NO991776L - Aminotiofenkarboksylsyreamider og anvendelse derav som fosfodiesteraseinhibitorer - Google Patents
Aminotiofenkarboksylsyreamider og anvendelse derav som fosfodiesteraseinhibitorerInfo
- Publication number
- NO991776L NO991776L NO991776A NO991776A NO991776L NO 991776 L NO991776 L NO 991776L NO 991776 A NO991776 A NO 991776A NO 991776 A NO991776 A NO 991776A NO 991776 L NO991776 L NO 991776L
- Authority
- NO
- Norway
- Prior art keywords
- acid amides
- phosphodiesterase inhibitors
- aminothiophenecarboxylic
- aminothiophenecarboxylic acid
- phosphodiesterase
- Prior art date
Links
- BKDZTJNNXCNSCK-UHFFFAOYSA-N 3-aminothiophene-2-carboxamide Chemical class NC(=O)C=1SC=CC=1N BKDZTJNNXCNSCK-UHFFFAOYSA-N 0.000 title 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19642451A DE19642451A1 (de) | 1996-10-15 | 1996-10-15 | Aminothiophencarbonsäureamide |
| PCT/EP1997/005531 WO1998016521A1 (de) | 1996-10-15 | 1997-10-08 | Aminothiophencarbonsäureamide und ihre verwendung als phosphodiesterase inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO991776D0 NO991776D0 (no) | 1999-04-14 |
| NO991776L true NO991776L (no) | 1999-06-09 |
Family
ID=7808775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO991776A NO991776L (no) | 1996-10-15 | 1999-04-14 | Aminotiofenkarboksylsyreamider og anvendelse derav som fosfodiesteraseinhibitorer |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6143777A (cs) |
| EP (1) | EP0934301B1 (cs) |
| JP (1) | JP4243352B2 (cs) |
| KR (1) | KR100479811B1 (cs) |
| CN (1) | CN1110493C (cs) |
| AR (1) | AR009985A1 (cs) |
| AT (1) | ATE202347T1 (cs) |
| AU (1) | AU725741B2 (cs) |
| BR (1) | BR9712321A (cs) |
| CA (1) | CA2268886C (cs) |
| CZ (1) | CZ297253B6 (cs) |
| DE (2) | DE19642451A1 (cs) |
| DK (1) | DK0934301T3 (cs) |
| ES (1) | ES2159851T3 (cs) |
| GR (1) | GR3036341T3 (cs) |
| HU (1) | HUP9904703A3 (cs) |
| NO (1) | NO991776L (cs) |
| PL (1) | PL192109B1 (cs) |
| PT (1) | PT934301E (cs) |
| RU (1) | RU2184731C2 (cs) |
| SI (1) | SI0934301T1 (cs) |
| SK (1) | SK283807B6 (cs) |
| TW (1) | TW438791B (cs) |
| WO (1) | WO1998016521A1 (cs) |
| ZA (1) | ZA979199B (cs) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6727258B2 (en) * | 1997-10-29 | 2004-04-27 | King Pharmaceutical Research & Development, Inc. | Allosteric adenosine receptor modulators |
| US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
| JP2002518471A (ja) * | 1998-06-19 | 2002-06-25 | ノバルティス アクチエンゲゼルシャフト | ピリミジノン誘導体の製法 |
| US6200771B1 (en) | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
| US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
| US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
| US6369092B1 (en) | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
| US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
| US6077842A (en) * | 1998-11-24 | 2000-06-20 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives |
| US6034099A (en) * | 1998-11-24 | 2000-03-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones |
| US6020379A (en) * | 1999-02-19 | 2000-02-01 | Cell Pathways, Inc. | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia |
| US6479493B1 (en) | 2001-08-23 | 2002-11-12 | Cell Pathways, Inc. | Methods for treatment of type I diabetes |
| DE60228295D1 (de) * | 2001-09-21 | 2008-09-25 | Smithkline Beecham Corp | Chemische verbindungen |
| ATE414697T1 (de) * | 2001-10-04 | 2008-12-15 | Smithkline Beecham Corp | Nf-kb-inhibitoren |
| US7276529B2 (en) | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| US7208516B2 (en) | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| EP1524271A4 (en) * | 2002-07-24 | 2007-07-04 | Mitsui Chemicals Inc | PROCESS FOR THE PREPARATION OF 2-ALKYL-3-AMINOTHIOPHENE DERIVATIVES |
| US7179836B2 (en) * | 2002-09-20 | 2007-02-20 | Smithkline Beecham Corporation | Chemical compounds |
| RU2397168C2 (ru) * | 2004-01-05 | 2010-08-20 | Астразенека Аб | Производные тиофена в качестве ингибиторов снк 1 |
| FR2875807B1 (fr) | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| CA2602474C (en) * | 2005-03-23 | 2014-06-10 | Actelion Pharmaceuticals Ltd | Hydrogenated benzo (c) thiophene derivatives as immunomodulators |
| EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | アンジオテンシン調節による神経新生 |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| BRPI0716604A2 (pt) * | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| RU2472791C2 (ru) * | 2008-08-27 | 2013-01-20 | КалсиМедика Инк. | Соединения, модулирующие внутриклеточный кальций |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| RU2503671C1 (ru) * | 2012-07-31 | 2014-01-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" | (Z)-2-[(3-КАРБАМОИЛ-4,5,6,7-ТЕТРАГИДРОБЕНЗО[b]ТИЕН-2-ИЛ)АМИНО]-4-(4-R-ФЕНИЛ)-4-ОКСОБУТ-2-ЕНОВЫЕ КИСЛОТЫ, ОБЛАДАЮЩИЕ АНАЛЬГЕТИЧЕСКОЙ АКТИВНОСТЬЮ |
| RU2501795C1 (ru) * | 2012-10-01 | 2013-12-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" | N-R-АМИДЫ (Z)-2[(3-ЭТОКСИКАРБОНИЛ)-4,5,6,7-ТЕТРАГИДРОБЕНЗО[b]ТИЕН-2-ИЛ)АМИНО]-4-ФЕНИЛ-4-ОКСОБУТ-2-ЕНОВЫХ КИСЛОТ, ОБЛАДАЮЩИЕ АНАЛЬГЕТИЧЕСКОЙ АКТИВНОСТЬЮ |
| JP6687550B2 (ja) | 2014-06-23 | 2020-04-22 | セルジーン コーポレイション | 肝疾患又は肝機能異常を治療するためのアプレミラスト |
| WO2019226490A1 (en) | 2018-05-22 | 2019-11-28 | Gilead Sciences, Inc. | Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives |
| RU2722176C1 (ru) * | 2019-09-06 | 2020-05-28 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" | (z)-2((4-r1-5-r2-3-(этоксикарбонил)тиофен-2-ил)амино)-4-оксо-4-r3-бут-2-еновые кислоты, обладающие противомикробной активностью |
| JP2023537271A (ja) * | 2020-07-24 | 2023-08-31 | イニファーム，インク． | チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 |
| IL302764A (en) | 2020-11-13 | 2023-07-01 | Inipharm Inc | Dichlorophenol HSD17B13 inhibitors and their uses |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075310A (en) * | 1988-07-01 | 1991-12-24 | Smith Kline & French Laboratories, Ltd. | Pyrimidone derivatives as bronchodilators |
| US5047555A (en) * | 1988-12-13 | 1991-09-10 | Tanabe Seiyaku Co., Ltd. | 4-aminophenol derivatives and processes for preparing the same |
| US5753692A (en) * | 1992-02-19 | 1998-05-19 | Industrial Technology Research Institute | Medicinal thiophene compounds |
| US5356926A (en) * | 1992-02-24 | 1994-10-18 | Warner-Lambert Company | 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion |
| DE4230755A1 (de) * | 1992-09-14 | 1994-03-17 | Schering Ag | Verwendung von PDE-Inhibitoren bei der Behandlung von Nieren- und Ureter-Erkrankungen |
| DE4233198A1 (de) * | 1992-10-02 | 1994-04-07 | Bayer Ag | Substituierte Thiophencarbonsäureamide |
| DK148292D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Forbindelser |
| GB9309324D0 (en) * | 1993-05-06 | 1993-06-16 | Bayer Ag | Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives |
| DE4317076A1 (de) * | 1993-05-21 | 1994-11-24 | Bayer Ag | Benzthiophencarbonsäureamid-S-oxide |
| DE69507197T2 (de) * | 1994-05-31 | 1999-05-27 | Bayer Ag, 51373 Leverkusen | Aminobenzofuryl- und -thienylderivate |
| US5863936A (en) * | 1995-04-18 | 1999-01-26 | Geron Corporation | Telomerase inhibitors |
| CA2268164A1 (en) * | 1996-10-08 | 1998-04-16 | Yao-Chang Xu | New serotonin 5-ht1f agonists |
| US5783597A (en) * | 1997-03-04 | 1998-07-21 | Ortho Pharmaceutical Corporation | 2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and inducible cyclooxygenase (COX-2) enzymes, composition and use |
-
1996
- 1996-10-15 DE DE19642451A patent/DE19642451A1/de not_active Withdrawn
-
1997
- 1997-10-06 TW TW086114589A patent/TW438791B/zh active
- 1997-10-08 CN CN97198839A patent/CN1110493C/zh not_active Expired - Fee Related
- 1997-10-08 DE DE59703869T patent/DE59703869D1/de not_active Expired - Lifetime
- 1997-10-08 ES ES97912140T patent/ES2159851T3/es not_active Expired - Lifetime
- 1997-10-08 US US09/284,501 patent/US6143777A/en not_active Expired - Fee Related
- 1997-10-08 WO PCT/EP1997/005531 patent/WO1998016521A1/de not_active Ceased
- 1997-10-08 RU RU99109576/04A patent/RU2184731C2/ru not_active IP Right Cessation
- 1997-10-08 SK SK432-99A patent/SK283807B6/sk unknown
- 1997-10-08 JP JP51798698A patent/JP4243352B2/ja not_active Expired - Fee Related
- 1997-10-08 BR BR9712321-8A patent/BR9712321A/pt not_active Application Discontinuation
- 1997-10-08 PT PT97912140T patent/PT934301E/pt unknown
- 1997-10-08 DK DK97912140T patent/DK0934301T3/da active
- 1997-10-08 CZ CZ0124099A patent/CZ297253B6/cs not_active IP Right Cessation
- 1997-10-08 EP EP97912140A patent/EP0934301B1/de not_active Expired - Lifetime
- 1997-10-08 AT AT97912140T patent/ATE202347T1/de not_active IP Right Cessation
- 1997-10-08 AU AU49451/97A patent/AU725741B2/en not_active Ceased
- 1997-10-08 CA CA002268886A patent/CA2268886C/en not_active Expired - Fee Related
- 1997-10-08 KR KR10-1999-7003246A patent/KR100479811B1/ko not_active Expired - Fee Related
- 1997-10-08 PL PL332802A patent/PL192109B1/pl unknown
- 1997-10-08 HU HU9904703A patent/HUP9904703A3/hu unknown
- 1997-10-08 SI SI9730192T patent/SI0934301T1/xx unknown
- 1997-10-14 ZA ZA9709199A patent/ZA979199B/xx unknown
- 1997-10-15 AR ARP970104736A patent/AR009985A1/es not_active Application Discontinuation
-
1999
- 1999-04-14 NO NO991776A patent/NO991776L/no not_active Application Discontinuation
-
2001
- 2001-08-07 GR GR20010401193T patent/GR3036341T3/el not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |