NO995687D0 - Fremgangsmåte for fremstilling av dispergerbare sterol- og stanol-forbindelser - Google Patents

Fremgangsmåte for fremstilling av dispergerbare sterol- og stanol-forbindelser

Info

Publication number
NO995687D0
NO995687D0 NO995687A NO995687A NO995687D0 NO 995687 D0 NO995687 D0 NO 995687D0 NO 995687 A NO995687 A NO 995687A NO 995687 A NO995687 A NO 995687A NO 995687 D0 NO995687 D0 NO 995687D0
Authority
NO
Norway
Prior art keywords
sterol
stanol
preparation
compounds
preparing
Prior art date
Application number
NO995687A
Other languages
English (en)
Other versions
NO995687L (no
Inventor
Richard D Bruce
Brid Burruano
Michael R Hoy
Nicholas R Paquette
Original Assignee
Mcneil Ppc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneil Ppc Inc filed Critical Mcneil Ppc Inc
Publication of NO995687D0 publication Critical patent/NO995687D0/no
Publication of NO995687L publication Critical patent/NO995687L/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
NO995687A 1998-11-30 1999-11-19 FremgangsmÕte for fremstilling av dispergerbare sterol- og stanol-forbindelser NO995687L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/200,623 US6242001B1 (en) 1998-11-30 1998-11-30 Method for producing dispersible sterol and stanol compounds

Publications (2)

Publication Number Publication Date
NO995687D0 true NO995687D0 (no) 1999-11-19
NO995687L NO995687L (no) 2000-05-31

Family

ID=22742487

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995687A NO995687L (no) 1998-11-30 1999-11-19 FremgangsmÕte for fremstilling av dispergerbare sterol- og stanol-forbindelser

Country Status (9)

Country Link
US (2) US6242001B1 (no)
EP (1) EP1005859B1 (no)
JP (1) JP2000191684A (no)
AT (1) ATE315381T1 (no)
CA (1) CA2290315C (no)
DE (1) DE69929411T2 (no)
DK (1) DK1005859T3 (no)
ES (1) ES2257011T3 (no)
NO (1) NO995687L (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376481B2 (en) * 1998-09-02 2002-04-23 Mcneil-Ppc, Inc. Sterol esters in tableted solid dosage forms
US6242001B1 (en) * 1998-11-30 2001-06-05 Mcneil-Ppc, Inc. Method for producing dispersible sterol and stanol compounds
DE50011218D1 (de) * 1999-06-25 2005-10-27 Cognis Ip Man Gmbh Verwendung von nanoskaligen sterolen und sterolestern
JP2003512850A (ja) * 1999-11-03 2003-04-08 フォーブス メディ−テック インコーポレーテッド 食用油または脂肪と、その中に実質的に溶解したフィトステロールおよび/またはフィロスタノールとを含む組成物、その製造方法、並びに心血管疾患およびその根底にある状態を治療または予防することにおけるその使用
US6391370B1 (en) * 1999-11-12 2002-05-21 Kraft Foods, Inc. Micromilling plant sterols and emulsifiers
EP1274319B1 (en) 2000-04-14 2009-08-12 Mars, Incorporated Compositions and methods for improving vascular health
KR20020026053A (ko) * 2000-09-30 2002-04-06 노승권 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료
US6576285B1 (en) * 2000-11-14 2003-06-10 Sunpure Ltd. Cholesterol lowering beverage
US20020107232A1 (en) * 2001-01-12 2002-08-08 Flickinger Brent D. Methods for producing sterol ester-rich compositions
BR0205721A (pt) * 2001-07-06 2003-09-30 Endo Pharmaceuticals Inc Formulações de oximorfona de liberação controlada
US7012297B2 (en) * 2001-08-30 2006-03-14 Micron Technology, Inc. Scalable flash/NV structures and devices with extended endurance
US7144595B2 (en) * 2001-11-16 2006-12-05 Brandeis University Prepared foods containing triglyceride-recrystallized non-esterified phytosterols
US7763663B2 (en) * 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
AU2002241368B2 (en) * 2002-03-20 2009-07-09 Eugene Science Inc. Plant sterol-containing food, and method for preparing the same
CN1297216C (zh) * 2002-03-20 2007-01-31 尤金科学(有限)公司 植物甾醇与乳化剂的混合粉末及其制备方法
US6623780B1 (en) 2002-03-26 2003-09-23 Cargill, Inc. Aqueous dispersible sterol product
AU2003230878A1 (en) * 2002-04-10 2003-10-27 Cargill, Incorporated Aqueous dispersible steryl ester compositions
US20030212046A1 (en) * 2002-05-07 2003-11-13 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
US20060093661A1 (en) 2002-05-07 2006-05-04 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
US7306819B2 (en) * 2002-06-12 2007-12-11 The Coca-Cola Company Beverages containing plant sterols
RU2329734C2 (ru) * 2002-06-12 2008-07-27 Дзе Кока-Кола Компани Способ получения дисперсии, напиток и композиция
IS6633A (is) * 2002-11-22 2004-05-23 Omega Farma Ehf. Samsetningar af fínasteríð töflum
US20060182820A1 (en) * 2004-02-10 2006-08-17 Cargill, Incorporated Homogeneous Dispersions Containing Citrus Pulp and Applications Thereof
US20050175672A1 (en) * 2004-02-10 2005-08-11 Kluetz Michael D. Particulate plant sterol compositions
EP1791578A2 (en) * 2004-02-26 2007-06-06 Tasker Products IP Holdings Corp. Antimicrobial composition for pre-harvest and post-harvest treatment of plants and animals
US20080213444A1 (en) * 2004-02-26 2008-09-04 Tasker Products, Inc. Compositions and methods for reducing microbial contamination in meat processing
CN103315954A (zh) 2005-07-18 2013-09-25 麻萨诸塞州洛厄尔大学 制备与使用纳米乳剂的组合物和方法
KR20080055956A (ko) * 2005-09-29 2008-06-19 레프로스 쎄라피우틱스 아이엔씨. 향상된 생체이용률을 가지며, 스테로이드 유도체와폴리글리콜리세드 글리세리드를 포함하는 제제
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
BRPI0619134B8 (pt) 2005-12-01 2021-05-25 Univ Massachusetts Lowell nanoemulsão, composição farmacêutica, composição, métodos cosméticos para o tratamento de rugas, linhas faciais e/ou linhas do pescoço, e de retardar o início das rugas, linhas faciais e/ou linhas do pescoço, e, método de fabricação de uma nanoemulsão
WO2007067735A2 (en) * 2005-12-08 2007-06-14 Tasker Products Ip Holdings Corp. Skin care composition for dermatological disorders
WO2007101581A2 (de) * 2006-03-08 2007-09-13 Cognis Ip Management Gmbh Sterolhaltige pulver
US20080124387A1 (en) 2006-11-27 2008-05-29 Kapac, Llc Methods and formulations for enhancing the absorption and decreasing the absorption variability of orally administered drugs, vitamins and nutrients
AU2007329579A1 (en) 2006-12-01 2008-06-12 Anterios, Inc. Amphiphilic entity nanoparticles
AU2007353340A1 (en) 2006-12-01 2008-11-20 Anterios, Inc. Peptide nanoparticles and uses therefor
CN103961315A (zh) 2007-05-31 2014-08-06 安特里奥公司 核酸纳米粒子和其用途
US20090088393A1 (en) * 2007-09-28 2009-04-02 Zomanex, Llc Methods and formulations for converting intravenous and injectable drugs into oral dosage forms
US20090092727A1 (en) * 2007-10-04 2009-04-09 Daniel Perlman Water-dispersible phytosterol-surfactant conglomerate particles
BRPI0914630A2 (pt) * 2008-06-26 2019-09-24 Anterios Inc liberação dérmica
US20110223312A1 (en) * 2009-11-30 2011-09-15 Daniel Perlman Triglyceride-encapsulated phytosterol microparticles dispersed in beverages
AU2017360346B2 (en) 2016-11-21 2023-11-23 Eirion Therapeutics, Inc. Transdermal delivery of large agents

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3085939A (en) 1959-05-11 1963-04-16 Upjohn Co Oil-in-water emulsion for oral administration, and process for preparation
US3004043A (en) 1959-10-09 1961-10-10 Eastman Kodak Co Water-soluble vegetable oil sterol derivatives
CA928140A (en) 1969-07-17 1973-06-12 A. Erickson Billy Clear cooking and salad oils having hypocholesterolemic properties
US3865939A (en) 1973-02-23 1975-02-11 Procter & Gamble Edible oils having hypocholesterolemic properties
US3881005A (en) 1973-08-13 1975-04-29 Lilly Co Eli Pharmaceutical dispersible powder of sitosterols and a method for the preparation thereof
US4391732A (en) 1975-06-06 1983-07-05 Henkel Corporation Phytosterol blends
US4005196A (en) 1976-02-12 1977-01-25 The Procter & Gamble Company Vitaminized compositions for treating hypercholesterolemia
US4195084A (en) 1977-01-07 1980-03-25 Eli Lilly And Company Taste-stable aqueous pharmaceutical suspension of tall oil sitosterols and a method for the preparation thereof
US4423041A (en) 1979-06-25 1983-12-27 Johnson & Johnson Products, Inc. Detackifying compositions
EP0053415B1 (en) 1980-12-02 1985-10-09 Duphar International Research B.V Method of isolating sterols in commercial quantities from sterol-containing material
FI63423C (fi) 1981-01-27 1983-06-10 Farmos Oy Foerfarande foer separering av beta-sitosterol fraon en sterolblandning utvunnen ur raosaopans neutralfraktion
EP0179583A1 (en) 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs
US5219733A (en) 1985-03-06 1993-06-15 Yoshikawa Oil & Fat Co., Ltd. Process for preparing fatty acid esters
JPS62186936A (ja) 1986-02-13 1987-08-15 Asahi Denka Kogyo Kk ステリン乳化乃至可溶化組成物
DE3829643A1 (de) 1988-09-01 1990-03-15 Roecar Holdings Nv Phyto- und zoosterole und deren derivate mit verbesserter wasserloeslichkeit
DE59004337D1 (de) 1989-07-21 1994-03-03 Marigen Sa Sterole, deren fettsäureester und glucoside; verfahren zu ihrer herstellung; spontan dispergierbare mittel mit diesen verbindungen, sowie ihre verwendung zur behandlung von tumoren.
US5723747A (en) 1991-02-22 1998-03-03 Calgene, Inc. Wax esters in transformed plants
DE69127207T2 (de) 1991-05-03 1998-01-22 Raision Tehtaat Oy Ab Substanz zur absenkung eines hohen cholesterolspiegels im serum und verfahren zu ihrer herstellung
IL102633A0 (en) * 1991-07-26 1993-01-14 Smithkline Beecham Corp Compositions
US5244887A (en) 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
JPH06329588A (ja) * 1993-05-19 1994-11-29 Riken Vitamin Co Ltd 水分散性モノグリセリド
AU676315B2 (en) 1993-06-30 1997-03-06 Takeda Chemical Industries Ltd. Stabilized solid pharmaceutical preparation and method of producing the same
AU3559795A (en) 1994-09-29 1996-04-19 University Of British Columbia, The Sterol compositions from pulping soap
US5492714A (en) 1994-11-08 1996-02-20 The Procter & Gamble Company Reduced calorie fats which comprise reduced calorie triglycerides containing medium and long chain fatty acids and which exhibit rapid crystallization to beta phase
US5486318A (en) 1994-12-29 1996-01-23 The Boc Group, Inc. Liquid-vapor contact column
US5578334A (en) 1995-04-07 1996-11-26 Brandeis University Increasing the HDL level and the HDL/LDL ratio in human serum with fat blends
BR9608914A (pt) 1995-06-01 1999-03-02 Unilever Nv Produto alimentício á base de gorgura pasta de gordura amarela e uso de um concentrado oleoso
US5698527A (en) 1995-08-08 1997-12-16 Merck & Co., Inc. Steroidal glycosides as antihyperlipidemic agents
GB9613858D0 (en) * 1996-07-02 1996-09-04 Cortecs Ltd Hydrophobic preparations
US6139872A (en) 1996-08-14 2000-10-31 Henkel Corporation Method of producing a vitamin product
US6383514B1 (en) * 1996-11-28 2002-05-07 Henkel Kommanditgesellschaft Auf Aktien Use of mixtures of active substances for the production of hypocholesterolemic agents
US5837714A (en) 1997-03-03 1998-11-17 Sanofi Solid pharmaceutical dispersions
ES2231940T3 (es) 1997-08-22 2005-05-16 Unilever N.V. Composicion de esteres de estanol.
WO1999018977A1 (en) 1997-10-16 1999-04-22 Medical Isotopes Inc. Readily absorbable phytosterol glycosides to treat hypercholesterolemia
US6025010A (en) 1997-11-21 2000-02-15 Lipton, Division Of Conopco, Inc. Multifunctional spread
US6045853A (en) 1997-12-05 2000-04-04 Lipton, Division Of Conopco, Inc. Fat continuous spread and process for making the same
US6110502A (en) 1998-02-19 2000-08-29 Mcneil-Ppc, Inc. Method for producing water dispersible sterol formulations
US6025348A (en) 1998-04-30 2000-02-15 Kao Corporation Oil and fat composition containing phytosterol
SE512958C2 (sv) 1998-04-30 2000-06-12 Triple Crown Ab Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning
US5932562A (en) 1998-05-26 1999-08-03 Washington University Sitostanol formulation to reduce cholesterol absorption and method for preparing and use of same
EP1082026A1 (en) 1998-06-05 2001-03-14 Forbes Medi-Tech Inc. Compositions comprising phytosterol and/or phytostanol having enhenced solubility and dispersa
US6242001B1 (en) * 1998-11-30 2001-06-05 Mcneil-Ppc, Inc. Method for producing dispersible sterol and stanol compounds

Also Published As

Publication number Publication date
ATE315381T1 (de) 2006-02-15
DE69929411D1 (de) 2006-04-06
CA2290315A1 (en) 2000-05-30
CA2290315C (en) 2008-11-18
NO995687L (no) 2000-05-31
US6242001B1 (en) 2001-06-05
DK1005859T3 (da) 2006-04-03
ES2257011T3 (es) 2006-07-16
US20010012521A1 (en) 2001-08-09
DE69929411T2 (de) 2006-08-24
JP2000191684A (ja) 2000-07-11
EP1005859A1 (en) 2000-06-07
US6387411B2 (en) 2002-05-14
EP1005859B1 (en) 2006-01-11

Similar Documents

Publication Publication Date Title
NO995687D0 (no) Fremgangsmåte for fremstilling av dispergerbare sterol- og stanol-forbindelser
DE60013130T2 (de) Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten
CA2022465A1 (en) Process for micronizing slightly-soluble drug
AU4161589A (en) 7-substituted derivatives of 3,5-dihydroxyhept-6-ynoic acid, a process for the preparation thereof, the use thereof as pharmaceuticals, and intermediates
AU5061190A (en) Novel benzimidazole and azabenzimidazole derivatives, their methods of preparation, synthesis intermediates and pharmaceutical compositions in which they are present and which are useful especially for the treatment of cardiovascular diseases and duodenal ulcers
CA2227761A1 (en) Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizers
AU609149B2 (en) 3-demthylmevalonic acid derivatives, a process for their preparation pharmaceutical products based on these compounds, their use and intermediates
FI934869A (fi) Menetelmä seerumin korkean kolesterolitason alentamiseen käytettävän aineen valmistamiseksi
JPS6029470B2 (ja) 9α−ヒドロキシアンドロステンジオンを生産する微生物
WO2001040240A3 (en) Mono- and disaccharide derivatives
Shikita et al. 20α-Hydroxysteroid dehydrogenase of testes
Yates et al. Fine structure and chemical composition of opaque cytoplasmic bodies of triparanol treated Syrian hamsters
AU2293588A (en) New androstane 17-carboxylic acid ester, process for their preparation and drugs containing them
AU4700389A (en) Phosphonic acid substituted steroids as steroid 5alpha- reductase inhibitors
AU2753292A (en) Cholesterol lowering compounds and process for making them
AU777377B2 (en) Dibenzo(a,g)quinolizinium derivatives and the salts thereof
AU580086B2 (en) New steroids substituted at position 10 by a radical including a double or triple bond, their preparation process, their use as medicaments, pharmaceutical compositions containing them
JP2004521941A (ja) 水分散性ステロール類含有自由流動粉体の製造方法
AU3929789A (en) New 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as medicinal agents, pharmaceutical products and intermediates
KR20050009737A (ko) 다양한 질병, 질환 및 장애의 치료 또는 예방에 있어서아스코르브산과 결합한 안드로스탄 및 안드로스텐의신규한 유도체 및 그 용도
AU5411099A (en) Improved process for the preparation of salts and esters of clavulanic acid
HUT55793A (en) Process for producing new monosaccharide derivatives and pharmaceutical compositions containing them
HU901875D0 (en) Process for production of galenical preparations providing optimal biological accessibility of 2-hydroxi-5-methyl-laurophenon-oxim as active substance
EP0172034A3 (en) Microbiological degradation of steroids
JPH01229000A (ja) 2(3―ハイドロキシ―1,3,5(10)―エストリエン―17―イル)プロピオン酸の製造法

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application