NO982950L - Fenyltiazolderivater med inti-herpesvirus-egenskaper - Google Patents

Fenyltiazolderivater med inti-herpesvirus-egenskaper

Info

Publication number
NO982950L
NO982950L NO982950A NO982950A NO982950L NO 982950 L NO982950 L NO 982950L NO 982950 A NO982950 A NO 982950A NO 982950 A NO982950 A NO 982950A NO 982950 L NO982950 L NO 982950L
Authority
NO
Norway
Prior art keywords
inti
herpes
methods
derivatives
phenylthiazole derivatives
Prior art date
Application number
NO982950A
Other languages
English (en)
Norwegian (no)
Other versions
NO982950D0 (no
Inventor
James J Crute
Anne-Marie Faucher
Christine A Grygon
Karl D Hargrave
Bruno Simoneau
Bounkham Thavonekham
Original Assignee
Boehringer Ingelheim Pharma
Boehringer Ingelheim Ca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Boehringer Ingelheim Ca Ltd filed Critical Boehringer Ingelheim Pharma
Publication of NO982950L publication Critical patent/NO982950L/no
Publication of NO982950D0 publication Critical patent/NO982950D0/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/40Unsubstituted amino or imino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/42Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/46Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/48Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO982950A 1995-12-29 1998-06-25 Fenyltiazolderivater med inti-herpesvirus-egenskaper NO982950D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US943395P 1995-12-29 1995-12-29
US2320996P 1996-08-02 1996-08-02
PCT/US1996/019131 WO1997024343A1 (en) 1995-12-29 1996-12-04 Phenyl thiazole derivatives with anti herpes virus properties

Publications (2)

Publication Number Publication Date
NO982950L true NO982950L (no) 1998-06-25
NO982950D0 NO982950D0 (no) 1998-06-25

Family

ID=26679472

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982950A NO982950D0 (no) 1995-12-29 1998-06-25 Fenyltiazolderivater med inti-herpesvirus-egenskaper

Country Status (26)

Country Link
US (3) US6057451A (de)
EP (1) EP0871619B1 (de)
JP (1) JP4327249B2 (de)
KR (1) KR19990076964A (de)
AR (1) AR037060A1 (de)
AT (1) ATE227279T1 (de)
AU (1) AU1682897A (de)
BG (1) BG102583A (de)
BR (1) BR9612435A (de)
CA (1) CA2192433C (de)
CZ (1) CZ207298A3 (de)
DE (1) DE69624728T2 (de)
DK (1) DK0871619T3 (de)
EA (1) EA199800611A1 (de)
EE (1) EE9800154A (de)
ES (1) ES2186811T3 (de)
HU (1) HUP9902341A2 (de)
IL (1) IL124436A0 (de)
MX (1) MX9805291A (de)
NO (1) NO982950D0 (de)
NZ (1) NZ331104A (de)
PL (1) PL327582A1 (de)
PT (1) PT871619E (de)
SK (1) SK89398A3 (de)
TR (1) TR199801244T2 (de)
WO (1) WO1997024343A1 (de)

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WO2000029399A1 (en) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds
US6166028A (en) 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
JP2002538151A (ja) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カテプシンの可逆的インヒビターとして有用な化合物
DE50008597D1 (de) * 1999-03-08 2004-12-16 Bayer Healthcare Ag Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel
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DE10038022A1 (de) * 2000-08-04 2002-02-14 Bayer Ag Inverse Thiazolylamid-Derivate
KR100453078B1 (ko) * 2000-08-21 2004-10-15 주식회사 태평양 신규 티오우레아 화합물 및 이를 함유하는 약제학적 조성물
ATE393141T1 (de) * 2000-08-21 2008-05-15 Pacific Corp Neue thiourea-derivate und pharmazeutische zusammensetzungen die diese enthalten
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KR20050039573A (ko) * 2003-10-23 2005-04-29 주식회사 태평양 티오우레아계 유도체의 용해성과 생체이용률이 개선된약제학적 조성물
WO2005051318A2 (en) * 2003-11-24 2005-06-09 Viropharma Incorporated Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
NZ549787A (en) 2004-03-12 2010-05-28 Vasgene Therapeutics Inc Antibodies binding to EphB4 for inhibiting angiogenesis and tumor growth
JP5011739B2 (ja) * 2005-02-03 2012-08-29 アステラス製薬株式会社 テトラヒドロ−2h−チオピラン−4−カルボキサミド誘導体を含有する医薬組成物
DE102005014248A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid
EA200702445A1 (ru) 2005-05-09 2008-04-28 Ачиллион Фармасьютикалз, Инк. Соединения тиазола и способы их применения
US20070021434A1 (en) * 2005-06-24 2007-01-25 Migenix Inc. Non-nucleoside anti-hepacivirus agents and uses thereof
CA2637530A1 (en) * 2006-01-18 2007-09-07 Siena Biotech S.P.A. Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof
EP2069286B1 (de) * 2006-08-30 2012-09-19 F. Hoffmann-La Roche AG Glyt-1-hemmer
TW200906826A (en) * 2007-06-12 2009-02-16 Genelabs Tech Inc Anti-viral inhibitors and methods of use
EP2351565A1 (de) 2008-10-20 2011-08-03 Astellas Pharma Inc. Medizin zur verhinderung oder behandlung von schmerzen aufgrund von gürtelrose
EP2384320B1 (de) 2009-01-05 2015-03-04 Boehringer Ingelheim International GmbH Den cb2-rezeptor modulierende pyrrolidinverbindungen
WO2011047390A2 (en) 2009-10-16 2011-04-21 University Of Maryland, Baltimore County Heterocyclic benzoxazole compositions as inhibitors of hepatitis c virus
WO2012113920A1 (en) 2011-02-24 2012-08-30 Katholieke Universiteit Leuven Arylsulfone derivatives with activity against human betaherpesviruses
KR101399484B1 (ko) * 2011-07-14 2014-05-29 한국화학연구원 허피스바이러스 엑소뉴클리에이즈 활성 억제 물질을 유효성분으로 함유하는 항허피스바이러스용 약학적 조성물
UY35772A (es) 2013-10-14 2015-05-29 Bayer Cropscience Ag Nuevos compuestos plaguicidas
WO2016077232A2 (en) * 2014-11-10 2016-05-19 Forge Life Science, Llc Anti-hcmv compositions and methods
EP3256461B1 (de) * 2015-02-13 2023-09-13 Azienda Ospedaliera Universitaria Senese Harnstoff- und sulfonamidderivate als humane helikase ddx3-hemmer zur behandlung von viruserkrankungen
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US11452717B2 (en) 2017-01-10 2022-09-27 Sanford Burnham Prebys Medical Discovery Institute Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof
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Also Published As

Publication number Publication date
US6348477B1 (en) 2002-02-19
CA2192433C (en) 2008-01-08
JP4327249B2 (ja) 2009-09-09
ES2186811T3 (es) 2003-05-16
PT871619E (pt) 2003-03-31
HUP9902341A2 (hu) 1999-10-28
AR037060A1 (es) 2004-10-20
JP2000502702A (ja) 2000-03-07
AU1682897A (en) 1997-07-28
CZ207298A3 (cs) 1998-11-11
WO1997024343A1 (en) 1997-07-10
MX9805291A (es) 1998-10-31
EE9800154A (et) 1998-12-15
KR19990076964A (ko) 1999-10-25
NO982950D0 (no) 1998-06-25
TR199801244T2 (xx) 1998-12-21
BG102583A (en) 1999-06-30
US6458959B1 (en) 2002-10-01
DK0871619T3 (da) 2003-03-03
BR9612435A (pt) 1999-07-13
DE69624728T2 (de) 2003-07-10
ATE227279T1 (de) 2002-11-15
EP0871619A1 (de) 1998-10-21
IL124436A0 (en) 1998-12-06
SK89398A3 (en) 1998-11-04
EA199800611A1 (ru) 1999-04-29
US6057451A (en) 2000-05-02
EP0871619B1 (de) 2002-11-06
DE69624728D1 (de) 2002-12-12
NZ331104A (en) 2000-03-27
PL327582A1 (en) 1998-12-21
CA2192433A1 (en) 1997-06-30

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