NO961345D0 - O-aryl, O-alkyl-, O-alkenyl- og O-alkynylmakrolider med immunundertrykkende aktivitet - Google Patents
O-aryl, O-alkyl-, O-alkenyl- og O-alkynylmakrolider med immunundertrykkende aktivitetInfo
- Publication number
- NO961345D0 NO961345D0 NO961345A NO961345A NO961345D0 NO 961345 D0 NO961345 D0 NO 961345D0 NO 961345 A NO961345 A NO 961345A NO 961345 A NO961345 A NO 961345A NO 961345 D0 NO961345 D0 NO 961345D0
- Authority
- NO
- Norway
- Prior art keywords
- alkenyl
- aryl
- alkyl
- immunosuppressive activity
- alkynyl macrolides
- Prior art date
Links
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- 239000003120 macrolide antibiotic agent Substances 0.000 title 1
- 229940041033 macrolides Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Color Printing (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/132,072 US5565560A (en) | 1991-05-13 | 1993-10-04 | O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
PCT/US1994/011114 WO1995009857A1 (en) | 1993-10-04 | 1994-09-30 | O-aryl, o-alkyl, o-alkenyl and o-alkynyl-macrolides having immunosuppressive activity |
Publications (2)
Publication Number | Publication Date |
---|---|
NO961345D0 true NO961345D0 (no) | 1996-04-02 |
NO961345L NO961345L (no) | 1996-06-03 |
Family
ID=22452330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO961345A NO961345L (no) | 1993-10-04 | 1996-04-02 | O-aryl, O-alkyl-, O-alkenyl- og O-alkynylmakrolider med immunundertrykkende aktivitet |
Country Status (18)
Country | Link |
---|---|
US (2) | US5565560A (no) |
EP (1) | EP0722448A4 (no) |
JP (1) | JPH09503507A (no) |
KR (1) | KR960704896A (no) |
CN (1) | CN1137275A (no) |
AU (1) | AU690157B2 (no) |
BG (1) | BG100474A (no) |
BR (1) | BR9407720A (no) |
CA (1) | CA2172124A1 (no) |
CZ (1) | CZ99396A3 (no) |
FI (1) | FI961496A0 (no) |
HU (1) | HUT74591A (no) |
LV (1) | LV11547B (no) |
NO (1) | NO961345L (no) |
NZ (1) | NZ275203A (no) |
PL (1) | PL313870A1 (no) |
SK (1) | SK43096A3 (no) |
WO (1) | WO1995009857A1 (no) |
Families Citing this family (51)
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US5563172A (en) * | 1991-09-05 | 1996-10-08 | Abbott Laboratories | Macrocyclic amide and urea immunomodulators |
EP0689545A4 (en) * | 1993-03-17 | 1996-04-24 | Abbott Lab | IMMUNOREGULATORS WITH MACROCYCLIC AMIDE AND UREA |
US5693648A (en) * | 1994-09-30 | 1997-12-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity |
US6413967B1 (en) * | 1995-03-30 | 2002-07-02 | The University Of Virginia Patents Foundation | Inhibition of novel calcium entry pathway in electrically non-excitable cells acting as an anti-proliferative therapy |
US6274602B1 (en) | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
US6271244B1 (en) | 1998-06-03 | 2001-08-07 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6187784B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Pipecolic acid derivative hair growth compositions and uses |
US6187796B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Sulfone hair growth compositions and uses |
US20010049381A1 (en) * | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
US6172087B1 (en) | 1998-06-03 | 2001-01-09 | Gpi Nil Holding, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
US6274617B1 (en) * | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic ester and amide hair growth compositions and uses |
US6429215B1 (en) | 1998-06-03 | 2002-08-06 | Gpi Nil Holdings, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
US6333340B1 (en) | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6399648B1 (en) | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
US6506788B1 (en) | 1998-08-14 | 2003-01-14 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders |
US6384056B1 (en) | 1998-08-14 | 2002-05-07 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters or ketones for vision and memory disorders |
US6337340B1 (en) | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
US6335348B1 (en) | 1998-08-14 | 2002-01-01 | Gpi Nil Holdings, Inc. | Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US7338976B1 (en) | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
US7410995B1 (en) | 1998-08-14 | 2008-08-12 | Gpi Nil Holdings Inc. | N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders |
US7265150B1 (en) | 1998-08-14 | 2007-09-04 | Gpi Nil Holdings Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders |
US6376517B1 (en) | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
AU2007237187B2 (en) * | 2002-07-16 | 2010-08-05 | Biotica Technology Limited | Production of polyketides |
PT1539157E (pt) * | 2002-09-18 | 2013-10-04 | Univ Pennsylvania | Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal |
DE10250870A1 (de) * | 2002-10-31 | 2004-05-13 | Switch Biotech Ag | Zusammensetzung enthaltend Aktivatoren von IK-Kaliumkanälen und Calcineurin-Antagonisten und deren Verwendung |
EP1682132A1 (en) * | 2003-09-18 | 2006-07-26 | Macusight, Inc. | Transscleral delivery |
TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
CA2571899A1 (en) * | 2004-07-01 | 2006-08-03 | Yale University | Targeted and high density drug loaded polymeric materials |
MX2007008662A (es) | 2005-01-20 | 2007-09-06 | Array Biopharma Inc | Analogos macrociclicos para el tratamiento de trastornos inmunorreguladores y enfermedades respiratorias. |
EP1848431B1 (en) | 2005-02-09 | 2016-02-03 | Santen Pharmaceutical Co., Ltd. | Liquid formulations for treatment of diseases or conditions |
US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
PT1889198E (pt) | 2005-04-28 | 2015-03-06 | Proteus Digital Health Inc | Sistema fármaco-informático |
WO2007092620A2 (en) | 2006-02-09 | 2007-08-16 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
ES2563288T3 (es) | 2006-03-23 | 2016-03-14 | Santen Pharmaceutical Co., Ltd | Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular |
WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
US10265407B2 (en) | 2007-02-15 | 2019-04-23 | Yale University | Modular nanodevices for smart adaptable vaccines |
WO2008109347A2 (en) * | 2007-03-02 | 2008-09-12 | Yale University | Methods for ex vivo administration of drugs to grafts using polymeric nanoparticles |
US20080265343A1 (en) * | 2007-04-26 | 2008-10-30 | International Business Machines Corporation | Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof |
WO2010021681A2 (en) * | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
EP2841098A4 (en) | 2012-04-23 | 2016-03-02 | Allertein Therapeutics Llc | NANOPARTICLES FOR THE TREATMENT OF ALLERGIES |
CN105188741A (zh) | 2013-04-03 | 2015-12-23 | 阿勒丁医疗公司 | 新型纳米颗粒组合物 |
WO2015073691A1 (en) | 2013-11-14 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of bmp signaling |
US10981951B2 (en) | 2014-01-31 | 2021-04-20 | Mayo Foundation For Medical Education And Research | Therapeutics for the treatment of glaucoma |
CN115768419A (zh) * | 2020-02-07 | 2023-03-07 | 奎拉里斯生物公司 | 用于色满卡林前药治疗的改进方法和组合物 |
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US3244592A (en) * | 1962-06-09 | 1966-04-05 | Arai Tadashi | Ascomycin and process for its production |
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US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
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WO1991002736A1 (en) * | 1989-08-18 | 1991-03-07 | Fisons Plc | Macrocyclic compounds |
EP0413532A3 (en) * | 1989-08-18 | 1991-05-15 | Fisons Plc | Macrocyclic compounds |
GR1001225B (el) * | 1989-09-14 | 1993-06-30 | Fisons Plc | Νέαι μακροκυκλικαί ενώσεις και νέα μέ?οδος χρήσεως τους. |
KR0159766B1 (ko) * | 1989-10-16 | 1998-12-01 | 후지사와 토모키치로 | 양모제 조성물 |
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GB8925797D0 (en) * | 1989-11-15 | 1990-01-04 | Fisons Plc | Compositions |
US5064835A (en) * | 1990-03-01 | 1991-11-12 | Merck & Co., Inc. | Hydroxymacrolide derivatives having immunosuppressive activity |
KR0177158B1 (ko) * | 1990-03-01 | 1999-03-20 | 후지사와 도모기찌로 | 면역억제 활성을 갖는 트리사이클릭 화합물 함유 용액 제제 |
WO1991013899A1 (en) * | 1990-03-12 | 1991-09-19 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclo compounds |
EP0594600A1 (en) * | 1990-03-13 | 1994-05-04 | FISONS plc | Immunosuppressive macrocyclic compounds |
CA2044846A1 (en) * | 1990-06-25 | 1991-12-26 | Thomas R. Beattie | Antagonists of immunosuppressive macrolides |
GB9014136D0 (en) * | 1990-06-25 | 1990-08-15 | Fujisawa Pharmaceutical Co | Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same |
US5190950A (en) * | 1990-06-25 | 1993-03-02 | Merck & Co., Inc. | Antagonists of immunosuppressive macrolides |
GB2245891A (en) * | 1990-07-09 | 1992-01-15 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
WO1992003441A1 (en) * | 1990-08-18 | 1992-03-05 | Fisons Plc | Macrocyclic compounds |
PT98990A (pt) * | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
US5118678A (en) * | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
US5262533A (en) * | 1991-05-13 | 1993-11-16 | Merck & Co., Inc. | Amino O-aryl macrolides having immunosuppressive activity |
US5162334A (en) * | 1991-05-13 | 1992-11-10 | Merck & Co., Inc. | Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity |
US5250678A (en) * | 1991-05-13 | 1993-10-05 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
US5118677A (en) * | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
US5189042A (en) * | 1991-08-22 | 1993-02-23 | Merck & Co. Inc. | Fluoromacrolides having immunosuppressive activity |
US5208241A (en) * | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
US5247076A (en) * | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
US5252732A (en) * | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
-
1993
- 1993-10-04 US US08/132,072 patent/US5565560A/en not_active Expired - Fee Related
-
1994
- 1994-09-30 CZ CZ96993A patent/CZ99396A3/cs unknown
- 1994-09-30 PL PL94313870A patent/PL313870A1/xx unknown
- 1994-09-30 CN CN94194139A patent/CN1137275A/zh active Pending
- 1994-09-30 HU HU9600870A patent/HUT74591A/hu unknown
- 1994-09-30 WO PCT/US1994/011114 patent/WO1995009857A1/en not_active Application Discontinuation
- 1994-09-30 EP EP94931789A patent/EP0722448A4/en not_active Withdrawn
- 1994-09-30 AU AU80737/94A patent/AU690157B2/en not_active Ceased
- 1994-09-30 BR BR9407720A patent/BR9407720A/pt not_active Application Discontinuation
- 1994-09-30 SK SK430-96A patent/SK43096A3/sk unknown
- 1994-09-30 CA CA002172124A patent/CA2172124A1/en not_active Abandoned
- 1994-09-30 NZ NZ275203A patent/NZ275203A/en unknown
- 1994-09-30 JP JP7510920A patent/JPH09503507A/ja active Pending
-
1995
- 1995-05-12 US US08/440,180 patent/US5532248A/en not_active Expired - Fee Related
-
1996
- 1996-04-02 NO NO961345A patent/NO961345L/no unknown
- 1996-04-03 FI FI961496A patent/FI961496A0/fi unknown
- 1996-04-03 BG BG100474A patent/BG100474A/xx unknown
- 1996-04-04 KR KR1019960701760A patent/KR960704896A/ko not_active Application Discontinuation
- 1996-04-15 LV LVP-96-112A patent/LV11547B/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR9407720A (pt) | 1997-03-04 |
HU9600870D0 (en) | 1996-06-28 |
EP0722448A4 (en) | 1998-04-29 |
SK43096A3 (en) | 1996-10-02 |
CN1137275A (zh) | 1996-12-04 |
AU8073794A (en) | 1995-05-01 |
PL313870A1 (en) | 1996-07-22 |
CZ99396A3 (en) | 1996-09-11 |
LV11547B (en) | 1997-02-20 |
CA2172124A1 (en) | 1995-04-13 |
FI961496A (fi) | 1996-04-03 |
FI961496A0 (fi) | 1996-04-03 |
US5565560A (en) | 1996-10-15 |
NZ275203A (en) | 1998-01-26 |
EP0722448A1 (en) | 1996-07-24 |
BG100474A (en) | 1996-12-31 |
KR960704896A (ko) | 1996-10-09 |
JPH09503507A (ja) | 1997-04-08 |
HUT74591A (en) | 1997-01-28 |
AU690157B2 (en) | 1998-04-23 |
US5532248A (en) | 1996-07-02 |
LV11547A (lv) | 1996-10-20 |
NO961345L (no) | 1996-06-03 |
WO1995009857A1 (en) | 1995-04-13 |
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