NZ502820A - Heteroaryl or aryl substituted carboxylic acid or carboxamide derivatives optionally substituted with a sulphonamido group - Google Patents
Heteroaryl or aryl substituted carboxylic acid or carboxamide derivatives optionally substituted with a sulphonamido groupInfo
- Publication number
- NZ502820A NZ502820A NZ502820A NZ50282098A NZ502820A NZ 502820 A NZ502820 A NZ 502820A NZ 502820 A NZ502820 A NZ 502820A NZ 50282098 A NZ50282098 A NZ 50282098A NZ 502820 A NZ502820 A NZ 502820A
- Authority
- NZ
- New Zealand
- Prior art keywords
- alkenyl
- alkynyl
- optionally substituted
- alkyl
- substituted alkyl
- Prior art date
Links
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title abstract 2
- -1 sulphonamido group Chemical group 0.000 title abstract 2
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 229910020008 S(O) Inorganic materials 0.000 abstract 10
- 125000003342 alkenyl group Chemical group 0.000 abstract 9
- 125000000304 alkynyl group Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052760 oxygen Inorganic materials 0.000 abstract 6
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 6
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 108010025020 Nerve Growth Factor Proteins 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 102000015336 Nerve Growth Factor Human genes 0.000 abstract 1
- 102000007072 Nerve Growth Factors Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229940053128 nerve growth factor Drugs 0.000 abstract 1
- 230000003961 neuronal insult Effects 0.000 abstract 1
- 239000003900 neurotrophic factor Substances 0.000 abstract 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 abstract 1
- 229940080818 propionamide Drugs 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92083897A | 1997-08-29 | 1997-08-29 | |
| US09/085,441 US6268384B1 (en) | 1997-08-29 | 1998-05-27 | Compounds possessing neuronal activity |
| PCT/US1998/017816 WO1999010340A1 (en) | 1997-08-29 | 1998-08-27 | Compounds possessing neuronal activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ502820A true NZ502820A (en) | 2002-10-25 |
Family
ID=26772724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ502820A NZ502820A (en) | 1997-08-29 | 1998-08-27 | Heteroaryl or aryl substituted carboxylic acid or carboxamide derivatives optionally substituted with a sulphonamido group |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7109215B2 (OSRAM) |
| EP (1) | EP1007521A1 (OSRAM) |
| JP (1) | JP2001514177A (OSRAM) |
| CN (1) | CN100436447C (OSRAM) |
| AU (1) | AU766579B2 (OSRAM) |
| BR (1) | BR9811923A (OSRAM) |
| CA (1) | CA2300134A1 (OSRAM) |
| ID (1) | ID23675A (OSRAM) |
| IL (1) | IL134536A0 (OSRAM) |
| IN (1) | IN191127B (OSRAM) |
| IS (1) | IS5379A (OSRAM) |
| NO (1) | NO321790B1 (OSRAM) |
| NZ (1) | NZ502820A (OSRAM) |
| PL (1) | PL195273B1 (OSRAM) |
| SG (1) | SG129998A1 (OSRAM) |
| TW (1) | TW570919B (OSRAM) |
| WO (1) | WO1999010340A1 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514686B2 (en) | 1997-04-28 | 2003-02-04 | The University Of British Columbia | Method and composition for modulating amyloidosis |
| US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
| JP2002516904A (ja) | 1998-06-03 | 2002-06-11 | ジーピーアイ ニル ホールディングス インコーポレイテッド | Ｎ−複素環式カルボン酸またはカルボン酸等配電子体のｎ−結合スルホンアミド |
| US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
| US6333340B1 (en) * | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
| US6300341B1 (en) * | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
| JP2003503478A (ja) * | 1999-07-06 | 2003-01-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | 神経学的疾患の治療のためのβ−アミノ酸誘導体 |
| EP1196387A1 (en) | 1999-07-06 | 2002-04-17 | Vertex Pharmaceuticals Incorporated | Azo amino acid derivatives for the treatment of neurological diseases |
| EP1196389A1 (en) | 1999-07-06 | 2002-04-17 | Vertex Pharmaceuticals Incorporated | N-heterocyclic derivatives with neuronal activity |
| WO2001009097A1 (en) * | 1999-07-30 | 2001-02-08 | Vertex Pharmaceuticals Incorporated | Cyclic amine derivatives for the treatment of neurological diseases |
| JP2003505508A (ja) * | 1999-07-30 | 2003-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | 非環式又は環式アミド誘導体 |
| AU6913700A (en) * | 1999-08-18 | 2001-03-13 | Schering Aktiengesellschaft | Piperidine and pyrrolidine derivatives displaying neuronal activity |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
| AU1464101A (en) | 1999-12-21 | 2001-07-03 | Gpi Nil Holdings, Inc. | Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same |
| JP2002068973A (ja) * | 2000-06-16 | 2002-03-08 | Meiji Milk Prod Co Ltd | 幹細胞分化誘導促進剤 |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| ES2324293T3 (es) * | 2002-10-03 | 2009-08-04 | Vertex Pharmaceuticals Incorporated | Derivados de piperacina y piperidina para el tratamiento de enfermedades neurologicas. |
| WO2005033068A1 (en) * | 2003-10-06 | 2005-04-14 | Oy Juvantia Pharma Ltd | Somatostatin receptor 1 and/or 4 selective agonists and antagonists |
| CA2556923A1 (en) * | 2004-02-20 | 2005-09-09 | Rinat Neuroscience Corp. | Methods of treating obesity or diabetes using nt-4/5 |
| AU2007210862A1 (en) * | 2006-02-02 | 2007-08-09 | Rinat Neuroscience Corp. | Methods for treating unwanted weight loss or eating disorders by administering a trkB agonist |
| EP1988920A1 (en) * | 2006-02-02 | 2008-11-12 | Rinat Neuroscience Corp. | Methods for treating obesity by administering a trkb antagonist |
| AU2007337809A1 (en) * | 2006-12-20 | 2008-07-03 | Rinat Neuroscience Corporation | TrkB agonists for treating autoimmune disorders |
| US9152929B2 (en) | 2013-01-23 | 2015-10-06 | Splunk Inc. | Real time display of statistics and values for selected regular expressions |
| TWI744300B (zh) * | 2016-03-23 | 2021-11-01 | 里爾中央醫學中心 | 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792555A (en) * | 1987-03-20 | 1988-12-20 | American Home Products Corporation | Phospholipase A2 inhibitors |
| MX9202466A (es) * | 1991-05-24 | 1994-06-30 | Vertex Pharma | Compuestos inmunosupresores novedosos. |
| NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
| US5686469A (en) * | 1993-02-09 | 1997-11-11 | Miles Inc. | Aminomethylene derivaties as immunosuppressants |
| US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
| US5721256A (en) * | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
-
1998
- 1998-08-27 CN CNB988093553A patent/CN100436447C/zh not_active Expired - Fee Related
- 1998-08-27 IL IL13453698A patent/IL134536A0/xx active IP Right Grant
- 1998-08-27 NZ NZ502820A patent/NZ502820A/xx unknown
- 1998-08-27 ID IDW20000402A patent/ID23675A/id unknown
- 1998-08-27 JP JP2000507669A patent/JP2001514177A/ja not_active Withdrawn
- 1998-08-27 SG SG200201262-3A patent/SG129998A1/en unknown
- 1998-08-27 CA CA002300134A patent/CA2300134A1/en not_active Abandoned
- 1998-08-27 WO PCT/US1998/017816 patent/WO1999010340A1/en active IP Right Grant
- 1998-08-27 BR BR9811923-0A patent/BR9811923A/pt not_active IP Right Cessation
- 1998-08-27 PL PL98338791A patent/PL195273B1/pl not_active IP Right Cessation
- 1998-08-27 EP EP98941093A patent/EP1007521A1/en not_active Withdrawn
- 1998-08-27 AU AU89236/98A patent/AU766579B2/en not_active Ceased
- 1998-08-28 TW TW087114310A patent/TW570919B/zh not_active IP Right Cessation
-
2000
- 2000-02-18 IS IS5379A patent/IS5379A/is unknown
- 2000-02-25 NO NO20000953A patent/NO321790B1/no not_active IP Right Cessation
- 2000-06-26 IN IN362CA2000 patent/IN191127B/en unknown
-
2001
- 2001-06-27 US US09/815,193 patent/US7109215B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR9811923A (pt) | 2000-08-15 |
| IN191127B (OSRAM) | 2003-09-27 |
| PL338791A1 (en) | 2000-11-20 |
| CN1271354A (zh) | 2000-10-25 |
| AU8923698A (en) | 1999-03-16 |
| JP2001514177A (ja) | 2001-09-11 |
| IL134536A0 (en) | 2001-04-30 |
| WO1999010340A1 (en) | 1999-03-04 |
| SG129998A1 (en) | 2007-03-20 |
| US20020013351A1 (en) | 2002-01-31 |
| TW570919B (en) | 2004-01-11 |
| NO20000953D0 (no) | 2000-02-25 |
| EP1007521A1 (en) | 2000-06-14 |
| NO321790B1 (no) | 2006-07-03 |
| US7109215B2 (en) | 2006-09-19 |
| NO20000953L (no) | 2000-05-02 |
| CA2300134A1 (en) | 1999-03-04 |
| ID23675A (id) | 2000-05-11 |
| CN100436447C (zh) | 2008-11-26 |
| IS5379A (is) | 2000-02-18 |
| AU766579B2 (en) | 2003-10-16 |
| PL195273B1 (pl) | 2007-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |