NO961812L - Humanproteaseinhibitorer av Kunitz-type - Google Patents

Humanproteaseinhibitorer av Kunitz-type

Info

Publication number
NO961812L
NO961812L NO961812A NO961812A NO961812L NO 961812 L NO961812 L NO 961812L NO 961812 A NO961812 A NO 961812A NO 961812 A NO961812 A NO 961812A NO 961812 L NO961812 L NO 961812L
Authority
NO
Norway
Prior art keywords
dna
kunitz
protease inhibitors
type human
dna segment
Prior art date
Application number
NO961812A
Other languages
English (en)
Norwegian (no)
Other versions
NO961812D0 (no
Inventor
Cindy A Sprecher
Walter Kisiel
Donald C Foster
Original Assignee
Zymogenetics Inc
Univ New Mexico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Univ New Mexico filed Critical Zymogenetics Inc
Publication of NO961812D0 publication Critical patent/NO961812D0/no
Publication of NO961812L publication Critical patent/NO961812L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NO961812A 1993-11-05 1996-05-03 Humanproteaseinhibitorer av Kunitz-type NO961812L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/147,710 US5455338A (en) 1993-11-05 1993-11-05 DNA encoding novel human kunitz-type inhibitors and methods relating thereto
PCT/US1994/012609 WO1995012674A1 (fr) 1993-11-05 1994-11-02 Proteases inhibitrices humaines de type kunitz

Publications (2)

Publication Number Publication Date
NO961812D0 NO961812D0 (no) 1996-05-03
NO961812L true NO961812L (no) 1996-07-05

Family

ID=22522614

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961812A NO961812L (no) 1993-11-05 1996-05-03 Humanproteaseinhibitorer av Kunitz-type

Country Status (12)

Country Link
US (7) US5455338A (fr)
EP (1) EP0726953B1 (fr)
JP (1) JP3201527B2 (fr)
KR (1) KR100243989B1 (fr)
CN (1) CN1073159C (fr)
AT (1) ATE262587T1 (fr)
AU (1) AU685190B2 (fr)
CA (1) CA2175797C (fr)
DE (1) DE69433647T2 (fr)
FI (1) FI961886A (fr)
NO (1) NO961812L (fr)
WO (1) WO1995012674A1 (fr)

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US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
CA2202131A1 (fr) * 1995-08-09 1997-02-20 Jun Utsumi Remede contre les troubles ophtalmiques
BR9708021A (pt) * 1996-03-11 1999-07-27 Bayer Ag Proteína substancialmente purificada composição farmacêutica sequência de ácido nucleico isolada vetor de express o de protéina auto-replicante e processos para inibir a atividade de protéinas de serina tratar uma condição e preparar um medicamento de uma proteína
DE69912988T2 (de) * 1998-12-22 2004-11-11 Bayer Ag Verwendung eines serinproteaseinhibitors vom kunitz-typ zur beschleunigung der schleimauflöserate
US20070140979A1 (en) * 1998-12-22 2007-06-21 Bayer Aktiengesellschaft Method for accelerating the rate of mucociliary clearance
WO2001009360A1 (fr) * 1999-08-02 2001-02-08 Avigen, Inc. Utilisation du vecteur viral adeno-associe (raav) a des fins de prevention de la proliferation cellulaire du muscle lisse dans une greffe vasculaire
US6180607B1 (en) 1999-08-05 2001-01-30 Christopher Davies Protein having proteinase inhibitor activity
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US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
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US6964764B2 (en) 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
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US7244616B2 (en) 2003-06-27 2007-07-17 Bayer Pharmaceuticals Corporation Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
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US7910550B2 (en) * 2004-04-16 2011-03-22 Stc.Unm Human kunitz-type inhibitor with enhanced antifibrinolytic activity
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WO2006098998A2 (fr) * 2005-03-10 2006-09-21 Genentech, Inc. Procedes et compositions de modulation de l'integrite vasculaire
DK1981519T3 (en) 2005-12-29 2018-02-19 Dyax Corp protease inhibition
EP1976985B1 (fr) 2005-12-29 2013-07-17 The Regents of the University of California Office of Technology Transfer Methodes et compositions associees au domaine kunitz mutant i de tfpi-2
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DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
DK2193196T3 (en) 2007-09-28 2016-11-07 Portola Pharm Inc Clinical profile of Factor Xa inhibitors, and methods of use thereof
US8268783B2 (en) 2007-09-28 2012-09-18 Portola Pharmaceuticals, Inc. Antidotes for factor Xa inhibitors and methods of using the same
KR20160110544A (ko) * 2008-06-04 2016-09-21 그리폴스 테라퓨틱스 인코포레이티드 플라스민의 제조를 위한 조성물, 방법 및 키트
BRPI0922344A2 (pt) 2008-12-19 2017-10-24 3B Pharmaceuticals Gmbh inibidores de tfpi e métodos de uso
RU2562114C2 (ru) 2008-12-22 2015-09-10 Ново Нордиск А/С Антитела против ингибитора метаболического пути тканевого фактора
US8637454B2 (en) * 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
US9206410B2 (en) 2009-03-03 2015-12-08 Grifols Therapeutics Inc. Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom
CN101588509B (zh) * 2009-06-23 2011-08-24 硅谷数模半导体（北京）有限公司 视频图像编码和解码方法
CA2767858C (fr) 2009-07-15 2019-02-12 Portola Pharmaceuticals, Inc. Formulation de dose unique d'antidotes pour des inhibiteurs de facteur xa et procedes d'utilisation de celle-ci
ES2905545T3 (es) 2010-01-06 2022-04-11 Takeda Pharmaceuticals Co Proteínas de unión a calicreína plasmática
DK2542257T3 (en) 2010-03-01 2017-10-16 Bayer Healthcare Llc OPTIMIZED MONOCLONAL ANTIBODIES AGAINST Tissue FACTOR ROAD INHIBITOR (TFPI)
ES2983470T3 (es) 2010-03-19 2024-10-23 Takeda Pharmaceuticals Co Inhibidores del TFPI y métodos de uso
KR102502293B1 (ko) 2011-01-06 2023-02-21 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
US11448657B2 (en) * 2011-01-18 2022-09-20 Rambam Med-Tech Methods and kits for assessing Heparanase procoagulant activity, compositions comprising Heparanase, and methods for the treatment of coagulation-related disorders
WO2013016449A2 (fr) 2011-07-26 2013-01-31 Indicator Systems International, Inc. Essais pour la détection de microbes
EP3626254A1 (fr) 2012-03-16 2020-03-25 University Health Network Protéine toso soluble et son utilisation dans le traitement des maladies auto-immunes
JP2015514070A (ja) 2012-03-21 2015-05-18 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Ｔｆｐｉ阻害剤および使用方法
EP2970434B1 (fr) * 2013-03-15 2018-12-05 The Regents of The University of California Inhibiteur de fibrinolyse du type kunitz, puissant et à double réactivité
CA2941697A1 (fr) 2014-03-07 2015-09-11 University Health Network Procedes et compositions pour modifier une reponse immunitaire
CA2942713A1 (fr) 2014-03-27 2015-10-01 Dyax Corp. Compositions et procedes pour le traitement de l'oedeme maculaire diabetique
US10287338B2 (en) 2015-07-10 2019-05-14 Miran NERSISSIAN Factor VIII protein compositions and methods of treating of hemophilia A
US10940204B2 (en) 2015-07-31 2021-03-09 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
WO2017066719A2 (fr) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Agents spécifiques interférant avec hu
EA201891388A1 (ru) 2015-12-11 2018-11-30 Дайэкс Корп. Ингибиторы калликреина плазмы и их применение для лечения обострения наследственного ангионевротического отека
US11564982B2 (en) 2017-01-04 2023-01-31 Research Institute At Nationwide Children's Hospital DNABII vaccines and antibodies with enhanced activity
CA3049114A1 (fr) 2017-01-04 2018-07-12 Lauren O. Bakaletz Fragments d'anticorps pour le traitement de troubles lies au biofilm
CA3056088A1 (fr) 2017-03-15 2018-09-20 Research Institute At Nationwide Children's Hospital Composition et procedes de rupture de biofilms bacteriens sans inflammation associee
CA3145385A1 (fr) 2019-07-08 2021-01-14 Steven D. Goodman Compositions d'anticorps pour detruire des biofilms
CN112206310B (zh) * 2020-09-23 2022-10-21 湖北医药学院 一组用于抑制补体的寄生绦虫多肽

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Also Published As

Publication number Publication date
US5728674A (en) 1998-03-17
US5914315A (en) 1999-06-22
CN1139955A (zh) 1997-01-08
FI961886A (fi) 1996-07-03
JP3201527B2 (ja) 2001-08-20
CN1073159C (zh) 2001-10-17
US20050004021A1 (en) 2005-01-06
ATE262587T1 (de) 2004-04-15
CA2175797A1 (fr) 1995-05-11
JPH09504696A (ja) 1997-05-13
US7541449B2 (en) 2009-06-02
US20020098560A1 (en) 2002-07-25
AU8131294A (en) 1995-05-23
EP0726953B1 (fr) 2004-03-24
US6656746B2 (en) 2003-12-02
DE69433647T2 (de) 2004-08-05
KR100243989B1 (ko) 2000-02-01
WO1995012674A1 (fr) 1995-05-11
US20040253686A1 (en) 2004-12-16
KR960705850A (ko) 1996-11-08
US20070092948A1 (en) 2007-04-26
NO961812D0 (no) 1996-05-03
CA2175797C (fr) 2000-07-18
AU685190B2 (en) 1998-01-15
DE69433647D1 (de) 2004-04-29
FI961886A0 (fi) 1996-05-03
US5455338A (en) 1995-10-03
EP0726953A1 (fr) 1996-08-21

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