NZ509178A - Compositions and methods for therapy and diagnosis of prostate cancer - Google Patents
Compositions and methods for therapy and diagnosis of prostate cancerInfo
- Publication number
- NZ509178A NZ509178A NZ509178A NZ50917899A NZ509178A NZ 509178 A NZ509178 A NZ 509178A NZ 509178 A NZ509178 A NZ 509178A NZ 50917899 A NZ50917899 A NZ 50917899A NZ 509178 A NZ509178 A NZ 509178A
- Authority
- NZ
- New Zealand
- Prior art keywords
- seq
- cdna sequence
- polypeptide
- polynucleotide
- prostate
- Prior art date
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Classifications
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/58—Prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
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- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/116,134 US7008772B1 (en) | 1997-02-25 | 1998-07-14 | Compounds for immunodiagnosis of prostate cancer and methods for their use |
| US09/115,453 US6657056B2 (en) | 1997-02-25 | 1998-07-14 | Compounds for immunotherapy of prostate cancer and methods for their use |
| US15982298A | 1998-09-23 | 1998-09-23 | |
| US09/159,812 US6613872B1 (en) | 1997-02-25 | 1998-09-23 | Compounds for immunotherapy of prostate cancer and methods for their use |
| US09/232,880 US7270980B2 (en) | 1997-02-25 | 1999-01-15 | Compounds for immunodiagnosis of prostate cancer and methods for their use |
| US09/232,149 US6465611B1 (en) | 1997-02-25 | 1999-01-15 | Compounds for immunotherapy of prostate cancer and methods for their use |
| US28894699A | 1999-04-09 | 1999-04-09 | |
| PCT/US1999/015838 WO2000004149A2 (en) | 1998-07-14 | 1999-07-14 | Compositions and methods for therapy and diagnosis of prostate cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ509178A true NZ509178A (en) | 2004-04-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ509178A NZ509178A (en) | 1998-07-14 | 1999-07-14 | Compositions and methods for therapy and diagnosis of prostate cancer |
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| Country | Link |
|---|---|
| EP (2) | EP1870466A3 (enExample) |
| JP (1) | JP2002520054A (enExample) |
| KR (2) | KR20070112860A (enExample) |
| CN (1) | CN100419079C (enExample) |
| AU (2) | AU762812B2 (enExample) |
| BR (1) | BR9912007A (enExample) |
| CA (1) | CA2334038A1 (enExample) |
| CZ (1) | CZ2001149A3 (enExample) |
| HU (1) | HUP0203035A3 (enExample) |
| IL (1) | IL140845A0 (enExample) |
| NO (1) | NO20010196L (enExample) |
| NZ (1) | NZ509178A (enExample) |
| PL (1) | PL200772B1 (enExample) |
| SA (1) | SA99200618B1 (enExample) |
| TR (1) | TR200100916T2 (enExample) |
| TW (2) | TW200728465A (enExample) |
| WO (1) | WO2000004149A2 (enExample) |
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| US7241876B2 (en) | 1996-01-11 | 2007-07-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| US6828431B1 (en) * | 1999-04-09 | 2004-12-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| US6630305B1 (en) | 1999-11-12 | 2003-10-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6894146B1 (en) | 1997-02-25 | 2005-05-17 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6657056B2 (en) | 1997-02-25 | 2003-12-02 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US20030185830A1 (en) * | 1997-02-25 | 2003-10-02 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6818751B1 (en) | 1997-08-01 | 2004-11-16 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6465611B1 (en) | 1997-02-25 | 2002-10-15 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US7033827B2 (en) | 1997-02-25 | 2006-04-25 | Corixa Corporation | Prostate-specific polynucleotide compositions |
| US6329505B1 (en) | 1997-02-25 | 2001-12-11 | Corixa Corporation | Compositions and methods for therapy and diagnosis of prostate cancer |
| US7517952B1 (en) | 1997-02-25 | 2009-04-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6800746B2 (en) | 1997-02-25 | 2004-10-05 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6759515B1 (en) | 1997-02-25 | 2004-07-06 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6620922B1 (en) | 1997-02-25 | 2003-09-16 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US7202342B1 (en) | 1999-11-12 | 2007-04-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6943236B2 (en) | 1997-02-25 | 2005-09-13 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| ES2324503T3 (es) | 1997-04-10 | 2009-08-07 | Stichting Katholieke Universiteit University Medical Centre Nijmegen | Pca3, genes pca3 y metodos de uso. |
| US6365369B1 (en) | 1998-04-01 | 2002-04-02 | Human Genome Sciences, Inc. | Prostate specific secreted protein |
| US6861215B1 (en) | 1998-05-21 | 2005-03-01 | Diadexus, Inc. | Method of diagnosing, monitoring, and staging prostate cancer |
| US6329503B1 (en) | 1998-06-01 | 2001-12-11 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| US7037667B1 (en) | 1998-06-01 | 2006-05-02 | Agensys, Inc. | Tumor antigen useful in diagnosis and therapy of prostate and colon cancer |
| US20060052321A1 (en) | 2002-04-05 | 2006-03-09 | Raitano Arthur B | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
| US20040141975A1 (en) | 1998-06-01 | 2004-07-22 | Raitano Arthur B. | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
| US20030149531A1 (en) | 2000-12-06 | 2003-08-07 | Hubert Rene S. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| US6833438B1 (en) | 1999-06-01 | 2004-12-21 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| WO2000020584A2 (en) * | 1998-10-02 | 2000-04-13 | Urogenesys, Inc. | Human gene expressed in cancers of prostate, bladder, pancreas and colon, 36p1a6 |
| US6902892B1 (en) | 1998-10-19 | 2005-06-07 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating prostate cancer |
| US6528054B1 (en) * | 1998-12-28 | 2003-03-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| NZ514646A (en) * | 1999-04-09 | 2005-04-29 | Corixa Corp | Compositions and methods for the treatment and diagnosis of breast cancer |
| US6943235B1 (en) | 1999-04-12 | 2005-09-13 | Agensys, Inc. | Transmembrane protein expressed in prostate cancer |
| WO2000065067A2 (en) * | 1999-04-23 | 2000-11-02 | University Of Washington | Prostate-specific polynucleotides, polypeptides and their methods of use |
| AU5416700A (en) * | 1999-05-20 | 2000-12-12 | Fahri Saatcioglu | Differentially expressed genes in prostate cancer |
| US20060073150A1 (en) | 2001-09-06 | 2006-04-06 | Mary Faris | Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer |
| WO2001004143A2 (en) * | 1999-07-13 | 2001-01-18 | Smithkline Beecham Biologicals S.A. | Prostase vaccine |
| JP2003510075A (ja) | 1999-09-29 | 2003-03-18 | ディグノキュアー・インコーポレーテッド | 良性および悪性の前立腺組織におけるｐｃａ３メッセンジャーｒｎａ種 |
| AU7917200A (en) * | 1999-09-30 | 2001-04-30 | Institut Pasteur | Hybrid or chimeric polynucleotides, proteins, and compositions comprising hepatitis b virus sequences |
| AU7994200A (en) * | 1999-10-04 | 2001-05-10 | Corixa Corporation | Compositions and methods for therapy and diagnosis of prostate cancer |
| US7208280B2 (en) | 1999-10-05 | 2007-04-24 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 101P3A41 useful in treatment and detection of cancer |
| ES2371212T3 (es) * | 1999-10-05 | 2011-12-28 | Agensys, Inc. | Receptor acoplado a proteína g regulado positivamente en el cáncer de próstata y usos del mismo. |
| US7361338B2 (en) | 1999-10-05 | 2008-04-22 | Agensys, Inc. | Methods to inhibit growth of prostate cancer cells |
| US6790631B1 (en) | 1999-10-05 | 2004-09-14 | Agensys, Inc. | G protein-coupled receptor up-regulated in prostate cancer and uses thereof |
| JP2003528584A (ja) * | 1999-10-07 | 2003-09-30 | シエーリング アクチエンゲゼルシャフト | Ｐｒｏｓｔ０７ポリペプチドをコードするｄｎａ |
| JP2004537252A (ja) * | 1999-11-12 | 2004-12-16 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| US20020048777A1 (en) | 1999-12-06 | 2002-04-25 | Shujath Ali | Method of diagnosing monitoring, staging, imaging and treating prostate cancer |
| HUP0203968A3 (en) * | 2000-01-14 | 2004-09-28 | Corixa Corp Seattle | Compositions and methods for the therapy and diagnosis of prostate cancer |
| AU2001236782A1 (en) * | 2000-02-08 | 2001-08-20 | Agensys, Inc. | 34p3d7: a tissue specific protein highly expressed in prostate cancer |
| WO2001060860A2 (en) * | 2000-02-17 | 2001-08-23 | Millennium Predictive Medicine, Inc. | Genes differentially expressed in human prostate cancer and their use |
| AU4592601A (en) * | 2000-03-21 | 2001-10-03 | Millennium Predictive Medicine | Novel genes, compositions, kits, and method for identification, assessment, prevention, and therapy of ovarian cancer |
| US7611892B2 (en) | 2000-03-24 | 2009-11-03 | President And Fellows Of Harvard College | Prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods |
| EP1311673A2 (en) * | 2000-03-27 | 2003-05-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| GB0015722D0 (en) * | 2000-06-27 | 2000-08-16 | Smithkline Beecham Sa | Vaccine |
| GB0015736D0 (en) * | 2000-06-27 | 2000-08-16 | Smithkline Beecham Biolog | Vaccine |
| SI2266603T1 (sl) | 2000-10-18 | 2012-12-31 | Glaxosmithkline Biologicals S.A. | Tumorska cepiva |
| US7048931B1 (en) | 2000-11-09 | 2006-05-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| PL362606A1 (en) | 2000-11-28 | 2004-11-02 | Wyeth | Expression analysis of kiaa nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| EP1356108A2 (en) | 2000-11-28 | 2003-10-29 | Wyeth | Expression analysis of fkbp nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| US7736654B2 (en) | 2001-04-10 | 2010-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
| CA2446788A1 (en) * | 2001-05-09 | 2002-11-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6897024B2 (en) | 2001-05-31 | 2005-05-24 | Stichting Katholieke Universiteit More Particularly The University Medical Centre Nijmegen | Nucleic acid molecules comprising the promoter for PCA3, and uses thereof |
| US7494646B2 (en) | 2001-09-06 | 2009-02-24 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
| CA2480811A1 (en) * | 2002-04-01 | 2003-10-16 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 213p1f11 useful in treatment and detection of cancer |
| JP2006501166A (ja) * | 2002-06-11 | 2006-01-12 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 異種前立腺タンパク質ｐ５０１ｓを含む免疫原性組成物 |
| US20060147477A1 (en) * | 2002-06-11 | 2006-07-06 | Glaxo Group Limited | Immunogenic compositions |
| US20040081653A1 (en) | 2002-08-16 | 2004-04-29 | Raitano Arthur B. | Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer |
| JP4824540B2 (ja) | 2003-02-07 | 2011-11-30 | ダイアノキュアー インク． | サンプル中の前立腺癌を検出する方法 |
| DE602004031681D1 (de) | 2003-07-21 | 2011-04-14 | Transgene Sa | Multifunktionelle Cytokine |
| PT1742966E (pt) | 2004-04-22 | 2014-02-05 | Agensys Inc | Anticorpos e moléculas derivadas daí que se ligam às proteínas steap-1 |
| CA2491067A1 (en) | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| US7718369B2 (en) | 2005-09-12 | 2010-05-18 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| US9957569B2 (en) | 2005-09-12 | 2018-05-01 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| JP5470848B2 (ja) | 2006-08-04 | 2014-04-16 | 味の素株式会社 | 肺癌の評価方法、肺癌評価装置、肺癌評価方法、肺癌評価システム、肺癌評価プログラム、記録媒体、および、情報通信端末装置 |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US8273361B2 (en) | 2006-09-26 | 2012-09-25 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| MX2009003938A (es) | 2006-10-27 | 2009-04-24 | Genentech Inc | Anticuerpos e inmunoconjugados y sus usos. |
| EP2103940A4 (en) | 2006-12-21 | 2013-04-24 | Ajinomoto Kk | METHOD, APPARATUS, METHOD, SYSTEM AND SOFTWARE FOR ASSESSING BREAST CANCER, AND RECORDING MEDIUM |
| EP2096439A4 (en) | 2006-12-21 | 2011-01-05 | Ajinomoto Kk | METHOD, APPARATUS, METHOD, SYSTEM AND SOFTWARE FOR EVALUATING COLORECTAL CANCER, AND RECORDING MEDIUM |
| JP5433572B2 (ja) | 2007-07-06 | 2014-03-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Ｍｉｐｏｌ１−ｅｔｖ１遺伝子再編成 |
| WO2009020521A2 (en) | 2007-08-03 | 2009-02-12 | The Brigham And Women's Hospital, Inc. | Identification and treatment of estrogen responsive prostate tumors |
| KR100976218B1 (ko) | 2008-05-26 | 2010-08-17 | 한국표준과학연구원 | 비행시간이차이온질량분광법을 이용한 질병의 진단 방법,질병 지표의 스크린 방법, 및 질병 지표 |
| JP5754137B2 (ja) | 2008-06-20 | 2015-07-29 | 味の素株式会社 | 前立腺癌の評価方法、前立腺癌評価装置、前立腺癌評価方法、前立腺癌評価プログラム、記録媒体、前立腺癌評価システム、および情報通信端末装置 |
| PL2733492T3 (pl) | 2008-08-05 | 2016-08-31 | Toray Industries | Sposób wykrywania nowotworów |
| BR122020027042B1 (pt) * | 2008-08-05 | 2022-11-08 | Toray Industries, Inc | Uso de um agente indutor de imunidade, uso de um polipeptídeo e uso de um vetor recombinante |
| AU2009278386B2 (en) | 2008-08-05 | 2015-05-21 | Toray Industries, Inc. | Pharmaceutical composition for treatment and prevention of cancers |
| JP2012526544A (ja) * | 2009-05-12 | 2012-11-01 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 悪性のホルモン感受性前立腺がんのマーカーとしてのホスホジエステラーゼ４ｄ７ |
| LT2437753T (lt) | 2009-06-05 | 2016-12-12 | Infectious Disease Research Institute | Sintetiniai gliukopiranozillipidų adjuvantai ir juos turinčios vakcinų kompozicijos |
| JP5800817B2 (ja) | 2009-09-17 | 2015-10-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 前立腺癌における再発性遺伝子融合 |
| CA2788718C (en) | 2010-02-04 | 2019-05-21 | Shinichi Kobayashi | Caprin-1 antibody for treating and/or preventing cancer |
| RU2598258C2 (ru) | 2010-02-04 | 2016-09-20 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или профилактики рака |
| WO2011096533A1 (ja) | 2010-02-04 | 2011-08-11 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
| MX340014B (es) | 2010-02-04 | 2016-06-22 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. |
| BR112012018943A8 (pt) | 2010-02-04 | 2017-12-19 | Toray Industries | medicamento e método para o tratamento e/ou prevenção de um câncer |
| US8945556B2 (en) | 2010-11-19 | 2015-02-03 | The Regents Of The University Of Michigan | RAF gene fusions |
| SG192759A1 (en) | 2011-02-15 | 2013-09-30 | Immune Design Corp | Methods for enhancing immunogen specific immune responses by vectored vaccines |
| WO2012141984A1 (en) | 2011-04-08 | 2012-10-18 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| CN103764825B (zh) | 2011-08-04 | 2015-09-02 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
| EP2740798B1 (en) | 2011-08-04 | 2016-12-07 | Toray Industries, Inc. | Cancer treatment and/or prevention drug composition |
| CA2844033C (en) | 2011-08-04 | 2021-07-27 | Toray Industries, Inc. | Method for detecting pancreatic cancer |
| CN103717739B (zh) | 2011-08-04 | 2015-07-29 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
| CN103717238B (zh) | 2011-08-04 | 2016-10-12 | 东丽株式会社 | 胰癌的治疗和/或预防用药物组合物 |
| CA2844042C (en) | 2011-08-04 | 2019-06-18 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
| CA2844038C (en) | 2011-08-04 | 2019-05-07 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
| US11510875B2 (en) | 2012-02-07 | 2022-11-29 | Access To Advanced Health Institute | Adjuvant formulations comprising TLR4 agonists and methods of using the same |
| WO2013125654A1 (ja) | 2012-02-21 | 2013-08-29 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
| MX360208B (es) | 2012-02-21 | 2018-10-24 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. |
| AU2013223147B2 (en) | 2012-02-21 | 2017-10-05 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
| PT2818481T (pt) | 2012-02-21 | 2019-10-25 | Toray Industries | Composição farmacêutica para tratamento e/ou prevenção de cancro |
| EP2832365B1 (en) | 2012-03-30 | 2017-11-01 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of liver cancer |
| JP6107655B2 (ja) | 2012-03-30 | 2017-04-05 | 東レ株式会社 | 胆嚢癌の治療及び／又は予防用医薬組成物 |
| LT2850431T (lt) | 2012-05-16 | 2018-06-25 | Immune Design Corp. | Vakcinos, skirtos hsv-2 |
| CA3133545C (en) * | 2012-05-25 | 2023-08-08 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| PT2876446T (pt) | 2012-07-19 | 2019-03-25 | Toray Industries | Método para deteção de cancro |
| RU2646464C2 (ru) | 2012-07-19 | 2018-03-05 | Торэй Индастриз, Инк. | Метод детекции рака |
| RU2663350C2 (ru) * | 2012-09-11 | 2018-08-03 | Онкотерапи Сайенс, Инк. | Пептиды ube2t и содержащие их вакцины |
| EP2912069B1 (en) | 2012-10-23 | 2019-07-31 | Emory University | Gm-csf and il-4 conjugates, compositions, and methods related thereto |
| KR102039520B1 (ko) | 2013-04-18 | 2019-11-01 | 이뮨 디자인 코포레이션 | 암 치료에 이용하기 위한 gla 단일요법 |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| PT3031826T (pt) | 2013-08-09 | 2019-01-18 | Toray Industries | Composição farmacêutica para o tratamento e/ou a prevenção do cancro |
| IL310015B1 (en) | 2013-12-31 | 2025-10-01 | Access To Advanced Health Inst | Single vial formulation |
| KR20170032373A (ko) | 2014-07-15 | 2017-03-22 | 이뮨 디자인 코포레이션 | Tlr4 작용제 보조제 및 렌티바이러스 벡터를 이용한 프라임-부스트 요법 |
| JOP20200228A1 (ar) * | 2015-12-21 | 2017-06-16 | Novartis Ag | تركيبات وطرق لخفض تعبير البروتين tau |
| EP3400005A1 (en) * | 2016-01-08 | 2018-11-14 | Vaccibody AS | Neoepitope rna cancer vaccine |
| WO2017180420A1 (en) | 2016-04-11 | 2017-10-19 | Board Of Regents, The University Of Texas System | Methods and compositions for detecting single t cell receptor affinity and sequence |
| AU2017268175B2 (en) | 2016-05-16 | 2023-02-23 | Access To Advanced Health Institute | PEGylated liposomes and methods of use |
| HUE059605T2 (hu) | 2016-05-16 | 2022-11-28 | Access To Advanced Health Inst | TLR agonista tartalmú készítmény és használati eljárások |
| JP7140684B2 (ja) | 2016-06-01 | 2022-09-21 | アクセス ツー アドバンスト ヘルス インスティチュート | サイジング剤含有ナノアラム粒子 |
| BR112019018767A2 (pt) | 2017-04-03 | 2020-05-05 | Hoffmann La Roche | anticorpos, molécula de ligação ao antígeno biespecífica, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método para produzir um anticorpo, composição farmacêutica, usos, método para tratar uma doença em um indivíduo e invenção |
| KR102673794B1 (ko) | 2017-06-15 | 2024-06-11 | 액세스 투 어드밴스드 헬스 인스티튜트 | 나노구조 지질 담체 및 안정적인 에멀션 그리고 이들의 용도 |
| CA3078223A1 (en) | 2017-09-08 | 2019-03-14 | Infectious Disease Research Institute | Liposomal formulations comprising saponin and methods of use |
| JP2022512921A (ja) * | 2018-11-07 | 2022-02-07 | アコーオス インコーポレイテッド | 有毛細胞の分化を誘導する組成物及び方法 |
| CN111000858B (zh) * | 2019-05-10 | 2021-04-09 | 常州市第二人民医院 | Nupr1抑制剂在制备膀胱癌治疗药物中的用途 |
| CN114340665A (zh) | 2019-05-25 | 2022-04-12 | 传染病研究所 | 用于对佐剂疫苗乳剂进行喷雾干燥的组合物和方法 |
| CA3179694A1 (en) * | 2020-04-17 | 2021-10-21 | The Francis Crick Institute Limited | Fusion proteins of ctl antigens for treating melanoma |
| CN111968751B (zh) * | 2020-06-29 | 2021-10-19 | 金电联行（北京）信息技术有限公司 | 一种使用多基线校正模型的传染病趋势预测方法与系统 |
| CA3173951A1 (en) | 2020-09-04 | 2022-03-10 | Emily VOIGT | Genetically-adjuvanted rna vaccines |
| US20230310323A1 (en) | 2020-09-04 | 2023-10-05 | Access To Advanced Health Institute | Co-lyophilized rna and nanostructured lipid carrier |
| AU2021406131A1 (en) | 2020-12-23 | 2023-08-03 | Access To Advanced Health Institute | Solanesol vaccine adjuvants and methods of preparing same |
| CA3266697A1 (en) | 2022-09-09 | 2024-03-14 | Access To Advanced Health Inst | COMPOSITION OF AN IMMUNOGENEOUS VACCINE CONTAINING A SAPONIN |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041289A (en) * | 1987-11-13 | 1991-08-20 | Becton Dickinson And Company | Method of purging residual tumor cells in vitro with lymphokine activated cytotoxic cells |
| NZ236114A (en) * | 1989-11-22 | 1993-04-28 | Merrell Dow Pharma | Peptide antagonists of bombesin and of gastrin releasing peptide, and pharmaceutical compositions |
| EP0822939A1 (en) * | 1995-04-28 | 1998-02-11 | Takeda Chemical Industries, Ltd. | Cyclic pentapeptide lh-rh receptor antagonists |
| EP0914335A2 (en) * | 1996-03-15 | 1999-05-12 | Corixa Corporation | Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer |
| EP1005546A2 (en) * | 1997-02-25 | 2000-06-07 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| WO1998037418A2 (en) * | 1997-02-25 | 1998-08-27 | Corixa Corporation | Compounds for immunodiagnosis of prostate cancer and methods for their use |
| WO1998050567A1 (en) * | 1997-05-02 | 1998-11-12 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the prostate |
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| KR20070112860A (ko) | 2007-11-27 |
| SA99200618B1 (ar) | 2007-01-20 |
| HUP0203035A3 (en) | 2007-12-28 |
| CN100419079C (zh) | 2008-09-17 |
| EP1870466A2 (en) | 2007-12-26 |
| BR9912007A (pt) | 2002-01-29 |
| AU2003248213A1 (en) | 2003-10-30 |
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