BR9714432A - Derivados de 3-aril-2-(1-substituìdo-4-piperidinil)-1(1-di(oxo-3h-bezo [d]-isoatiazol, sua preparação e seu uso como moduladores de função neurotransmissora - Google Patents

Derivados de 3-aril-2-(1-substituìdo-4-piperidinil)-1(1-di(oxo-3h-bezo [d]-isoatiazol, sua preparação e seu uso como moduladores de função neurotransmissora

Info

Publication number
BR9714432A
BR9714432A BR9714432-0A BR9714432A BR9714432A BR 9714432 A BR9714432 A BR 9714432A BR 9714432 A BR9714432 A BR 9714432A BR 9714432 A BR9714432 A BR 9714432A
Authority
BR
Brazil
Prior art keywords
aryl
acyl
hydrogen
piperidinyl
useful
Prior art date
Application number
BR9714432-0A
Other languages
English (en)
Inventor
Gregory H Merriman
Barbara S Rauckmann
Original Assignee
Hoeschst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoeschst Marion Roussel Inc filed Critical Hoeschst Marion Roussel Inc
Publication of BR9714432A publication Critical patent/BR9714432A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Patente de Invenção: <B>"DERIVADOS DE 3-ARIL-2-(1-SUBSTITUìDO-4-PIPERIDINIL)-1(1-DI(OXO-3H-BENZ O[D]-ISOTIAZOL, SUA PREPARAçãO E SEU USO COMO MODULADORES DE FUNçãO NEUROTRANSMISSORA"<D>. Esta invenção refere-se a 3-aril-2-(1-substituído-4-piperidinil)-1,1-dioxo-3H-benzo[d]isotiazóis e compostos correlatos da fórmula (I) onde X e Y são independentemente halogênio, alquila inferior, alcóxi inferior, arila - alcóxi inferior, acila, hidróxi, nitro, amino, trifluorometila e hidrogênio; n, p e q são independentemente números inteiros de 1 ou 2; R é hidrogênio, alquila inferior, arila - alquila inferior, acila, -(CH2)~ m~-OR1, -(CH2)~ m~NHR1. fórmulas (a) e (b), onde R~ 1~ é hidrogênio, alquila inferior, arila - alquila inferior, acila e alcóxi inferior - carbonila; Z é hidrogênio, halogênio, alquila inferior, alcóxi inferior e acila; m é um número inteiro de 2 a 4; s é um número inteiro de 1 ou 2; e os seus sais de adição de ácido farmaceuticamente aceitáveis e os seus isómeros ópticos onde tais isómeros existem. Os compostos da fórmula (I) da presente invenção são úteis como moduladores de função neurotransmissora tais como serotonérgica e adrenérgica, e como tais são úteis como antidepressores, e função dopaminérgica e como tais podem ser úteis para doenças onde a potenciação da atividade dopaminérgica pode ser útil, por exemplo, Doença de Parkinson.
BR9714432-0A 1996-12-23 1997-11-13 Derivados de 3-aril-2-(1-substituìdo-4-piperidinil)-1(1-di(oxo-3h-bezo [d]-isoatiazol, sua preparação e seu uso como moduladores de função neurotransmissora BR9714432A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77486696A 1996-12-23 1996-12-23
PCT/US1997/021178 WO1998028295A1 (en) 1996-12-23 1997-11-13 3-aryl-2-(1-substituted-4-piperidinyl)-1(1-di)oxo-3h-benzo[d]-isothiazole derivatives, their preparation and their use as modulators of neurotransmitter function

Publications (1)

Publication Number Publication Date
BR9714432A true BR9714432A (pt) 2000-05-02

Family

ID=25102528

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9714432-0A BR9714432A (pt) 1996-12-23 1997-11-13 Derivados de 3-aril-2-(1-substituìdo-4-piperidinil)-1(1-di(oxo-3h-bezo [d]-isoatiazol, sua preparação e seu uso como moduladores de função neurotransmissora

Country Status (17)

Country Link
EP (1) EP0956287B1 (pt)
JP (1) JP3282827B2 (pt)
KR (1) KR20000062283A (pt)
AR (1) AR009440A1 (pt)
AT (1) ATE247111T1 (pt)
AU (1) AU716689B2 (pt)
BR (1) BR9714432A (pt)
CA (1) CA2273181C (pt)
DE (1) DE69724148T2 (pt)
DK (1) DK0956287T3 (pt)
ES (1) ES2200205T3 (pt)
HU (1) HUP9904071A3 (pt)
IL (1) IL130605A0 (pt)
NO (1) NO993085L (pt)
PT (1) PT956287E (pt)
WO (1) WO1998028295A1 (pt)
ZA (1) ZA9711337B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1393351B1 (it) * 2009-03-16 2012-04-20 Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2509797C2 (de) * 1975-03-06 1985-07-18 Dr. Karl Thomae Gmbh, 7950 Biberach Phthalimidine, deren physiologisch verträgliche Säureadditionssalze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
AT345806B (de) * 1975-03-06 1978-10-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer substituierter arylalkylamine und deren salze
EP0429341A3 (en) * 1989-11-20 1991-11-13 Rhone-Poulenc Sante Heterocyclic derivatives, their preparation and pharmaceuticals containing them
FR2662696A2 (fr) * 1989-12-13 1991-12-06 Rhone Poulenc Sante Antagonistes de la serotonine, leur preparation et medicaments les contenant.
US5567718A (en) * 1994-08-11 1996-10-22 Hoechst Marion Roussel Inc. 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors

Also Published As

Publication number Publication date
IL130605A0 (en) 2000-06-01
DK0956287T3 (da) 2003-11-24
NO993085L (no) 1999-08-20
NO993085D0 (no) 1999-06-22
PT956287E (pt) 2003-11-28
DE69724148D1 (de) 2003-09-18
WO1998028295A1 (en) 1998-07-02
AU5358898A (en) 1998-07-17
ZA9711337B (en) 1998-06-23
CA2273181C (en) 2004-01-20
ES2200205T3 (es) 2004-03-01
EP0956287B1 (en) 2003-08-13
HUP9904071A3 (en) 2000-07-28
ATE247111T1 (de) 2003-08-15
EP0956287A1 (en) 1999-11-17
KR20000062283A (ko) 2000-10-25
CA2273181A1 (en) 1998-07-02
JP3282827B2 (ja) 2002-05-20
DE69724148T2 (de) 2004-06-09
JP2001520641A (ja) 2001-10-30
AR009440A1 (es) 2000-04-12
AU716689B2 (en) 2000-03-02
HUP9904071A2 (hu) 2000-05-28

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: AVENTIS PHARMACEUTICALS INC. (US)

Free format text: ALTERADO DE: HOESCHST MARION ROUSSEL, INC.

B25I Requirement for requested change of headquarter

Owner name: AVENTIS PHARMACEUTICALS INC. (US)

Free format text: AFIM DE ATENDER A ALTERACAO DE SEDE SOLICITADA NA PETICAO NO 020080090002/RJ DE 27/06/2008, QUEIRAAPRESENTAR A GUIA DE PAGAMENTO REFERENTE A ESTE SERVICO.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25G Requested change of headquarter approved

Owner name: AVENTIS PHARMACEUTICALS INC. (US)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020090058737/RJ DE 15/06/2009.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8,13,24 E 25 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.