 (ja) * | 2015-08-10 | 2021-09-01 | アルジオン, インコーポレイテッド | 神経変性疾患を治療および予防するための組成物および方法 |
JP6675167B2 (ja) * | 2015-08-28 | 2020-04-01 | シスメックス株式会社 | ペプチドの遊離方法及び回収方法、並びにペプチド遊離剤及び試薬キット |
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US10632084B2 (en) | 2016-03-04 | 2020-04-28 | Niigata University | Aquaporin 4 function promotor and pharmaceutical composition for neurological disorders |
RU2657844C1 (ru) * | 2017-01-09 | 2018-06-15 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Осетинская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Способ лечения экспериментальной амилоидной кардиопатии у крыс |
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WO2020025066A1 (en) * | 2018-08-03 | 2020-02-06 | The University Of Hong Kong | Compositions and methods for detection and imaging of amyloid fibrils, amyloid plaques, rna, and nucleoli |
JP2022059674A (ja) * | 2020-10-02 | 2022-04-14 | 国立大学法人高知大学 | アミロイドβの凝集抑制剤、アミロイドβ凝集疾患用医薬組成物、およびその用途 |
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CN113433325A (zh) * | 2021-06-07 | 2021-09-24 | 西安市第一医院 | 血清vitronectin在AL型淀粉样变的诊断及疾病分期中的应用 |
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DD287256A5 (de) * | 1989-08-21 | 1991-02-21 | Akademie Der Wissenschaften Der Ddr,De | Verfahren zur herstellung von chiralen wasserloeslichen ammoniumalkansulfonsaeuren sowie deren salzen und sulfobetainen |
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JP4440446B2 (ja) * | 1999-10-05 | 2010-03-24 | 花王株式会社 | 皮膚外用剤 |
US20020094335A1 (en) * | 1999-11-29 | 2002-07-18 | Robert Chalifour | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases |
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- 2004-06-21 KR KR1020057024647A patent/KR101124935B1/ko not_active IP Right Cessation
- 2004-06-21 MX MXPA05014166A patent/MXPA05014166A/es active IP Right Grant
- 2004-06-21 AU AU2004249527A patent/AU2004249527A1/en not_active Abandoned
-
2005
- 2005-12-12 NO NO20055894A patent/NO335084B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BRPI0411743A (pt) | 2006-08-08 |
WO2004113277A2 (en) | 2004-12-29 |
EA012429B1 (ru) | 2009-10-30 |
WO2004113275A3 (en) | 2005-10-27 |
KR101124935B1 (ko) | 2012-04-12 |
NO335084B1 (no) | 2014-09-08 |
CA2529257A1 (en) | 2004-12-29 |
CA2529257C (en) | 2013-04-23 |
JP2007516939A (ja) | 2007-06-28 |
AU2004249529A1 (en) | 2004-12-29 |
NO20055894L (no) | 2006-03-21 |
EP1658264A2 (en) | 2006-05-24 |
WO2004113277A8 (en) | 2005-07-14 |
CA2529256A1 (en) | 2004-12-29 |
MXPA05014166A (es) | 2006-03-13 |
JP5146714B2 (ja) | 2013-02-20 |
WO2004113275A2 (en) | 2004-12-29 |
EA200600078A1 (ru) | 2006-08-25 |
UA96115C2 (uk) | 2011-10-10 |
MXPA05013977A (es) | 2006-03-09 |
KR20060023172A (ko) | 2006-03-13 |
EP1644325A2 (en) | 2006-04-12 |
WO2004113277A3 (en) | 2005-10-13 |
JP2007516938A (ja) | 2007-06-28 |
AU2004249527A1 (en) | 2004-12-29 |
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Owner name: BELLUS HEALTH INC., CA Free format text: OLD OWNER(S): BELLUS HEALTH (INTERNATIONAL) LIMITED |
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