NO971453L - Anvendelse av bradykinin-antagonister for fremstilling av legemidler for behandling av kroniske fibrogenetiske og akutte leversykdommer - Google Patents
Anvendelse av bradykinin-antagonister for fremstilling av legemidler for behandling av kroniske fibrogenetiske og akutte leversykdommerInfo
- Publication number
- NO971453L NO971453L NO971453A NO971453A NO971453L NO 971453 L NO971453 L NO 971453L NO 971453 A NO971453 A NO 971453A NO 971453 A NO971453 A NO 971453A NO 971453 L NO971453 L NO 971453L
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- drugs
- manufacture
- liver diseases
- chronic
- Prior art date
Links
- 230000001684 chronic effect Effects 0.000 title abstract 3
- 208000019423 liver disease Diseases 0.000 title abstract 3
- 230000001154 acute effect Effects 0.000 title abstract 2
- 239000003152 bradykinin antagonist Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 230000001842 fibrogenetic effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 2
- 208000007232 portal hypertension Diseases 0.000 abstract 2
- 206010069729 Collateral circulation Diseases 0.000 abstract 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 abstract 1
- 206010020565 Hyperaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010041660 Splenomegaly Diseases 0.000 abstract 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/043—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Anvendelse av bradykinin-antagonister for fremstilling av legemidler for behandling av kroniske fibrogenetiske leversykdommer (leverzirrhose og leverfibrose) og akutte leversykdommer, og for forhindring av komplikasjoner, spesielt for proiylakse henholdsvis behandling av portal hypertoni, dekompensasjonsfiemkomster som aszites, ødemdannelse, hepatorenaJt syndrom, hypertensiv gastro- og cholopati, splenomegali samt blødningskomplikasjoner i mage-tarm-kanalen ved portal hypertoni, kollateralt kretsløp og hyperemi og en kardiopati som følge av en kronisk hyperdynam kretsløp- situasjon og fialger derav, er beskrevet.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19612067A DE19612067A1 (de) | 1996-03-27 | 1996-03-27 | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen |
Publications (2)
Publication Number | Publication Date |
---|---|
NO971453D0 NO971453D0 (no) | 1997-03-26 |
NO971453L true NO971453L (no) | 1997-09-29 |
Family
ID=7789557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO971453A NO971453L (no) | 1996-03-27 | 1997-03-26 | Anvendelse av bradykinin-antagonister for fremstilling av legemidler for behandling av kroniske fibrogenetiske og akutte leversykdommer |
Country Status (24)
Country | Link |
---|---|
US (1) | US5863901A (no) |
EP (1) | EP0797997B1 (no) |
JP (1) | JP4185169B2 (no) |
KR (1) | KR100453394B1 (no) |
CN (1) | CN1164421A (no) |
AT (1) | ATE297749T1 (no) |
AU (1) | AU1651697A (no) |
BR (1) | BR9701455A (no) |
CA (1) | CA2200040A1 (no) |
CZ (1) | CZ90797A3 (no) |
DE (2) | DE19612067A1 (no) |
DK (1) | DK0797997T3 (no) |
ES (1) | ES2242973T3 (no) |
HR (1) | HRP970171A2 (no) |
HU (1) | HUP9700642A3 (no) |
ID (1) | ID16413A (no) |
IL (1) | IL120521A0 (no) |
NO (1) | NO971453L (no) |
PL (1) | PL319193A1 (no) |
PT (1) | PT797997E (no) |
SI (1) | SI0797997T1 (no) |
SK (1) | SK39297A3 (no) |
TR (1) | TR199700228A2 (no) |
ZA (1) | ZA972599B (no) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1914236A1 (en) | 2002-04-10 | 2008-04-23 | Ortho-McNeil Pharmaceutical, Inc. | Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators |
TWI407960B (zh) | 2007-03-23 | 2013-09-11 | Jerini Ag | 小分子緩激肽b2受體調節劑 |
CA2728766A1 (en) * | 2008-06-20 | 2009-12-23 | Kinemed, Inc. | Compositions for the treatment of fibrotic diseases or conditions |
EP3998259A1 (en) | 2017-11-24 | 2022-05-18 | Pharvaris Netherlands B.V. | Novel bradykinin b2 receptor antagonists |
AR118983A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
AR118982A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4350704A (en) * | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
US4374847A (en) * | 1980-10-27 | 1983-02-22 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
US4693993A (en) * | 1985-06-13 | 1987-09-15 | Stewart John M | Bradykinin antagonist peptides |
US4923963A (en) * | 1987-09-02 | 1990-05-08 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
WO1989009230A1 (en) * | 1988-03-25 | 1989-10-05 | Administrators Of The Tulane Educational Fund | Therapeutic peptides |
DE3926822A1 (de) * | 1989-08-14 | 1991-02-21 | Hoechst Ag | Peptide mit bradykinin-antagonistischer wirkung |
DE4013270A1 (de) * | 1990-04-26 | 1991-10-31 | Hoechst Ag | Peptide mit bradykinin-antagonistischer wirkung |
IE63490B1 (en) * | 1988-11-24 | 1995-05-03 | Hoechst Ag | Peptides having bradykinin antagonist action |
WO1991009055A1 (en) * | 1989-12-08 | 1991-06-27 | Boston University | Acylated bradykinin antagonists and uses therefor |
MX9100717A (es) * | 1990-08-24 | 1992-04-01 | Syntex Inc | Antagonistas de la bradiquinina |
CA2106677A1 (en) * | 1991-04-01 | 1992-10-02 | John C. Cheronis | Bradykinin antagonists |
JPH07504155A (ja) * | 1991-04-19 | 1995-05-11 | シオス・ノヴァ・インコーポレイテット | ブラジキニンアンタゴニストペプチド |
WO1992018155A1 (en) * | 1991-04-19 | 1992-10-29 | Nova Technology Limited Partnership | Bradykinin type peptides |
WO1993011789A1 (en) * | 1991-12-12 | 1993-06-24 | Scios Nova Inc. | Modified position (7) bradykinin antagonist peptides |
FR2686343B1 (fr) * | 1992-01-17 | 1994-03-11 | Adir Cie | Nouveaux derives pseudopeptidiques a activite antagoniste de la bradykinine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
TW258739B (no) * | 1992-04-04 | 1995-10-01 | Hoechst Ag | |
FR2692581B1 (fr) * | 1992-06-18 | 1994-08-19 | Adir | Nouveaux dérivés peptidiques à activité antagoniste de la bradykinine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
AU5098593A (en) * | 1992-09-11 | 1994-04-12 | Lajos Gera | Bradykinin antagonists containing aliphatic amino acids in the 5-position |
US5521158A (en) * | 1992-10-08 | 1996-05-28 | Scios Nova Inc. | Pseudopeptide bradykinin receptor antagonists |
IL107400A0 (en) * | 1992-11-10 | 1994-01-25 | Cortech Inc | Bradykinin antagonists |
WO1994019372A1 (en) * | 1993-02-17 | 1994-09-01 | Scios Nova Inc. | Cyclic bradykinin antagonist peptides |
AU680870B2 (en) * | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
EP0716661B1 (en) * | 1993-09-09 | 2000-04-05 | Scios Inc. | Pseudo- and non-peptide bradykinin receptor antagonists |
DE4345062A1 (de) * | 1993-12-31 | 1995-07-13 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von Viruserkrankungen |
KR100360639B1 (ko) * | 1994-03-09 | 2003-01-30 | 코르텍, 인크. | N-치환글리신함유브라디키닌길항제펩티드 |
-
1996
- 1996-03-27 DE DE19612067A patent/DE19612067A1/de not_active Withdrawn
-
1997
- 1997-03-04 US US08/810,012 patent/US5863901A/en not_active Expired - Lifetime
- 1997-03-14 DK DK97104345T patent/DK0797997T3/da active
- 1997-03-14 CA CA002200040A patent/CA2200040A1/en not_active Abandoned
- 1997-03-14 AT AT97104345T patent/ATE297749T1/de active
- 1997-03-14 DE DE59712344T patent/DE59712344D1/de not_active Expired - Lifetime
- 1997-03-14 SI SI9730710T patent/SI0797997T1/xx unknown
- 1997-03-14 EP EP97104345A patent/EP0797997B1/de not_active Expired - Lifetime
- 1997-03-14 PT PT97104345T patent/PT797997E/pt unknown
- 1997-03-14 ES ES97104345T patent/ES2242973T3/es not_active Expired - Lifetime
- 1997-03-24 BR BR9701455A patent/BR9701455A/pt not_active Application Discontinuation
- 1997-03-25 TR TR97/00228A patent/TR199700228A2/xx unknown
- 1997-03-25 SK SK392-97A patent/SK39297A3/sk unknown
- 1997-03-25 AU AU16516/97A patent/AU1651697A/en not_active Abandoned
- 1997-03-25 HU HU9700642A patent/HUP9700642A3/hu unknown
- 1997-03-25 CZ CZ97907A patent/CZ90797A3/cs unknown
- 1997-03-25 IL IL12052197A patent/IL120521A0/xx unknown
- 1997-03-25 CN CN97104542A patent/CN1164421A/zh active Pending
- 1997-03-26 JP JP07293897A patent/JP4185169B2/ja not_active Expired - Fee Related
- 1997-03-26 HR HR19612067.5A patent/HRP970171A2/xx not_active Application Discontinuation
- 1997-03-26 ZA ZA9702599A patent/ZA972599B/xx unknown
- 1997-03-26 NO NO971453A patent/NO971453L/no unknown
- 1997-03-27 KR KR1019970010677A patent/KR100453394B1/ko not_active IP Right Cessation
- 1997-03-27 PL PL97319193A patent/PL319193A1/xx unknown
- 1997-03-27 ID IDP971032A patent/ID16413A/id unknown
Also Published As
Publication number | Publication date |
---|---|
HRP970171A2 (en) | 1998-04-30 |
US5863901A (en) | 1999-01-26 |
JPH1017491A (ja) | 1998-01-20 |
EP0797997B1 (de) | 2005-06-15 |
HUP9700642A2 (hu) | 1998-01-28 |
AU1651697A (en) | 1997-10-02 |
SI0797997T1 (en) | 2005-10-31 |
DE19612067A1 (de) | 1997-10-02 |
PT797997E (pt) | 2005-09-30 |
CZ90797A3 (en) | 1997-10-15 |
DE59712344D1 (de) | 2005-07-21 |
KR100453394B1 (ko) | 2004-12-30 |
JP4185169B2 (ja) | 2008-11-26 |
CA2200040A1 (en) | 1997-09-27 |
ZA972599B (en) | 1997-09-29 |
IL120521A0 (en) | 1997-07-13 |
EP0797997A2 (de) | 1997-10-01 |
PL319193A1 (en) | 1997-09-29 |
EP0797997A3 (de) | 2000-05-31 |
ID16413A (id) | 1997-09-25 |
DK0797997T3 (da) | 2005-10-17 |
MX9702292A (es) | 1997-09-30 |
BR9701455A (pt) | 1998-08-18 |
NO971453D0 (no) | 1997-03-26 |
SK39297A3 (en) | 1997-10-08 |
TR199700228A2 (xx) | 1997-10-21 |
ATE297749T1 (de) | 2005-07-15 |
CN1164421A (zh) | 1997-11-12 |
HU9700642D0 (en) | 1997-05-28 |
ES2242973T3 (es) | 2005-11-16 |
HUP9700642A3 (en) | 1998-03-02 |
KR970064622A (ko) | 1997-10-13 |
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