NO972892L - Bicykliske lavmolekylvekts-trombin-inhibitorer - Google Patents
Bicykliske lavmolekylvekts-trombin-inhibitorerInfo
- Publication number
- NO972892L NO972892L NO972892A NO972892A NO972892L NO 972892 L NO972892 L NO 972892L NO 972892 A NO972892 A NO 972892A NO 972892 A NO972892 A NO 972892A NO 972892 L NO972892 L NO 972892L
- Authority
- NO
- Norway
- Prior art keywords
- bicyclic
- molecular weight
- low molecular
- thrombin inhibitors
- weight thrombin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Foreliggende oppfinnelse angår heterocykliske, kompetitive inhibitorer av enzymet trombin, fremstilling av (dem og farmasøytiske preparater derav. Oppfinnelsen angår også anvendelse av slike forbindelser og preparater in vitro som antikoaguleringsmidler og in vivo som midler for befiandling og profylakse av trombotiske lidelser så som venøs trombose, lungeemboli og arterien trombose som er et resultat av akutte ischemi, så som myokardialt infarkt eller cerebralt infarkt. Disse forbindelsene og preparatene er videre terapeutisk nyttige for forhindring og behandling av koagulopatier knyttet til hjerte-bypass-operasjoner så vel som restenose etter transluminal angioplasti.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9426038.7A GB9426038D0 (en) | 1994-12-22 | 1994-12-22 | Low molecular weight bicyclic thrombin inhibitors |
GBGB9503136.5A GB9503136D0 (en) | 1994-12-22 | 1995-02-17 | Low molecular weight bicyclic thrombin inhibitors |
GBGB9510267.9A GB9510267D0 (en) | 1995-05-22 | 1995-05-22 | Low molecular weight thiobicyclic thrombin inhibitors |
GBGB9510265.3A GB9510265D0 (en) | 1995-05-22 | 1995-05-22 | Low molecular weight diaminobicyclic thrombin inhibitors |
GBGB9510266.1A GB9510266D0 (en) | 1995-05-22 | 1995-05-22 | Low molecular weight bicyclic thrombin inhibitors |
PCT/CA1995/000708 WO1996019483A1 (en) | 1994-12-22 | 1995-12-21 | Low molecular weight bicyclic thrombin inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO972892D0 NO972892D0 (no) | 1997-06-20 |
NO972892L true NO972892L (no) | 1997-08-20 |
Family
ID=27517273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO972892A NO972892L (no) | 1994-12-22 | 1997-06-20 | Bicykliske lavmolekylvekts-trombin-inhibitorer |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0802916A1 (no) |
JP (1) | JPH11508535A (no) |
CN (1) | CN1175259A (no) |
AP (1) | AP9701004A0 (no) |
AU (2) | AU4250596A (no) |
BG (1) | BG101647A (no) |
CA (1) | CA2208772A1 (no) |
CZ (1) | CZ189997A3 (no) |
EE (1) | EE9700113A (no) |
FI (1) | FI972466A (no) |
HU (1) | HUT77651A (no) |
IL (1) | IL116503A0 (no) |
IS (1) | IS4504A (no) |
LV (1) | LV12019B (no) |
MD (1) | MD970253A (no) |
MX (1) | MX9704718A (no) |
NO (1) | NO972892L (no) |
NZ (1) | NZ297360A (no) |
OA (1) | OA10493A (no) |
PL (1) | PL320965A1 (no) |
SK (1) | SK83897A3 (no) |
WO (1) | WO1996019483A1 (no) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6699869B1 (en) | 1995-03-24 | 2004-03-02 | Myriad Genetics Inc. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
US6020331A (en) * | 1995-03-24 | 2000-02-01 | Molecumetics, Ltd. | β-sheet mimetics and use thereof as protease inhibitors |
US6245764B1 (en) | 1995-03-24 | 2001-06-12 | Molecumetics Ltd. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
IT1277405B1 (it) * | 1995-08-01 | 1997-11-10 | Menarini Farma Ind | Derivati di lattami biciclici come inibitori della trombina |
IL119466A (en) | 1995-11-03 | 2001-08-26 | Akzo Nobel Nv | Thrombin inhibitors, their preparation and pharmaceutical compositions containing them |
US6034067A (en) * | 1996-02-13 | 2000-03-07 | Akzo Nobel, N.V. | Serine protease inhibitors |
IL120310A (en) * | 1996-03-01 | 2002-02-10 | Akzo Nobel Nv | Serine protease inhibitors and pharmaceuticals containing them |
TW523513B (en) * | 1996-03-01 | 2003-03-11 | Akzo Nobel Nv | Serine protease inhibitors |
US6124291A (en) * | 1996-06-18 | 2000-09-26 | Warner-Lambert Company | Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors |
EP1661566A3 (en) * | 1996-08-05 | 2008-04-16 | Myriad Genetics, Inc. | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors |
CA2262900A1 (en) * | 1996-08-05 | 1998-02-12 | Molecumetics Ltd. | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors |
US6117896A (en) | 1997-02-10 | 2000-09-12 | Molecumetics Ltd. | Methods for regulating transcription factors |
AU4172397A (en) * | 1996-09-06 | 1998-03-26 | Biochem Pharma Inc. | Lactam inhibitors of thrombin |
US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
WO1998028326A1 (en) * | 1996-12-23 | 1998-07-02 | Biochem Pharma Inc. | Bicyclic thrombin inhibitors |
EP0975659A1 (en) * | 1997-04-14 | 2000-02-02 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
AU6896298A (en) | 1997-04-14 | 1998-11-11 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
NZ500352A (en) | 1997-04-14 | 2001-10-26 | Cor Therapeutics Inc | Cyclic diaza selective factor Xa inhibitors |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
AU740447B2 (en) * | 1997-09-23 | 2001-11-01 | Merck & Co., Inc. | Thrombin inhibitors |
ES2192764T3 (es) * | 1998-02-12 | 2003-10-16 | Molecumetics Ltd | Mimeticos de lamina beta y metodos relacionados con el uso de los mismos. |
US6323219B1 (en) | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
US8093293B2 (en) | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
US8106094B2 (en) | 1998-07-06 | 2012-01-31 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for treating skin conditions |
EP1140862A4 (en) | 1998-12-23 | 2004-07-28 | Bristol Myers Squibb Pharma Co | THROMBIN OR Xa FACTOR INHIBITORS |
EA200100815A1 (ru) | 1999-01-27 | 2002-08-29 | Орто-Макнейл Фармасьютикал, Инк. | Пептидильные гетероциклические кетоны, применимые в качестве ингибиторов триптазы |
FR2795072B1 (fr) * | 1999-06-15 | 2001-07-27 | Adir | Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CA2401749A1 (en) * | 2000-03-23 | 2001-09-27 | Elan Pharmaceuticals, Inc. | Compounds and methods to treat alzheimer's disease |
US6586418B2 (en) | 2000-06-29 | 2003-07-01 | Bristol-Myers Squibb Company | Thrombin or factor Xa inhibitors |
US8431550B2 (en) | 2000-10-27 | 2013-04-30 | Johnson & Johnson Consumer Companies, Inc. | Topical anti-cancer compositions and methods of use thereof |
FR2818277B1 (fr) * | 2000-12-14 | 2003-01-24 | Servier Lab | Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US7192615B2 (en) | 2001-02-28 | 2007-03-20 | J&J Consumer Companies, Inc. | Compositions containing legume products |
CN1642550A (zh) | 2002-02-14 | 2005-07-20 | 美瑞德生物工程公司 | β-折叠模拟物和组合物及其有关方法 |
WO2003082197A2 (en) | 2002-03-22 | 2003-10-09 | Gpc Biotech Ag | Immunosuppressant compounds, methods and uses related thereto |
BR112017006920A8 (pt) | 2014-10-06 | 2023-03-07 | Quince Therapeutics Inc | Inibidores de lisina gingipaína |
JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
CA3004095A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
TWI787202B (zh) | 2016-09-16 | 2022-12-21 | 美商昆斯治療公司 | 離胺酸牙齦蛋白酶(gingipain)之酮抑制劑 |
TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗rsv活性之吡唑并嘧啶 |
EA202091835A1 (ru) | 2018-01-31 | 2020-10-20 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Замещенные циклоалкилом пиразолопиримидины, обладающие активностью против rsv |
AU2019260109B2 (en) | 2018-04-23 | 2023-07-13 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against RSV |
-
1995
- 1995-12-21 WO PCT/CA1995/000708 patent/WO1996019483A1/en not_active Application Discontinuation
- 1995-12-21 PL PL95320965A patent/PL320965A1/xx unknown
- 1995-12-21 EE EE9700113A patent/EE9700113A/xx unknown
- 1995-12-21 JP JP8519383A patent/JPH11508535A/ja active Pending
- 1995-12-21 NZ NZ297360A patent/NZ297360A/xx unknown
- 1995-12-21 CZ CZ971899A patent/CZ189997A3/cs unknown
- 1995-12-21 EP EP95940923A patent/EP0802916A1/en not_active Ceased
- 1995-12-21 HU HU9800216A patent/HUT77651A/hu unknown
- 1995-12-21 AU AU42505/96A patent/AU4250596A/en not_active Abandoned
- 1995-12-21 CN CN95197614A patent/CN1175259A/zh active Pending
- 1995-12-21 CA CA002208772A patent/CA2208772A1/en not_active Abandoned
- 1995-12-21 AP APAP/P/1997/001004A patent/AP9701004A0/en unknown
- 1995-12-21 MD MD97-0253A patent/MD970253A/ro unknown
- 1995-12-21 SK SK838-97A patent/SK83897A3/sk unknown
- 1995-12-22 AU AU40628/95A patent/AU715378B2/en not_active Ceased
- 1995-12-22 IL IL11650395D patent/IL116503A0/xx unknown
-
1997
- 1997-06-11 IS IS4504A patent/IS4504A/is unknown
- 1997-06-11 FI FI972466A patent/FI972466A/fi unknown
- 1997-06-18 OA OA70029A patent/OA10493A/en unknown
- 1997-06-20 BG BG101647A patent/BG101647A/xx unknown
- 1997-06-20 NO NO972892A patent/NO972892L/no unknown
- 1997-06-23 MX MX9704718A patent/MX9704718A/es unknown
- 1997-07-15 LV LVP-97-141A patent/LV12019B/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL116503A0 (en) | 1996-03-31 |
AU4062895A (en) | 1996-07-04 |
CN1175259A (zh) | 1998-03-04 |
CA2208772A1 (en) | 1996-06-27 |
WO1996019483A1 (en) | 1996-06-27 |
MD970253A (ro) | 1999-05-31 |
AP9701004A0 (en) | 1997-07-31 |
AU715378B2 (en) | 2000-02-03 |
EE9700113A (et) | 1997-12-15 |
BG101647A (en) | 1998-03-31 |
HUT77651A (hu) | 1998-07-28 |
IS4504A (is) | 1997-06-11 |
SK83897A3 (en) | 1998-05-06 |
MX9704718A (es) | 1998-06-28 |
PL320965A1 (en) | 1997-11-24 |
LV12019B (en) | 1998-07-20 |
AU4250596A (en) | 1996-07-10 |
FI972466A (fi) | 1997-08-19 |
EP0802916A1 (en) | 1997-10-29 |
FI972466A0 (fi) | 1997-06-11 |
NZ297360A (en) | 2000-03-27 |
JPH11508535A (ja) | 1999-07-27 |
NO972892D0 (no) | 1997-06-20 |
LV12019A (lv) | 1998-04-20 |
OA10493A (en) | 2002-04-10 |
CZ189997A3 (cs) | 1998-09-16 |
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