NO960303D0 - Antisens-oligonukleotidhemming av ekspresjon av vaskulær endotelial vekstfaktor - Google Patents
Antisens-oligonukleotidhemming av ekspresjon av vaskulær endotelial vekstfaktorInfo
- Publication number
- NO960303D0 NO960303D0 NO960303A NO960303A NO960303D0 NO 960303 D0 NO960303 D0 NO 960303D0 NO 960303 A NO960303 A NO 960303A NO 960303 A NO960303 A NO 960303A NO 960303 D0 NO960303 D0 NO 960303D0
- Authority
- NO
- Norway
- Prior art keywords
- growth factor
- vascular endothelial
- antisense oligonucleotide
- endothelial growth
- factor expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
- C12N2310/3125—Methylphosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/316—Phosphonothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/098,942 US6410322B1 (en) | 1993-07-27 | 1993-07-27 | Antisense oligonucleotide inhibition of vascular endothelial growth factor expression |
PCT/US1994/008537 WO1995004142A2 (en) | 1993-07-27 | 1994-07-26 | Antisense oligonucleotide inhibition of vascular endothelial growth factor expression |
Publications (2)
Publication Number | Publication Date |
---|---|
NO960303D0 true NO960303D0 (no) | 1996-01-25 |
NO960303L NO960303L (no) | 1996-03-13 |
Family
ID=22271667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO960303A NO960303L (no) | 1993-07-27 | 1996-01-25 | Antisens-oligonukleotidhemming av ekspresjon av vaskulær endotelial vekstfaktor |
Country Status (9)
Country | Link |
---|---|
US (1) | US6410322B1 (no) |
EP (1) | EP0711343A1 (no) |
JP (1) | JPH09503651A (no) |
CN (1) | CN1131437A (no) |
AU (1) | AU7516894A (no) |
CA (1) | CA2167680A1 (no) |
FI (1) | FI960374A (no) |
NO (1) | NO960303L (no) |
WO (1) | WO1995004142A2 (no) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7238673B2 (en) * | 1989-03-31 | 2007-07-03 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
US5731294A (en) * | 1993-07-27 | 1998-03-24 | Hybridon, Inc. | Inhibition of neovasularization using VEGF-specific oligonucleotides |
US5639872A (en) * | 1993-07-27 | 1997-06-17 | Hybridon, Inc. | Human VEGF-specific oligonucleotides |
US5641756A (en) * | 1993-07-27 | 1997-06-24 | Hybridon, Inc. | Modified VEGF oligonucleotides |
EP0769552A4 (en) * | 1994-06-27 | 1997-06-18 | Toagosei Co Ltd | ANTISENSE NUCLEIC ACID COMPOUND |
EP0859636A4 (en) * | 1995-10-23 | 2002-05-02 | Hyal Pharmaceutical Australia | HYALURONIC ACID USED AS A DNA CARRIER FOR GENE THERAPY AND ANTI-SENSE DNA OF THE VASCULAR ENDOTHELIUM GROWTH FACTOR FOR THE TREATMENT OF ABNORMAL RETINA VASCULARIZATION |
AU721060B2 (en) * | 1995-10-23 | 2000-06-22 | Meditech Research Limited | Hyaluronic acid as DNA carrier for gene therapy and VEGF antisense DNA to treat abnormal retinal vascularization |
US7034009B2 (en) | 1995-10-26 | 2006-04-25 | Sirna Therapeutics, Inc. | Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R) |
AU769175B2 (en) * | 1995-10-26 | 2004-01-15 | Chiron Corporation | Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor |
US6346398B1 (en) | 1995-10-26 | 2002-02-12 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor |
AU1686997A (en) * | 1995-12-08 | 1997-06-27 | Hybridon, Inc. | Modified vegf antisense oligonucleotides for treatment of skin disorders |
JP2000501941A (ja) * | 1995-12-08 | 2000-02-22 | ハイブリドン・インコーポレイテッド | 修飾vegfアンチセンスオリゴヌクレオチド |
AU2733697A (en) * | 1996-04-17 | 1997-11-07 | Aronex Pharmaceuticals, Inc. | Antisense inhibitors of vascular endothelial growth factor (vegf/vpf) expression |
US6790443B2 (en) * | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
EP1017421B1 (en) | 1997-03-07 | 2005-05-25 | The Wistar Institute Of Anatomy And Biology | Use of adenoviral vectors expressing VEGF or PDGF FOR HEALING TISSUE DEFECTS AND INDUCING HYPERVASCULARITY IN MAMMALIAN TISSUE |
WO1998048009A2 (en) * | 1997-04-21 | 1998-10-29 | University Of Florida | Materials and methods for ribozyme treatment of retinal diseases |
CN1063755C (zh) * | 1997-07-24 | 2001-03-28 | 中国科学院上海生物化学研究所 | 血管内皮细胞生长因子反义寡聚脱氧核苷酸 |
JPH1142091A (ja) * | 1997-07-25 | 1999-02-16 | Toagosei Co Ltd | アンチセンス核酸化合物 |
EP1017389A1 (en) * | 1997-08-25 | 2000-07-12 | Harold Brem | Prevention of adhesions and excessive scar formation using angiogenesis inhibitors |
CN1069322C (zh) * | 1997-12-12 | 2001-08-08 | 中国人民解放军军事医学科学院放射医学研究所 | 反义寡核苷酸及用途 |
CN1057301C (zh) * | 1997-12-30 | 2000-10-11 | 杭州赛狮生物技术开发有限公司北京分公司 | 抑制人体肿瘤细胞生长的反义寡核苷酸 |
CN1056380C (zh) * | 1998-02-27 | 2000-09-13 | 中科院成都地奥制药公司 | 抑制人体恶性肿瘤生长的反义寡核苷酸 |
DE19813774A1 (de) * | 1998-03-27 | 1999-09-30 | Max Planck Gesellschaft | Parapockenvirus-kodierter vaskulärer Endothelzell Wachstumsfaktor (PPV-VEGF) |
EP0979869A1 (en) * | 1998-08-07 | 2000-02-16 | Hoechst Marion Roussel Deutschland GmbH | Short oligonucleotides for the inhibition of VEGF expression |
ATE252387T1 (de) * | 1998-11-23 | 2003-11-15 | Novartis Pharma Gmbh | Verwendung von staurosporine derivaten zur behandlung von okularen neovaskularen erkrankungen |
AU4807400A (en) | 1999-04-30 | 2000-11-17 | University Of Florida | Adeno-associated virus-delivered ribozyme compositions and methods of use |
EP1564292A1 (en) * | 2000-01-19 | 2005-08-17 | Parkash S. Gill | Pharmaceutical compositions and methods of treatment based on VEGF antisense oligonucleotides |
WO2002081628A2 (en) | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
EP1311277A4 (en) * | 2000-07-18 | 2004-08-25 | Joslin Diabetes Center Inc | FIBROSIS MODULATION METHOD |
US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
US7109165B2 (en) | 2001-05-18 | 2006-09-19 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
US20050148530A1 (en) | 2002-02-20 | 2005-07-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US20030207834A1 (en) * | 2001-07-10 | 2003-11-06 | Dale Roderic M.K. | Oligonucleotide-containing pharmacological compositions and their use |
JP4689956B2 (ja) * | 2001-08-01 | 2011-06-01 | ユニバーシティ オブ ブリストル | 増殖因子イソ型 |
AU2002331669A1 (en) | 2001-08-23 | 2003-03-10 | The Wistar Institute Of Anatomy And Biology | An organotypic intestinal culture and methods of use thereof |
US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
AU2003207708A1 (en) * | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
EP1495120B1 (en) | 2002-04-18 | 2012-10-10 | Acuity Pharmaceuticals, Inc | Means and methods for the specific modulation of target genes in the eye |
US7435419B2 (en) | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
CA2922031C (en) * | 2002-07-19 | 2020-12-15 | Beth Israel Deaconess Medical Center, Inc. | Methods of diagnosing and treating pre-eclampsia or eclampsia |
US7335362B2 (en) * | 2002-07-19 | 2008-02-26 | Beth Israel Deaconess Medical Center | Methods of treating pre-eclampsia or eclampsia |
US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
AU2003295600A1 (en) * | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
WO2006006948A2 (en) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
WO2005000223A2 (en) * | 2003-06-04 | 2005-01-06 | Children's Medical Center Corporation | Method of treating retinopathies and disorders associated with blood vessel loss |
JP4951339B2 (ja) | 2003-08-27 | 2012-06-13 | オプソテツク・コーポレイシヨン | 眼血管新生疾患の治療のための併用療法 |
EP1713915B1 (en) | 2004-02-10 | 2009-12-16 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING MULTIFUNCTIONAL SHORT INTERFERING NUCLEIC ACID (MULTIFUNCTIONAL siNA) |
WO2005110462A2 (en) * | 2004-05-04 | 2005-11-24 | Children's Medical Center Corporation | Methods and compositions for treatment of preeclampsia |
US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
DE602005024850D1 (de) * | 2004-09-24 | 2010-12-30 | Beth Israel Hospital | Verfahren zur diagnose und behandlung von schwangerschaftsskomplikationen |
US7740849B2 (en) * | 2004-09-24 | 2010-06-22 | Beth Israel Deaconess Medical Center | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders |
US7955805B2 (en) * | 2004-12-15 | 2011-06-07 | Beth Israel Deaconess Medical Center | Nucleic acids and polypeptides useful for diagnosing complications of pregnancy |
WO2007013704A1 (en) * | 2005-07-27 | 2007-02-01 | Juseong College Industry Academy Cooperation Group | Recombinant adeno-associated virus comprising antisense cdnas of vegf-a, vegf-b and vegf-c and gene therapeutic agent specific to large intestine cancer, bladder cancer and/or lung cancer comprising the same |
WO2007058323A1 (ja) * | 2005-11-17 | 2007-05-24 | Napa Jenomics Co., Ltd. | 核酸ホモポリマー結合機能性核酸医薬品の製造法 |
CN100371444C (zh) * | 2005-12-12 | 2008-02-27 | 清华大学深圳研究生院 | 一种抑制VEGF表达的siRNA及其应用 |
US20090286271A1 (en) * | 2006-05-31 | 2009-11-19 | Karumanchi Ananth S | Methods of Diagnosing and Treating Complications of Pregnancy |
EP2235189A1 (en) * | 2008-01-14 | 2010-10-06 | Genentech, Inc. | Methods for inhibiting angiogenesis using egfl8 antagonists |
US8927511B2 (en) * | 2008-12-04 | 2015-01-06 | Curna, Inc. | Treatment of vascular endothelial growth factor (VEGF) related diseases by inhibition of natural antisense transcript to VEGF |
JP5832293B2 (ja) | 2008-12-04 | 2015-12-16 | オプコ ファーマシューティカルズ、エルエルシー | 血管新生促進vegfイソ型を選択的に抑制する組成物および方法 |
WO2010129799A2 (en) * | 2009-05-06 | 2010-11-11 | Curna, Inc. | Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene |
RU2013102545A (ru) | 2010-07-28 | 2014-09-10 | Алкон Ресерч, Лтд. | Связывающая vegfa си-рнк и способы лечения in vivo |
EP2609198B8 (en) | 2010-08-24 | 2018-03-28 | Sirna Therapeutics, Inc. | SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER |
EP2632472B1 (en) | 2010-10-29 | 2017-12-13 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina) |
CN110193009A (zh) | 2013-07-12 | 2019-09-03 | 伊维希比奥公司 | 用于治疗或预防眼科病的方法 |
EP3279325A4 (en) | 2015-03-30 | 2018-11-21 | Nissan Chemical Corporation | Nucleic acid aptamer capable of bonding to vascular endothelial growth factor receptor |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4456550A (en) | 1982-11-22 | 1984-06-26 | President And Fellows Of Harvard College | Vascular permeability factor |
US5220007A (en) | 1990-02-15 | 1993-06-15 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of RNA and production of encoded polypeptides |
US5149797A (en) * | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
-
1993
- 1993-07-27 US US08/098,942 patent/US6410322B1/en not_active Expired - Fee Related
-
1994
- 1994-07-26 JP JP7505976A patent/JPH09503651A/ja active Pending
- 1994-07-26 AU AU75168/94A patent/AU7516894A/en not_active Abandoned
- 1994-07-26 CA CA002167680A patent/CA2167680A1/en not_active Abandoned
- 1994-07-26 CN CN94193482A patent/CN1131437A/zh active Pending
- 1994-07-26 EP EP94925136A patent/EP0711343A1/en not_active Withdrawn
- 1994-07-26 WO PCT/US1994/008537 patent/WO1995004142A2/en not_active Application Discontinuation
-
1996
- 1996-01-25 NO NO960303A patent/NO960303L/no unknown
- 1996-01-26 FI FI960374A patent/FI960374A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1131437A (zh) | 1996-09-18 |
US6410322B1 (en) | 2002-06-25 |
WO1995004142A2 (en) | 1995-02-09 |
FI960374A (fi) | 1996-03-25 |
JPH09503651A (ja) | 1997-04-15 |
AU7516894A (en) | 1995-02-28 |
FI960374A0 (fi) | 1996-01-26 |
EP0711343A1 (en) | 1996-05-15 |
WO1995004142A3 (en) | 1995-03-23 |
NO960303L (no) | 1996-03-13 |
CA2167680A1 (en) | 1995-02-09 |
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