NO983991L - Serin-protease-inhibitorer - Google Patents
Serin-protease-inhibitorerInfo
- Publication number
- NO983991L NO983991L NO983991A NO983991A NO983991L NO 983991 L NO983991 L NO 983991L NO 983991 A NO983991 A NO 983991A NO 983991 A NO983991 A NO 983991A NO 983991 L NO983991 L NO 983991L
- Authority
- NO
- Norway
- Prior art keywords
- protease inhibitors
- serine protease
- thrombin
- prodrug
- prevention
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96200543 | 1996-03-01 | ||
PCT/EP1997/000938 WO1997031937A1 (en) | 1996-03-01 | 1997-02-26 | Serine protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO983991D0 NO983991D0 (no) | 1998-08-31 |
NO983991L true NO983991L (no) | 1998-10-30 |
Family
ID=8223736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO983991A NO983991L (no) | 1996-03-01 | 1998-08-31 | Serin-protease-inhibitorer |
Country Status (26)
Country | Link |
---|---|
US (1) | US6410684B1 (ru) |
EP (1) | EP0886647B1 (ru) |
JP (1) | JP2000506837A (ru) |
KR (1) | KR19990087415A (ru) |
CN (1) | CN1212704A (ru) |
AR (1) | AR006310A1 (ru) |
AT (1) | ATE221080T1 (ru) |
AU (1) | AU709330B2 (ru) |
BR (1) | BR9707808A (ru) |
CA (1) | CA2246246A1 (ru) |
CZ (1) | CZ277898A3 (ru) |
DE (1) | DE69714222T2 (ru) |
DK (1) | DK0886647T3 (ru) |
ES (1) | ES2180933T3 (ru) |
HK (1) | HK1021541A1 (ru) |
HU (1) | HUP9900390A3 (ru) |
IL (1) | IL120310A (ru) |
NO (1) | NO983991L (ru) |
NZ (1) | NZ331484A (ru) |
PL (1) | PL328875A1 (ru) |
PT (1) | PT886647E (ru) |
RU (1) | RU2178419C2 (ru) |
TR (1) | TR199801704T2 (ru) |
TW (1) | TW442452B (ru) |
WO (1) | WO1997031937A1 (ru) |
ZA (1) | ZA971667B (ru) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ291690B6 (cs) * | 1996-02-13 | 2003-05-14 | Akzo Nobel N. V. | Inhibitory serinové proteázy a farmaceutický prostředek |
AU7292398A (en) | 1997-05-15 | 1998-12-08 | Eli Lilly And Company | Antithrombotic compound |
CN1198838C (zh) | 1998-04-30 | 2005-04-27 | 阿格罗尼制药公司 | 抗小rna病毒化合物及其制备方法和用途 |
EP1105412A1 (en) * | 1998-08-17 | 2001-06-13 | Cortech, Inc. | Serine protease inhibitors comprising alpha-keto heterocycles |
AU3731400A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
US6849605B1 (en) | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
US6489308B1 (en) | 1999-03-05 | 2002-12-03 | Trustees Of University Of Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions |
ES2230135T3 (es) * | 1999-08-04 | 2005-05-01 | Agouron Pharmaceuticals, Inc. | Compuestos y composiciones anti-picornavirales; utilizaciones farmaceuticas y materiales utilizados para su sintesis. |
HUP0301331A3 (en) | 2000-06-14 | 2004-03-01 | Agouron Pharmaceuticals Inc La | Antipicornaviral compounds process for their preparation and compositions containing them, their pharmaceutical uses, and intermediates for their synthesis |
PL206255B1 (pl) | 2000-07-21 | 2010-07-30 | Dendreon Corporationdendreon Corporation | Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii |
CZ2003195A3 (cs) * | 2000-07-21 | 2003-04-16 | Schering Corporation | Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostředek |
US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
WO2002060894A2 (en) | 2001-01-30 | 2002-08-08 | Bristol-Myers Squibb Company | Sulfonamide lactam inhibitors of factor xa |
US7405210B2 (en) * | 2003-05-21 | 2008-07-29 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
WO2005085245A1 (en) | 2004-03-08 | 2005-09-15 | Prosidion Limited | Pyrrolopyridine-2-carboxylic acid hydrazides |
ATE424821T1 (de) | 2004-12-02 | 2009-03-15 | Prosidion Ltd | Pyrrolopyridin-2-karbonsäureamide |
BRPI0823193A2 (pt) * | 2008-10-15 | 2019-09-24 | Danisco Us Inc | inibidores de protease de bowman birk variantes modificados |
EP4257191A3 (en) | 2016-06-21 | 2023-11-22 | Orion Ophthalmology LLC | Heterocyclic prolinamide derivatives |
JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556655A (en) * | 1984-09-24 | 1985-12-03 | Schering Corporation | Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity |
ZW11290A1 (en) | 1989-07-14 | 1990-10-31 | Smithkline Beecham Corp | Hemoregulatory peptides |
EP0699074B1 (en) * | 1993-04-30 | 2002-11-13 | Merck & Co. Inc. | Thrombin inhibitors |
SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
ZA951618B (en) | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
ZA951617B (en) | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
WO1995035311A1 (en) * | 1994-06-17 | 1995-12-28 | Corvas International, Inc. | 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors |
JPH0820597A (ja) * | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
EE9700113A (et) * | 1994-12-22 | 1997-12-15 | Biochem Pharma Inc. | Madala molekulmassiga bitsüklilised trombiini inhibiitorid |
-
1997
- 1997-02-25 IL IL12031097A patent/IL120310A/en not_active IP Right Cessation
- 1997-02-25 TW TW086102261A patent/TW442452B/zh not_active IP Right Cessation
- 1997-02-26 CZ CZ982778A patent/CZ277898A3/cs unknown
- 1997-02-26 WO PCT/EP1997/000938 patent/WO1997031937A1/en not_active Application Discontinuation
- 1997-02-26 CN CN97192682A patent/CN1212704A/zh active Pending
- 1997-02-26 US US09/142,110 patent/US6410684B1/en not_active Expired - Fee Related
- 1997-02-26 DE DE69714222T patent/DE69714222T2/de not_active Expired - Fee Related
- 1997-02-26 BR BR9707808A patent/BR9707808A/pt not_active Application Discontinuation
- 1997-02-26 AU AU18775/97A patent/AU709330B2/en not_active Ceased
- 1997-02-26 PT PT97905099T patent/PT886647E/pt unknown
- 1997-02-26 RU RU98117949/04A patent/RU2178419C2/ru active
- 1997-02-26 JP JP9530600A patent/JP2000506837A/ja not_active Ceased
- 1997-02-26 DK DK97905099T patent/DK0886647T3/da active
- 1997-02-26 ZA ZA9701667A patent/ZA971667B/xx unknown
- 1997-02-26 HU HU9900390A patent/HUP9900390A3/hu unknown
- 1997-02-26 KR KR1019980706833A patent/KR19990087415A/ko not_active Application Discontinuation
- 1997-02-26 AT AT97905099T patent/ATE221080T1/de not_active IP Right Cessation
- 1997-02-26 PL PL97328875A patent/PL328875A1/xx unknown
- 1997-02-26 TR TR1998/01704T patent/TR199801704T2/xx unknown
- 1997-02-26 ES ES97905099T patent/ES2180933T3/es not_active Expired - Lifetime
- 1997-02-26 NZ NZ331484A patent/NZ331484A/xx unknown
- 1997-02-26 CA CA002246246A patent/CA2246246A1/en not_active Abandoned
- 1997-02-26 EP EP97905099A patent/EP0886647B1/en not_active Expired - Lifetime
- 1997-03-03 AR ARP970100833A patent/AR006310A1/es unknown
-
1998
- 1998-08-31 NO NO983991A patent/NO983991L/no not_active Application Discontinuation
-
1999
- 1999-06-22 HK HK99102658A patent/HK1021541A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1212704A (zh) | 1999-03-31 |
DE69714222T2 (de) | 2003-02-20 |
RU2178419C2 (ru) | 2002-01-20 |
NO983991D0 (no) | 1998-08-31 |
CZ277898A3 (cs) | 1999-06-16 |
AU709330B2 (en) | 1999-08-26 |
EP0886647B1 (en) | 2002-07-24 |
WO1997031937A1 (en) | 1997-09-04 |
TR199801704T2 (xx) | 1998-12-21 |
IL120310A (en) | 2002-02-10 |
DK0886647T3 (da) | 2002-11-04 |
JP2000506837A (ja) | 2000-06-06 |
HUP9900390A2 (hu) | 1999-06-28 |
US6410684B1 (en) | 2002-06-25 |
HUP9900390A3 (en) | 2000-11-28 |
NZ331484A (en) | 2000-01-28 |
IL120310A0 (en) | 1997-06-10 |
DE69714222D1 (de) | 2002-08-29 |
PT886647E (pt) | 2002-12-31 |
AR006310A1 (es) | 1999-08-25 |
AU1877597A (en) | 1997-09-16 |
ATE221080T1 (de) | 2002-08-15 |
ZA971667B (en) | 1997-09-10 |
PL328875A1 (en) | 1999-03-01 |
TW442452B (en) | 2001-06-23 |
ES2180933T3 (es) | 2003-02-16 |
KR19990087415A (ko) | 1999-12-27 |
BR9707808A (pt) | 1999-07-27 |
HK1021541A1 (en) | 2000-06-16 |
CA2246246A1 (en) | 1997-09-04 |
EP0886647A1 (en) | 1998-12-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |