NZ332278A - Process for producing 5-hydroxymethyl substituted oxazolidinone alcohols and transformation to 5 aminomethyl substituted oxazolidinone amines which are useful in production of antibacterial pharmaceuticals - Google Patents
Process for producing 5-hydroxymethyl substituted oxazolidinone alcohols and transformation to 5 aminomethyl substituted oxazolidinone amines which are useful in production of antibacterial pharmaceuticalsInfo
- Publication number
- NZ332278A NZ332278A NZ332278A NZ33227897A NZ332278A NZ 332278 A NZ332278 A NZ 332278A NZ 332278 A NZ332278 A NZ 332278A NZ 33227897 A NZ33227897 A NZ 33227897A NZ 332278 A NZ332278 A NZ 332278A
- Authority
- NZ
- New Zealand
- Prior art keywords
- substituted oxazolidinone
- transformation
- alcohols
- producing
- amines
- Prior art date
Links
- -1 oxazolidinone alcohols Chemical class 0.000 title abstract 7
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 230000009466 transformation Effects 0.000 title abstract 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- NRKYWOKHZRQRJR-UHFFFAOYSA-N 2,2,2-trifluoroacetamide Chemical compound NC(=O)C(F)(F)F NRKYWOKHZRQRJR-UHFFFAOYSA-N 0.000 abstract 2
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1549996P | 1996-04-11 | 1996-04-11 | |
| PCT/US1997/003458 WO1997037980A1 (en) | 1996-04-11 | 1997-03-28 | Process to prepare oxazolidinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ332278A true NZ332278A (en) | 2000-05-26 |
Family
ID=21771765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ332278A NZ332278A (en) | 1996-04-11 | 1997-03-28 | Process for producing 5-hydroxymethyl substituted oxazolidinone alcohols and transformation to 5 aminomethyl substituted oxazolidinone amines which are useful in production of antibacterial pharmaceuticals |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5837870A (Direct) |
| EP (2) | EP0892792B1 (Direct) |
| JP (2) | JP2000508312A (Direct) |
| KR (1) | KR100530297B1 (Direct) |
| CN (3) | CN1319952C (Direct) |
| AT (2) | ATE209193T1 (Direct) |
| AU (1) | AU706117B2 (Direct) |
| CA (1) | CA2248143C (Direct) |
| CZ (2) | CZ298060B6 (Direct) |
| DE (2) | DE69738457T2 (Direct) |
| DK (2) | DK1114819T3 (Direct) |
| ES (2) | ES2298198T3 (Direct) |
| HU (1) | HUP0500044A3 (Direct) |
| NO (2) | NO311837B1 (Direct) |
| NZ (1) | NZ332278A (Direct) |
| PL (1) | PL192691B1 (Direct) |
| PT (2) | PT892792E (Direct) |
| RU (1) | RU2176643C2 (Direct) |
| SG (1) | SG85683A1 (Direct) |
| SI (1) | SI0892792T1 (Direct) |
| SK (1) | SK284703B6 (Direct) |
| TW (1) | TW449593B (Direct) |
| WO (1) | WO1997037980A1 (Direct) |
| ZA (1) | ZA972983B (Direct) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| KR20010052615A (ko) * | 1998-06-05 | 2001-06-25 | 다비드 에 질레스 | 옥사졸리디논 유도체, 이것의 제조 방법 및 이것을함유하는 약학 조성물 |
| US6403804B1 (en) * | 1998-12-07 | 2002-06-11 | Takasago International Corporation | Process for preparing optically active oxazolidinone derivative |
| PL349911A1 (en) | 1999-02-01 | 2002-10-07 | Upjohn Co | Process to prepare cyclic-sulfur fluorine containing oxazolidinones |
| US6297242B1 (en) | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| US6413981B1 (en) | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6608081B2 (en) | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| US6518285B2 (en) | 1999-12-21 | 2003-02-11 | Ortho Mcneil Pharmaceutical, Inc. | Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials |
| US6444813B2 (en) | 2000-02-02 | 2002-09-03 | Pharmacia & Upjohn Company | Linezolid-crystal form II |
| AR027261A1 (es) * | 2000-02-02 | 2003-03-19 | Upjohn Co | Linezolid forma cristalina ii |
| US6514529B2 (en) | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
| MY127336A (en) | 2000-03-22 | 2006-11-30 | Upjohn Co | Container for linezolid iv solution |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| US6544991B2 (en) | 2000-06-30 | 2003-04-08 | Pharmacia & Upjohn Company | Compositions and methods for treating bacterial infections |
| PE20020300A1 (es) * | 2000-08-22 | 2002-05-10 | Pharmacia Corp | Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco |
| US6288239B1 (en) | 2000-09-19 | 2001-09-11 | Board Of Trustees Operating Michigan State University | 5-trityloxymethyl-oxazolidinones and process for the preparation thereof |
| AR031135A1 (es) | 2000-10-10 | 2003-09-10 | Upjohn Co | Composiciones de antibiotico topico para el tratamiento de infecciones oculares |
| WO2002081470A1 (en) * | 2001-04-07 | 2002-10-17 | Astrazeneca Ab | Oxazolidinones containing a sulfonimid group as antibiotics |
| AU2002255803B2 (en) * | 2001-04-20 | 2008-07-03 | Pharmacia And Upjohn Company | Process to prepare oxazolidinones |
| ES2186550B2 (es) * | 2001-06-27 | 2003-11-16 | Vita Lab | Nuevos derivados de oxazolidinonas como antibacterianos. |
| CA2464109A1 (en) * | 2001-10-18 | 2003-12-24 | Michigan State University | Process for the preparation of oxazolidinones and method of use thereof |
| BR0307898A (pt) * | 2002-02-22 | 2004-12-07 | Pharmacia Corp | Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio |
| EP1476135A1 (en) * | 2002-02-22 | 2004-11-17 | Pharmacia Corporation | Ophthalmic formulation with gum system |
| ES2803516T3 (es) * | 2003-10-16 | 2021-01-27 | Symed Labs Ltd | Una forma cristalina de linezolid |
| ES2294494T3 (es) * | 2004-04-19 | 2008-04-01 | Symed Labs Limited | Un nuevo procedimiento para la preparacion de linezolid y compuestos relacionados. |
| WO2006008754A1 (en) | 2004-07-20 | 2006-01-26 | Symed Labs Limited | Novel intermediates for linezolid and related compounds |
| WO2007116284A1 (en) * | 2006-04-07 | 2007-10-18 | Pfizer Products Inc. | Process for preparing linezolid |
| CN100395270C (zh) * | 2006-05-25 | 2008-06-18 | 湖北大学 | 线型聚苯乙烯支载的(4s)-5,5-二取代基噁唑烷酮及其制备方法和用途 |
| EP2033960A3 (en) * | 2007-09-04 | 2009-04-29 | Dipharma Francis S.r.l. | Linezolid crystalline hydrate form and linezolid salts |
| US20090093631A1 (en) * | 2007-09-06 | 2009-04-09 | Ben-Zion Dolitzky | Processes for the preparation of a linezolid intermediate, linezolid hydroxide |
| EP2163547A1 (en) | 2008-09-16 | 2010-03-17 | Unión Químico Farmacéutica, S.A. (UQUIFA) | Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof |
| JP5561462B2 (ja) * | 2009-09-17 | 2014-07-30 | 日東化成株式会社 | 漁網防汚塗料組成物、該組成物を用いて形成される防汚塗膜、該塗膜の形成方法、および該塗膜を表面に有する漁網、漁網用具又は水中構造物 |
| US20130137864A1 (en) * | 2009-12-26 | 2013-05-30 | Jayaraman Venkat Raman | Process for the preparation of linezolid |
| CN102822167A (zh) | 2010-01-04 | 2012-12-12 | 埃南蒂亚有限公司 | 用于制备利伐沙班的方法及其中间体 |
| EP2690100A1 (en) | 2010-08-11 | 2014-01-29 | Synhton B.V. | Process for making linezolid |
| CN103140487A (zh) | 2010-08-11 | 2013-06-05 | 斯索恩有限公司 | 制备利奈唑胺的方法 |
| EP2635589A1 (en) | 2010-11-03 | 2013-09-11 | Wockhardt Limited | Process for the preparation of phosphoric acid mono- (l-{4- [(s) -5- (acetylaminomethyl) - 2 - oxo - oxazolidin- 3 - yl]- 2, 6 - difluorophenyl} - 4 -methoxymethylpiperidin- 4 - yl) ester |
| WO2012094622A2 (en) * | 2011-01-07 | 2012-07-12 | The Regents Of The University Of California | Amination of aryl alcohol derivatives |
| CN102153521B (zh) * | 2011-01-31 | 2012-09-12 | 宁波市鄞州百特佳医药科技有限公司 | 一种用于制备利奈唑胺的中间体及其制备方法 |
| WO2012114354A1 (en) | 2011-02-24 | 2012-08-30 | Lee Pharma Limited | Anhydrous linezolid crystalline form-ii |
| SI2595968T1 (sl) * | 2011-02-24 | 2016-01-29 | Lee Pharma Limited | Novi postopek za pripravo linezolida in njegovih novih intermediatov |
| CN102311402B (zh) * | 2011-07-18 | 2013-08-21 | 苏州敬业医药化工有限公司 | 3-取代苯基-5-羟甲基噁唑烷-2-酮的制备方法 |
| CN102321042B (zh) * | 2011-07-18 | 2013-12-04 | 苏州敬业医药化工有限公司 | 3-取代苯基-5-羟甲基噁唑烷-2-酮的制备方法 |
| WO2013072923A1 (en) | 2011-09-19 | 2013-05-23 | Cadila Healthcare Limited | Process for the preparation of crystalline linezolid |
| US20150025236A1 (en) | 2012-01-24 | 2015-01-22 | Jubilant Life Sciences Limited | Process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent |
| CN103626712B (zh) * | 2012-08-23 | 2016-06-01 | 重庆药友制药有限责任公司 | 一种用于制备利奈唑胺的中间体及其制备方法 |
| WO2014071990A1 (en) | 2012-11-09 | 2014-05-15 | Synthon Bv | Process for making linezolid |
| WO2015173664A1 (en) | 2014-05-14 | 2015-11-19 | Wockhardt Limited | Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide |
| WO2021184339A1 (en) | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
| CN119119019B (zh) * | 2024-09-11 | 2025-11-11 | 遵义医科大学 | 一种杂环磺酰胺/磺酸酯衍生物及其制备方法、应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA681830A (en) * | 1964-03-10 | X. Markley Francis | Process for 5-(aryloxymethyl)-2-oxazolidinones | |
| US3547951A (en) * | 1969-06-17 | 1970-12-15 | Waldo R Hardie | 1,3-dioxolan-4-yl-alkyl guanidines |
| US4062862A (en) * | 1975-07-04 | 1977-12-13 | Nippon Chemiphar Co., Ltd. | 5-Benzyl-2-oxazolidone derivatives and a process for producing the same |
| FR2356422A1 (fr) * | 1976-03-01 | 1978-01-27 | Delalande Sa | Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique |
| LU80081A1 (fr) * | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
| JPS6014032B2 (ja) * | 1978-01-20 | 1985-04-11 | 日本ケミフア株式会社東京 | ５‐フエネチル‐２‐オキサゾリドン誘導体およびその製法 |
| US4340606A (en) * | 1980-10-23 | 1982-07-20 | E. I. Du Pont De Nemours And Company | 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents |
| FR2500450A1 (fr) * | 1981-02-25 | 1982-08-27 | Delalande Sa | Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique |
| US4461773A (en) * | 1982-09-15 | 1984-07-24 | E. I. Dupont De Nemours And Company | P-Oxooxazolidinylbenzene compounds as antibacterial agents |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
| US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
| US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
| US5231188A (en) * | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
| JP2908510B2 (ja) * | 1990-04-20 | 1999-06-21 | イハラケミカル工業株式会社 | ベンジルアミン類の製造方法 |
| DE69210919T2 (de) * | 1991-09-05 | 1997-01-23 | Nippon Paint Co Ltd | Hitzehärtbare Harzmischung, enthaltend eine polyfunktionelle Oxazolidon-Komponente und eine Polyamin-Komponente |
| KR100257418B1 (ko) * | 1991-11-01 | 2000-05-15 | 로렌스 티. 마이젠헬더 | 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논 |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| JPH0873455A (ja) * | 1994-03-15 | 1996-03-19 | Upjohn Co:The | オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物 |
| PT788498E (pt) * | 1994-10-26 | 2002-02-28 | Upjohn Co | Compostos antimicrobianos de feniloxazolidinona |
| AU702733B2 (en) * | 1994-11-15 | 1999-03-04 | Pharmacia & Upjohn Company | Bicyclic oxazine and thiazine oxazolidinone antibacterials |
| DK0828741T3 (da) * | 1995-05-11 | 2001-11-26 | Upjohn Co | Spirocykliske og bicykliske diazinyl- og carbazinyloxazolidinoner |
-
1997
- 1997-03-28 CZ CZ0287198A patent/CZ298060B6/cs not_active IP Right Cessation
- 1997-03-28 SK SK1336-98A patent/SK284703B6/sk unknown
- 1997-03-28 PT PT97915865T patent/PT892792E/pt unknown
- 1997-03-28 DE DE69738457T patent/DE69738457T2/de not_active Expired - Fee Related
- 1997-03-28 CN CNB031594743A patent/CN1319952C/zh not_active Expired - Fee Related
- 1997-03-28 DE DE69709718T patent/DE69709718T2/de not_active Expired - Fee Related
- 1997-03-28 DK DK01302264T patent/DK1114819T3/da active
- 1997-03-28 CN CN97193658A patent/CN1082953C/zh not_active Expired - Fee Related
- 1997-03-28 PL PL329295A patent/PL192691B1/pl not_active IP Right Cessation
- 1997-03-28 PT PT01302264T patent/PT1114819E/pt unknown
- 1997-03-28 SI SI9730273T patent/SI0892792T1/xx unknown
- 1997-03-28 CA CA002248143A patent/CA2248143C/en not_active Expired - Fee Related
- 1997-03-28 AT AT97915865T patent/ATE209193T1/de not_active IP Right Cessation
- 1997-03-28 ES ES01302264T patent/ES2298198T3/es not_active Expired - Lifetime
- 1997-03-28 AT AT01302264T patent/ATE383347T1/de not_active IP Right Cessation
- 1997-03-28 US US08/828,923 patent/US5837870A/en not_active Expired - Fee Related
- 1997-03-28 RU RU98120398/04A patent/RU2176643C2/ru not_active IP Right Cessation
- 1997-03-28 KR KR10-2004-7009934A patent/KR100530297B1/ko not_active Expired - Fee Related
- 1997-03-28 AU AU23182/97A patent/AU706117B2/en not_active Ceased
- 1997-03-28 EP EP97915865A patent/EP0892792B1/en not_active Expired - Lifetime
- 1997-03-28 EP EP01302264A patent/EP1114819B1/en not_active Expired - Lifetime
- 1997-03-28 WO PCT/US1997/003458 patent/WO1997037980A1/en not_active Ceased
- 1997-03-28 HU HU0500044A patent/HUP0500044A3/hu unknown
- 1997-03-28 CZ CZ2007-88A patent/CZ200788A3/cs unknown
- 1997-03-28 CN CNB011330031A patent/CN1167701C/zh not_active Expired - Fee Related
- 1997-03-28 NZ NZ332278A patent/NZ332278A/xx unknown
- 1997-03-28 JP JP9536189A patent/JP2000508312A/ja not_active Ceased
- 1997-03-28 ES ES97915865T patent/ES2166073T3/es not_active Expired - Lifetime
- 1997-03-28 DK DK97915865T patent/DK0892792T3/da active
- 1997-03-28 SG SG9905133A patent/SG85683A1/en unknown
- 1997-04-02 TW TW086104216A patent/TW449593B/zh not_active IP Right Cessation
- 1997-04-08 ZA ZA972983A patent/ZA972983B/xx unknown
-
1998
- 1998-10-09 NO NO19984737A patent/NO311837B1/no unknown
-
2001
- 2001-10-26 NO NO20015253A patent/NO312728B1/no unknown
-
2008
- 2008-03-04 JP JP2008053675A patent/JP2008239621A/ja not_active Withdrawn
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