NZ260385A - 2-amino-4-heteroaryl-1,4-dihydropyridine-3-carboxylic and -phosphonic acid derivatives; pharmaceutical compositions and naphthyridine and benzopyridazine aldehyde intermediates - Google Patents

2-amino-4-heteroaryl-1,4-dihydropyridine-3-carboxylic and -phosphonic acid derivatives; pharmaceutical compositions and naphthyridine and benzopyridazine aldehyde intermediates

Info

Publication number
NZ260385A
NZ260385A NZ260385A NZ26038594A NZ260385A NZ 260385 A NZ260385 A NZ 260385A NZ 260385 A NZ260385 A NZ 260385A NZ 26038594 A NZ26038594 A NZ 26038594A NZ 260385 A NZ260385 A NZ 260385A
Authority
NZ
New Zealand
Prior art keywords
tha
whioh
haviag
aad
group
Prior art date
Application number
NZ260385A
Other languages
English (en)
Inventor
Alexander Straub
Siegfried Goldmann
Jurgen Stoltefuss
Martin Bechem
Rainer Gross
Siegbert Hebisch
Joachem Hutter
Howard-Paul Rounding
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NZ260385A publication Critical patent/NZ260385A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
NZ260385A 1993-04-27 1994-04-22 2-amino-4-heteroaryl-1,4-dihydropyridine-3-carboxylic and -phosphonic acid derivatives; pharmaceutical compositions and naphthyridine and benzopyridazine aldehyde intermediates NZ260385A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4313696A DE4313696A1 (de) 1993-04-27 1993-04-27 2-Amino-4-heteroaryl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln

Publications (1)

Publication Number Publication Date
NZ260385A true NZ260385A (en) 1996-04-26

Family

ID=6486454

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ260385A NZ260385A (en) 1993-04-27 1994-04-22 2-amino-4-heteroaryl-1,4-dihydropyridine-3-carboxylic and -phosphonic acid derivatives; pharmaceutical compositions and naphthyridine and benzopyridazine aldehyde intermediates

Country Status (17)

Country Link
US (2) US5434153A (OSRAM)
EP (1) EP0622365A1 (OSRAM)
JP (1) JPH06321943A (OSRAM)
CN (1) CN1100725A (OSRAM)
AU (1) AU671001B2 (OSRAM)
CA (1) CA2121963A1 (OSRAM)
CZ (1) CZ99594A3 (OSRAM)
DE (1) DE4313696A1 (OSRAM)
FI (1) FI941915A7 (OSRAM)
HU (1) HUT70540A (OSRAM)
IL (1) IL109439A0 (OSRAM)
NO (1) NO941519L (OSRAM)
NZ (1) NZ260385A (OSRAM)
PH (1) PH30808A (OSRAM)
RU (2) RU94014627A (OSRAM)
SK (1) SK47994A3 (OSRAM)
ZA (1) ZA942884B (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007505137A (ja) * 2003-09-10 2007-03-08 シンタ ファーマシューティカルズ コーポレイション 代謝性障害を処置または予防するためのジヒドロピリジン化合物
JP5638011B2 (ja) 2009-02-18 2014-12-10 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 二および三環式インダゾール置換１，４−ジヒドロピリジン誘導体およびそれらの使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3946026A (en) * 1972-03-06 1976-03-23 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
US3989708A (en) * 1972-08-31 1976-11-02 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
DE2242786A1 (de) * 1972-08-31 1974-03-14 Bayer Ag Verfahren zur herstellung von neuen 2-amino-1,4-dihydropyridinen mit einer carbonylfunktion sowie ihre verwendung als arzneimittel
DE2639257A1 (de) * 1976-09-01 1978-03-02 Bayer Ag Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3311003A1 (de) * 1983-03-25 1984-09-27 Bayer Ag, 5090 Leverkusen Chromon- und thiochromonsubstituierte 1,4-dihydropyridinlactone, mehrere verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4011106A1 (de) * 1990-04-06 1991-10-10 Bayer Ag Neue heterocyclisch substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5254692A (en) * 1990-04-06 1993-10-19 Bayer Aktiengesellschaft 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines
DE4117750A1 (de) * 1991-05-30 1992-12-24 Bayer Ag Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4134760A1 (de) * 1991-10-22 1993-07-08 Bayer Ag Aryl-chinolyl-substituierte 1,4-dihydropyridin-dicarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4202526A1 (de) * 1992-01-30 1993-08-05 Bayer Ag Neue 4-cinnolinyl- und 4-naphthyridinyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
EP0622365A1 (de) 1994-11-02
JPH06321943A (ja) 1994-11-22
RU94014255A (ru) 1997-02-20
FI941915A7 (fi) 1994-10-28
CN1100725A (zh) 1995-03-29
SK47994A3 (en) 1994-12-07
RU94014627A (ru) 1997-02-20
DE4313696A1 (de) 1994-11-03
AU671001B2 (en) 1996-08-08
IL109439A0 (en) 1994-07-31
CZ99594A3 (en) 1994-11-16
US5478937A (en) 1995-12-26
PH30808A (en) 1997-10-17
AU5922294A (en) 1994-11-03
HUT70540A (en) 1995-10-30
HU9401191D0 (en) 1994-07-28
ZA942884B (en) 1995-01-04
NO941519D0 (OSRAM) 1994-04-26
NO941519L (no) 1994-10-28
US5434153A (en) 1995-07-18
CA2121963A1 (en) 1994-10-28
FI941915A0 (fi) 1994-04-25

Similar Documents

Publication Publication Date Title
TWI801388B (zh) 二氮雜雙環經取代之咪唑并嘧啶類及其用途
KR102444687B1 (ko) 치환된 디아자헤테로비시클릭 화합물 및 그의 용도
AU2019277547B2 (en) Polycyclic pyridone derivative
FI90343C (fi) Menetelmä korkeaa verenpainetta alentavien ja rytmihäiriöitä vastustavien trans-2,2-dimetyylikroman-3-olijohdannaisten valmistamiseksi
JP2001505567A (ja) 心臓循環系疾患の処置のための新規な置換ピラゾール誘導体
JPWO2006001318A1 (ja) スルホンアミド化合物
KR20180088462A (ko) 수면-관련 호흡기 장애의 치료를 위한 TASK-1 및 TASK-2 채널의 차단제로서의 2-페닐-3-(피페라지노메틸)이미다조[1,2-a]피리딘 유도체
TW200843755A (en) Substituted 4-aryl-1, 4-dihydro-1, 6-naphthyridine amides and their use
CN108699084A (zh) 取代全氢吡咯并[3,4-c]吡咯衍生物及其用途
EP3257857A1 (en) Substituted amino six-membered saturated heterocyclic fat used as long-acting dpp-iv inhibitor
CN107382966B (zh) 一类荜茇酰胺-川芎嗪杂合物、制备方法及医药用途
HU195833B (en) Process for producing new pyridyl-carbonyl derivatives of 1,4:3,6-dianhydrohexites and pharmaceutics comprising such active ingredient
SK47894A3 (en) 2-amino-4-chinolyl-dihydropyridines, method of their production treatments containing thereof, method of their production, and using of these compounds
NZ260385A (en) 2-amino-4-heteroaryl-1,4-dihydropyridine-3-carboxylic and -phosphonic acid derivatives; pharmaceutical compositions and naphthyridine and benzopyridazine aldehyde intermediates
NZ260383A (en) 4-quinolinyl-5-oxo-1,4-dihydrocyclopentano and -1,4,5,7-tetrahydrothienopyridin-3-carboxylic acid derivatives and pharmaceutical compositions
NZ260384A (en) 4-quinolinyldihydropyridin-3-carboxylic acid derivatives and 5,6-fused (hetero)cyclic-4-quinolinyl-dihydropyridin-3-carboxylic acid derivatives and pharmaceutical compositions
JPH0276852A (ja) Ｎ―置換された―ｎ―ニトロソ―アミノアセトニトリル、その製造方法及びその使用法
US10456400B2 (en) Aza-ellipticine analogs, methods of synthesis and methods of treatment
EP2578588A1 (en) Novel 1,4-diazepam pde-5 inhibitor derivatives
JP2005507893A (ja) ２０（ｓ）−カンプトテシンの薬学的に許容可能な塩
HK40085266A (en) Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
HK40085269A (en) Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
HK40085267A (en) Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
CN118684631A (zh) 外核苷酸焦磷酸酶/磷酸二酯酶1(enpp1)抑制剂及其组合物和用途
JPWO2004024142A1 (ja) Ｈｓｐ９０ファミリー蛋白質阻害剤