YU42503A - Arilovani furan-1 tiofen-amidi-karbonske kiseline sa blokirajućim dejstvom kalijumovog kanala - Google Patents

Arilovani furan-1 tiofen-amidi-karbonske kiseline sa blokirajućim dejstvom kalijumovog kanala

Info

Publication number
YU42503A
YU42503A YU42503A YUP42503A YU42503A YU 42503 A YU42503 A YU 42503A YU 42503 A YU42503 A YU 42503A YU P42503 A YUP42503 A YU P42503A YU 42503 A YU42503 A YU 42503A
Authority
YU
Yugoslavia
Prior art keywords
arylated
furane
carboxylic acid
acid amides
thiophene carboxylic
Prior art date
Application number
YU42503A
Other languages
English (en)
Inventor
Stefan Peukert
Joachim Brendel
Horst Hemmerle
Heinz-Werner Kleemann
Original Assignee
Aventis Pharma Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland filed Critical Aventis Pharma Deutschland
Publication of YU42503A publication Critical patent/YU42503A/sh
Publication of RS50336B publication Critical patent/RS50336B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Pronalazak se odnosi na arilovane fenil- i tiofen-amide-karbonske kiseline, na postupak za njihovu proizvodnju i njihovu primenu u svojstvu medikamenta, kao i na farmaceutski preparat koji sadrži ta jedinjenja. Jedinjenja formule (la) i (lb), u kojima X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(30) i R(31) imaju značenja navedena u patentnim zahtevima, su naročito podesna kao nova vrsta antiaritmijskih aktivnih supstanci, posebno za lečenje i profilaksu aritmija srčane predkomore, na primer atrialne fibracije (AF) ili lepršanja srčane predkomore (atriale Flattern).[The invention relates to arylated furane and thiophene carboxylic acid amides, a method for the production thereof, the use thereof as medicaments, in addition to pharmaceutical preparations containing the compounds of formula (la) and (lb) wherein X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(30) and R(31) have the same meaning as cited in the claims. According to the invention, the compounds are particularly suitable as novel anti-arrhythmic active ingredients, particularly for the treatment and prophylaxis of atrial arrhythmia for example, atrial fibrillation, AF, or atrial flutter.
YUP-425/03A 2000-12-12 2001-11-29 Arilovani furan-1 tiofen-amidi-karbonske kiseline sa blokirajućim dejstvom kalijumovog kanala RS50336B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10061876A DE10061876A1 (de) 2000-12-12 2000-12-12 Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen

Publications (2)

Publication Number Publication Date
YU42503A true YU42503A (sh) 2006-05-25
RS50336B RS50336B (sr) 2009-11-10

Family

ID=7666837

Country Status (30)

Country Link
US (1) US6982279B2 (sh)
EP (1) EP1349846B1 (sh)
JP (1) JP4252798B2 (sh)
KR (1) KR20030061846A (sh)
CN (1) CN1225463C (sh)
AR (1) AR032781A1 (sh)
AT (1) ATE288906T1 (sh)
AU (2) AU2002235743B2 (sh)
BR (1) BR0116084A (sh)
CA (1) CA2431095A1 (sh)
CZ (1) CZ20031633A3 (sh)
DE (2) DE10061876A1 (sh)
DK (1) DK1349846T3 (sh)
EE (1) EE05306B1 (sh)
ES (1) ES2236335T3 (sh)
HK (1) HK1061850A1 (sh)
HR (1) HRP20030469A2 (sh)
HU (1) HUP0303665A3 (sh)
IL (2) IL156314A0 (sh)
MX (1) MXPA03004770A (sh)
NO (1) NO329163B1 (sh)
NZ (1) NZ526383A (sh)
PL (1) PL362410A1 (sh)
PT (1) PT1349846E (sh)
RS (1) RS50336B (sh)
RU (1) RU2275366C2 (sh)
SK (1) SK287464B6 (sh)
TW (1) TWI288134B (sh)
WO (1) WO2002048131A1 (sh)
ZA (1) ZA200304091B (sh)

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GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
EP1493739A1 (fr) * 2003-07-03 2005-01-05 Warner-Lambert Company LLC Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
EP1879879B1 (en) * 2005-05-13 2013-03-27 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
JP4943429B2 (ja) * 2005-07-22 2012-05-30 メルク・シャープ・エンド・ドーム・コーポレイション カリウムチャネル阻害剤
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
EP2012758A2 (en) * 2006-04-27 2009-01-14 Sanofi-Aventis Deutschland GmbH Inhibitors of the task-1 and task-3 ion channel
SI2104674T1 (sl) 2006-11-15 2013-09-30 Vertex Pharmaceuticals (Canada) Incorporated Tiofenski analogi za zdravljenje ali preprečevanje flavivirusnih infekcij
CN101854933A (zh) 2007-09-10 2010-10-06 钙医学公司 调节细胞内钙的化合物
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
WO2009076454A2 (en) 2007-12-12 2009-06-18 Calcimedica, Inc. Compounds that modulate intracellular calcium
CA2734500A1 (en) 2008-08-27 2010-03-11 Calcimedica Inc. Compounds that modulate intracellular calcium
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
EP4242206A1 (en) * 2009-01-30 2023-09-13 Novartis AG Crystalline n-{(1-s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
WO2011034962A2 (en) 2009-09-16 2011-03-24 Calcimedica Inc. Compounds that modulate intracellular calcium
SG186229A1 (en) 2010-06-07 2013-01-30 Novomedix Llc Furanyl compounds and the use thereof
US9079891B2 (en) 2010-08-27 2015-07-14 Calcimedica, Inc. Compounds that modulate intracellular calcium
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (sh) 2011-07-01 2018-04-28
EP2806865A1 (en) 2012-01-27 2014-12-03 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103012381B (zh) * 2013-01-10 2015-01-07 山东大学 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用
KR101721490B1 (ko) * 2014-07-30 2017-03-30 한국생명공학연구원 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물
EP3366683A1 (en) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

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Also Published As

Publication number Publication date
WO2002048131A1 (de) 2002-06-20
EE05306B1 (et) 2010-06-15
NO329163B1 (no) 2010-08-30
BR0116084A (pt) 2003-10-14
RU2275366C2 (ru) 2006-04-27
EP1349846B1 (de) 2005-02-09
SK7252003A3 (en) 2003-12-02
AU2002235743B2 (en) 2006-07-20
CA2431095A1 (en) 2002-06-20
RS50336B (sr) 2009-11-10
DE10061876A1 (de) 2002-06-20
ES2236335T3 (es) 2005-07-16
DK1349846T3 (da) 2005-05-30
EP1349846A1 (de) 2003-10-08
ZA200304091B (en) 2004-04-23
IL156314A0 (en) 2004-01-04
NO20032535D0 (no) 2003-06-04
CZ20031633A3 (cs) 2003-08-13
US6982279B2 (en) 2006-01-03
IL156314A (en) 2008-12-29
HUP0303665A2 (hu) 2004-03-01
PT1349846E (pt) 2005-05-31
ATE288906T1 (de) 2005-02-15
AR032781A1 (es) 2003-11-26
NZ526383A (en) 2004-11-26
JP2004526680A (ja) 2004-09-02
MXPA03004770A (es) 2003-09-10
HK1061850A1 (en) 2004-10-08
US20040068120A1 (en) 2004-04-08
CN1225463C (zh) 2005-11-02
EE200300240A (et) 2003-08-15
HRP20030469A2 (en) 2005-04-30
DE50105337D1 (de) 2005-03-17
TWI288134B (en) 2007-10-11
AU3574302A (en) 2002-06-24
CN1479734A (zh) 2004-03-03
JP4252798B2 (ja) 2009-04-08
NO20032535L (no) 2003-07-29
PL362410A1 (en) 2004-11-02
HUP0303665A3 (en) 2005-02-28
KR20030061846A (ko) 2003-07-22
SK287464B6 (sk) 2010-10-07

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