NZ504501A - Enterococcus antigens and vaccines - Google Patents
Enterococcus antigens and vaccinesInfo
- Publication number
- NZ504501A NZ504501A NZ504501A NZ50450198A NZ504501A NZ 504501 A NZ504501 A NZ 504501A NZ 504501 A NZ504501 A NZ 504501A NZ 50450198 A NZ50450198 A NZ 50450198A NZ 504501 A NZ504501 A NZ 504501A
- Authority
- NZ
- New Zealand
- Prior art keywords
- antigen
- enterococcus
- faecalis
- isolated
- antibody
- Prior art date
Links
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- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006894 reductive elimination reaction Methods 0.000 description 1
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940071127 thioglycolate Drugs 0.000 description 1
- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229940086542 triethylamine Drugs 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/949,757 US6756361B1 (en) | 1997-10-14 | 1997-10-14 | Enterococcus antigens and vaccines |
| PCT/US1998/021561 WO1999018996A1 (en) | 1997-10-14 | 1998-10-14 | Enterococcus antigens and vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ504501A true NZ504501A (en) | 2003-09-26 |
Family
ID=25489514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ504501A NZ504501A (en) | 1997-10-14 | 1998-10-14 | Enterococcus antigens and vaccines |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6756361B1 (enExample) |
| EP (3) | EP2269635A1 (enExample) |
| JP (2) | JP2001519402A (enExample) |
| AT (1) | ATE397456T1 (enExample) |
| AU (1) | AU754890B2 (enExample) |
| BR (1) | BR9813254A (enExample) |
| CA (1) | CA2306476A1 (enExample) |
| CY (1) | CY1108307T1 (enExample) |
| DE (1) | DE69839587D1 (enExample) |
| DK (1) | DK1028749T3 (enExample) |
| ES (1) | ES2308818T3 (enExample) |
| NZ (1) | NZ504501A (enExample) |
| PT (1) | PT1028749E (enExample) |
| WO (1) | WO1999018996A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6905670B2 (en) | 1995-03-28 | 2005-06-14 | The General Hospital Corporation | Methods of screening compounds useful for prevention of infection or pathogenicity |
| KR100217772B1 (ko) * | 1996-09-03 | 1999-09-01 | 최진호 | 조명기기의 램프 과열방지 장치 및 방법 |
| US6756361B1 (en) * | 1997-10-14 | 2004-06-29 | Nabi | Enterococcus antigens and vaccines |
| US7078584B2 (en) | 2000-03-17 | 2006-07-18 | The General Hospital Corporation | Salmonella typhimurium-infected Caenorhabditis elegans for identifying inhibitors of infection |
| US7112716B2 (en) | 2000-04-06 | 2006-09-26 | The General Hospital Corporation | Methods for screening and identifying host pathogen defense genes |
| US6710403B2 (en) | 2002-07-30 | 2004-03-23 | Fairchild Semiconductor Corporation | Dual trench power MOSFET |
| US20080175856A1 (en) * | 2003-05-30 | 2008-07-24 | Intercell Ag | Enterococcus Antigens |
| EP2583678A3 (en) | 2004-06-24 | 2013-11-13 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| CA2575548A1 (en) | 2004-07-29 | 2006-07-27 | John L. Telford | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
| AU2005324448A1 (en) * | 2005-01-10 | 2006-07-20 | Glaxosmithkline Biologicals Sa | Method of treating Staphylococcus aureus infection |
| JP2009511636A (ja) | 2005-10-18 | 2009-03-19 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | アルファウイルスレプリコン粒子による粘膜免疫および全身免疫 |
| US7527801B2 (en) | 2005-11-22 | 2009-05-05 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and Sapovirus antigens |
| WO2008019162A2 (en) | 2006-01-18 | 2008-02-14 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
| CA2647100A1 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Methods for the preparation of imidazole-containing compounds |
| US8173657B2 (en) * | 2006-03-23 | 2012-05-08 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
| WO2007109812A2 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Immunopotentiating compounds |
| EP3018142A1 (en) | 2006-06-06 | 2016-05-11 | Crucell Holland B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
| JP5586952B2 (ja) | 2006-06-06 | 2014-09-10 | クルセル ホランド ベー ヴェー | 腸球菌に対する殺活性を有するヒトの結合分子及びその使用方法 |
| JP5658564B2 (ja) | 2007-08-31 | 2015-01-28 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物 |
| JP5653215B2 (ja) | 2007-09-12 | 2015-01-14 | ノバルティス アーゲー | Gas57変異体抗原およびgas57抗体 |
| EP2537857B1 (en) | 2007-12-21 | 2017-01-18 | GlaxoSmithKline Biologicals SA | Mutant forms of streptolysin O |
| AU2009302582A1 (en) | 2008-10-06 | 2010-04-15 | University Of Chicago | Compositions and methods related to bacterial Eap, Emp, and/or AdsA proteins |
| NZ594029A (en) | 2009-01-12 | 2014-01-31 | Novartis Ag | Cna_b domain antigens in vaccines against gram positive bacteria |
| HUE026855T2 (en) | 2009-04-03 | 2016-07-28 | Univ Chicago | Compositions and methods related to protein a (spa) variants |
| EP2443250B8 (en) | 2009-06-16 | 2016-09-21 | GlaxoSmithKline Biologicals SA | High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays |
| US10266585B2 (en) | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
| AU2010342872B2 (en) * | 2010-01-19 | 2014-09-25 | Universitatsklinikum Freiburg | Enterococcal cell wall components and antibacterial use thereof |
| EP2555794A4 (en) | 2010-04-05 | 2014-01-15 | Univ Chicago | COMPOSITIONS AND METHODS RELATING TO PROTEIN A (SPA) ANTIBODIES AS IMMUNE REACTION AMPLIFIERS |
| KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
| SG186290A1 (en) | 2010-07-02 | 2013-01-30 | Univ Chicago | Compositions and methods related to protein a (spa) variants |
| EP2614074A1 (en) | 2010-09-09 | 2013-07-17 | The University of Chicago | Methods and compositions involving protective staphylococcal antigens |
| WO2012051498A2 (en) | 2010-10-15 | 2012-04-19 | The Board Of Regents Of The University Of Texas System | Antibodies that bind amyloid oligomers |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| EP2526951B1 (en) * | 2011-05-27 | 2015-09-30 | Universitätsklinikum Freiburg | Rhamno-polysaccharide from Enterococcus faecium clonal complex 17 and uses thereof |
| BR112014003315A2 (pt) | 2011-08-15 | 2017-03-01 | Univ Chicago | composições e métodos relacionados a anticorpos para a proteína a estafilocócica |
| CA2910320A1 (en) | 2012-04-26 | 2013-10-31 | University Of Chicago | Compositions and methods related to antibodies that neutralize coagulase activity during staphylococcus aureus disease |
| BR112014026861A2 (pt) | 2012-04-26 | 2018-05-15 | Univ Chicago | antígenos de estafilococos coagulase e métodos de seu uso |
| WO2014013375A1 (en) | 2012-07-16 | 2014-01-23 | Pfizer Inc. | Saccharides and uses thereof |
| WO2014116721A1 (en) | 2013-01-22 | 2014-07-31 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Geminiviral vector for expression of rituximab |
| EP2915543B1 (en) * | 2014-03-04 | 2018-05-09 | Albert-Ludwigs-Universität Freiburg | Polypeptides derived from Enterococcus and their use for vaccination and the generation of therapeutic antibodies |
| WO2017173398A1 (en) | 2016-04-01 | 2017-10-05 | Duke University | Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform |
| US11413336B2 (en) | 2018-03-23 | 2022-08-16 | Board Of Regents, The University Of Texas System | Coccidioides antigens and methods of their use |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2466251B1 (fr) * | 1979-10-03 | 1983-03-18 | Agronomique Inst Nat Rech | Vaccin animal anticolibacillaire, obtention et application |
| US4439422A (en) | 1980-01-02 | 1984-03-27 | Research Corporation | Group B Streptococcus antigens and vaccines |
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| JPS5927833A (ja) * | 1982-08-06 | 1984-02-14 | Advance Res & Dev Co Ltd | コレステロール乃至トリグリセリド低下剤 |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| FR2546756B1 (fr) * | 1983-06-03 | 1985-11-29 | Centre Nat Rech Scient | Nouveaux derives immunostimulants, leur preparation et leur application comme medicament |
| US4761283A (en) * | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
| JPS6028401A (ja) | 1983-07-27 | 1985-02-13 | Advance Res & Dev Co Ltd | トリグリセリド低下活性多糖類 |
| US4626502A (en) * | 1984-01-27 | 1986-12-02 | Abbott Laboratories | Method for exposing bacterial antigen in bacterial cells assay using same |
| US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| GB8414273D0 (en) * | 1984-06-05 | 1984-07-11 | Oxoid Ltd | Identifying streptococcal grouping |
| JPS615022A (ja) * | 1984-06-19 | 1986-01-10 | Advance Res & Dev Co Ltd | 腸内細菌叢改善剤 |
| GB8517895D0 (en) * | 1985-07-16 | 1985-08-21 | Technology Licence Co Ltd | Monoclonal antibodies |
| US4695524A (en) * | 1986-05-21 | 1987-09-22 | Xerox Corporation | Process for ultra high quality images with magnetic developer composition |
| US5143845A (en) * | 1986-09-03 | 1992-09-01 | Toa Pharmaceutical Co., Ltd. | Mixture of saccarifying lactic acid producing and butyric acid producing bacteria |
| CA1301645C (en) * | 1986-10-08 | 1992-05-26 | David Bernstein | Method for exposing group a streptococcal antigens and an improved diagnostictest for the identification of group a streptococci |
| US5032505A (en) | 1988-11-21 | 1991-07-16 | Chembiomed, Ltd. | Inhibitors for glycosaminosyl transferase V |
| US5175279A (en) * | 1989-01-19 | 1992-12-29 | Hakuto Co., Ltd. | Polysaccharide, and water absorbent, moisture absorbent or humectant and thickening agent chiefly made of the polysaccharide |
| US5032401A (en) * | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5010062A (en) * | 1989-09-25 | 1991-04-23 | Vanderbilt University | Therapeutic agent and method of inhibiting vascularization of tumors |
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| US5858728A (en) * | 1991-03-13 | 1999-01-12 | Common Services Agency | Monoclonal antibody against LPS core |
| US5225331A (en) * | 1991-04-25 | 1993-07-06 | National Research Council Of Canada | Immunoassay for detecting group b streptococcus |
| US5205917A (en) * | 1991-05-07 | 1993-04-27 | Glyko, Inc. | Fluorophore assisted carbohydrate electrophoresis diagnosis |
| US5651968A (en) * | 1991-08-23 | 1997-07-29 | Alberta Research Council | Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients |
| US5478557A (en) * | 1992-07-29 | 1995-12-26 | The United States Of America, As Represented By The Secretary Of Agriculture | Probiotic for control of salmonella |
| RU2101029C1 (ru) * | 1992-11-26 | 1998-01-10 | Товарищество с ограниченной ответственностью "ХИМЭК" | Способ получения препарата для идентификации стрептококка группы д |
| GB9310468D0 (en) * | 1993-05-20 | 1993-07-07 | Oxford Glycosystems Ltd | Sugar complexes |
| US5367058A (en) * | 1993-08-25 | 1994-11-22 | Becton, Dickinson And Company | Modified antibodies with increased affinity |
| JPH0782158A (ja) * | 1993-09-16 | 1995-03-28 | Yakult Honsha Co Ltd | 抗腫瘍剤 |
| JP2717497B2 (ja) * | 1993-12-28 | 1998-02-18 | 不二ラテックス株式会社 | 酸性多糖類被覆コンドーム |
| GB9401689D0 (en) * | 1994-01-28 | 1994-03-23 | Univ Manchester | Diagnosis and treatment of endocarditis |
| US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
| US5489302A (en) * | 1994-05-24 | 1996-02-06 | Skottun; Bernt C. | Accommodating intraocular lens |
| JPH0827010A (ja) * | 1994-07-19 | 1996-01-30 | Nichinichi Seiyaku Kk | 制癌免疫療法剤 |
| US5700787A (en) * | 1994-09-02 | 1997-12-23 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| US5871751A (en) * | 1994-10-12 | 1999-02-16 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Renibacterium salmoninarum vaccine and method for its preparation |
| US5569366A (en) * | 1995-01-27 | 1996-10-29 | Beckman Instruments, Inc. | Fluorescent labelled carbohydrates and their analysis |
| US5760213A (en) * | 1995-06-05 | 1998-06-02 | Tayca Corporation | Immunoactivating agent |
| US5695768A (en) * | 1995-06-07 | 1997-12-09 | Alberta Research Council | Immunostimulating activity of Streptococcus pneumoniae serotype 8 oligosaccharides |
| DE19524515A1 (de) * | 1995-07-05 | 1997-01-09 | Deutsches Krebsforsch | Saccharid-Konjugate |
| US6722062B2 (en) * | 1997-08-20 | 2004-04-20 | The Brigham And Women's Hospital, Inc. | Capsular polysaccharides from enterococci |
| WO1999008705A1 (en) * | 1997-08-20 | 1999-02-25 | Brigham And Women's Hospital | Capsular polysaccharides from enterococci |
| US6756361B1 (en) * | 1997-10-14 | 2004-06-29 | Nabi | Enterococcus antigens and vaccines |
| DK1121135T3 (da) * | 1998-09-14 | 2009-03-23 | Nabi Biopharmaceuticals | Præparater af beta-glucaner og specifikke immunglobuliner |
| US7030101B2 (en) * | 1998-09-14 | 2006-04-18 | Nabi Biopharmaceuticals | Compositions of β-glucans and specific antibodies |
| TR200202066T2 (tr) * | 1999-03-12 | 2004-12-21 | University Of Massachusetts | Lipoglikan bileşimleri ve parazit enfeksiyonlarını tedavi etme metotları |
| US6720160B2 (en) * | 2001-10-11 | 2004-04-13 | Helica Biosystems, Inc. | Method for simultaneous detection of multiple microbial antigens in biological specimens from mastitic animals |
-
1997
- 1997-10-14 US US08/949,757 patent/US6756361B1/en not_active Expired - Fee Related
-
1998
- 1998-10-14 AU AU96949/98A patent/AU754890B2/en not_active Ceased
- 1998-10-14 AT AT98951058T patent/ATE397456T1/de active
- 1998-10-14 NZ NZ504501A patent/NZ504501A/en not_active IP Right Cessation
- 1998-10-14 PT PT98951058T patent/PT1028749E/pt unknown
- 1998-10-14 ES ES98951058T patent/ES2308818T3/es not_active Expired - Lifetime
- 1998-10-14 BR BR9813254-7A patent/BR9813254A/pt not_active IP Right Cessation
- 1998-10-14 DK DK98951058T patent/DK1028749T3/da active
- 1998-10-14 EP EP10178313A patent/EP2269635A1/en not_active Withdrawn
- 1998-10-14 JP JP2000515628A patent/JP2001519402A/ja active Pending
- 1998-10-14 WO PCT/US1998/021561 patent/WO1999018996A1/en not_active Ceased
- 1998-10-14 EP EP98951058A patent/EP1028749B1/en not_active Expired - Lifetime
- 1998-10-14 EP EP08008590A patent/EP1970073A1/en not_active Withdrawn
- 1998-10-14 CA CA002306476A patent/CA2306476A1/en not_active Abandoned
- 1998-10-14 DE DE69839587T patent/DE69839587D1/de not_active Expired - Lifetime
-
2004
- 2004-06-28 US US10/876,758 patent/US7291343B2/en not_active Expired - Fee Related
-
2008
- 2008-09-02 CY CY20081100934T patent/CY1108307T1/el unknown
-
2009
- 2009-05-18 JP JP2009119505A patent/JP2009227680A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20050008658A1 (en) | 2005-01-13 |
| WO1999018996B1 (en) | 1999-06-03 |
| EP2269635A1 (en) | 2011-01-05 |
| DE69839587D1 (de) | 2008-07-17 |
| DK1028749T3 (da) | 2008-09-01 |
| US7291343B2 (en) | 2007-11-06 |
| AU754890B2 (en) | 2002-11-28 |
| EP1028749A4 (en) | 2003-03-12 |
| EP1028749B1 (en) | 2008-06-04 |
| EP1028749A1 (en) | 2000-08-23 |
| CY1108307T1 (el) | 2014-02-12 |
| PT1028749E (pt) | 2008-09-04 |
| BR9813254A (pt) | 2001-11-20 |
| ES2308818T3 (es) | 2008-12-01 |
| WO1999018996A1 (en) | 1999-04-22 |
| ATE397456T1 (de) | 2008-06-15 |
| JP2001519402A (ja) | 2001-10-23 |
| CA2306476A1 (en) | 1999-04-22 |
| AU9694998A (en) | 1999-05-03 |
| JP2009227680A (ja) | 2009-10-08 |
| EP1970073A1 (en) | 2008-09-17 |
| US6756361B1 (en) | 2004-06-29 |
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