NO985518L - Morfinanderivater og medisinsk anvendelse derav - Google Patents

Morfinanderivater og medisinsk anvendelse derav

Info

Publication number
NO985518L
NO985518L NO985518A NO985518A NO985518L NO 985518 L NO985518 L NO 985518L NO 985518 A NO985518 A NO 985518A NO 985518 A NO985518 A NO 985518A NO 985518 L NO985518 L NO 985518L
Authority
NO
Norway
Prior art keywords
medical use
morphine derivatives
morphinan derivatives
opioid
epsilon
Prior art date
Application number
NO985518A
Other languages
English (en)
Norwegian (no)
Other versions
NO985518D0 (no
Inventor
Hiroshi Nagase
Hideaki Fujii
Takashi Endoh
Koji Kawai
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of NO985518D0 publication Critical patent/NO985518D0/no
Publication of NO985518L publication Critical patent/NO985518L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO985518A 1997-03-27 1998-11-26 Morfinanderivater og medisinsk anvendelse derav NO985518L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7634097 1997-03-27
PCT/JP1998/001376 WO1998043978A1 (fr) 1997-03-27 1998-03-27 Derives de morphinane et usage medical de ces derniers

Publications (2)

Publication Number Publication Date
NO985518D0 NO985518D0 (no) 1998-11-26
NO985518L true NO985518L (no) 1999-01-21

Family

ID=13602637

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985518A NO985518L (no) 1997-03-27 1998-11-26 Morfinanderivater og medisinsk anvendelse derav

Country Status (12)

Country Link
US (1) US6187782B1 (fr)
EP (1) EP0915094B1 (fr)
KR (1) KR20000016052A (fr)
CN (1) CN1150196C (fr)
AT (1) ATE377602T1 (fr)
AU (1) AU743929B2 (fr)
CA (1) CA2256897C (fr)
DE (1) DE69838662T2 (fr)
ES (1) ES2297882T3 (fr)
NO (1) NO985518L (fr)
NZ (1) NZ333101A (fr)
WO (1) WO1998043978A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2308990T3 (es) * 1999-08-24 2008-12-16 Toray Industries, Inc. Remedios para el dolor neuropatico y modelos animales de dolor neuropatico.
CA2674915C (fr) * 2006-10-17 2015-06-30 Penick Corporation Procede servant a preparer de l'oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
EP2073636B1 (fr) 2006-10-17 2012-09-05 Penick Corporation Procédé servant à préparer de l'oxymorphone
AU2012216358B2 (en) * 2006-10-17 2014-11-20 Penick Corporation Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
PL2522667T3 (pl) 2007-05-01 2015-01-30 Concert Pharmaceuticals Inc Związki morfinanu
CA3208128A1 (fr) 2007-05-01 2008-11-13 Sun Pharmaceutical Industries, Inc. Composes de morphinane
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
US8686158B2 (en) 2008-06-05 2014-04-01 President And Fellows Of Harvard College High-valent palladium fluoride complexes and uses thereof
KR101682963B1 (ko) * 2008-10-24 2016-12-06 도레이 카부시키가이샤 4,5-에폭시모르피난 유도체를 함유하는 안정한 정제
KR20110095898A (ko) 2008-11-20 2011-08-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 유기 화합물의 플루오르화
KR20110104097A (ko) * 2009-01-09 2011-09-21 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 불소 함유 화합물 및 이의 사용방법
JP2014073964A (ja) * 2011-01-28 2014-04-24 Kitasato Institute モルヒナン誘導体
US9150516B2 (en) 2011-04-12 2015-10-06 President And Fellows Of Harvard College Fluorination of organic compounds
JP6061857B2 (ja) 2011-09-09 2017-01-18 学校法人北里研究所 モルヒナン誘導体
WO2014021273A1 (fr) * 2012-07-30 2014-02-06 学校法人北里研究所 Dérivés morphinane
WO2014052622A1 (fr) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Complexes de fluoration de nickel et leurs utilisations
JP6181770B2 (ja) 2012-12-31 2017-08-16 ローズ テクノロジーズ ７β−置換６α，１４α−エテノモルフィナンおよび７β−置換６α，１４α−エタノモルフィナンを調製するための方法
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
WO2015058047A2 (fr) 2013-10-18 2015-04-23 President And Fellows Of Harvard College Fluoration de composés organiques
JP6814470B2 (ja) * 2017-02-10 2021-01-20 国立大学法人 筑波大学 モルヒナン誘導体
WO2019045006A1 (fr) * 2017-08-31 2019-03-07 日本ケミファ株式会社 Dérivé de morphinane
WO2019168025A1 (fr) * 2018-02-28 2019-09-06 日本ケミファ株式会社 Procédé de production de dérivés de morphinane
JP2021104932A (ja) * 2018-03-30 2021-07-26 日本ケミファ株式会社 モルヒナン誘導体の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2229770A1 (de) 1972-06-19 1974-01-10 Boehringer Sohn Ingelheim N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung
ZA855058B (en) 1984-07-05 1987-03-25 Du Pont Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes
PT95069B (pt) 1989-08-24 1997-10-31 Searle & Co Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos
ES2121988T3 (es) * 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.

Also Published As

Publication number Publication date
EP0915094B1 (fr) 2007-11-07
ES2297882T3 (es) 2008-05-01
AU743929B2 (en) 2002-02-07
DE69838662D1 (de) 2007-12-20
AU6518998A (en) 1998-10-22
EP0915094A4 (fr) 2004-09-22
EP0915094A1 (fr) 1999-05-12
WO1998043978A1 (fr) 1998-10-08
NZ333101A (en) 2000-05-26
CA2256897A1 (fr) 1998-10-08
CN1150196C (zh) 2004-05-19
DE69838662T2 (de) 2008-08-28
CA2256897C (fr) 2006-10-03
KR20000016052A (ko) 2000-03-25
ATE377602T1 (de) 2007-11-15
CN1220667A (zh) 1999-06-23
US6187782B1 (en) 2001-02-13
NO985518D0 (no) 1998-11-26

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