NZ503044A - Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors - Google Patents

Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors

Info

Publication number
NZ503044A
NZ503044A NZ503044A NZ50304498A NZ503044A NZ 503044 A NZ503044 A NZ 503044A NZ 503044 A NZ503044 A NZ 503044A NZ 50304498 A NZ50304498 A NZ 50304498A NZ 503044 A NZ503044 A NZ 503044A
Authority
NZ
New Zealand
Prior art keywords
alkyl
aryl
hydrogen
compound
aryialkyl
Prior art date
Application number
NZ503044A
Other languages
English (en)
Inventor
Jarmo Pystynen
Eija Tiainen
Kari Lonnberg
Pentti Nore
Seppo Parhi
Arto Karjalainen
Heimo Haikala
Jouko Levijoki
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of NZ503044A publication Critical patent/NZ503044A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
NZ503044A 1997-09-24 1998-09-24 Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors NZ503044A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93711997A 1997-09-24 1997-09-24
US99015097A 1997-12-12 1997-12-12
US10411498A 1998-06-25 1998-06-25
PCT/FI1998/000755 WO1999015523A1 (fr) 1997-09-24 1998-09-24 Bisethers de 1-oxa, aza et thianaphtalene-2-one inhibiteurs du phospholambane

Publications (1)

Publication Number Publication Date
NZ503044A true NZ503044A (en) 2001-08-31

Family

ID=27379660

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ503044A NZ503044A (en) 1997-09-24 1998-09-24 Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors

Country Status (18)

Country Link
EP (1) EP1017691A1 (fr)
JP (1) JP2003525838A (fr)
KR (1) KR20010015607A (fr)
CN (1) CN1143857C (fr)
AU (1) AU735729B2 (fr)
BR (1) BR9813216A (fr)
CA (1) CA2304849A1 (fr)
EA (1) EA003084B1 (fr)
EE (1) EE04494B1 (fr)
HU (1) HUP0003647A3 (fr)
ID (1) ID24373A (fr)
IL (1) IL134662A0 (fr)
NO (1) NO20001569L (fr)
NZ (1) NZ503044A (fr)
PL (1) PL339493A1 (fr)
SK (1) SK3902000A3 (fr)
TR (1) TR200000764T2 (fr)
WO (1) WO1999015523A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026491B2 (en) 2000-07-21 2006-04-11 Chugai Seiyaku Kabushiki Kaisha Coumarin derivatives useful as TNFα inhibitors
AU2002226634B2 (en) * 2001-03-30 2007-01-25 Pfizer Products Inc. Pyridazinone aldose reductase inhibitors
US7572910B2 (en) 2003-02-20 2009-08-11 Pfizer, Inc. Pyridazinone aldose reductase inhibitors
FR2970964B1 (fr) * 2011-01-28 2013-12-13 Univ Claude Bernard Lyon Nouveaux derives d'azacoumarines presentant une activite inhibitrice des pompes mdr

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2543945A1 (de) * 1975-10-02 1977-04-21 Troponwerke Gmbh & Co Kg 2-benzopyranonderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
DK391189A (da) * 1988-08-10 1990-02-11 Otsuka Pharma Co Ltd Carbostyrilderivater
CA2022236A1 (fr) * 1989-07-31 1991-02-01 Hiroaki Yanagisawa Derives de coumarin, leur preparation et leur utilisation pour le traitement des troubles cerebrovasculaires
DE4337906A1 (de) * 1993-11-08 1995-05-11 Cassella Ag Verwendung von Cumarinderivaten

Also Published As

Publication number Publication date
BR9813216A (pt) 2000-08-29
AU9350898A (en) 1999-04-12
EE04494B1 (et) 2005-06-15
CN1271357A (zh) 2000-10-25
EE200000179A (et) 2001-04-16
PL339493A1 (en) 2000-12-18
HUP0003647A2 (hu) 2001-08-28
ID24373A (id) 2000-07-13
CN1143857C (zh) 2004-03-31
EA003084B1 (ru) 2002-12-26
TR200000764T2 (tr) 2001-03-21
HUP0003647A3 (en) 2002-12-28
IL134662A0 (en) 2001-04-30
AU735729B2 (en) 2001-07-12
JP2003525838A (ja) 2003-09-02
NO20001569D0 (no) 2000-03-24
NO20001569L (no) 2000-03-24
KR20010015607A (ko) 2001-02-26
EP1017691A1 (fr) 2000-07-12
CA2304849A1 (fr) 1999-04-01
SK3902000A3 (en) 2000-12-11
WO1999015523A1 (fr) 1999-04-01
EA200000352A1 (ru) 2000-10-30

Similar Documents

Publication Publication Date Title
JP7113009B2 (ja) 置換ピリジノン含有三環式化合物およびそれを使用する方法
US4725691A (en) 2-[8-quinolinyl]-sulphinyl-1H-benzimidazole
KR102137517B1 (ko) 신규 5-아미노테트라히드로퀴놀린-2-카르복실산 및 그의 용도
JP6324956B2 (ja) 置換アミノインダン−およびアミノテトラリンカルボン酸ならびにその使用
EP1039884B1 (fr) Methode de prevention et de traitement de la sideration myocardique
BR112021014079A2 (pt) Ácidos carboxílicos policíclicos substituídos, análogos dos mesmos e métodos usando os mesmos
WO2004050082A1 (fr) Nouveaux derives coumarine-amide et leur preparation, composition medicamenteuse associee et son utilisation
KR20080091948A (ko) 락탐형 피리딘 화합물을 포함하는 허혈성 질환의 예방 및치료용 약학조성물
JPS6360936A (ja) 複合薬剤
US4707479A (en) Circulation active dihydropyridine-3-carboxamides
US6265421B1 (en) Phospholamban inhibitors and a method for increasing coronary flow
BG60403B2 (bg) Оксадиазолови алкил-пуринови производни,полезни като агенти против кашлица
US4910206A (en) 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and their use as PAF receptor antagonists
NZ503044A (en) Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors
EP1001774B1 (fr) Utilisation d'inhibiteurs de phospholamban pour augmenter le debit coronaire
BG65859B1 (bg) Пиридазинил фенил хидразони, полезни срещу конгестивна сърдечна недостатъчност
MXPA00002954A (en) Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors
CA1059511A (fr) Acide 4-oxo-4h-pyrano-(3,2,-c)-quinoline-2-carboxyliques et leurs sels
CZ2000937A3 (cs) Bisethery 1-oxa, aza a thianaftalen-2-onu jako inhibitory fosfolambanu a farmaceutické prostředky
EP1450812A2 (fr) Utilisation de benzopyranones pour le traitement ou la prevention d'un cancer primitif du cerveau ou d'une metastase cerebrale
JP2000509726A (ja) 糖尿病処置用のオキシランカルボン酸
KR20080091949A (ko) 락톤형 피리딘 화합물을 포함하는 허혈성 질환의 예방 및치료용 약학조성물
HUT70483A (en) Quinolyl-dihydropyridin-esters, process for producing them and their use for preparing pharmaceutical compositions
EP1280783A2 (fr) Methodes de traitement mettant en oeuvre des benzoxazinones comme modulateurs du recepteur gamma active par le proliferateur du peroxisome

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)