NO993085L - 3-aryl-2-(1-substituerte-4-piperidinyl)-1(1-di)okso-3H-benzo[d]-isothiazolderivater, deres fremstilling og deres anvendelse som modulatorer av neurotransmitter funksjon - Google Patents
3-aryl-2-(1-substituerte-4-piperidinyl)-1(1-di)okso-3H-benzo[d]-isothiazolderivater, deres fremstilling og deres anvendelse som modulatorer av neurotransmitter funksjonInfo
- Publication number
- NO993085L NO993085L NO993085A NO993085A NO993085L NO 993085 L NO993085 L NO 993085L NO 993085 A NO993085 A NO 993085A NO 993085 A NO993085 A NO 993085A NO 993085 L NO993085 L NO 993085L
- Authority
- NO
- Norway
- Prior art keywords
- aryl
- lower alkyl
- acyl
- hydrogen
- piperidinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår 3- aryl-2-(l-substituert-4-piperidinyl)- l ,1-dioxo ¿ 3H-benzo[d]isothiazol- derivater og beslektede forbindelser av formel (I) hvor X og Y er halogen, lavere alkyl, lavere alkoxy, aryl-lavere alkoxy, acyl, hydroxy, nitro, amino, trifluormethyl og hydrogen; n, p og q er uavhengig hele tall på l eller 2; R er hydrogen, lavere alkyl, aryl-lavere alkyl, acyl, ~<CH2)m~ORl' -(CH2)mNHR1, formler (a) og O. ^-^^^-^"^^ (a) (b) hvor R, er hydrogen, lavere alkyl, aryl- lavere alkyl, acyl og lavere alkoxy- carbonyl; Z er hydrogen, halogen, lavere alkyl, lavere alkoxy og acyl; m er et helt tall på 2 til 4; s er et helt tall på l eller 2; og farmasøytisk akseptable syreaddisjonssalter derav og optiske isomertir derav hvor slike isomerer eksisterer. Forbindelsene av formel (I) ifølge foreliggende oppfinnelse er anvendbare som modulatorer av neuro- transmitterfunksjon slik som seroto- nergisk og adrenergisk, og er som sådanne anvendbare som antidepressive midler, og dopaminergisk funksjon, og kan som sådanne være anvendbare for sykdommer hvor potensiering av dopaminerg aktivitet kan være av hjelp, for eksempel Parkinsons sykdom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77486696A | 1996-12-23 | 1996-12-23 | |
| PCT/US1997/021178 WO1998028295A1 (en) | 1996-12-23 | 1997-11-13 | 3-aryl-2-(1-substituted-4-piperidinyl)-1(1-di)oxo-3h-benzo[d]-isothiazole derivatives, their preparation and their use as modulators of neurotransmitter function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO993085D0 NO993085D0 (no) | 1999-06-22 |
| NO993085L true NO993085L (no) | 1999-08-20 |
Family
ID=25102528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO993085A NO993085L (no) | 1996-12-23 | 1999-06-22 | 3-aryl-2-(1-substituerte-4-piperidinyl)-1(1-di)okso-3H-benzo[d]-isothiazolderivater, deres fremstilling og deres anvendelse som modulatorer av neurotransmitter funksjon |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0956287B1 (no) |
| JP (1) | JP3282827B2 (no) |
| KR (1) | KR20000062283A (no) |
| AR (1) | AR009440A1 (no) |
| AT (1) | ATE247111T1 (no) |
| AU (1) | AU716689B2 (no) |
| BR (1) | BR9714432A (no) |
| CA (1) | CA2273181C (no) |
| DE (1) | DE69724148T2 (no) |
| DK (1) | DK0956287T3 (no) |
| ES (1) | ES2200205T3 (no) |
| HU (1) | HUP9904071A3 (no) |
| IL (1) | IL130605A0 (no) |
| NO (1) | NO993085L (no) |
| PT (1) | PT956287E (no) |
| WO (1) | WO1998028295A1 (no) |
| ZA (1) | ZA9711337B (no) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1393351B1 (it) * | 2009-03-16 | 2012-04-20 | Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa | Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2509797C2 (de) * | 1975-03-06 | 1985-07-18 | Dr. Karl Thomae Gmbh, 7950 Biberach | Phthalimidine, deren physiologisch verträgliche Säureadditionssalze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| AT345806B (de) * | 1975-03-06 | 1978-10-10 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer substituierter arylalkylamine und deren salze |
| EP0429341A3 (en) * | 1989-11-20 | 1991-11-13 | Rhone-Poulenc Sante | Heterocyclic derivatives, their preparation and pharmaceuticals containing them |
| FR2662696A2 (fr) * | 1989-12-13 | 1991-12-06 | Rhone Poulenc Sante | Antagonistes de la serotonine, leur preparation et medicaments les contenant. |
| US5567718A (en) * | 1994-08-11 | 1996-10-22 | Hoechst Marion Roussel Inc. | 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors |
-
1997
- 1997-11-13 AU AU53588/98A patent/AU716689B2/en not_active Ceased
- 1997-11-13 WO PCT/US1997/021178 patent/WO1998028295A1/en not_active Application Discontinuation
- 1997-11-13 CA CA002273181A patent/CA2273181C/en not_active Expired - Fee Related
- 1997-11-13 KR KR1019997005678A patent/KR20000062283A/ko not_active Application Discontinuation
- 1997-11-13 ES ES97950636T patent/ES2200205T3/es not_active Expired - Lifetime
- 1997-11-13 DK DK97950636T patent/DK0956287T3/da active
- 1997-11-13 EP EP97950636A patent/EP0956287B1/en not_active Expired - Lifetime
- 1997-11-13 IL IL13060597A patent/IL130605A0/xx unknown
- 1997-11-13 AT AT97950636T patent/ATE247111T1/de not_active IP Right Cessation
- 1997-11-13 PT PT97950636T patent/PT956287E/pt unknown
- 1997-11-13 JP JP52874198A patent/JP3282827B2/ja not_active Expired - Fee Related
- 1997-11-13 BR BR9714432-0A patent/BR9714432A/pt not_active Application Discontinuation
- 1997-11-13 DE DE69724148T patent/DE69724148T2/de not_active Expired - Fee Related
- 1997-11-13 HU HU9904071A patent/HUP9904071A3/hu unknown
- 1997-12-17 ZA ZA9711337A patent/ZA9711337B/xx unknown
- 1997-12-19 AR ARP970106005A patent/AR009440A1/es unknown
-
1999
- 1999-06-22 NO NO993085A patent/NO993085L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT956287E (pt) | 2003-11-28 |
| DE69724148T2 (de) | 2004-06-09 |
| EP0956287B1 (en) | 2003-08-13 |
| HUP9904071A3 (en) | 2000-07-28 |
| AU716689B2 (en) | 2000-03-02 |
| AR009440A1 (es) | 2000-04-12 |
| CA2273181C (en) | 2004-01-20 |
| DK0956287T3 (da) | 2003-11-24 |
| IL130605A0 (en) | 2000-06-01 |
| WO1998028295A1 (en) | 1998-07-02 |
| ATE247111T1 (de) | 2003-08-15 |
| KR20000062283A (ko) | 2000-10-25 |
| HUP9904071A2 (hu) | 2000-05-28 |
| EP0956287A1 (en) | 1999-11-17 |
| ZA9711337B (en) | 1998-06-23 |
| ES2200205T3 (es) | 2004-03-01 |
| AU5358898A (en) | 1998-07-17 |
| CA2273181A1 (en) | 1998-07-02 |
| JP2001520641A (ja) | 2001-10-30 |
| JP3282827B2 (ja) | 2002-05-20 |
| NO993085D0 (no) | 1999-06-22 |
| DE69724148D1 (de) | 2003-09-18 |
| BR9714432A (pt) | 2000-05-02 |
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| Date | Code | Title | Description |
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| FC2A | Withdrawal, rejection or dismissal of laid open patent application |