NZ247630A - Preparation comprising 9-cis or 13-cis-retinoic acid or acitretin and a vitamin d derivative - Google Patents
Preparation comprising 9-cis or 13-cis-retinoic acid or acitretin and a vitamin d derivativeInfo
- Publication number
- NZ247630A NZ247630A NZ247630A NZ24763093A NZ247630A NZ 247630 A NZ247630 A NZ 247630A NZ 247630 A NZ247630 A NZ 247630A NZ 24763093 A NZ24763093 A NZ 24763093A NZ 247630 A NZ247630 A NZ 247630A
- Authority
- NZ
- New Zealand
- Prior art keywords
- vitamin
- cis
- retinoic acid
- preparation according
- derivative
- Prior art date
Links
- 229960001445 alitretinoin Drugs 0.000 title claims description 27
- 238000002360 preparation method Methods 0.000 title claims description 23
- 150000003710 vitamin D derivatives Chemical class 0.000 title claims description 14
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 title claims description 11
- 229960005280 isotretinoin Drugs 0.000 title claims description 11
- SHGAZHPCJJPHSC-UHFFFAOYSA-N Panrexin Chemical compound OC(=O)C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-UHFFFAOYSA-N 0.000 title claims description 9
- 229960005339 acitretin Drugs 0.000 title claims description 9
- IHUNBGSDBOWDMA-AQFIFDHZSA-N all-trans-acitretin Chemical compound COC1=CC(C)=C(\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O)C(C)=C1C IHUNBGSDBOWDMA-AQFIFDHZSA-N 0.000 title claims description 9
- 229960005084 calcitriol Drugs 0.000 claims description 22
- SHGAZHPCJJPHSC-ZVCIMWCZSA-N 9-cis-retinoic acid Chemical compound OC(=O)/C=C(\C)/C=C/C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-ZVCIMWCZSA-N 0.000 claims description 18
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims description 18
- 235000020964 calcitriol Nutrition 0.000 claims description 18
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- 206010028980 Neoplasm Diseases 0.000 claims description 5
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- 239000004480 active ingredient Substances 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000011647 vitamin D3 Substances 0.000 description 18
- 229940021056 vitamin d3 Drugs 0.000 description 18
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- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 4
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
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- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 2
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical compound C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003704 vitamin D3 derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH161992 | 1992-05-20 | ||
| CH92693 | 1993-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ247630A true NZ247630A (en) | 1995-12-21 |
Family
ID=25686129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ247630A NZ247630A (en) | 1992-05-20 | 1993-05-14 | Preparation comprising 9-cis or 13-cis-retinoic acid or acitretin and a vitamin d derivative |
Country Status (12)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6461622B2 (en) * | 1994-09-07 | 2002-10-08 | Johnson & Johnson Consumer Companies, Inc. | Topical compositions |
| DK128494A (da) * | 1994-11-08 | 1996-05-09 | Edel K Seidenschnur | Behandling af keratinøse og psoriatiske sygdomstilstande med neglelak indeholdende vitamin D metabolit, eller derivat, og/eller vitamin A derivat |
| US5837728A (en) * | 1995-01-27 | 1998-11-17 | Molecular Design International | 9-cis retinoic acid esters and amides and uses thereof |
| WO1997011703A1 (fr) * | 1995-09-28 | 1997-04-03 | Teijin Limited | Preventif ou remede contre l'hyperthyroidie |
| US5716946A (en) * | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
| US5827878A (en) * | 1996-07-01 | 1998-10-27 | Nisshin Flour Milling Co., Ltd. | Pharmaceutical composition for the treatment of leukemia containing 9-cis-retinoic acid-α-tocopherol ester |
| US5891865A (en) * | 1996-10-04 | 1999-04-06 | Wisconsin Alumni Research Foundation | Treatment of arthritic disease induced by infectious agents |
| FR2767058B1 (fr) * | 1997-08-05 | 2000-05-05 | Centre Nat Rech Scient | Utilisation d'un compose de type retinoide, notamment l'acide retinoique pour la preparation d' un medicament destine au traitement de l'obesite. |
| EP0908179A1 (en) * | 1997-08-23 | 1999-04-14 | Werner Bollag | Treatment of cell-mediated immune diseases |
| US8541469B2 (en) | 1997-08-23 | 2013-09-24 | Glaxo Group Limited | Treatment of cell-mediated immune diseases |
| US6552009B2 (en) | 1998-07-16 | 2003-04-22 | Gentrix Llc | Compositions and methods of treating abnormal cell proliferation |
| US20010002396A1 (en) * | 1998-07-16 | 2001-05-31 | Charles Achkar | Compositions and methods of treating skin conditions |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6479474B2 (en) | 1999-07-08 | 2002-11-12 | Wisconsin Alumni Research Foundation | Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis |
| US6733779B2 (en) * | 1999-08-26 | 2004-05-11 | L. Dean Parks | Method of treating benign prostatic hyperplasia and other benign prostate conditions |
| FR2807662A1 (fr) * | 2000-04-12 | 2001-10-19 | Cll Pharma | Procede pour stabiliser la granulometrie d'un principe actif verulent disperse dans un liquide et ses applications |
| US6339107B1 (en) | 2000-08-02 | 2002-01-15 | Syntex (U.S.A.) Llc | Methods for treatment of Emphysema using 13-cis retinoic acid |
| RU2168996C1 (ru) * | 2000-09-19 | 2001-06-20 | Фармацевтическое научно-производственное предприятие "Ретиноиды" (акционерное общество закрытого типа) | Стабильный раствор ретинола пальмитата и способ лечения заболеваний кожи |
| JP2002104995A (ja) * | 2000-09-29 | 2002-04-10 | Masahiko Hosaka | テロメラーゼ活性抑制剤 |
| JP4326159B2 (ja) | 2001-02-09 | 2009-09-02 | 株式会社ジェイテクト | 玉軸受 |
| WO2004098612A2 (en) * | 2003-05-07 | 2004-11-18 | Ab Science | Calcitriol analogs of uses thereof |
| BRPI0410646A (pt) * | 2003-05-20 | 2006-07-04 | Ranbaxy Lab Ltd | composições farmacêuticas de acitretina e processo para sua preparação |
| WO2005102296A2 (en) * | 2004-04-23 | 2005-11-03 | Heptagen Limited | Combinations for the treatment of immunoproliferative skin disorders such as psoriasis |
| CN102727476B (zh) * | 2012-06-14 | 2014-05-14 | 合肥博太医药生物技术发展有限公司 | 视黄酸及其衍生物在制备防治骨质疏松药物中的应用 |
| JP2019014676A (ja) * | 2017-07-06 | 2019-01-31 | 東海カプセル株式会社 | カプセル剤 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6360910A (ja) * | 1986-09-01 | 1988-03-17 | Shiseido Co Ltd | 皮膚外用剤 |
-
1993
- 1993-04-14 TW TW082102845A patent/TW272187B/zh active
- 1993-04-23 AU AU37161/93A patent/AU3716193A/en not_active Abandoned
- 1993-05-06 CZ CZ93832A patent/CZ83293A3/cs unknown
- 1993-05-08 EP EP93107492A patent/EP0579915A1/de not_active Withdrawn
- 1993-05-13 CA CA002096196A patent/CA2096196A1/en not_active Abandoned
- 1993-05-14 HU HU9301404A patent/HUT66864A/hu unknown
- 1993-05-14 NZ NZ247630A patent/NZ247630A/en unknown
- 1993-05-14 IL IL105700A patent/IL105700A0/xx unknown
- 1993-05-17 JP JP5114777A patent/JPH0632740A/ja active Pending
- 1993-05-18 KR KR1019930008442A patent/KR940005278A/ko not_active Withdrawn
- 1993-05-19 CN CN93106248A patent/CN1080525A/zh active Pending
- 1993-05-19 NO NO931831A patent/NO931831L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL105700A0 (en) | 1993-09-22 |
| KR940005278A (ko) | 1994-03-21 |
| CN1080525A (zh) | 1994-01-12 |
| AU3716193A (en) | 1993-11-25 |
| HUT66864A (en) | 1995-01-30 |
| TW272187B (enrdf_load_html_response) | 1996-03-11 |
| JPH0632740A (ja) | 1994-02-08 |
| EP0579915A1 (de) | 1994-01-26 |
| NO931831L (no) | 1993-11-22 |
| CZ83293A3 (en) | 1993-12-15 |
| CA2096196A1 (en) | 1993-11-21 |
| HU9301404D0 (en) | 1993-09-28 |
| NO931831D0 (no) | 1993-05-19 |
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