NZ245504A - Bile acid derivatives containing an ethylenically unsaturated grouping - Google Patents

Bile acid derivatives containing an ethylenically unsaturated grouping

Info

Publication number
NZ245504A
NZ245504A NZ245504A NZ24550492A NZ245504A NZ 245504 A NZ245504 A NZ 245504A NZ 245504 A NZ245504 A NZ 245504A NZ 24550492 A NZ24550492 A NZ 24550492A NZ 245504 A NZ245504 A NZ 245504A
Authority
NZ
New Zealand
Prior art keywords
group
iva
mmol
hydrogen
alkyl
Prior art date
Application number
NZ245504A
Other languages
English (en)
Inventor
Alfons Enhsen
Heiner Glombik
Stefan Mullner
Gunther Wess
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NZ245504A publication Critical patent/NZ245504A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NZ245504A 1991-12-20 1992-12-17 Bile acid derivatives containing an ethylenically unsaturated grouping NZ245504A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4142323 1991-12-20
DE4229033 1992-09-01

Publications (1)

Publication Number Publication Date
NZ245504A true NZ245504A (en) 1995-08-28

Family

ID=25910367

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ245504A NZ245504A (en) 1991-12-20 1992-12-17 Bile acid derivatives containing an ethylenically unsaturated grouping

Country Status (7)

Country Link
US (1) US5559258A (fr)
EP (1) EP0548793A3 (fr)
JP (1) JPH061797A (fr)
AU (1) AU664059B2 (fr)
CA (1) CA2085830A1 (fr)
IL (1) IL104165A (fr)
NZ (1) NZ245504A (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0540670T3 (da) * 1990-07-26 1996-04-29 Monsanto Co Fremgangsmåde til fremstilling af tværbundne polyaminer
ES2111092T3 (es) * 1992-06-12 1998-03-01 Hoechst Ag Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos.
TW289021B (fr) * 1993-05-08 1996-10-21 Hoechst Ag
EP0624593A3 (fr) * 1993-05-08 1995-06-07 Hoechst Ag Dérivés des acides biliaires, un procédé pour leur production et leur utilisation comme médicaments.
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
DE4432708A1 (de) * 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19633268A1 (de) * 1996-08-19 1998-02-26 Hoechst Ag Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
KR20010102965A (ko) 1998-12-23 2001-11-17 윌리암스 로저 에이 심장혈관의 징후에 대한 회장 담즙산 수송 저해제 및담즙산 격리제의 병용
US6458851B1 (en) 1998-12-23 2002-10-01 G. D. Searle, Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
ATE240120T1 (de) 1998-12-23 2003-05-15 Searle Llc Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
WO2000038724A1 (fr) 1998-12-23 2000-07-06 G.D. Searle Llc Combinaisons d'inhibiteurs de la proteine de transfert de l'ester de cholesteryle et de derives de l'acide fibrique utilisees dans le cadre de troubles cardio-vasculaires
JP2002533409A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤および胆汁酸隔離剤の組み合わせ
DK1140184T3 (da) 1998-12-23 2003-09-29 Searle Llc Kombinationer af cholesterylestertransferproteinhæmmere og nikotinsyrederivater til hjertekar indikationer
KR100327338B1 (ko) * 1999-09-14 2002-03-06 윤종용 감광성 리소콜산 에스테르 유도체 및 이를 포함하는 화학 증폭형 포토레지스트 조성물
US6586434B2 (en) 2000-03-10 2003-07-01 G.D. Searle, Llc Method for the preparation of tetrahydrobenzothiepines
MXPA04003524A (es) 2001-11-02 2004-07-23 Searle Llc Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato.
BR0306643A (pt) 2002-01-17 2004-10-19 Pharmacia Corp Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical
EP3197459A4 (fr) * 2014-09-28 2018-06-20 Huahui Health Ltd. Dérivés d'acide biliaire polymère inhibant les virus de l'hépatite b et d et le transport de ntcp
JP2019055913A (ja) * 2016-01-28 2019-04-11 国立大学法人お茶の水女子大学 ビタミンｄ活性を有するリトコール酸誘導体

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3383281A (en) * 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
IT1137459B (it) * 1981-04-14 1986-09-10 Erregierre Spa Prodesso per la preparazione di acido ursodeossicolico ad alta purezza
IT1167479B (it) * 1981-07-24 1987-05-13 Carlo Scolastico Derivati dell'acido chenodesossicolico
IT1167478B (it) * 1981-07-24 1987-05-13 Carlo Scolastico Derivati dell'acido ursodesossicolico
JPS5946300A (ja) * 1982-09-09 1984-03-15 Mitsubishi Petrochem Co Ltd 新規胆汁酸誘導体およびその製造方法
JPS6363698A (ja) * 1986-09-05 1988-03-22 Wakunaga Pharmaceut Co Ltd 胆汁酸誘導体およびその塩ならびにその製造法
NZ235818A (en) * 1987-04-29 1992-06-25 Smithkline Beckman Corp 3-halogenated steroid 3,5-dienes
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
US5041433A (en) * 1987-04-29 1991-08-20 Smithkline Beecham Corporation 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
NZ230957A (en) * 1989-10-10 1992-09-25 Smithkline Beckman Corp Aromatic steroid 5-alpha-reductase inhibitors and pharmaceutical compositions
DE4000397A1 (de) * 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
FI106800B (fi) * 1990-12-06 2001-04-12 Hoechst Ag Menetelmä uusien terapeuttisesti käyttökelpoisten dimeeristen sappihappojohdannaisten valmistamiseksi
US5430116A (en) * 1991-12-20 1995-07-04 Hoechst Aktiengesellschaft Polymers and oligomers of bile acid derivatives, process for their preparation and their use as pharmaceuticals

Also Published As

Publication number Publication date
CA2085830A1 (fr) 1993-06-21
AU664059B2 (en) 1995-11-02
IL104165A0 (en) 1993-05-13
EP0548793A2 (fr) 1993-06-30
EP0548793A3 (en) 1995-11-02
IL104165A (en) 1999-12-31
US5559258A (en) 1996-09-24
AU3020892A (en) 1993-06-24
JPH061797A (ja) 1994-01-11

Similar Documents

Publication Publication Date Title
NZ245504A (en) Bile acid derivatives containing an ethylenically unsaturated grouping
US5256812A (en) Carboxamides and sulfonamides
WO1999001420A1 (fr) Procede de preparation de derives d'acide 2-aminomalonique, et intermediaires utilises dans ce procede
EP2321260A2 (fr) Procédé amélioré pour la production de bimatoprost
US6239305B1 (en) Method for producing optically active phenylpropionic acid derivative
JP4299677B2 (ja) コンブレタスタチンの製造方法
JP2001504125A (ja) シクロプロピルアミンの製造法
US5886046A (en) Dicarbonyl-containing compounds
EP0585440B1 (fr) Derives de 2-amino-1,2,3,4-tetrahydronaphtalene actifs au niveau de l'appareil cardio-vasculaire, leurs procedes de preparation et compositions pharmaceutiques les contenant
KR20150091150A (ko) 트라보프로스트의 제조 방법
WO2022204947A1 (fr) Procédé de préparation d'un conjugué de médicament de liaison et intermédiaire de celui-ci
US3903077A (en) Direct synthesis of dopamine amino acid amides
JPH10114788A (ja) Ｄｎａ／ｐｎａコ・オリゴマーの構築用ブロツク
CA1295086C (fr) Derives de 4-acide aminoburanoique, leur procede de preparation et leurutilisation
JPH09512012A (ja) グリシンカチオン均等体への有機ハライドの亜鉛介在付加によるＮ−Ｂｏｃ−Ｌ−プロパルギルグリシンの合成
WO2019239364A1 (fr) Procédé de préparation de lifitegrast
JP3193597B2 (ja) グリシン誘導体の製造方法
JP2763214B2 (ja) Ｌ−プロリン誘導体の製造法
MXPA03000607A (es) Procedimiento quimico.
JP2003509504A (ja) リトナビルの合成方法
RU2304583C1 (ru) Способ синтеза ди- и триаминохлоринов
CN115385926A (zh) 一种连接基药物偶联物的制备方法及其中间体
CA2268544A1 (fr) N.alpha.-(2-(4-nitrophenylsulfonyl)ethoxycarbonyl-aminoacides
JP3855323B2 (ja) ３−アミノ−２−オキソ−１−ハロゲノプロパン誘導体の製造方法
JPH04305565A (ja) Ｌ−プロリン誘導体の製造法