NO960256L - Ekspresjon, rensing og refolding av Neisseria Meningitidis ytre membran gruppe B protein proteiner - Google Patents
Ekspresjon, rensing og refolding av Neisseria Meningitidis ytre membran gruppe B protein proteinerInfo
- Publication number
- NO960256L NO960256L NO960256A NO960256A NO960256L NO 960256 L NO960256 L NO 960256L NO 960256 A NO960256 A NO 960256A NO 960256 A NO960256 A NO 960256A NO 960256 L NO960256 L NO 960256L
- Authority
- NO
- Norway
- Prior art keywords
- refolding
- purification
- expression
- outer membrane
- neisseria meningitidis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/096,182 US5439808A (en) | 1993-07-23 | 1993-07-23 | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| PCT/US1994/008327 WO1995003413A1 (fr) | 1993-07-23 | 1994-07-22 | Expression a haut niveau, purification et repliement des proteines porines du groupe b de membrane externe de neisseria meningitidis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO960256D0 NO960256D0 (no) | 1996-01-22 |
| NO960256L true NO960256L (no) | 1996-03-20 |
Family
ID=22256136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO960256A NO960256L (no) | 1993-07-23 | 1996-01-22 | Ekspresjon, rensing og refolding av Neisseria Meningitidis ytre membran gruppe B protein proteiner |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US5439808A (fr) |
| EP (1) | EP0713530A4 (fr) |
| JP (1) | JPH09500538A (fr) |
| AU (1) | AU690570B2 (fr) |
| BR (1) | BR9407092A (fr) |
| CA (1) | CA2167677A1 (fr) |
| FI (1) | FI960309A7 (fr) |
| NO (1) | NO960256L (fr) |
| NZ (1) | NZ269996A (fr) |
| PL (1) | PL182573B1 (fr) |
| RU (1) | RU2181378C2 (fr) |
| WO (1) | WO1995003413A1 (fr) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6153406A (en) * | 1993-07-23 | 2000-11-28 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B |
| US5830479A (en) * | 1994-02-09 | 1998-11-03 | Willmar Poultry Company, Inc. | Active immunization using a siderophore receptor protein |
| EP0749321B1 (fr) * | 1994-02-09 | 2007-01-24 | Epitopix LLC | Immunisation active au moyen d'un recepteur proteique de siderophore |
| EP0817647A4 (fr) * | 1995-03-24 | 2002-10-30 | Promega Corp | Traitement contre escherichia coli producteur de verotoxines |
| US6284884B1 (en) | 1995-06-07 | 2001-09-04 | North American Vaccine, Inc. | Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof |
| PL328096A1 (en) * | 1996-02-01 | 1999-01-04 | North American Vaccine | Expression of external membrane (mb3) protein of neisseria meningitidis of b group in yeasts and vaccines |
| GB9614700D0 (en) | 1996-07-12 | 1996-09-04 | Medical Res Council | Over-expression of proteins in E.Coli |
| US6030810A (en) * | 1997-02-26 | 2000-02-29 | Delgado; Stephen Gregory | Cloned tetrodotoxin-sensitive sodium channel α-subunit and a splice variant thereof |
| CA2297072A1 (fr) * | 1997-07-17 | 1999-01-28 | Baxter Healthcare S.A. | Conjugues immunogenes renfermant une porine meningococcique du groupe b et un polysaccharide h. influenzae |
| RU2233172C2 (ru) * | 1997-07-17 | 2004-07-27 | Бакстэ Хелскеа С.А. | Иммуногенный коньюгат полисахарид h. influenzae - порин менингококка группы b (варианты), способ его получения, фармацевтическая композиция и способ индукции иммунного ответа у животного в отношении h.influenzae |
| SE9704175D0 (sv) * | 1997-11-14 | 1997-11-14 | Alfa Laval Agri Ab | An animal stall |
| US7335477B2 (en) * | 1997-12-24 | 2008-02-26 | The United States Of America As Represented By The Secretary Of The Navy | Truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines |
| US7638130B2 (en) * | 1997-12-24 | 2009-12-29 | The United States Of America As Represented By The Secretary Of The Navy | Truncated recombinant major outer membrane protein antigen (R56) of Orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines |
| US6482415B1 (en) * | 1997-12-24 | 2002-11-19 | The United States Of America As Represented By The Secretary Of The Navy | Expression and refolding of truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi and its use in antibody based detection assays and vaccines |
| WO1999036544A2 (fr) * | 1998-01-14 | 1999-07-22 | Chiron S.P.A. | Antigenes du $i(neisseria meningitidis) |
| US6284250B1 (en) * | 1998-02-05 | 2001-09-04 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Simplified method for removing free protein during preparation of protein-polysaccharide conjugates and vaccines using restricted-access media |
| EP2261347A3 (fr) | 1998-05-01 | 2012-01-11 | Novartis Vaccines and Diagnostics, Inc. | Antigènes de Neisseria meningitidis et compositions |
| CN1263510C (zh) * | 1998-08-19 | 2006-07-12 | 巴克斯特健康护理股份有限公司 | 多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用 |
| US20110045011A1 (en) * | 1998-12-22 | 2011-02-24 | Wei-Mei Ching | TRUNCATED RECOMBINANT MAJOR OUTER MEMBRANE PROTEIN ANTIGEN (R56) OF ORIENTIA TSUTSUGAMUSHI STRAINS KARP, KATO and GILLIAM AND ITS USE IN ANTIBODY BASED DETECTION ASSAYS AND VACCINES |
| US7081244B2 (en) * | 1999-02-22 | 2006-07-25 | Health Protection Agency | Neisserial vaccine compositions and methods |
| CA2371928C (fr) | 1999-02-22 | 2013-08-13 | Microbiological Research Authority | Compositions de vaccin a neisseria et procedes correspondants |
| CA2372235A1 (fr) | 1999-04-30 | 2000-11-09 | Rino Rappuoli | Antigenes de neisseria conserves |
| AU783894B2 (en) | 1999-05-19 | 2005-12-22 | Novartis Vaccines And Diagnostics S.R.L. | Combination neisserial compositions |
| EP1234039A2 (fr) | 1999-11-29 | 2002-08-28 | Chiron Spa | ANTIGENE DE NEISSERIA A 85kDa |
| GB9928196D0 (en) * | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| CA2871789C (fr) | 2000-01-17 | 2017-04-04 | Novartis Vaccines And Diagnostics S.R.L. | Vaccin a base de vesicule de membrane externe (omv) comprenant des proteines de membrane externe du serogroupe b de n. meningitis |
| DK1947187T5 (da) * | 2000-02-28 | 2011-10-24 | Novartis Vaccines & Diagnostic | Hybrid ekspression af neisserial-proteiner |
| CA2433561C (fr) * | 2001-01-03 | 2014-04-01 | Willmar Poultry Company, Inc. | Compositions comportant des proteines du recepteur siderophore gram negatif et methodes pour les utiliser |
| WO2002083069A2 (fr) * | 2001-04-13 | 2002-10-24 | United States Of America As Represented By The Secretary Of The Navy | Antigene tronque recombine majeur de proteine membranaire externe (r56) de souches karp, kato et gilliam d'orientia tsutsugamushi et son utilisation dans des dosages de detection bases sur des anticorps et des vaccins |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| US20040096461A1 (en) * | 2002-07-30 | 2004-05-20 | Baxter Healthcare Corporation | Chimeric multivalent polysaccharide conjugate vaccines |
| CA2493124C (fr) * | 2002-08-02 | 2014-04-29 | Glaxosmithkline Biologicals S.A. | Vaccin |
| US20040197845A1 (en) * | 2002-08-30 | 2004-10-07 | Arjang Hassibi | Methods and apparatus for pathogen detection, identification and/or quantification |
| CN1809380B (zh) | 2002-10-11 | 2010-05-12 | 启龙有限公司 | 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 |
| EP1638602A1 (fr) | 2003-06-23 | 2006-03-29 | Baxter International Inc. | Vaccins contre neisseria meningitidis du groupe y et combinaisons meningococciques desdits vaccins |
| ES2395022T3 (es) * | 2003-09-19 | 2013-02-07 | Epitopix, Llc | Polipéptidos de Campylobacter y sus métodos de uso |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| LT2682126T (lt) | 2005-01-27 | 2017-02-27 | Children`s Hospital & Research Center at Oakland | Gna1870 pagrindu gaminamos pūslelių pavidalo vakcinos, skirtos plataus spektro apsaugai nuo neisseria meningitidis sukeltų ligų |
| CA2753814C (fr) | 2009-02-27 | 2018-07-31 | Novartis Ag | Systeme de vecteurs d'expression comprenant deux marqueurs de selection |
| BR112013005626B1 (pt) | 2010-09-10 | 2022-07-26 | Glaxosmithkline Biologicals Sa | Meningococo, processo para a preparação de uma cepa meningocócica, vesículas de membrana externa, composição farmacêutica imunogênica, e, uso de uma composição |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| MX357538B (es) | 2012-06-14 | 2018-07-13 | Novartis Ag | Vacunas para meningococo de serogrupo x. |
| EP3027646B1 (fr) | 2013-07-31 | 2018-06-27 | Novartis AG | Nouveaux vecteurs de sélection et procédés de sélection de cellules hôtes eucaryotes |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US10166280B2 (en) | 2016-06-08 | 2019-01-01 | Epitopix, Llc | Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP4034157A1 (fr) | 2019-09-27 | 2022-08-03 | Pfizer Inc. | Compositions de neisseria meningitidis et méthodes associées |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4134214A (en) * | 1977-08-05 | 1979-01-16 | Merck & Co., Inc. | Freeze-drying process for the preparation of meningococcus vaccine without degradation of potency |
| US4271147A (en) * | 1980-01-10 | 1981-06-02 | Behringwerke Aktiengesellschaft | Process for the isolation of membrane proteins from Neisseria meningitidis and vaccines containing same |
| DE3070388D1 (en) * | 1980-10-02 | 1985-05-02 | Schering Corp | Injectable rabies vaccine composition and method for preparing same |
| US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4451446A (en) * | 1982-03-04 | 1984-05-29 | Smithkline-Rit | Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them |
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| ES2051909T3 (es) * | 1988-04-19 | 1994-07-01 | American Cyanamid Co | Vacuna del conjugado de polisacarido-proteina de membrana externa contra la haemophilus influenzae tipo b. |
| US5192540A (en) * | 1988-04-19 | 1993-03-09 | American Cyanamid Company | Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine |
| EP0351604B1 (fr) * | 1988-06-29 | 1994-09-14 | The Rockefeller University | Vaccins contre Neisseria |
| EP0449958B9 (fr) * | 1988-12-19 | 2003-05-28 | American Cyanamid Company | Vaccin meningocoque de la proteine de la membrane externe de la classe 1 |
| AU5343390A (en) * | 1989-03-31 | 1990-11-05 | Immunomed Corporation | Preparation of unassembled pilus subunits and vaccines containing them |
| IL95578A (en) * | 1989-09-15 | 1998-08-16 | Gen Hospital Corp | Conjugate vaccine formed from a polysaccharide and a c protein of b-streptococcus |
| ATE121947T1 (de) * | 1989-12-14 | 1995-05-15 | Ca Nat Research Council | Verbessertes meningokokkale polysaccharidkonjugatvakzin. |
| SU1761807A1 (ru) * | 1990-06-27 | 1992-09-15 | Всесоюзный научно-исследовательский институт антибиотиков | Штамм бактерий ЕSснеRIснIа coLI |
| FI903414A7 (fi) * | 1990-07-06 | 1992-01-07 | Kansanterveyslaitos | Produktion av proteiner i grampositiva bakterier. |
| CU22302A1 (es) * | 1990-09-07 | 1995-01-31 | Cigb | Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales |
| DE69133276T2 (de) * | 1990-07-16 | 2003-11-27 | University Of North Carolina At Chapel Hill, Chapel Hill | Mit der familie der hämolysin-toxine verwandte antigene eisen-ubnterdrückende proteine des n. meningitis |
| CA2047031A1 (fr) * | 1990-07-19 | 1992-01-20 | Stephen Marburg | Vaccins conjugues de peptide-polysaccharide-proteine |
| EP0467714A1 (fr) * | 1990-07-19 | 1992-01-22 | Merck & Co. Inc. | Classe II de la membrane extérieure de Neisseria meningitidis et raccins la contenant |
| JP3532563B2 (ja) * | 1990-08-23 | 2004-05-31 | ザ ユニバーシティー オブ ノースカロライナ アット チャペル ヒル | Neisseria gonorrhoeaeおよびNeisseria meningitidis由来トランスフェリン結合蛋白質 |
| CA2057536C (fr) | 1990-12-21 | 1999-10-26 | John J. Dunn | Clonage et expression des lipoproteines de borrelia |
| CA2059692C (fr) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Vaccin conjugue de polysaccharide contre les pneumocoques |
| CA2105965A1 (fr) * | 1991-03-15 | 1992-09-16 | Nelson Teng | Conjugues de vehicules immunogenes/analogues de lipides a; leur emploi comme vaccins et gammaglobulines hyperimmunes polyvalentes |
| CA2071088A1 (fr) * | 1991-06-19 | 1992-12-20 | Emilio A. Emini | Conjugues de la proteine de classe ii de la membrane externe de neisseria meningitidis et de peptides relies au vih-1, et vaccins en contenant |
| US5425946A (en) * | 1992-08-31 | 1995-06-20 | North American Vaccine, Inc. | Vaccines against group C Neisseria meningitidis |
-
1993
- 1993-07-23 US US08/096,182 patent/US5439808A/en not_active Expired - Fee Related
-
1994
- 1994-07-22 EP EP94922701A patent/EP0713530A4/fr not_active Withdrawn
- 1994-07-22 WO PCT/US1994/008327 patent/WO1995003413A1/fr not_active Ceased
- 1994-07-22 RU RU96103644/13A patent/RU2181378C2/ru not_active IP Right Cessation
- 1994-07-22 NZ NZ269996A patent/NZ269996A/en unknown
- 1994-07-22 AU AU73716/94A patent/AU690570B2/en not_active Ceased
- 1994-07-22 PL PL94312712A patent/PL182573B1/pl unknown
- 1994-07-22 CA CA002167677A patent/CA2167677A1/fr not_active Abandoned
- 1994-07-22 JP JP7505354A patent/JPH09500538A/ja active Pending
- 1994-07-22 BR BR9407092A patent/BR9407092A/pt not_active Application Discontinuation
- 1994-07-22 FI FI960309A patent/FI960309A7/fi not_active IP Right Cessation
-
1996
- 1996-01-22 NO NO960256A patent/NO960256L/no not_active Application Discontinuation
-
1997
- 1997-02-11 US US08/798,760 patent/US6013267A/en not_active Expired - Fee Related
- 1997-05-08 US US08/853,504 patent/US5879686A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2167677A1 (fr) | 1995-02-02 |
| JPH09500538A (ja) | 1997-01-21 |
| AU7371694A (en) | 1995-02-20 |
| US5879686A (en) | 1999-03-09 |
| US5439808A (en) | 1995-08-08 |
| PL182573B1 (pl) | 2002-01-31 |
| AU690570B2 (en) | 1998-04-30 |
| FI960309A0 (fi) | 1996-01-23 |
| WO1995003413A1 (fr) | 1995-02-02 |
| BR9407092A (pt) | 1996-09-03 |
| FI960309L (fi) | 1996-03-22 |
| FI960309A7 (fi) | 1996-03-22 |
| EP0713530A4 (fr) | 2002-09-18 |
| EP0713530A1 (fr) | 1996-05-29 |
| NZ269996A (en) | 1997-10-24 |
| NO960256D0 (no) | 1996-01-22 |
| PL312712A1 (en) | 1996-05-13 |
| US6013267A (en) | 2000-01-11 |
| RU2181378C2 (ru) | 2002-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO960256D0 (no) | Ekspresjon, rensing og refolding av Neisseria Meningitidis ytre membran gruppe B protein proteiner | |
| NO983474D0 (no) | Ekspresjon av gruppe B Neisseria meningsitidis yttermembran-protein (MB3) fra gjµr og vaksiner | |
| DK0539530T3 (da) | Rensningsstyret kloning af peptider | |
| ATE244016T1 (de) | Protein der ausseren membran von moraxella catarrhalis omp-106, dessen gensequenz und dessen verwendung | |
| DE69623116D1 (de) | Gasdurchlässiges membran | |
| DK470489D0 (da) | Fremgangsmaade til oprensning og foldning af rekombinante proteiner | |
| IS4345A (is) | Setin N-(indól-2-karbónýl)-b-alaninamíð, notkun þeirra og lyfjaefnablöndur | |
| AU657487B2 (en) | Nucleotide sequence coding for an outer membrane protein from neisseria meningitidis and use of said protein in vaccine preparations | |
| NO972214L (no) | Fremgangsmåte for rensing og isolering av 2'-deoksy-2',2'-difluornukleosider | |
| DE69333802T8 (de) | Äusseres membranprotein von haemophilus | |
| DK57391A (da) | Hiv proteiner og peptider til anvendelse ved diagnosticering, profylakse og behandling af aids | |
| ES2156602T3 (es) | Expresion de albumina en levaduras. | |
| NO893549L (no) | Semipermeabel membran av komposittmateriale og fremgangsmaate til fremstilling derav. | |
| HUP9802349A2 (hu) | Allergén - XCD32 fúziós fehérjék és eljárás allergiaellenes gyógyszerkészítmény előállítására | |
| DK441386A (da) | Understoettet membran og fremgangsmaade til fremstilling deraf | |
| NO960255D0 (no) | Fremgangsmåte for ekspresjon og rensing av P2 protein fra haemophilus influenzae type B | |
| DK278289D0 (da) | Ekspressionsvektorer, deres fremstilling og anvendelse til fremstilling af ufusionerede proteiner i mikroorganismer | |
| DK614086D0 (da) | Sammensat semipermeabel membran og fremstilling deraf | |
| NO991227L (no) | PTX-sensitive G-proteiner, deres fremstilling og bruk | |
| NO982734L (no) | FremgangsmÕte for rensing av rekombinant humaninterleukin-8 | |
| AU7614798A (en) | High level expression, purification and refolding of the Neisseria meningitidis outer membrane group B porin proteins | |
| DE69204136D1 (de) | Membran und Trennverfahren. | |
| NO874163D0 (no) | Fremgangsmaate for rensing av rekombinante proteiner og produkter derav. | |
| DK0845040T3 (da) | Plastidindre kappemembranmålretningspolypeptider; fremstilling og anvendelse deraf |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |