NZ535903A - Copper silicate in topical compositions to prevent and treat infection with microbial nail pathogens - Google Patents
Copper silicate in topical compositions to prevent and treat infection with microbial nail pathogensInfo
- Publication number
- NZ535903A NZ535903A NZ535903A NZ53590303A NZ535903A NZ 535903 A NZ535903 A NZ 535903A NZ 535903 A NZ535903 A NZ 535903A NZ 53590303 A NZ53590303 A NZ 53590303A NZ 535903 A NZ535903 A NZ 535903A
- Authority
- NZ
- New Zealand
- Prior art keywords
- nail
- copper
- medicament
- use according
- infection
- Prior art date
Links
- ZZBBCSFCMKWYQR-UHFFFAOYSA-N copper;dioxido(oxo)silane Chemical compound [Cu+2].[O-][Si]([O-])=O ZZBBCSFCMKWYQR-UHFFFAOYSA-N 0.000 title claims abstract description 51
- 230000000813 microbial effect Effects 0.000 title claims abstract description 20
- 230000000699 topical effect Effects 0.000 title claims abstract description 10
- 208000015181 infectious disease Diseases 0.000 title claims description 31
- 239000000203 mixture Substances 0.000 title claims description 30
- 244000052769 pathogen Species 0.000 title description 2
- 208000010195 Onychomycosis Diseases 0.000 claims abstract description 28
- 201000005882 tinea unguium Diseases 0.000 claims abstract description 28
- 201000010099 disease Diseases 0.000 claims abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims description 48
- 239000010949 copper Substances 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 16
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 15
- 229910052802 copper Inorganic materials 0.000 claims description 15
- 241000223229 Trichophyton rubrum Species 0.000 claims description 12
- 241001480043 Arthrodermataceae Species 0.000 claims description 10
- 241001045770 Trichophyton mentagrophytes Species 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 10
- 230000037304 dermatophytes Effects 0.000 claims description 10
- 238000011200 topical administration Methods 0.000 claims description 9
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 8
- 241001480035 Epidermophyton Species 0.000 claims description 8
- 241000222122 Candida albicans Species 0.000 claims description 6
- 241001480048 Trichophyton tonsurans Species 0.000 claims description 6
- 230000000845 anti-microbial effect Effects 0.000 claims description 6
- 241000893980 Microsporum canis Species 0.000 claims description 5
- 241000893976 Nannizzia gypsea Species 0.000 claims description 5
- 239000004599 antimicrobial Substances 0.000 claims description 5
- 229940095731 candida albicans Drugs 0.000 claims description 5
- 241000555676 Malassezia Species 0.000 claims description 4
- 241000555688 Malassezia furfur Species 0.000 claims description 4
- 241001291478 Malassezia sympodialis Species 0.000 claims description 4
- 241000223238 Trichophyton Species 0.000 claims description 4
- 241001480046 Trichophyton schoenleinii Species 0.000 claims description 4
- 241000222126 [Candida] glabrata Species 0.000 claims description 4
- 208000032343 candida glabrata infection Diseases 0.000 claims description 4
- 241000894007 species Species 0.000 claims description 4
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 claims description 3
- 241000228212 Aspergillus Species 0.000 claims description 3
- 241001480037 Microsporum Species 0.000 claims description 3
- 206010034016 Paronychia Diseases 0.000 claims description 2
- 241000178274 Trichomonascus ciferrii Species 0.000 claims description 2
- 206010061304 Nail infection Diseases 0.000 claims 1
- 210000000282 nail Anatomy 0.000 description 74
- 239000000243 solution Substances 0.000 description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 208000031888 Mycoses Diseases 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 238000003756 stirring Methods 0.000 description 12
- 239000012071 phase Substances 0.000 description 11
- 239000000047 product Substances 0.000 description 7
- 208000007163 Dermatomycoses Diseases 0.000 description 6
- 206010017533 Fungal infection Diseases 0.000 description 6
- 239000004115 Sodium Silicate Substances 0.000 description 6
- 230000000855 fungicidal effect Effects 0.000 description 6
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 6
- 229910052911 sodium silicate Inorganic materials 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000003860 topical agent Substances 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 229940121375 antifungal agent Drugs 0.000 description 3
- 239000003429 antifungal agent Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000003349 gelling agent Substances 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229960003749 ciclopirox Drugs 0.000 description 2
- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical group ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- MFBSQKPUGUXFPV-UHFFFAOYSA-L copper acetic acid sulfate pentahydrate Chemical compound C(C)(=O)O.O.O.O.O.O.S(=O)(=O)([O-])[O-].[Cu+2] MFBSQKPUGUXFPV-UHFFFAOYSA-L 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 210000004904 fingernail bed Anatomy 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 239000000346 nonvolatile oil Substances 0.000 description 2
- OQILCOQZDHPEAZ-UHFFFAOYSA-N octyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 description 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 description 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- 241000589291 Acinetobacter Species 0.000 description 1
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 241001225321 Aspergillus fumigatus Species 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 241000222178 Candida tropicalis Species 0.000 description 1
- 241000588919 Citrobacter freundii Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 101100348017 Drosophila melanogaster Nazo gene Proteins 0.000 description 1
- 239000004150 EU approved colour Substances 0.000 description 1
- 241000588697 Enterobacter cloacae Species 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
- 241000587112 Enterobacteriaceae sp. Species 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000194031 Enterococcus faecium Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000588915 Klebsiella aerogenes Species 0.000 description 1
- 241000588749 Klebsiella oxytoca Species 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 244000285963 Kluyveromyces fragilis Species 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- 241000588655 Moraxella catarrhalis Species 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 241000235645 Pichia kudriavzevii Species 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 241000588768 Providencia Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000132889 Scedosporium Species 0.000 description 1
- 241000122799 Scopulariopsis Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000122971 Stenotrophomonas Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000730665 Streptococcus pneumoniae 27 Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 229940031955 anhydrous lanolin Drugs 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000012871 anti-fungal composition Substances 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003683 cardiac damage Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229940081733 cetearyl alcohol Drugs 0.000 description 1
- 229940056318 ceteth-20 Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 210000000078 claw Anatomy 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229960003913 econazole Drugs 0.000 description 1
- 229940092559 enterobacter aerogenes Drugs 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 210000004905 finger nail Anatomy 0.000 description 1
- 229960004884 fluconazole Drugs 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 210000000003 hoof Anatomy 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229960004130 itraconazole Drugs 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- OZGNYLLQHRPOBR-DHZHZOJOSA-N naftifine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)C\C=C\C1=CC=CC=C1 OZGNYLLQHRPOBR-DHZHZOJOSA-N 0.000 description 1
- 229960004313 naftifine Drugs 0.000 description 1
- 208000026721 nail disease Diseases 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 229960003483 oxiconazole Drugs 0.000 description 1
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- -1 patches Chemical compound 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229940100460 peg-100 stearate Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 210000004906 toe nail Anatomy 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPS1793A AUPS179302A0 (en) | 2002-04-17 | 2002-04-17 | Use of topical compositions for the control of microbial diseases of the nail |
| PCT/AU2003/000471 WO2003088983A1 (en) | 2002-04-17 | 2003-04-17 | Use of topical compositions for the control of microbial diseases of the nail |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ535903A true NZ535903A (en) | 2005-06-24 |
Family
ID=3835370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ535903A NZ535903A (en) | 2002-04-17 | 2003-04-17 | Copper silicate in topical compositions to prevent and treat infection with microbial nail pathogens |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1494688A4 (https=) |
| JP (1) | JP2005523317A (https=) |
| CN (1) | CN1649605A (https=) |
| AP (1) | AP1777A (https=) |
| AU (2) | AUPS179302A0 (https=) |
| BR (1) | BR0309266A (https=) |
| CA (1) | CA2482439A1 (https=) |
| EA (1) | EA200401395A1 (https=) |
| HK (1) | HK1079983A1 (https=) |
| IL (1) | IL164557A0 (https=) |
| MX (1) | MXPA04010131A (https=) |
| NZ (1) | NZ535903A (https=) |
| OA (1) | OA12808A (https=) |
| WO (1) | WO2003088983A1 (https=) |
| ZA (1) | ZA200408372B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070116745A1 (en) * | 2004-02-16 | 2007-05-24 | Conve Ltd. | Spermicidal preparations and uses thereof |
| CA2587029C (en) * | 2004-11-07 | 2013-09-10 | The Cupron Corporation | Methods and materials for treating wounds, burns, and skin conditions |
| KR101254818B1 (ko) | 2004-11-09 | 2013-04-15 | 쿠프론 인코포레이티드 | 피부 보호 방법 및 물질 |
| CN101115475A (zh) * | 2004-12-10 | 2008-01-30 | 塔利马治疗公司 | 用于治疗指甲单位病症的组合物和方法 |
| WO2006096937A1 (en) * | 2005-03-16 | 2006-09-21 | Conve Ltd | Use of copper silicate for the control of herpes infections |
| CN118634190B (zh) * | 2024-08-12 | 2024-11-22 | 上海方予健康医药科技有限公司 | 一种三唑类药物混悬液及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL173260B (nl) * | 1970-07-23 | 1983-08-01 | Degussa | Werkwijze voor het bereiden van kopersilicaten. |
| SG47493A1 (en) * | 1991-10-17 | 1998-04-17 | Sheen Biotechnology Pty Ltd | Pesticide and fungicide |
| AUPP068497A0 (en) * | 1997-12-02 | 1998-01-08 | Sheen Biotechnology Pty Ltd | Use of copper for the control of legionella |
| CA2431651A1 (en) * | 2000-11-16 | 2002-05-23 | Kenneth T. Zeiler | Antifungal nail composition and method of use |
-
2002
- 2002-04-17 AU AUPS1793A patent/AUPS179302A0/en not_active Abandoned
-
2003
- 2003-04-17 OA OA1200400283A patent/OA12808A/en unknown
- 2003-04-17 CA CA002482439A patent/CA2482439A1/en not_active Abandoned
- 2003-04-17 NZ NZ535903A patent/NZ535903A/en unknown
- 2003-04-17 BR BR0309266-6A patent/BR0309266A/pt not_active IP Right Cessation
- 2003-04-17 AU AU2003227095A patent/AU2003227095B2/en not_active Ceased
- 2003-04-17 ZA ZA200408372A patent/ZA200408372B/en unknown
- 2003-04-17 MX MXPA04010131A patent/MXPA04010131A/es unknown
- 2003-04-17 EA EA200401395A patent/EA200401395A1/ru unknown
- 2003-04-17 EP EP03746769A patent/EP1494688A4/en not_active Withdrawn
- 2003-04-17 AP APAP/P/2004/003163A patent/AP1777A/en active
- 2003-04-17 HK HK06100021.7A patent/HK1079983A1/zh unknown
- 2003-04-17 CN CNA03809987XA patent/CN1649605A/zh active Pending
- 2003-04-17 WO PCT/AU2003/000471 patent/WO2003088983A1/en not_active Ceased
- 2003-04-17 JP JP2003585735A patent/JP2005523317A/ja active Pending
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2004
- 2004-10-13 IL IL16455704A patent/IL164557A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003088983A1 (en) | 2003-10-30 |
| OA12808A (en) | 2006-07-11 |
| EP1494688A1 (en) | 2005-01-12 |
| HK1079983A1 (zh) | 2006-04-21 |
| AU2003227095B2 (en) | 2007-05-31 |
| JP2005523317A (ja) | 2005-08-04 |
| MXPA04010131A (es) | 2005-06-08 |
| BR0309266A (pt) | 2005-03-01 |
| AP2004003163A0 (en) | 2004-12-31 |
| AUPS179302A0 (en) | 2002-05-30 |
| EP1494688A4 (en) | 2007-07-04 |
| IL164557A0 (en) | 2005-12-18 |
| CA2482439A1 (en) | 2003-10-30 |
| AP1777A (en) | 2007-09-03 |
| EA200401395A1 (ru) | 2005-06-30 |
| CN1649605A (zh) | 2005-08-03 |
| AU2003227095A1 (en) | 2003-11-03 |
| ZA200408372B (en) | 2007-10-31 |
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| RENW | Renewal (renewal fees accepted) |