HUP0303665A2 - Káliumcsatorna-blokkoló hatású arilezett furán- és tiofén-karbonsavamidok - Google Patents

Káliumcsatorna-blokkoló hatású arilezett furán- és tiofén-karbonsavamidok

Info

Publication number
HUP0303665A2
HUP0303665A2 HU0303665A HUP0303665A HUP0303665A2 HU P0303665 A2 HUP0303665 A2 HU P0303665A2 HU 0303665 A HU0303665 A HU 0303665A HU P0303665 A HUP0303665 A HU P0303665A HU P0303665 A2 HUP0303665 A2 HU P0303665A2
Authority
HU
Hungary
Prior art keywords
arylated
furane
carboxylic acid
acid amides
potassium channel
Prior art date
Application number
HU0303665A
Other languages
English (en)
Inventor
Joachim Brendel
Horst Hemmerle
Heinz-Werner Kleemann
Stefan Peukert
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of HUP0303665A2 publication Critical patent/HUP0303665A2/hu
Publication of HUP0303665A3 publication Critical patent/HUP0303665A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány (Ia) és (Ib) általános képletű vegyületekre,előállításukra és alkalmazásukra, különösen gyógyszerkéntialkalmazásukra vonatkozik. A vegyületek az (Ia), ill. (Ib) általánosképletnek felelnek meg, amelyben X, R(1), R(2), R(3), R(4), R(5),R(6), R(7), R(30) és R(31) jelentése az igénypontokban megadott. Ezeka vegyületek különösen jól alkalmazhatók új típusú antiarritmiáshatóanyagként, előnyösen szívpitvari arritmia, így szívpitvarifibrilláció, szívpitvari remegés kezelésére és megelőzésére. Ó
HU0303665A 2000-12-12 2001-11-29 Arylated furane- and thiophene carboxylic acid amides with potassium channel blocking effect HUP0303665A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10061876A DE10061876A1 (de) 2000-12-12 2000-12-12 Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013958 WO2002048131A1 (de) 2000-12-12 2001-11-29 Arylierte furan- und thiophencarbonsäureamide mit kalium kanal blockierender wirkung

Publications (2)

Publication Number Publication Date
HUP0303665A2 true HUP0303665A2 (hu) 2004-03-01
HUP0303665A3 HUP0303665A3 (en) 2005-02-28

Family

ID=7666837

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303665A HUP0303665A3 (en) 2000-12-12 2001-11-29 Arylated furane- and thiophene carboxylic acid amides with potassium channel blocking effect

Country Status (30)

Country Link
US (1) US6982279B2 (hu)
EP (1) EP1349846B1 (hu)
JP (1) JP4252798B2 (hu)
KR (1) KR20030061846A (hu)
CN (1) CN1225463C (hu)
AR (1) AR032781A1 (hu)
AT (1) ATE288906T1 (hu)
AU (2) AU3574302A (hu)
BR (1) BR0116084A (hu)
CA (1) CA2431095A1 (hu)
CZ (1) CZ20031633A3 (hu)
DE (2) DE10061876A1 (hu)
DK (1) DK1349846T3 (hu)
EE (1) EE05306B1 (hu)
ES (1) ES2236335T3 (hu)
HK (1) HK1061850A1 (hu)
HR (1) HRP20030469A2 (hu)
HU (1) HUP0303665A3 (hu)
IL (2) IL156314A0 (hu)
MX (1) MXPA03004770A (hu)
NO (1) NO329163B1 (hu)
NZ (1) NZ526383A (hu)
PL (1) PL362410A1 (hu)
PT (1) PT1349846E (hu)
RS (1) RS50336B (hu)
RU (1) RU2275366C2 (hu)
SK (1) SK287464B6 (hu)
TW (1) TWI288134B (hu)
WO (1) WO2002048131A1 (hu)
ZA (1) ZA200304091B (hu)

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BR0210357A (pt) * 2001-06-11 2004-06-29 Shire Biochem Inc Composto e métodos para o tratamento ou a prevenção de infecções pelo flavivìrus
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GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
EP1493739A1 (fr) * 2003-07-03 2005-01-05 Warner-Lambert Company LLC Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
EA016071B1 (ru) * 2005-05-13 2012-01-30 Вирокем Фарма Инк. Соединения и способы лечения или предотвращения флавивирусных инфекций
CA2615440A1 (en) * 2005-07-22 2007-02-08 Merck & Co., Inc. Potassium channel inhibitors
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
JP5161871B2 (ja) * 2006-04-27 2013-03-13 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｔａｓｋ−１およびｔａｓｋ−３イオンチャンネルの阻害剤
AU2007321677B2 (en) * 2006-11-15 2013-04-11 Vertex Pharmaceuticals (Canada) Incorporated Thiophene analogues for the treatment or prevention of flavivirus infections
JP5411141B2 (ja) 2007-09-10 2014-02-12 カルシメディカ，インク． 細胞内カルシウムを調節する化合物
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
WO2009076454A2 (en) 2007-12-12 2009-06-18 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2010027875A2 (en) 2008-08-27 2010-03-11 Calcimedica Inc. Compounds that modulate intracellular calcium
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
EP4242206A1 (en) * 2009-01-30 2023-09-13 Novartis AG Crystalline n-{(1-s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
US8618307B2 (en) 2009-09-16 2013-12-31 Calcimedica, Inc. Compounds that modulate intracellular calcium
JP5855095B2 (ja) 2010-06-07 2016-02-09 ノボメディックス, エルエルシーNovomedix, Llc フラニル化合物およびその使用
CN103180316A (zh) 2010-08-27 2013-06-26 钙医学公司 调节细胞内钙的化合物
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (hu) 2011-07-01 2018-04-28
US20150045305A1 (en) 2012-01-27 2015-02-12 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103012381B (zh) * 2013-01-10 2015-01-07 山东大学 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用
KR101721490B1 (ko) * 2014-07-30 2017-03-30 한국생명공학연구원 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물
EP3366683A1 (en) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

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Also Published As

Publication number Publication date
PT1349846E (pt) 2005-05-31
PL362410A1 (en) 2004-11-02
HRP20030469A2 (en) 2005-04-30
AU2002235743B2 (en) 2006-07-20
AR032781A1 (es) 2003-11-26
SK7252003A3 (en) 2003-12-02
DE50105337D1 (de) 2005-03-17
DK1349846T3 (da) 2005-05-30
WO2002048131A1 (de) 2002-06-20
YU42503A (sh) 2006-05-25
NZ526383A (en) 2004-11-26
EP1349846A1 (de) 2003-10-08
DE10061876A1 (de) 2002-06-20
NO20032535L (no) 2003-07-29
BR0116084A (pt) 2003-10-14
AU3574302A (en) 2002-06-24
CN1479734A (zh) 2004-03-03
RU2275366C2 (ru) 2006-04-27
KR20030061846A (ko) 2003-07-22
NO329163B1 (no) 2010-08-30
HUP0303665A3 (en) 2005-02-28
SK287464B6 (sk) 2010-10-07
JP2004526680A (ja) 2004-09-02
TWI288134B (en) 2007-10-11
ZA200304091B (en) 2004-04-23
JP4252798B2 (ja) 2009-04-08
EE05306B1 (et) 2010-06-15
HK1061850A1 (en) 2004-10-08
ES2236335T3 (es) 2005-07-16
EE200300240A (et) 2003-08-15
IL156314A (en) 2008-12-29
US6982279B2 (en) 2006-01-03
CZ20031633A3 (cs) 2003-08-13
RS50336B (sr) 2009-11-10
CA2431095A1 (en) 2002-06-20
NO20032535D0 (no) 2003-06-04
EP1349846B1 (de) 2005-02-09
IL156314A0 (en) 2004-01-04
ATE288906T1 (de) 2005-02-15
US20040068120A1 (en) 2004-04-08
MXPA03004770A (es) 2003-09-10
CN1225463C (zh) 2005-11-02

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished