NZ335919A - (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor - Google Patents

(4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Info

Publication number
NZ335919A
NZ335919A NZ335919A NZ33591997A NZ335919A NZ 335919 A NZ335919 A NZ 335919A NZ 335919 A NZ335919 A NZ 335919A NZ 33591997 A NZ33591997 A NZ 33591997A NZ 335919 A NZ335919 A NZ 335919A
Authority
NZ
New Zealand
Prior art keywords
butyl
hiv protease
phaenylmethyl
aminoinazole
diazepin
Prior art date
Application number
NZ335919A
Other languages
English (en)
Inventor
David James Rodgers
Patrick Yuk-Sun Lam
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of NZ335919A publication Critical patent/NZ335919A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NZ335919A 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor NZ335919A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74710396A 1996-11-08 1996-11-08
US2974696P 1996-11-08 1996-11-08
PCT/US1997/020036 WO1998020009A1 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (1)

Publication Number Publication Date
NZ335919A true NZ335919A (en) 2000-09-29

Family

ID=26705295

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ335919A NZ335919A (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Country Status (19)

Country Link
EP (1) EP0937066A1 (ru)
JP (1) JP2001503429A (ru)
KR (1) KR20000053123A (ru)
CN (1) CN1235601A (ru)
AU (1) AU722489B2 (ru)
BR (1) BR9712755A (ru)
CA (1) CA2270963A1 (ru)
CZ (1) CZ157499A3 (ru)
EA (1) EA001154B1 (ru)
EE (1) EE9900187A (ru)
HU (1) HUP9904143A3 (ru)
IL (1) IL129726A0 (ru)
LV (1) LV12374B (ru)
NO (1) NO992229L (ru)
NZ (1) NZ335919A (ru)
PL (1) PL333412A1 (ru)
SI (1) SI9720071A (ru)
SK (1) SK59599A3 (ru)
WO (1) WO1998020009A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0973767A1 (en) * 1997-03-31 2000-01-26 Dupont Pharmaceuticals Company Indazoles of cyclic ureas useful as hiv protease inhibitors
AU4716299A (en) * 1998-06-24 2000-01-10 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
FR2810039B1 (fr) 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
DE69221309T2 (de) * 1991-10-11 1997-12-11 The Du Pont Merck Pharmaceutical Co., Wilmington, Del. Cyclische harnstoffe und analoga verwendbar als retrovirale proteasehemmer

Also Published As

Publication number Publication date
NO992229D0 (no) 1999-05-07
CN1235601A (zh) 1999-11-17
EA199900451A1 (ru) 1999-12-29
KR20000053123A (ko) 2000-08-25
SK59599A3 (en) 1999-12-10
WO1998020009A1 (en) 1998-05-14
JP2001503429A (ja) 2001-03-13
IL129726A0 (en) 2000-02-29
AU5103398A (en) 1998-05-29
LV12374A (lv) 1999-11-20
CZ157499A3 (cs) 1999-11-17
PL333412A1 (en) 1999-12-06
LV12374B (en) 2000-04-20
EA001154B1 (ru) 2000-10-30
HUP9904143A3 (en) 2002-11-28
BR9712755A (pt) 1999-10-19
EP0937066A1 (en) 1999-08-25
NO992229L (no) 1999-06-07
SI9720071A (sl) 1999-12-31
AU722489B2 (en) 2000-08-03
EE9900187A (et) 1999-12-15
CA2270963A1 (en) 1998-05-14
HUP9904143A2 (hu) 2000-06-28

Similar Documents

Publication Publication Date Title
MXPA02004415A (es) Pirazolonas sustituidas con heterociclicas.
ATE297203T1 (de) Antithrombotische mitteln
YU16899A (sh) Aralkil i aralkiliden heterociklicni laktami i imidi
EE200100558A (et) Triarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi raviotstarbeline kasutamine
AU2001280438A1 (en) Substituted heterocyclic amides
BR0015836A (pt) Cristal de 4-carboxiamino-2-etil-1,2,3,4-tetra-hidroquinolina como inibidor de cetp
BR0108816A (pt) Derivados de quinolina como antagonistas alfa-2
AU7517400A (en) N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
NO984470L (no) Pyrrolopyrrolon-derivater som inhibitorer for neutrofil elastase
AU2364000A (en) Heterocyclic amides as inhibitors of factor xa
AU2658695A (en) N-(3-amino-2-hydroxybutyl)sulphonamide derivatives as hiv protease inhibitors
AU7270798A (en) Antithrombotic agents
NO963331L (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
NO983444D0 (no) Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer
NZ335919A (en) (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoinazole)methyl]-3-butyl-5 ,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor
AU2001296699A1 (en) Condensed pyrazindione derivatives as pde inhibitors
ATE286395T1 (de) Antithrombotische mittel
YU3203A (sh) Jedinjenja tricikličnog 2-piridona koja se koriste kao inhibitori hiv reverznih transkriptaza
NO992228D0 (no) 1-(3-aminoindazol-5-yl)-3-fenylmetyl-syklisk urea egnet som HIV protease inhibitor
WO2002018363A3 (en) 3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors
AU1434201A (en) Antithrombotic agents
WO2000073284A3 (en) 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors
DE69824410D1 (en) Antithrombosemittel
ATE258934T1 (de) Azaindol derivate und ihre verwendung als antithrombotische wirkstoffe
WO2002078628A3 (en) Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazapines as hiv reverse transcriptase inhibitors

Legal Events

Date Code Title Description
RENW Renewal (renewal fees accepted)