NO963814L - Inhibitor av det 26S proteolytiske kompleks og 20S proteasomet inneholdt deri - Google Patents
Inhibitor av det 26S proteolytiske kompleks og 20S proteasomet inneholdt deriInfo
- Publication number
- NO963814L NO963814L NO963814A NO963814A NO963814L NO 963814 L NO963814 L NO 963814L NO 963814 A NO963814 A NO 963814A NO 963814 A NO963814 A NO 963814A NO 963814 L NO963814 L NO 963814L
- Authority
- NO
- Norway
- Prior art keywords
- proteasome
- inhibitor
- contained
- proteolytic complex
- animal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Omhandlet heri er en fremgangsmåte for redusering av raten av ' nedbrytning av proteiner i et dyr omfattende å kontakte celler av dyret med visse proteasominhibitorer. Strukturen : av inhibitorene er også omhandlet. Fremgangsmåte for redusering av raten av tap av muskel- masse i et dyr, karakterisert ved at den omfatter å kontakte celler av muskelen med en proteasominhibitor med strukturen:
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21290994A | 1994-03-15 | 1994-03-15 | |
PCT/US1995/003449 WO1995024914A1 (en) | 1994-03-15 | 1995-03-15 | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
Publications (2)
Publication Number | Publication Date |
---|---|
NO963814D0 NO963814D0 (no) | 1996-09-12 |
NO963814L true NO963814L (no) | 1996-11-14 |
Family
ID=22792895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO963814A NO963814L (no) | 1994-03-15 | 1996-09-12 | Inhibitor av det 26S proteolytiske kompleks og 20S proteasomet inneholdt deri |
Country Status (9)
Country | Link |
---|---|
US (1) | US5693617A (no) |
EP (1) | EP0804216A1 (no) |
JP (1) | JPH09511501A (no) |
AU (1) | AU682600B2 (no) |
CA (1) | CA2185326A1 (no) |
FI (1) | FI963602A (no) |
MX (1) | MX9604048A (no) |
NO (1) | NO963814L (no) |
WO (1) | WO1995024914A1 (no) |
Families Citing this family (73)
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EP0583536B1 (en) * | 1992-08-14 | 1997-03-05 | The Procter & Gamble Company | Liquid detergents containing an alpha-amino boronic acid |
US5384410A (en) * | 1993-03-24 | 1995-01-24 | The Du Pont Merck Pharmaceutical Company | Removal of boronic acid protecting groups by transesterification |
IL111176A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them |
JP5401105B2 (ja) * | 2009-01-25 | 2014-01-29 | 日本電産シンポ株式会社 | モータ内蔵ローラ |
-
1995
- 1995-01-15 US US08/404,866 patent/US5693617A/en not_active Expired - Fee Related
- 1995-03-15 WO PCT/US1995/003449 patent/WO1995024914A1/en not_active Application Discontinuation
- 1995-03-15 MX MX9604048A patent/MX9604048A/es unknown
- 1995-03-15 CA CA002185326A patent/CA2185326A1/en not_active Abandoned
- 1995-03-15 JP JP7524213A patent/JPH09511501A/ja active Pending
- 1995-03-15 EP EP95915389A patent/EP0804216A1/en not_active Withdrawn
- 1995-03-15 AU AU22283/95A patent/AU682600B2/en not_active Ceased
-
1996
- 1996-09-12 FI FI963602A patent/FI963602A/fi not_active Application Discontinuation
- 1996-09-12 NO NO963814A patent/NO963814L/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP0804216A1 (en) | 1997-11-05 |
AU2228395A (en) | 1995-10-03 |
WO1995024914A1 (en) | 1995-09-21 |
EP0804216A4 (no) | 1997-12-03 |
JPH09511501A (ja) | 1997-11-18 |
AU682600B2 (en) | 1997-10-09 |
MX9604048A (es) | 1997-12-31 |
US5693617A (en) | 1997-12-02 |
NO963814D0 (no) | 1996-09-12 |
FI963602A (fi) | 1996-11-04 |
FI963602A0 (fi) | 1996-09-12 |
CA2185326A1 (en) | 1995-09-21 |
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