NZ520914A - 1,5-disubstituted-3,4-dihydro-1H-pyrimido[4,5-D] pyrimidin-2-one compounds and their preparation and use in treating CSBP/P38 kinase mediated diseases - Google Patents

Info

Publication number

NZ520914A

NZ520914A NZ520914A NZ52091401A NZ520914A NZ 520914 A NZ520914 A NZ 520914A NZ 520914 A NZ520914 A NZ 520914A NZ 52091401 A NZ52091401 A NZ 52091401A NZ 520914 A NZ520914 A NZ 520914A

Authority

NZ

New Zealand

Prior art keywords

alkyl

optionally substituted

dihydro

pyrimido

pyrimidin

Prior art date

2000-03-02

Links

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• Global Dossier
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• -1 1,5-disubstituted-3,4-dihydro-1H-pyrimido[4,5-D] pyrimidin-2-one compounds Chemical class 0.000 title claims abstract description 77
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• JPOJBQLUJAIHHL-UHFFFAOYSA-N 1h-pyrimido[4,5-d]pyrimidin-2-one Chemical class N1=CN=C2NC(=O)N=CC2=C1 JPOJBQLUJAIHHL-UHFFFAOYSA-N 0.000 claims abstract description 15
• 125000000217 alkyl group Chemical group 0.000 claims description 469
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• 229910052739 hydrogen Inorganic materials 0.000 claims description 129
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• VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 claims description 60
• 238000011282 treatment Methods 0.000 claims description 60
• RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 56
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• POIUUYBLAPDZRL-AWEZNQCLSA-N 4-(4-fluoro-2-methylphenyl)-2-methylsulfanyl-8-[(1s)-1-phenylethyl]-5,6-dihydropyrimido[4,5-d]pyrimidin-7-one Chemical compound C1([C@H](C)N2C=3N=C(N=C(C=3CNC2=O)C=2C(=CC(F)=CC=2)C)SC)=CC=CC=C1 POIUUYBLAPDZRL-AWEZNQCLSA-N 0.000 claims 1
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