MX9704594A - Peptidos heterociclicos de la ceto-arginina, como inhibidores de la trombina. - Google Patents
Peptidos heterociclicos de la ceto-arginina, como inhibidores de la trombina.Info
- Publication number
- MX9704594A MX9704594A MX9704594A MX9704594A MX9704594A MX 9704594 A MX9704594 A MX 9704594A MX 9704594 A MX9704594 A MX 9704594A MX 9704594 A MX9704594 A MX 9704594A MX 9704594 A MX9704594 A MX 9704594A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- compounds
- treatment
- thrombin inhibitors
- well
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
La invencion se refiere a nuevos y utiles inhibidores de la enzima trombina de la formula (I): AS -X, y, más particularmente, el compuesto (1), en la preparacion, y a composiciones farmacéuticas. Igualmente, esta invencion se refiere al uso de tales compuestos y composiciones in vitro, como anticoagulantes e in vivo como agentes para el tratamiento venosa, embolismo pulmonar y trombosis arterial, que resulta en eventos isquémicos agudos, tal como el infarto al miocardio o infarto cerebral. Asimismo, estos compuestos y composiciones tienen utilidad terapéutica para la prevencion y tratamiento de coagulopatías asociadas con operaciones de puentes coronarios, al igual que eventos restenoticos que siguen a la angioplastia transluminal.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9426038.7 | 1994-12-22 | ||
| GBGB9426038.7A GB9426038D0 (en) | 1994-12-22 | 1994-12-22 | Low molecular weight bicyclic thrombin inhibitors |
| GBGB9503136.5A GB9503136D0 (en) | 1994-12-22 | 1995-02-17 | Low molecular weight bicyclic thrombin inhibitors |
| GB9503136.5 | 1995-02-17 | ||
| GB9504403.8 | 1995-03-06 | ||
| GB9504404.6 | 1995-03-06 | ||
| GBGB9504403.8A GB9504403D0 (en) | 1995-03-06 | 1995-03-06 | Heterocyclic keto arginine peptides as thrombin inhibitors |
| GBGB9504404.6A GB9504404D0 (en) | 1995-03-06 | 1995-03-06 | Heterocyclic keto arginine peptides as thrombin inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9704594A true MX9704594A (es) | 1998-07-31 |
| MXPA97004594A MXPA97004594A (es) | 1998-11-09 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| AU4250896A (en) | 1996-07-10 |
| JPH10513151A (ja) | 1998-12-15 |
| CA2208773A1 (en) | 1996-06-27 |
| AU699679B2 (en) | 1998-12-10 |
| IL116502A0 (en) | 1996-03-31 |
| AU4062795A (en) | 1996-06-27 |
| EP0799240A1 (en) | 1997-10-08 |
| WO1996019491A1 (en) | 1996-06-27 |
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