NO960303L - Antisens-oligonukleotidhemming av ekspresjon av vaskulær endotelial vekstfaktor - Google Patents

Antisens-oligonukleotidhemming av ekspresjon av vaskulær endotelial vekstfaktor

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Publication number
NO960303L
NO960303L NO960303A NO960303A NO960303L NO 960303 L NO960303 L NO 960303L NO 960303 A NO960303 A NO 960303A NO 960303 A NO960303 A NO 960303A NO 960303 L NO960303 L NO 960303L
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Norway
Prior art keywords
vegf
growth factor
endothelial growth
vascular endothelial
oligonucleotides
Prior art date
Application number
NO960303A
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English (en)
Other versions
NO960303D0 (no
Inventor
Gregory S Robinson
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Publication of NO960303D0 publication Critical patent/NO960303D0/no
Publication of NO960303L publication Critical patent/NO960303L/no

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/53—Physical structure partially self-complementary or closed

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Biophysics (AREA)
  • Endocrinology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Vaskulær endotelial vekstfaktor (VEGF), også kjent som vaskulær permeabilitetsfaktor (VPF), har blitt vist å spille en viktig rolle l abnormal anglogenese forbundet med forskjellige patologiske tilstander. Det blir her beskrevet forbindelser, sammensetninger og fremgangs- måter for hemming av silke abnormale anglogenser. Spesielt blir det beskrevet flere antlsens-ollgonukleo- tlder fra 19 til 21 baser lange som binder til VEGF RNA, og som hemmer produksjon av ekspresjonsproduktet. Disse antlsens-oligonukletidene er nyttige i behand- lingen av patologiske tilstander i hvilke VEGF-ekspre- sjon spiller en rolle. Oligonukleotidene er komplementere til deler av VEGF mRNA og VEGF genet, deriblant til start- og stoppsekvenser. Oliognukleotidene er stabilisert ved at forsfodiesterbindingene er modifisert (fosforthioatintemukleotidbindinger).
NO960303A 1993-07-27 1996-01-25 Antisens-oligonukleotidhemming av ekspresjon av vaskulær endotelial vekstfaktor NO960303L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/098,942 US6410322B1 (en) 1993-07-27 1993-07-27 Antisense oligonucleotide inhibition of vascular endothelial growth factor expression
PCT/US1994/008537 WO1995004142A2 (en) 1993-07-27 1994-07-26 Antisense oligonucleotide inhibition of vascular endothelial growth factor expression

Publications (2)

Publication Number Publication Date
NO960303D0 NO960303D0 (no) 1996-01-25
NO960303L true NO960303L (no) 1996-03-13

Family

ID=22271667

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960303A NO960303L (no) 1993-07-27 1996-01-25 Antisens-oligonukleotidhemming av ekspresjon av vaskulær endotelial vekstfaktor

Country Status (9)

Country Link
US (1) US6410322B1 (no)
EP (1) EP0711343A1 (no)
JP (1) JPH09503651A (no)
CN (1) CN1131437A (no)
AU (1) AU7516894A (no)
CA (1) CA2167680A1 (no)
FI (1) FI960374A (no)
NO (1) NO960303L (no)
WO (1) WO1995004142A2 (no)

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Also Published As

Publication number Publication date
AU7516894A (en) 1995-02-28
CA2167680A1 (en) 1995-02-09
WO1995004142A2 (en) 1995-02-09
FI960374A (fi) 1996-03-25
FI960374A0 (fi) 1996-01-26
US6410322B1 (en) 2002-06-25
CN1131437A (zh) 1996-09-18
EP0711343A1 (en) 1996-05-15
NO960303D0 (no) 1996-01-25
JPH09503651A (ja) 1997-04-15
WO1995004142A3 (en) 1995-03-23

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