NZ503815A - Biphenyl compounds, pharmaceuticals thereof and their use for the treatment of epilepsy, stroke and brain or spinal trauma - Google Patents
Biphenyl compounds, pharmaceuticals thereof and their use for the treatment of epilepsy, stroke and brain or spinal traumaInfo
- Publication number
- NZ503815A NZ503815A NZ503815A NZ50381598A NZ503815A NZ 503815 A NZ503815 A NZ 503815A NZ 503815 A NZ503815 A NZ 503815A NZ 50381598 A NZ50381598 A NZ 50381598A NZ 503815 A NZ503815 A NZ 503815A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- formula
- methoxy
- trifluoromethyl
- free base
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9723134.4A GB9723134D0 (en) | 1997-11-03 | 1997-11-03 | Organic compounds |
| GBGB9723133.6A GB9723133D0 (en) | 1997-11-03 | 1997-11-03 | Organic compounds |
| PCT/EP1998/006880 WO1999023073A1 (en) | 1997-11-03 | 1998-10-30 | Biphenyl derivatives as pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ503815A true NZ503815A (en) | 2002-05-31 |
Family
ID=26312535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ503815A NZ503815A (en) | 1997-11-03 | 1998-10-30 | Biphenyl compounds, pharmaceuticals thereof and their use for the treatment of epilepsy, stroke and brain or spinal trauma |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1037876A1 (id) |
| JP (1) | JP2001521923A (id) |
| KR (1) | KR20010031699A (id) |
| CN (1) | CN1278249A (id) |
| AR (1) | AR016148A1 (id) |
| AU (1) | AU740448B2 (id) |
| BR (1) | BR9813897A (id) |
| CA (1) | CA2308151A1 (id) |
| CO (1) | CO5011067A1 (id) |
| ID (1) | ID24413A (id) |
| IL (1) | IL135580A0 (id) |
| NO (1) | NO20002321D0 (id) |
| NZ (1) | NZ503815A (id) |
| PE (1) | PE123599A1 (id) |
| PL (1) | PL339922A1 (id) |
| SK (1) | SK6412000A3 (id) |
| TR (1) | TR200001122T2 (id) |
| WO (1) | WO1999023073A1 (id) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858592B2 (en) | 2001-06-29 | 2005-02-22 | Genzyme Corporation | Aryl boronic acids for treating obesity |
| US7041280B2 (en) | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
| TW200840566A (en) * | 2006-12-22 | 2008-10-16 | Esteve Labor Dr | Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments |
| WO2010059393A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| US8575364B2 (en) * | 2008-10-30 | 2013-11-05 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
| DE102009015697A1 (de) | 2009-03-31 | 2010-10-07 | Markus Dr. Heinrich | Verfahren zur Arylierung von ringsubstituierten Phenolen und Phenylethern |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2114122A (en) * | 1938-04-12 | Alcohols and process fob making | ||
| DE674968C (de) * | 1935-01-15 | 1939-04-26 | Roehm & Haas Company | Verfahren zur Herstellung von phenolartigen Aralkylaminoalkoholen |
| US2040039A (en) * | 1935-02-26 | 1936-05-05 | Rohm & Haas | Phenolic morpholines |
| US2485550A (en) * | 1946-06-25 | 1949-10-25 | Hoffmann La Roche | Quaternary salts of carbamic acid esters of tertiary-hydroxybenzyl-amines |
| US2493710A (en) * | 1947-03-21 | 1950-01-03 | Hoffmann La Roche | Carbamic acid esters |
| US2872477A (en) * | 1957-04-05 | 1959-02-03 | Dow Chemical Co | alpha-(dialkylamino)-6-phenyl-o-cresol esters |
| JPS5328150A (en) * | 1976-08-25 | 1978-03-16 | Sugai Chemical Ind Co Ltd | Novel orthophenyl phenol derivative process for preparing same |
| DK0382213T3 (da) * | 1989-02-08 | 1995-07-10 | Otsuka Pharma Co Ltd | Biphenylderivat, middel til reparation af eller beskyttelse mod nervecelledegeneration og fremgangsmåde til fremstilling af et phenylderivat, som indgår i dette middel |
| US5428037A (en) * | 1993-04-09 | 1995-06-27 | Syntex Pharmaceuticals, Ltd. | Heterocyclic derivatives in the treatment of Ischaemia and related diseases |
| JPH072655A (ja) * | 1993-06-18 | 1995-01-06 | Otsuka Pharmaceut Co Ltd | 末梢神経変性修復又は保護剤 |
| SI0707007T1 (en) * | 1994-10-14 | 2002-04-30 | Merck Patent Gmbh | (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent |
| AU4420296A (en) * | 1994-11-23 | 1996-06-17 | Neurogen Corporation | Aminomethyl aryl compounds; dopamine receptor subtype selective ligands |
| IL116249A (en) * | 1994-12-12 | 2003-07-06 | Pfizer | Nk-1 receptor antagonists for the treatment of neuronal damage and stroke |
| DE19637237A1 (de) * | 1996-09-13 | 1998-03-19 | Merck Patent Gmbh | Piperazin-Derivate |
-
1998
- 1998-10-29 CO CO98063635A patent/CO5011067A1/es unknown
- 1998-10-30 CN CN98810761A patent/CN1278249A/zh active Pending
- 1998-10-30 JP JP2000518948A patent/JP2001521923A/ja active Pending
- 1998-10-30 IL IL13558098A patent/IL135580A0/xx unknown
- 1998-10-30 SK SK641-2000A patent/SK6412000A3/sk unknown
- 1998-10-30 PL PL98339922A patent/PL339922A1/xx unknown
- 1998-10-30 NZ NZ503815A patent/NZ503815A/en unknown
- 1998-10-30 KR KR1020007004762A patent/KR20010031699A/ko not_active Application Discontinuation
- 1998-10-30 WO PCT/EP1998/006880 patent/WO1999023073A1/en not_active Application Discontinuation
- 1998-10-30 CA CA002308151A patent/CA2308151A1/en not_active Abandoned
- 1998-10-30 BR BR9813897-9A patent/BR9813897A/pt not_active IP Right Cessation
- 1998-10-30 ID IDW20000790A patent/ID24413A/id unknown
- 1998-10-30 EP EP98958884A patent/EP1037876A1/en not_active Withdrawn
- 1998-10-30 AR ARP980105469A patent/AR016148A1/es not_active Application Discontinuation
- 1998-10-30 AU AU14872/99A patent/AU740448B2/en not_active Ceased
- 1998-10-30 TR TR2000/01122T patent/TR200001122T2/xx unknown
- 1998-11-02 PE PE1998001034A patent/PE123599A1/es not_active Application Discontinuation
-
2000
- 2000-05-02 NO NO20002321A patent/NO20002321D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2308151A1 (en) | 1999-05-14 |
| CN1278249A (zh) | 2000-12-27 |
| EP1037876A1 (en) | 2000-09-27 |
| WO1999023073A1 (en) | 1999-05-14 |
| PL339922A1 (en) | 2001-01-15 |
| KR20010031699A (ko) | 2001-04-16 |
| CO5011067A1 (es) | 2001-02-28 |
| JP2001521923A (ja) | 2001-11-13 |
| PE123599A1 (es) | 1999-12-20 |
| ID24413A (id) | 2000-07-20 |
| BR9813897A (pt) | 2000-09-26 |
| AR016148A1 (es) | 2001-06-20 |
| NO20002321L (no) | 2000-05-02 |
| SK6412000A3 (en) | 2000-09-12 |
| NO20002321D0 (no) | 2000-05-02 |
| TR200001122T2 (tr) | 2000-08-21 |
| AU740448B2 (en) | 2001-11-01 |
| AU1487299A (en) | 1999-05-24 |
| IL135580A0 (en) | 2001-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |