NZ268513A - A process for preparing a diphenylmethyl substituted piperidine derivative - Google Patents

A process for preparing a diphenylmethyl substituted piperidine derivative

Info

Publication number
NZ268513A
NZ268513A NZ268513A NZ26851394A NZ268513A NZ 268513 A NZ268513 A NZ 268513A NZ 268513 A NZ268513 A NZ 268513A NZ 26851394 A NZ26851394 A NZ 26851394A NZ 268513 A NZ268513 A NZ 268513A
Authority
NZ
New Zealand
Prior art keywords
formula
process according
mixture
regioisomers
piperidine derivative
Prior art date
Application number
NZ268513A
Other languages
English (en)
Inventor
Ambra Thomas E D
Original Assignee
Albany Molecular Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22176189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ268513(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Albany Molecular Res Inc filed Critical Albany Molecular Res Inc
Priority to NZ286641A priority Critical patent/NZ286641A/en
Priority to NZ286116A priority patent/NZ286116A/en
Publication of NZ268513A publication Critical patent/NZ268513A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
NZ268513A 1993-06-24 1994-06-21 A process for preparing a diphenylmethyl substituted piperidine derivative NZ268513A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NZ286641A NZ286641A (en) 1993-06-24 1994-06-21 4-keto-aralkyl carboxylic acids and esters as intermediates
NZ286116A NZ286116A (en) 1993-06-24 1994-06-21 Substantially pure diphenylmethyl piperidin-1-yl substituted dimethylphenylacetic acid and esters; pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8310293A 1993-06-24 1993-06-24

Publications (1)

Publication Number Publication Date
NZ268513A true NZ268513A (en) 1996-09-25

Family

ID=22176189

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ268513A NZ268513A (en) 1993-06-24 1994-06-21 A process for preparing a diphenylmethyl substituted piperidine derivative

Country Status (16)

Country Link
US (9) US5750703A (https=)
EP (4) EP0703902B1 (https=)
JP (4) JP3034047B2 (https=)
KR (2) KR100387347B1 (https=)
AT (3) ATE322473T1 (https=)
AU (1) AU670004B2 (https=)
CA (1) CA2147126C (https=)
DE (3) DE69433346T2 (https=)
DK (3) DK1026147T3 (https=)
ES (3) ES2261871T3 (https=)
FI (1) FI109691B (https=)
HU (1) HU226559B1 (https=)
NO (2) NO308599B1 (https=)
NZ (1) NZ268513A (https=)
PT (2) PT1026147E (https=)
WO (1) WO1995000482A1 (https=)

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JP3712208B2 (ja) * 1993-06-25 2005-11-02 メレルファーマスーティカルズ インコーポレイテッド 抗ヒスタミン性の４−ジフェニルメチル／ジフェニルメトキシピペリジン誘導体類を製造する新規な中間体
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Also Published As

Publication number Publication date
US20060052610A1 (en) 2006-03-09
JP3034047B2 (ja) 2000-04-17
US20080227983A1 (en) 2008-09-18
DK1026147T3 (da) 2004-03-22
NO955023D0 (no) 1995-12-12
JP4124998B2 (ja) 2008-07-23
US5589487A (en) 1996-12-31
ATE254594T1 (de) 2003-12-15
HU9503719D0 (en) 1996-02-28
WO1995000482A1 (en) 1995-01-05
KR100387347B1 (ko) 2003-11-28
US7390906B2 (en) 2008-06-24
US5994549A (en) 1999-11-30
EP0703902A1 (en) 1996-04-03
DE69434696T2 (de) 2006-11-16
EP1026147B1 (en) 2003-11-19
JP3195297B2 (ja) 2001-08-06
US20060241303A1 (en) 2006-10-26
EP1369409A1 (en) 2003-12-10
DE69433346D1 (de) 2003-12-24
JP2002212166A (ja) 2002-07-31
ES2129130T3 (es) 1999-06-01
CA2147126C (en) 1999-08-24
DE69434696D1 (de) 2006-05-18
US5578610A (en) 1996-11-26
NO955023L (no) 1995-12-12
NO308599B1 (no) 2000-10-02
EP0703902B1 (en) 1998-12-16
ATE174589T1 (de) 1999-01-15
FI956270A0 (fi) 1995-12-27
HU226559B1 (en) 2009-03-30
DE69433346T2 (de) 2004-09-09
US5750703A (en) 1998-05-12
ES2211444T3 (es) 2004-07-16
DK0703902T3 (da) 1999-08-23
ATE322473T1 (de) 2006-04-15
EP0703902A4 (https=) 1996-04-10
PT1369409E (pt) 2006-08-31
KR100387348B1 (ko) 2003-06-12
AU7174894A (en) 1995-01-17
DK1369409T3 (da) 2006-08-14
FI956270L (fi) 1995-12-27
DE69415319D1 (de) 1999-01-28
US7238834B2 (en) 2007-07-03
PT1026147E (pt) 2004-04-30
ES2261871T3 (es) 2006-11-16
CA2147126A1 (en) 1995-01-05
JP2001031650A (ja) 2001-02-06
JPH11236373A (ja) 1999-08-31
NO994582D0 (no) 1999-09-21
EP0723958A1 (en) 1996-07-31
FI109691B (fi) 2002-09-30
HUT73235A (en) 1996-07-29
JPH08511806A (ja) 1996-12-10
DE69415319T2 (de) 1999-06-10
AU670004B2 (en) 1996-06-27
EP1026147A1 (en) 2000-08-09
US5663412A (en) 1997-09-02
US5581011A (en) 1996-12-03
JP3658291B2 (ja) 2005-06-08
KR960703398A (ko) 1996-08-17
EP1369409B1 (en) 2006-04-05
NO994582L (no) 1995-12-12

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