HK1061850A1 - Arylated furane and thiop}hene carboxylic acid amides with potassium chennel blockin effect - Google Patents

Arylated furane and thiop}hene carboxylic acid amides with potassium chennel blockin effect

Info

Publication number
HK1061850A1
HK1061850A1 HK04104841A HK04104841A HK1061850A1 HK 1061850 A1 HK1061850 A1 HK 1061850A1 HK 04104841 A HK04104841 A HK 04104841A HK 04104841 A HK04104841 A HK 04104841A HK 1061850 A1 HK1061850 A1 HK 1061850A1
Authority
HK
Hong Kong
Prior art keywords
thiop
blockin
chennel
arylated
furane
Prior art date
Application number
HK04104841A
Other languages
English (en)
Inventor
Stefan Peukert
Joachim Brendel
Horst Hemmerle
Heinz-Werner Kleemann
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of HK1061850A1 publication Critical patent/HK1061850A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK04104841A 2000-12-12 2004-07-06 Arylated furane and thiop}hene carboxylic acid amides with potassium chennel blockin effect HK1061850A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10061876A DE10061876A1 (de) 2000-12-12 2000-12-12 Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013958 WO2002048131A1 (de) 2000-12-12 2001-11-29 Arylierte furan- und thiophencarbonsäureamide mit kalium kanal blockierender wirkung

Publications (1)

Publication Number Publication Date
HK1061850A1 true HK1061850A1 (en) 2004-10-08

Family

ID=7666837

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04104841A HK1061850A1 (en) 2000-12-12 2004-07-06 Arylated furane and thiop}hene carboxylic acid amides with potassium chennel blockin effect

Country Status (30)

Country Link
US (1) US6982279B2 (xx)
EP (1) EP1349846B1 (xx)
JP (1) JP4252798B2 (xx)
KR (1) KR20030061846A (xx)
CN (1) CN1225463C (xx)
AR (1) AR032781A1 (xx)
AT (1) ATE288906T1 (xx)
AU (2) AU3574302A (xx)
BR (1) BR0116084A (xx)
CA (1) CA2431095A1 (xx)
CZ (1) CZ20031633A3 (xx)
DE (2) DE10061876A1 (xx)
DK (1) DK1349846T3 (xx)
EE (1) EE05306B1 (xx)
ES (1) ES2236335T3 (xx)
HK (1) HK1061850A1 (xx)
HR (1) HRP20030469A2 (xx)
HU (1) HUP0303665A3 (xx)
IL (2) IL156314A0 (xx)
MX (1) MXPA03004770A (xx)
NO (1) NO329163B1 (xx)
NZ (1) NZ526383A (xx)
PL (1) PL362410A1 (xx)
PT (1) PT1349846E (xx)
RS (1) RS50336B (xx)
RU (1) RU2275366C2 (xx)
SK (1) SK287464B6 (xx)
TW (1) TWI288134B (xx)
WO (1) WO2002048131A1 (xx)
ZA (1) ZA200304091B (xx)

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KR20080016597A (ko) 2005-05-13 2008-02-21 바이로켐 파마 인코포레이티드 플라비바이러스 감염의 예방 또는 치료용 화합물 및 그의예방 또는 치료 방법
WO2007015775A2 (en) * 2005-07-22 2007-02-08 Merck & Co., Inc. Potassium channel inhibitors
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WO2007124849A2 (en) * 2006-04-27 2007-11-08 Sanofi-Aventis Deutschland Gmbh Inhibitors of the task-1 and task-3 ion channel
SI2104674T1 (sl) 2006-11-15 2013-09-30 Vertex Pharmaceuticals (Canada) Incorporated Tiofenski analogi za zdravljenje ali preprečevanje flavivirusnih infekcij
AU2008299220B2 (en) * 2007-09-10 2011-07-21 Calcimedica, Inc. Compounds that modulate intracellular calcium
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
WO2009076454A2 (en) 2007-12-12 2009-06-18 Calcimedica, Inc. Compounds that modulate intracellular calcium
US7981925B2 (en) 2008-08-27 2011-07-19 Calcimedica, Inc. Compounds that modulate intracellular calcium
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
JP2012516344A (ja) * 2009-01-30 2012-07-19 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 結晶質ｎ−｛（１ｓ）−２−アミノ−１−［（３−フルオロフェニル）メチル］エチル｝−５−クロロ−４−（４−クロロ−１−メチル−１ｈ−ピラゾール−５−イル）−２−チオフェンカルボキサミド塩酸塩
EP2477982A4 (en) 2009-09-16 2013-04-03 Calcimedica Inc COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
NZ604018A (en) 2010-06-07 2015-02-27 Novomedix Llc Furanyl compounds and the use thereof
MX337711B (es) 2010-08-27 2016-03-15 Calcimedica Inc Compuestos que modulan el calcio intracelular.
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (xx) 2011-07-01 2018-04-28
CA2862670A1 (en) 2012-01-27 2013-08-01 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014059333A1 (en) 2012-10-12 2014-04-17 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103012381B (zh) * 2013-01-10 2015-01-07 山东大学 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用
KR101721490B1 (ko) * 2014-07-30 2017-03-30 한국생명공학연구원 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물
EP3366683A1 (en) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

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Also Published As

Publication number Publication date
MXPA03004770A (es) 2003-09-10
SK287464B6 (sk) 2010-10-07
NO20032535D0 (no) 2003-06-04
IL156314A0 (en) 2004-01-04
RU2275366C2 (ru) 2006-04-27
RS50336B (sr) 2009-11-10
HUP0303665A3 (en) 2005-02-28
ZA200304091B (en) 2004-04-23
WO2002048131A1 (de) 2002-06-20
CZ20031633A3 (cs) 2003-08-13
AR032781A1 (es) 2003-11-26
AU3574302A (en) 2002-06-24
CN1479734A (zh) 2004-03-03
JP4252798B2 (ja) 2009-04-08
YU42503A (sh) 2006-05-25
PT1349846E (pt) 2005-05-31
NZ526383A (en) 2004-11-26
NO20032535L (no) 2003-07-29
ATE288906T1 (de) 2005-02-15
US20040068120A1 (en) 2004-04-08
EP1349846A1 (de) 2003-10-08
TWI288134B (en) 2007-10-11
EP1349846B1 (de) 2005-02-09
DE10061876A1 (de) 2002-06-20
IL156314A (en) 2008-12-29
JP2004526680A (ja) 2004-09-02
EE200300240A (et) 2003-08-15
HRP20030469A2 (en) 2005-04-30
ES2236335T3 (es) 2005-07-16
EE05306B1 (et) 2010-06-15
SK7252003A3 (en) 2003-12-02
CA2431095A1 (en) 2002-06-20
US6982279B2 (en) 2006-01-03
NO329163B1 (no) 2010-08-30
KR20030061846A (ko) 2003-07-22
PL362410A1 (en) 2004-11-02
CN1225463C (zh) 2005-11-02
HUP0303665A2 (hu) 2004-03-01
AU2002235743B2 (en) 2006-07-20
DE50105337D1 (de) 2005-03-17
DK1349846T3 (da) 2005-05-30
BR0116084A (pt) 2003-10-14

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20111129